Article
Pharmacology & Pharmacy
Julie Fahier, Branko Vukosavljevic, Laure De Kinder, Hugues Florin, Jean-Francois Goossens, Maike Windbergs, Florence Siepmann, Juergen Siepmann, Susanne Muschert
Summary: This study aimed to investigate the mass transport mechanisms controlling drug release from polymer-coated pellets using non-invasive analytical tools. The results revealed that crack formation in the film coatings plays a major role in drug release, with significant differences observed at different pH conditions.
Article
Food Science & Technology
Dipan Roy, Kuradi Jayaram Kumar
Summary: In this study, starch extracted from mankanda (Alocaisa macrrorhizos) tubers showed characteristics of neutral pH, high water holding capacity, low ash values, and excellent flow. The starches exhibited good thermal stability and shear thinning behavior. In vitro drug release studies indicated that the extracted native starch has potential for developing sustained release formulations to target the lower gastrointestinal region.
Article
Chemistry, Applied
Jingshun Liao, Hongxun Li, Changkai Linghu, Zhu Luo, Fayuan Chen, Ting Lei, Yichun Liu, Yechun Lin, Bangsheng Wang, Le Yang
Summary: In this study, modified biodegradable PBAT-based slow-release urea is prepared by using inorganic solvents, which is important for the current use of environmentally friendly slow-release fertilizers in agriculture. The addition of TDBSP to modify PBAT reduces the molecular weight and crystallinity, while the addition of ATBC as a plasticizer improves the flowability of the material for melt-coated urea.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Chemistry, Multidisciplinary
Adeline Espinasse, Manibarsha Goswami, Junshu Yang, Onanong Vorasin, Yinduo Ji, Erin E. Carlson
Summary: The emergence of drug-resistant bacteria has led to the need for novel approaches and targets to combat this challenge. Bacterial two-component systems (TCSs) are important in bacterial adaptive responses and are linked to antibiotic resistance and virulence. A study developed maleimide-based compounds and evaluated them against a model histidine kinase, resulting in the identification of a molecule that decreased the lesion size caused by methicillin-resistant S. aureus skin infection by 65% in a murine model.
Article
Biochemistry & Molecular Biology
Azeem Ullah, Yusuke Saito, Sana Ullah, Md Kaiser Haider, Hifza Nawaz, Phan Duy-Nam, Davood Kharaghani, Ick Soo Kim
Summary: Blumea balsamifera oil loaded cellulose acetate nanofiber mats were prepared by electrospinning. The inclusion of blumea oil increased the nanofiber diameter, decreased tensile strength, and reduced porosity. The mats showed antibacterial and antioxidant efficacy, as well as positive impact on cell viability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Medicinal
Yajing Wang, Tao Zhang, Jie Liu, Xianfeng Huang, Xiaojing Yan
Summary: In this study, Gingerol oil was extracted and purified using a scalable and cost-effective process, with a productivity of 2.72±0.38% (w/w). The quality control of gingerol oil was established by HPLC fingerprinting, identifying 6-gingerol, 8-gingerol, 6-shogaol, and 10-gingerol as the major components. Gingerol oil showed protective effects against inflammation and oxidative stress in vitro and colitis in mice. The absorption kinetics of gingerol oil in rats were studied, and colon-targeted pellets were prepared for reliable therapeutic application.
Article
Food Science & Technology
Shuo Mao, Fangyu Li, Xiaobin Zhou, Chengwen Lu, Tiehua Zhang
Summary: This study aimed to develop sustainable active films with starch/carvacrol for potential food packaging. The findings showed that carvacrol nanoemulsion was uniformly dispersed in the film matrix and interacted with hydrogen bonds. The addition of carvacrol improved the thermal stability, UV shielding, water solubility, and water vapor permeability of the films, but reduced their mechanical properties. The sustainable composite films exhibited desirable physical properties and bioactivity, making them suitable for food preservation, especially for extending the shelf life of acidic foods.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Suk Fun Chin, Asniar Salim, Suh Cem Pang
Summary: This study synthesized starch acetate nanoparticles for controlled release of piperine, which showed higher loading capacity and slow sustained release compared to native starch nanoparticles.
