Article
Ophthalmology
Filippos Vingopoulos, Augustine Bannerman, Paul Zhou, Thomas Koch, Hannah E. Wescott, Leo Kim, Demetrios Vavvas, Joan W. Miller, John B. Miller
Summary: This study investigated the correlation between contrast sensitivity (CS) and vision-related quality of life (VRQoL) in bilateral age-related macular degeneration (AMD). The results showed that CS has a stronger correlation with NEI VFQ-25 visual function and socioemotional scales compared to visual acuity (VA), especially in patients with VA over 20/25.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Food Science & Technology
Nilushni Sivapragasam, Nilanivetha Neelakandan, H. P. Vasantha Rupasinghe
Summary: Fermented food has gained popularity as a value-added category, and blueberries are considered superfoods. However, the bioavailability of bioactives in blueberries is low. This review focuses on the fermentation processes of blueberry, and how it enhances the bioavailability of nutrients and bioactive compounds, leading to potential health benefits when consumed as fermented blueberry products.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daniela D. Herrera-Balandrano, Zhi Chai, Ruth P. Hutabarat, Trust Beta, Jin Feng, Kaiyang Ma, Dajing Li, Wuyang Huang
Summary: Blueberries are rich in bioactive anthocyanins, such as malvidin, which have antioxidant benefits and can reduce the risk of diabetes. Studies have shown that blueberry anthocyanin extract can help lower oxidative stress, increase cell viability, inhibit hyperglycemia and hyperlipidemia, and enhance AMPK signaling pathway, making it a promising functional food or medicine for diabetes treatment.
Article
Biotechnology & Applied Microbiology
Haiyang Wang, Lulu Zhai, Shouwen Wang, Botian Zheng, Honglu Hu, Xuyan Li, Shaomin Bian
Summary: In this study, the roles of MYB family in blueberry in response to anthocyanin biosynthesis were explored. A total of 437 unique MYB sequences were identified and characterized in blueberry, and their transcriptional patterns during fruit development and fruit tissues related to anthocyanin biosynthesis were investigated. The results provide valuable insights into the functional roles of VcMYBs and their regulatory mechanisms for anthocyanin production and accumulation in blueberry.
Article
Nutrition & Dietetics
Chao-wei Zhu, Han Lu, Lan-lan Du, Jing Li, Han Chen, Hui-fang Zhao, Wen-long Wu, Jian Chen, Wei-lin Li
Summary: The dual epidemic of obesity and diabetes mellitus is becoming an important worldwide public health issue. Diabesity is the term used to describe the combined detrimental health effects of both diabetes mellitus and obesity/overweight. Currently, food-derived bioactive compounds are suggested to alleviate diabesity.
FRONTIERS IN NUTRITION
(2023)
Article
Ophthalmology
Andrew W. Stacey, Mai Tsukikawa, Ido Didi Fabian, Sarah Turner, Helen Jenkinson, Vicky Smith, Zishan Naeem, Bruce Morland, John R. Ainsworth, M. Ashwin Reddy, Manoj Parulekar, Mandeep S. Sagoo
Summary: The adjuvant use of laser with systemic chemotherapy for retinoblastoma does not increase the rate of vitreous recurrence, and final visual acuity is primarily determined by the presence of tumor at the fovea rather than the use of laser therapy.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Horticulture
Zhaohui Mu, Yuchun Yang, Ayimgul Yusuyin, Yige Xu, Hui Yuan, Cheng Liu
Summary: This study investigates the mechanisms underlying striped color mutations in blueberry fruits through transcriptome analysis. Differentially expressed genes (DEGs) related to anthocyanin synthesis were found in light stripes compared to dark stripes. Further experiments revealed higher levels of anthocyanin content and expression of transcription factors related to anthocyanin synthesis in dark stripes.
Article
Biochemistry & Molecular Biology
Zening Zhang, Pengyan Qu, Siyi Hao, Ruide Li, Yongyan Zhang, Qi Zhao, Pengfei Wen, Chunzhen Cheng
Summary: In this study, we characterized and studied the CHS gene family in highbush blueberry. We identified 22 CHS genes and classified them into four subfamilies. Gene expression analysis showed that VcCHSs in subfamily I were highly expressed in late ripening stages of the fruit. By transient overexpression, we found that three VcCHSs could enhance anthocyanin accumulation and up-regulate the expression of flavonoid biosynthetic genes. Promoter analysis revealed multiple cis-acting elements and transcription factor binding sites in VcCHSs. Our study provides insights into the characteristics and functions of blueberry CHSs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Arland T. Hotchkiss, Hoa K. Chau, Gary D. Strahan, Alberto Nunez, Stefanie Simon, Andre K. White, Senghane Dieng, Eugene R. Heuberger, Madhav P. Yadav, Julie Hirsch
Summary: Blueberry pomace contains high levels of dietary fiber, protein, fat, and anthocyanins, with insoluble dietary fiber and pectin being the main components. The anthocyanin content in blueberry pomace is slightly higher than in fresh whole blueberry fruit, indicating that most anthocyanins in blueberries are attached to the pomace fiber, particularly the insoluble pectin, during and after processing.
FOOD HYDROCOLLOIDS
(2021)
Review
Medicine, General & Internal
Antony Raharja, Laurence Whitefield
Summary: Visual loss can be caused by ocular issues or optic neuropathies, and clinical evaluation relies on thorough history and examination.
