Review
Food Science & Technology
Marlene Costa, Vania Costa, Margarida Lopes, Fatima Paiva-Martins
Summary: The chemistry of phenolic compounds in virgin olive oil is complex, especially due to the specific phenol class called secoiridoids. Research on secoiridoids is relatively scarce compared to other classes of phenolic compounds, and secoiridoids may include non-phenolic compounds as well. It is important to study the structures and chemistry of these compounds to understand their bioactivity and metabolism.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Annalisa Noce, Giulia Marrone, Silvia Urciuoli, Francesca Di Daniele, Manuela Di Lauro, Anna Pietroboni Zaitseva, Nicola Di Daniele, Annalisa Romani
Summary: The Mediterranean diet with extra virgin olive oil appears beneficial for patients with chronic kidney disease, improving renal function, reducing oxidative stress and inflammation, enhancing body composition, with more significant and long-lasting effects observed in those consuming high MPC EVOO content.
Article
Chemistry, Applied
Eduardo Lopez-Huertas, Jesus Lozano-Sanchez, Antonio Segura-Carretero
Summary: Virgin and extra virgin olive oils contain polyphenols that have beneficial physiological effects, with a standard of at least 250 mg/kg to be considered healthy. The polyphenol content varies among different olive oil varieties, and the results may have potential applications in producing a category of healthy antioxidant olive oils.
Article
Biochemistry & Molecular Biology
Rosaria Notariale, Pasquale Perrone, Luigi Mele, Gennaro Lettieri, Marina Piscopo, Caterina Manna
Summary: Phosphatidylserine translocation is a significant mechanism in human erythrocytes. Olive oil phenols can prevent cell alterations induced by mercury or calcium ionophore, protecting the red blood cells. The bioactive compounds in olive oil have important implications for human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Guodong Rao, Jianguo Zhang, Xiaoxia Liu, Xue Li, Chenhe Wang
Summary: The study revealed the variation in fatty acids and minor components in olive fruits of different colors, providing insights into the determination of optimal harvest strategies for olive oil production. Additionally, genes related to the biosynthetic pathways of hydroxytyrosol and oleuropein were identified through the combined analysis of gene expression data.
Article
Chemistry, Multidisciplinary
Arrigo F. G. Cicero, Federica Fogacci, Antonio Di Micoli, Maddalena Veronesi, Elisa Grandi, Claudio Borghi
Summary: This study evaluated the effect of dietary supplementation with highly standardized polyphenols derived from Coratina Olive on the plasma cholesterol levels of hypercholesterolemic individuals. Results showed significant improvement in several blood markers with this supplementation, indicating its potential in the prevention and treatment of metabolic syndrome.
APPLIED SCIENCES-BASEL
(2022)
Article
Engineering, Chemical
Adrian Hernandez-Fernandez, Yolanda Garrido, Eduardo Iniesta-Lopez, Antonia Perez de los Rios, Joaquin Quesada-Medina, Francisco Jose Hernandez-Fernandez
Summary: This study investigated the polyphenols extracted from olive mill wastewater and olive leaf in an aqueous medium compared to traditional methanol-water extraction. The results showed that the polyphenol content in the aqueous extract of olive mill wastewater was similar to that obtained with methanol-water extraction, while the aqueous extract of olive leaf had lower total phenol content compared to the methanolic extract. However, both aqueous extracts exhibited similar antioxidant capacity, making them suitable for use as antioxidants in biological systems.
Review
Agriculture, Multidisciplinary
Sebastia Galmes, Barbara Reynes, Mariona Palou, Andreu Palou-March, Andreu Palou
Summary: The effects of olive tree polyphenols in humans are largely dependent on their bioavailability and metabolization processes. Studies show that polyphenols are absorbable by intestinal cells and undergo metabolism mainly in enterocytes and the liver. Understanding the ADME processes of polyphenols is crucial for future nutritional and toxicological studies in this area.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Cheila Brito, Ana Tomas, Sandra Silva, Maria Rosario Bronze, Ana Teresa Serra, Marta Pojo
Summary: Hydroxytyrosol exhibits cytotoxic potential in melanoma cells with predominant glycolytic metabolism and JNK activation, while other olive oil compounds show varying effects on melanoma cells depending on their metabolic and molecular mechanisms.
