Article
Nutrition & Dietetics
Jian Zhang, Xixi Wang, He Li, Cunshe Chen, Xinqi Liu
Summary: CBH and HD exhibit immunomodulatory effects in CTX-induced immunosuppressed mice, reducing organ atrophy, stimulating lymphocyte proliferation, and improving immunoglobulin levels, indicating their potential in preventing immunosuppression.
Article
Agriculture, Dairy & Animal Science
Sukanya Charoensin, Banyat Laopaiboon, Wuttigrai Boonkum, Jutarop Phetcharaburanin, Myra O. Villareal, Hiroko Isoda, Monchai Duangjinda
Summary: This study identified the presence of anserine in Thai native chickens and their crossbred meat, demonstrating their potential as functional meat sources rich in anserine and antioxidants. The research used nuclear magnetic resonance spectroscopy to distinguish metabolites and relative concentrations, showing significantly higher levels of anserine in Thai native and crossbred chicken compared to commercial broiler chickens.
Article
Nutrition & Dietetics
Silvia Barbaresi, Laura Blancquaert, Zoran Nikolovski, Sarah de Jager, Mathew Wilson, Inge Everaert, Siegrid De Baere, Siska Croubels, Stefaan De Smet, N. Tim Cable, Wim Derave
Summary: The study found that pre-exercise ingestion of homemade chicken broth can improve short-lasting, high-intensity exercise performance, and increase post-exercise plasma carnosine and anserine levels. However, chicken broth supplementation did not have a significant effect on blood glutathione levels or capillary blood analysis.
JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
(2021)
Article
Chemistry, Analytical
Marco Maspero, Ettore Gilardoni, Chiara Bonfanti, Graziella Messina, Luca Regazzoni, Marco De Amici, Marina Carini, Giancarlo Aldini, Clelia Dallanoce
Summary: The physiological properties of L-carnosine make it suitable for nutritional ergogenic applications and therapeutic potential. The use of HPLC-MS procedures with isotope-labeled internal standards is the state-of-the-art approach for quantitation in biological matrices. A convenient strategy for the synthesis of 13C-labeled carnosine analogs as internal standards is presented in this study.
Article
Multidisciplinary Sciences
Rekha Sharma, Renuka Sehrawat, Sonika Ahlawat, Vivek Sharma, Alka Parmar, M. S. Thakur, A. K. Mishra, M. S. Tantia
Summary: The indigenous black chicken of India, Kadaknath, is at risk of extinction due to declining numbers. Its meat is used in tribal medicine for invigorating and health-promoting properties. Comparison with commercial broiler chicken showed that Kadaknath meat is a rich source of functional biomolecules and has superior antioxidant and anti-AGEs properties.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Arthur Robin, Supratim Ghosh, Batel Gabay, Klimentiy Levkov, Alexander Golberg
Summary: In this study, the extraction of carnosine and anserine from chicken meat was improved using pulsed electric fields and mechanical pressing. The incubation time in water after the pretreatment was found to be the most significant factor affecting the extraction of dipeptides. The developed method is scalable and can be applied to extract bioactive compounds from animal tissues.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2022)
Article
Multidisciplinary Sciences
Tatsuhiko Goto, Saki Shimamoto, Masahiro Takaya, Shun Sato, Kanna Takahashi, Kenji Nishimura, Yasuko Morii, Kyoko Kunishige, Akira Ohtsuka, Daichi Ijiri
Summary: The study showed significant breed effects on egg quality and amino acid traits, with significant heterosis effect. Positive correlations were found within each trait category, while weak correlations were observed among different trait categories.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Karuntarat Teeravirote, Khaetthareeya Sutthanut, Unchalee Thonsri, Panupong Mahalapbutr, Wunchana Seubwai, Sukanya Luang, Patcharaporn Tippayawat, Sakawrat Kanthawong, Chonlatip Pipattanaboon, Monchai Duangjinda, Vibuntita Chankitisakul, Atit Silsirivanit
Summary: This study found that anserine/carnosine-rich chicken extract from Thai native chicken meat has potential cosmeceutical properties, including antioxidation and anti-melanogenic effects, which are achieved through biomolecular regulating mechanisms.
Article
Chemistry, Applied
Jun Qi, Wen-wen Zhang, Ying Xu, Xiao-fei Xie, Guo-yuan Xiong, Xing-lian Xu, Guang-hong Zhou, Min Ye
Summary: The study showed that the contents of free amino acids, nucleotides, and mineral elements in chicken broth decreased as the frozen raw material storage duration increased, while volatile compounds showed the opposite trend. After 4 weeks of storage at -18 degrees C, sensory scores for meaty and fatty traits in chicken broth reached their peak, likely due to increased levels of aldehydes and 2-pentyl furan. Ultimately, limited storage duration of frozen raw meat can enhance the flavor of chicken broth.
Article
Neurosciences
Darel Wee Kiat Toh, Chun Hong Wong, Johnson Fam, Jung Eun Kim
Summary: Essence of chicken is a dietary supplement that may benefit cognitive performance, with daily intake showing improvements in working memory and positive effects in the healthy population.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Chemistry, Applied
Arichaya Malison, Pornlert Arpanutud, Suwimon Keeratipibul
Summary: Chicken foot broth byproduct can be processed to obtain calcium and bioactive peptides from the separated bones and meat residues. The peptides derived from this byproduct exhibit diverse bioactivities, such as inhibition of dipeptidyl peptidase IV and angiotensin-converting enzyme, and can form peptide-calcium chelates.