Article
Plant Sciences
Yan Song, Bin Ma, Qingxun Guo, Lianxia Zhou, Xintong Zhou, Ziqing Ming, Honglin You, Chunyu Zhang
Summary: UV-B promotes the accumulation of anthocyanin and improves fruit quality in plants. Through transcriptome sequencing analysis and weighted gene co-expression network analysis, it was found that VcMYBA2 and VcMYB114 were upregulated and positively correlated with anthocyanin structural genes under UV-B radiation. The VcUVR8-VcCOP1-VcHY5 pathway enhances anthocyanin accumulation by upregulating VcMYBA2 and VcMYB114 or regulating the VcBBXs-VcMYB pathway. In contrast, VcMYB4a and VcUSP1 were downregulated under UV-B treatment, and VcMYB4a repressed UV-B-induced anthocyanin accumulation through the VcUSP1-VcMYB4a pathway.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Ophthalmology
Karen M. Wai, Filippos Vingopoulos, Itika Garg, Megan Kasetty, Rebecca F. Silverman, Raviv Katz, Ines Lains, Joan W. Miller, Deeba Husain, Demetrios G. Vavvas, Leo A. Kim, John B. Miller
Summary: The contrast sensitivity function (CSF) measured with the qCSF method was significantly reduced in eyes affected by macular disease despite good visual acuity compared to healthy control eyes. Reductions in CS thresholds were most notable at low and intermediate spatial frequencies (1.5 cpd, 3 cpd, and 6 cpd). The qCSF method shows promise as a clinical tool for quantifying subtle visual deficits that may be missed by current testing methods.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Jason Q. Core, Peiying Hua, Ebenezer Daniel, Juan E. Grunwald, Glenn Jaffe, Maureen G. Maguire, Gui-Shuang Ying
Summary: In this study, it was found that diabetic patients treated with thiazolidinediones for neovascular AMD had worse visual acuity, greater reductions in subretinal and subretinal tissue complex thickness, and a higher proportion of intraretinal fluid compared to those not taking thiazolidinediones.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Genetics & Heredity
Liangliang Tian, Liangqin Liu, Yanqin Jiang, Yiru Yang, Gangqiang Dong, Hong Yu
Summary: Blueberry is an important fruit crop worldwide, and developing superior cultivars with excellent fruit traits is essential for higher yield and meeting consumer preferences. Genetic transformation and VIGS systems like TRV-VIGS have been utilized to study fruit quality-related genes, such as VcANS, and their functions in blueberry fruits. The successful establishment of TRV-VIGS in blueberry fruits provides an effective method for functional identification of unknown genes in blueberry fruits.
Article
Nutrition & Dietetics
Stuart Richer, Steven Novil, Taylor Gullett, Avni Dervishi, Sherwin Nassiri, Co Duong, Robert Davis, Pinakin Gunvant Davey
Summary: This study found that after taking carotenoid vitamin supplements for six months, participants showed improvements in night vision function and useful field of view, including increased macular pigment optical density, improved contrast sensitivity, reduced glare recovery time, and decreased preferred luminance required to complete visual tasks. The results also showed significant improvements in divided attention and reduced composite crash risk score in the supplemented group, while no significant changes were observed in the placebo group.
Letter
Ophthalmology
Hesham Lakosha, Francois Tremblay, Inge De Becker
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2009)
Article
Biology
Benjamin J. Smith, Patrice D. Cote, Francois Tremblay
CHRONOBIOLOGY INTERNATIONAL
(2015)
Article
Ophthalmology
Benjamin J. Smith, Xu Wang, Balwantray C. Chauhan, Patrice D. Cote, Francois Tremblay
DOCUMENTA OPHTHALMOLOGICA
(2014)
Article
Neurosciences
Bryan A. Daniels, Leah Wood, Francois Tremblay, William H. Baldridge
EUROPEAN JOURNAL OF NEUROSCIENCE
(2012)
Article
Ophthalmology
Benjamin J. Smith, Francois Tremblay, Patrice D. Cote
EXPERIMENTAL EYE RESEARCH
(2013)
Article
Ophthalmology
Karen McMain, Johane Robitaille, Isabel Smith, Judy Johnson, Ellen Wood, Francois Tremblay, Kim Blake
Article
Ophthalmology
Joan Parkinson, Francois Tremblay
Article
Agriculture, Multidisciplinary
Wilhelmina Kalt, Anne Hanneken, Paul Milbury, Francois Tremblay
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Francois Tremblay, Jenna Waterhouse, Janette Nason, Wilhelmina Kalt
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2013)
Article
Cell & Tissue Engineering
Tomoyuki Inoue, Brenda L. K. Coles, Kim Dorval, Rod Bremner, Yasumasa Bessho, Ryoichiro Kageyama, Shinjiro Hino, Masao Matsuoka, Cheryl M. Craft, Roderick R. McInnes, Francois Tremblay, Glen T. Prusky, Derek van der Kooy
Article
Developmental Biology
Benjamin J. Smith, Patrice D. Cote, Francois Tremblay
Summary: The study demonstrates that Na(v)1.6 channels play a significant role in photoreceptor function during mouse eye development, with modulation through activity-dependent retinal ganglion cell axonal signaling targeting TrkB receptors. Blocking Na(v) channels or prolonged dark adaptation can reduce photoreceptor function, but restoration is possible with a TrkB receptor agonist, highlighting the transient nature of Na(v)-dependent modulation on photoreceptor function postnatal day 16.
DEVELOPMENTAL NEUROBIOLOGY
(2021)
Article
Ophthalmology
Joan Parkinson, Francois Tremblay
DOCUMENTA OPHTHALMOLOGICA
(2008)
Article
Ophthalmology
Joan Parkinson, Heather Sandusky, Francois Tremblay
Article
Ophthalmology
Francois Tremblay, Joan Parkinson
DOCUMENTA OPHTHALMOLOGICA
(2008)