Article
Chemistry, Medicinal
Nikolaos Iakovis, Ignatios Ikonomidis, Ioanna Andreadou, Andrew Xanthopoulos, Aikaterini Chamaidi, Nikolaos Chrysakis, Grigorios Giamouzis, John Skoularigis, Ioulia Tseti, Filippos Triposkiadis
Summary: Short-term use of OE enriched with HT showed a trend towards improvement of LV diastolic function and arterial elastic properties in chronic CAD patients, suggesting potential benefits for cardiovascular function.
JOURNAL OF MEDICINAL FOOD
(2023)
Article
Engineering, Environmental
Mohammed O. J. Azzam, Saja A. Hazaimeh
Summary: Olive mill wastewater (OMW) is a by-product of olive oil extraction systems and its treatment is necessary to prevent pollution to the ecosystem. Liquid/liquid extraction using ethyl acetate (EA) was studied to recover valuable compounds, aiming to produce clean water and economically valuable extracts.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2021)
Article
Food Science & Technology
Maria F. C. Romeu, Jorge Bernardo, Carla I. Daniel, Nuno Costa, Joao G. Crespo, Luis Silva Pinto, Manuel Nunes da Ponte, Ana V. M. Nunes
Summary: This study utilized pilot-scale nanofiltration to extract aqueous solutions rich in hydroxytyrosol and tyrosol from olive oil by-products. A large-scale simple process was employed for pre-treating olive pomace with water, followed by direct feed to a nanofiltration unit and concentration by reverse osmosis. The resulting aqueous solution, obtained as the retentate stream, exhibited high and stable concentrations of hydroxytyrosol and tyrosol for at least 14 months.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Chemistry, Analytical
Antonella Maria Aresta, Nicolella De Vietro, Maria Lisa Clodoveo, Riccardo Amirante, Filomena Corbo, Francesco Paolo Schena, Carlo Zambonin
Summary: The study found that EVOO obtained through ultrasound technology contained higher levels of total polyphenols, hydroxytyrosol and tyrosol, leading to greater absorption after ingestion. Compared to EVOO obtained through conventional mechanical methods, olive oil processed with ultrasound had a higher concentration of beneficial compounds that were more readily assimilated by the human body.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Henrik Terholsen, Jasmin Kaur, Nikolaos Kaloudis, Amanda Staudt, Henrik Mueller, Ioannis V. Pavlidis, Uwe T. Bornscheuer
Summary: Enzymatic transesterification of hydroxytyrosol in an aqueous system in the presence of ethyl acetate yielded a rich extract of 3-hydroxytyrosol acetate. A mutant of the acyltransferase enzyme, immobilized on EziG(2) beads, achieved high hydroxytyrosol conversions of 82-89% in one hour, for at least ten reaction cycles. However, the conversions from olive mill wastewater were lower, ranging from 51% to 62%. A preparative scale reaction resulted in the extraction of 13.8 mg (57%) of 3-hydroxytyrosol acetate from 60 mL of OMWW.
Review
Nutrition & Dietetics
Paula Silva, Maria Rodriguez-Perez, Oscar Gomez-Torres, Emma Burgos-Ramos
Summary: This study reviews the protective effect of polyphenolic compounds from extra virgin olive oil and wine in Alzheimer's disease (AD) and emphasizes that they could be potential therapeutic tools. Polyphenols have beneficial effects in beta-aggregation, neurofibrillary tangles, autophagy, mitochondrial function, and cerebral insulin resistance. Additionally, no harmful dose has been identified.
NUTRITION RESEARCH REVIEWS
(2023)
Article
Pediatrics
Ermelinda Santos Silva, Susana Rocha, Rita Candeias Ramos, Helena Coutinho, Cristina Catarino, Fernanda Teixeira, Graca Henriques, Ana Isabel Lopes, Alice Santos-Silva, Dora Brites
Summary: This study found a potential association between bile acids profile and redox status in healthy infants, with the type of diet potentially influencing this relationship.