Article
Agricultural Engineering
Malihe Pooresmaeil, Hassan Namazi
Summary: Recently, covalent organic frameworks (COFs) have been recognized as efficient drug-loading platforms due to their desired structure. In this study, a spherical COF was constructed as a platform for loading 5-fluorouracil (5-Fu). The synthesized COF exhibited a larger pore size than the dimensions of 5-Fu and had a high surface area. However, the imine bond in COFs was found to be relatively unstable in acidic conditions. To address this issue, COF/5-Fu was capped into a carboxymethyl starch-gelatin (CMS-Gel) coat, resulting in COF/5-Fu@CMS-Gel. Drug release tests showed that the loaded 5-Fu was released at a higher rate in pH 7.4 compared to pH 1.2. The structural analyses confirmed the successful formation of the prepared samples, and MTT assays demonstrated the biocompatible nature and cytotoxic potential of neat COF@CMS-Gel after drug loading. These findings suggest that COF/5-Fu@CMS-Gel has promising applications in controlled colon drug delivery.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Review
Food Science & Technology
Yidi Wang, Zhiying Li, Yiwen Bao, Huijun Cui, Jiaxin Li, Baoge Song, Mengzhu Wang, Haikun Li, Xingyue Cui, Yi Chen, Wei Chen, Shufang Yang, Yiyun Yang, Zhufeng Jin, Xu Si, Bin Li
Summary: This paper mainly introduces the research on colon-targeted controlled release of polyphenols, discusses the physiological features affecting the dissolution, release and absorption of polyphenol-loaded delivery systems in the colon, describes the types of colon-targeted carriers with different release mechanisms, and summarizes the colon-targeting assessment models that have been studied so far and their advantages and limitations. Based on the current research on polyphenols colon-targeting, outlook and reflections are proposed to inspire strategic development of new colon-targeted therapeutics.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Nanoscience & Nanotechnology
Khorshid Kamguyan, Anders Meyer Torp, Juliane Fjelrad Christfort, Priscila R. Guerra, Tine Rask Licht, Line Hagner Nielsen, Kinga Zor, Anja Boisen
Summary: This study focuses on the proof of concept for engineered delivery of probiotics using micrometer-sized polymeric containers, and demonstrates that chitosan-genipin coated microcontainers enable effective local delivery in the cecum and colon.
ACS APPLIED BIO MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Chao Wang, Shuhui Song, Liqing Du, Ziming Yang, Yunhao Liu, Zuyu He, Chuang Zhou, Puwang Li
Summary: In this study, a new coating material with cross-linked network structure and hydrophobic surface was synthesized to improve the nutrient controlled-release performance of coated fertilizers. The modified material showed improved density and reduced pores on the coating shells, and the introduction of siloxane improved its hydrophobicity and delayed water entry. The synergistic effects of the modified material improved the nitrogen controlled-release performance of bio-based coated fertilizers, with the nutrient release longevity reaching over 63 days.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Chenxi Wang, David Julian McClements, Aiquan Jiao, Jinpeng Wang, Zhengyu Jin, Chao Qiu
Summary: This review highlights the recent advances in the green synthesis and applications of resistant starch (RS) and its nanoparticles. The potential effects of RS and its nanoparticles on the human gastrointestinal tract (GIT) and health are discussed, including their ability to inhibit amylase, delay gastric emptying, exhibit prebiotic effects, and act as colon specific delivery systems for bioactive agents.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Oncology
Jamie M. Sperger, Kyle T. Helzer, Charlotte N. Stahlfeld, Dawei Jiang, Anupama Singh, Katherine R. Kaufmann, David J. Niles, Erika Heninger, Nicholas R. Rydzewski, Liguo Wang, Liewei Wang, Rendong Yang, Yanan Ren, Jonathan W. Engle, Peng Huang, Christos E. Kyriakopoulos, Susan F. Slovin, Howard R. Soule, Shuang G. Zhao, Manish Kohli, Scott T. Tagawa, Weibo Cai, Scott M. Dehm, Joshua M. Lang
Summary: This study analyzed the expression of biomarkers in prostate cancer patients and demonstrated that TROP-2 can serve as a cell surface target for isolating circulating tumor cells, and it may serve as a predictive biomarker for antibody-drug conjugates.
CLINICAL CANCER RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Beibei Zhao, Zhengbiao Gu, Li Cheng, Yan Hong
Summary: Oral delivery of chemotherapeutic drugs has the potential to revolutionize intestinal tumor care, and a new approach using chitosan-coated porous starch coupled with hyaluronic acid has shown promising results. This oral carrier provides a platform for targeted release of the chemotherapeutic drug paclitaxel, leading to effective colonic adenoma therapy both in vitro and in vivo.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Engineering, Chemical
Taoyan Mao, Runhui Xiao, Peng Liu, Jiale Chen, Junqiang Luo, Su Luo, Fengwei Xie, Cheng Zheng
Summary: Oil contamination is a major cause of water pollution and a global environmental challenge. Existing oil/water separation materials suffer from weaknesses in durability, chemical tolerance, environmental resistance, and potential negative impact on health and the environment. This study presents a simple method to fabricate eco-friendly and durable oil/water separation membrane fabrics by alkaline hydrolysis and silicon polyurethane coating. The modified fabrics exhibit stable superhydrophobic properties and excellent oil/water separation efficiency, making them promising for large-scale oil/water separation applications.