PEDIATRIC RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Sara C. Silva-Reis, Ivo E. Sampaio-Dias, Vera M. Costa, Xavier Cruz Correia, Hugo F. Costa-Almeida, Xerardo Garcia-Mera, Jose E. Rodriguez-Borges
Summary: Neurodegenerative diseases of the central nervous system (CNS) are a global health concern, especially in developed countries due to increased life expectancy and the lack of restorative treatments. Glypromate, a brain-derived peptide, shows promise in treating these diseases, but its limited pharmacokinetic properties hinder its clinical application. This review explores the chemical derivatizations of more than 100 analogs of Glypromate and their structure-activity relationships, aiming to guide the discovery of new Glypromate-based neuroprotective drugs.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Mariana Luz-Veiga, Manuela Amorim, Ines Pinto-Ribeiro, Ana L. S. Oliveira, Sara Silva, Ligia L. Pimentel, Luis M. Rodriguez-Alcala, Raquel Madureira, Manuela Pintado, Joao Azevedo-Silva, Joao Fernandes
Summary: Cannabidiol (CBD) and cannabigerol (CBG) are phytocannabinoids found in Cannabis sativa L. They have antimicrobial activity against bacteria and biofilms, with CBG showing higher activity than CBD. These findings suggest that phytocannabinoids could be promising topical antimicrobial agents for treating various skin conditions. Further research is needed to understand their mechanisms of action and develop practical applications in dermatology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Mariana Luz-Veiga, Joao Azevedo-Silva, Joao C. Fernandes
Summary: The phytocannabinoid cannabidiol (CBD) is attracting attention for its pharmacological properties. Unlike psychoactive Delta 9-tetrahydrocannabinol (THC), CBD extracted from cannabis has anti-inflammatory, antioxidant, anticonvulsant, and anxiolytic potential. CBD's biological effects are not limited to cannabinoid receptors but also involve other receptors and signaling cascades, demonstrating its therapeutic potential in cancer, neurodegeneration, and autoimmune diseases.
Article
Chemistry, Analytical
Teresa Guerra Barroso, Lenio Ribeiro, Hugo Gregorio, Filipe Monteiro-Silva, Filipe Neves dos Santos, Rui Costa Martins
Summary: White blood cell count is an important parameter in medical diagnostics, and spectroscopy shows potential for direct detection in veterinary applications. Chemometric methods can correlate with spectral features, but self-learning artificial intelligence methods have higher correlation and lower error.
Article
Biochemistry & Molecular Biology
Susana Rocha, Rita Felix, Maria Joao Valente, Andreia Bento-Silva, Rute Rebelo, Celia Gomes Amorim, Alberto da Nova Araujo, Rui Moreira, Alice Santos-Silva, Maria Conceicao B. S. M. Montenegro
Summary: This study aimed to evaluate the bioactivity and biocompatibility of polysulfone (PSU) hemodialysis (HD) membranes doped with human neutrophil elastase inhibitors (HNEIs). The results showed that all biomaterials were bioactive and hemocompatible. Compared to Sivelestat, both D4L-1 and D4L-2 exhibited stronger inhibitory abilities.
Article
Biochemistry & Molecular Biology
Marco Duarte, Maria Joao Carvalho, Nelson Mota de Carvalho, Joao Azevedo-Silva, Adelia Mendes, Ines Pinto Ribeiro, Joao Carlos Fernandes, Ana L. S. Oliveira, Carla Oliveira, Manuela Pintado, Ana Amaro, Ana Raquel Madureira
Summary: Postbiotics, produced using sugarcane straw, showed bioactive properties that make them suitable for use in cosmetic and skincare products.