CHINESE JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Applied
Zengjiang Zhang, Bo Zheng, Yukuo Tang, Ling Chen
Summary: Controlling the digestibility of starch through Hot-extrusion 3D printing (HE-3DP) allows for personalized customization of starch-based foods. This study found that increasing the concentration of starch gel material resulted in a more ordered structure and higher content of slowly digestible starch and resistant starch in the printed samples.
Article
Chemistry, Applied
Shuangxia Huang, Chengdeng Chi, Xiaoxi Li, Yiping Zhang, Ling Chen
Summary: In this study, the effects of xanthan and dodecyl gallate (DG) on the structures, digestibility, texture, and aromas of rice noodles were investigated. Results showed that these additives increased slowly digestible starch and resistant starch, while reducing glycemic index and glycemic load values, and improving texture and aroma qualities.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Applied
Fei Ren, Jinwei Wang, Jinglin Yu, Cheng Zhong, Fengwei Xie, Shujun Wang
Summary: This study demonstrates the synthesis of acetylated maize starches (AMS) with different degrees of substitution (DS) in the presence of ionic liquids (ILs) without catalyst. The DS and reaction efficiency of AMS increase with decreasing alkyl chain length of cations or anions. AMS synthesized in imidazolium-based ILs exhibit higher hydrophobicity and thermal stability. The viscosity of ILs and the interactions between acetic anhydride molecules are crucial for the acetylation of starch.
CARBOHYDRATE POLYMERS
(2022)
Review
Food Science & Technology
Zihang Cheng, Dongling Qiao, Siming Zhao, Binjia Zhang, Qinlu Lin, Fengwei Xie
Summary: Dietary intervention plays an important role in regulating metabolic syndrome, and whole grain rice, rich in dietary fiber and bioactive compounds, has the ability to regulate glucose and lipid metabolism. This review examines the factors affecting the starch digestibility of whole grain rice and discusses the correlation between the intake of whole grain rice or its products and the reduction in blood glucose and lipid levels, as well as the incidence of diabetes and obesity. Information on developing healthy whole grain rice products is also provided.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Jing Wang, Xinyu Sun, Xingfeng Xu, Qingjie Sun, Man Li, Yanfei Wang, Fengwei Xie
Summary: This work investigates the structure, rheological properties, and film performance of wheat flour hydrocolloids and their comparison with that of a wheat starch (WS)-gluten blend system. The incorporation of gluten could decrease inter-chain hydrogen bonding of starch, thereby reducing the viscosity and solid-like behavior of the film-forming solution and improving the frequency-dependence, but reducing the surface smoothness, compactness, water vapor barrier performance, and mechanical properties of the films.However, good compatibility between starch and gluten could improve the density of self-similar structure, the processability of the film-forming solution, and film performance. The films based on wheat flours showed a denser film structure, better mechanical properties, and thermal stability that was no worse than that based on WS-gluten blends. The knowledge gained from this study could provide guidance to the development of other flour-based edible packaging materials, thereby promoting energy conservation and environmental protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Shuwei Tang, Zhengguo Wu, Xiaoyun Li, Fengwei Xie, Dongdong Ye, Eduardo Ruiz-Hitzky, Lansheng Wei, Xiaoying Wang
Summary: In this study, a flexible gas barrier film with a nacre-like layered structure was developed. The film exhibited superior mechanical properties, acid-base stability, and barrier properties to gases and volatile organic compounds. It also possessed antibacterial properties, biocompatibility, and degradability.