Article
Biophysics
Joana R. Costa, Tania Neto, Silvia S. Pedrosa, Sergio C. Sousa, Joao Azevedo-Silva, Diana Tavares-Valente, Adelia Mendes, Manuela E. Pintado, Joao C. Fernandes, Ana L. S. Oliveira, Ana Raquel Madureira
Summary: The demand for sustainable products is increasing worldwide, and the cosmetic industry is no exception. In this study, biogenic silica microparticles were synthesized from sugarcane ash and evaluated for their potential as cosmetic and skincare ingredients.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Pharmacology & Pharmacy
Francisca Casanova, Carla F. Pereira, Alessandra B. Ribeiro, Eduardo M. Costa, Ricardo Freixo, Pedro M. Castro, Joao C. Fernandes, Manuela Pintado, Oscar L. Ramos
Summary: This study investigates the potential use of cellulose nanostructures as carriers for the delivery of curcumin. Surface-modified cellulose showed improved encapsulation and sustained release properties for curcumin. The modified cellulose carriers reduced cytotoxicity and could be a promising drug delivery system.
Article
Biochemistry & Molecular Biology
Irina Lousa, Flavio Reis, Sofia Viana, Pedro Vieira, Helena Vala, Luis Belo, Alice Santos-Silva
Summary: The inflammatory pathway driven by TNF-alpha, through its receptors TNFR1 and TNFR2, is a common feature in the pathogenesis of chronic kidney disease (CKD). TNF receptors, especially TNFR2, have potential as biomarkers for early detection and progression of CKD. Further investigation is needed to fully understand the potential value of TNFR2 as a biomarker.
Article
Biochemistry & Molecular Biology
Susana Coimbra, Cristina Catarino, Maria Sameiro Faria, Jose Pedro L. Nunes, Susana Rocha, Maria Joao Valente, Petronila Rocha-Pereira, Elsa Bronze-da-Rocha, Nuno Bettencourt, Ana Beco, Sofia Homem de Melo Marques, Jose Gerardo Oliveira, Jose Madureira, Joao Carlos Fernandes, Vasco Miranda, Luis Belo, Alice Santos-Silva
Summary: Left ventricular hypertrophy (LVH) is common in end-stage kidney disease (ESKD) patients, and is associated with lower leptin levels, higher biomarkers of myocardial stress/injury, and specific nutritional status. Leptin and NT-proBNP are independent determinants of LVH, while dialysis vintage, hemoglobin, calcium, NT-proBNP, and leptin are predictive markers for LVH development. Further studies are needed to elucidate the role of leptin in LVH in ESKD patients.
Article
Chemistry, Analytical
F. M. Silva, C. Queiros, T. Pinho, J. Boaventura, F. Santos, T. G. Barroso, M. R. Pereira, M. Cunha, R. C. Martins
Summary: This study introduces a spectroscopic method for quantitative analysis of nutrients in hydroponic systems using orthogonal covariance modes. The results demonstrate accurate quantification of nitrogen, phosphate, and potassium, with improved results for phosphate analysis by including pH information.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Food Science & Technology
Dirce Moura, Joana Vilela, Sonia Saraiva, Filipe Monteiro-Silva, Jose M. M. M. De Almeida, Cristina Saraiva
Summary: This study assessed the antimicrobial effects of myrtle essential oil on pathogenic and spoilage microorganisms in beef and determined its minimum inhibitory concentration (MIC) and antioxidant activity. The results showed that myrtle essential oil had a strong antimicrobial activity against various pathogens and spoilage microorganisms, making it a viable natural alternative to enhance meat safety.
Article
Chemistry, Applied
Claudia Castro, Ines Pinto-ribeiro, Isabel Pereira, Maria Joao Carvalho, Claudia Popov, Diana Tavares-valente, Helene R. Moreira, Joao C. Fernandes, Manuela Pintado, Ana Raquel Madureira
Summary: The researchers developed a plant-based formulation for ABHS that possesses antimicrobial properties and improves skin hydration and moisture retention, while also being sensorially pleasing to consumers.
JOURNAL OF COSMETIC SCIENCE
(2023)
Review
Chemistry, Applied
Pedro Sousa, Diana Tavares-Valente, Manuela Amorim, Joao Azevedp-Silva, Manuela Pintado, Joao Fernandes
Summary: Beta-glucans, naturally found in cereals, yeast, and mushrooms, are considered as potential sources for functional foods and pharmaceuticals. They interact with the immune system, possess soothing and antioxidant properties, and can benefit overall skin health and delay skin aging.
CARBOHYDRATE POLYMERS
(2023)