CARBOHYDRATE POLYMERS
(2023)
Article
Agricultural Engineering
Fengyi Chen, Chengdu Miao, Qingfei Duan, Shuai Jiang, Hongsheng Liu, Litao Ma, Zhongxian Li, Xianyang Bao, Bifeng Lan, Ling Chen, Long Yu
Summary: A novel method for developing slow-release fertilizers by in-situ radiation-synthesizing urea-embedded starch-based hydrogels was introduced. The effects of irradiation intensity on hydrogels with different AM/starch ratios, concentrations, and urea loading were studied. The structures and performances of the gel were investigated, and the relationships between the gel structures and properties, and release rate were established.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Multidisciplinary
Linhua Zhang, Chengcheng Gao, Zhenjiong Wang, Fengwei Xie, Ying Chen, Linghan Meng, Xiaozhi Tang
Summary: This study prepared biomimetic materials based on chitosan and silk peptides using thermomechanical processing and investigated the effect of chitosan molecular weight on the structure and properties of the composites. The results showed that chitosan molecular weight significantly influenced the structure and properties of the composites, and a certain molecular weight of chitosan achieved excellent strength and toughness, which could be further enhanced by rehydration after drying. Therefore, this research provides a reference for processing natural polymeric materials using hot-melt methods.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Applied
Zengjiang Zhang, Bo Zheng, Anlin Du, Jin Chen, Ling Chen
Summary: This study investigated the retrogradation of chestnut starch and found that it can be inhibited by heat-moisture treatment (HMT) combined with flavonoid addition. Different flavonoids showed varying degrees of retardation, with epicatechin being the most effective. Structural analysis and theoretical calculations showed that the retardation effect was due to hydrogen bond interactions between starch and flavonoids, which prevented the aggregation of starch molecules. The findings of this study are important for the production of high-quality chestnut products.
Article
Agricultural Engineering
Zhipeng Qiu, Xixi Zeng, Jinchuan Xu, Bo Zheng, Ling Chen
Summary: The regioselective oxidation of native maize starch (NMS) using the laccase-TEMPO system resulted in the development of oxidized maize starch (OMS) with enhanced water absorption properties. The regioselective oxidation caused a shift from ordered to disordered structures, leading to a slight degradation of OMS chains and destruction of part of the short-range ordered structure, aggregate structure, and crystalline structure. However, the crystalline type, amorphous lamellae thickness, and morphology of the starch granules were largely maintained.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Gulden Goksen, Didem Demir, Kuldeep Dhama, Manoj Kumar, Ping Shao, Fengwei Xie, Noemi Echegaray, Jose Manuel Lorenzo
Summary: Current trends favor the use of natural components for creating healthful, environmentally friendly, sustainable, and profitable goods. In response, the food industry is seeking safe natural ingredients to produce low-fat, artificial-additive-free, gluten-free, prebiotic, and fortified foods. Similarly, the pharmaceutical and medical industries are exploring the application of natural ingredients, specifically plant mucilage, to address biomaterial challenges more efficiently. Plant mucilage has proven to have excellent health features and technological properties, making it useful for both food and biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Biomaterials
Pei Cao, Nasim Amiralian, Jingjing Wang, Bing Sun, Amirali Popat, Fengwei Xie, Zhi Ping Xu, Yan Li, Li Li
Summary: Oral vaccine is an ideal non-invasive method to protect communities from infectious diseases. Researchers developed alginate/chitosan-coated cellulose nanocrystal and nanofibril nanocomposites to enhance ovalbumin delivery in the intestine. In vitro and in vivo experiments showed that the nanocomposites generated strong immune responses. However, no significant differences in specific ovalbumin immune responses were observed due to the complexity of the small intestine.
BIOMATERIALS ADVANCES
(2023)
Article
Food Science & Technology
Ziwen Zhang, Mengshan Shang, Xiaoyu Chen, Lei Dai, Na Ji, Yang Qin, Yanfei Wang, Liu Xiong, Qingjie Sun, Fengwei Xie
Summary: This study evaluated the characteristics of indica rice kernels (IRK) and flour (IRF) annealed under different conditions, and determined the quality of rice noodles made with these annealed IRK and IRF. Annealing increased the paste viscosity of IRK while decreasing that of IRF. Both annealed IRK and IRF showed increases in gelatinization enthalpy change and relative crystallinity. Annealed IRK noodles exhibited denser pores, while annealed IRF noodles exhibited a looser microstructure. With increasing annealing temperature and time, both annealed IRK and IRF noodles showed enhanced tensile properties.
Article
Green & Sustainable Science & Technology
Binjia Zhang, Yabin Guo, Lisong Lin, Dongling Qiao, Fengwei Xie
Summary: Considering the renewability and chemical versatility of natural biopolymers, there is a high demand for innovative solvation processes to efficiently disrupt the native supramolecular structures of natural polymers for their modification, derivation, and materials fabrication. This study compares the structural disorganization behavior of different starches in an aqueous ionic liquid, and finds that A-type starches are more susceptible to structural disruption than B-type starches. The ease of starch gelation in the aqueous ionic liquid is not determined by amylose content, but by the compactness of the granule surface.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2023)