Article
Biochemistry & Molecular Biology
Somei Komae, Shingo Kasamatsu, Koji Uchida, Hideshi Ihara
Summary: This study developed a method for the quantitative analysis of 2-oxo-IDPs with high sensitivity, selectivity, and absolute quantification. The method was successfully applied to various types of meat, and provided the first evidence for the endogenous production of 2-oxo-balenine in meats.
Article
Multidisciplinary Sciences
Kenji Nishimura, Daichi Ijiri, Saki Shimamoto, Masahiro Takaya, Akira Ohtsuka, Tatsuhiko Goto
Summary: Genetic background has a significant impact on egg quality traits and amino acid contents in yolks and albumen. Phenotypic correlations differ among traits within each category, with limited correlations between different trait categories. The Araucana cross exhibits a unique feature with moderate positive correlations between amino acids in yolk and albumen.
Article
Food Science & Technology
Rong Jia, Xiaoyan Yin, Guozhou Liao, Zijiang Yang, Dahai Gu, Yuehong Pu, Changrong Ge, Ming Huang, Guiying Wang
Summary: The chicken broth was subjected to ultrasound treatment at different power levels before stewing, and the effects on its composition and sensory evaluation were investigated. The 600 W ultrasonic treatment group showed superior sensory evaluation results compared to the other groups. Various changes were observed in the composition of the chicken broth, including fatty acids, small molecular compounds, volatile flavor compounds, and umami polypeptides. The inclusion of ultrasound treatment at 600 W power level improved the taste and flavor of the chicken broth.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Shuyang Hu, Xinlu Ning, Jie Lv, Yuxin Wei, Huiran Zhang, Meng Li
Summary: Preventing Aβ aggregation is a promising strategy for Alzheimer's disease treatment. In this study, chiral polyoxometalates (POMs) were designed as novel chiral Aβ inhibitors. The chiral POM enantiomers exhibited different binding behavior with Aβ40, leading to enantioselective inhibitory effects on Aβ aggregation. The d-POM enantiomer showed higher Aβ40-binding affinity, greater brain biodistribution, and better rescue of memory deficits in AD mice.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Agriculture, Multidisciplinary
Sebastian Dirndorfer, Richard Hammerl, Seiji Kitajima, Ryo Kitada, Oliver Frank, Andreas Dunkel, Thomas Hofmann
Summary: The application of sensomics on dried scallops revealed the presence of taste-modulating compounds and opines in active fractions. Two quantitation approaches were compared for recreating the taste of dried scallops, both yielding similar results and successfully recreating the taste based on the data obtained.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Chemistry, Analytical
Jana Weisser, Teresa Pohl, Michael Heinzinger, Natalia P. Ivleva, Thomas Hofmann, Karl Glas
Summary: This article discusses data analysis methods for identifying microplastics using vibrational spectra, introduces relevant programs provided by the scientific community, and aims to provide guidance for those who want to establish or enhance data analysis routines for vibrational spectra of microplastics.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Correction
Agriculture, Multidisciplinary
Sebastian Baur, Nicole Belle, Hans Hausladen, Sebastian Wurzer, Laura Brehm, Timo D. Stark, Ralph Huckelhoven, Thomas Hofmann, Corinna Dawid
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Sebastian Baur, Nicole Belle, Hans Hausladen, Sebastian Wurzer, Laura Brehm, Timo D. Stark, Ralph Huecklhoven, Thomas Hofmann, Corinna Dawid
Summary: This study quantitatively investigates the changes of SGAs and saponins in potatoes induced by post-harvest LED light exposure, using advanced analytical techniques. The results show that the SGA contents in potatoes exceed the safety limit, and the levels of saponins vary significantly among different cultivars. Moreover, cultivar-specific regulations of SGAs and saponins are observed due to light exposure.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Peter Christa, Andreas Dunkel, Alin Krauss, Timo D. Stark, Corinna Dawid, Thomas Hofmann
Summary: Sensory-guided fractionation techniques were used to identify taste-active and taste-enhancing compounds in kimchi. N-acylated amino acids derived from succinic acid and lactic acid were found to have taste-modulating properties in food matrices, contributing to the umami, mouthful, and complex taste profile of kimchi.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Editorial Material
Agriculture, Multidisciplinary
Thomas F. Hofmann
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Alessandro Nicoli, Franziska Haag, Patrick Marcinek, Ruiming He, Johanna Kreissl, Joerg Stein, Alessandro Marchetto, Andreas Dunkel, Thomas Hofmann, Dietmar Krautwurst, Antonella Di Pizio
Summary: With approximately 400 encoding genes in humans, odorant receptors (ORs) are the largest subfamily of class A G protein-coupled receptors (GPCRs), but their structural characterization is poor. This study focuses on the characterization of the odorant receptor OR5K1 by identifying its cognate agonists and investigating its binding modes using AI-driven modeling and homology modeling. The obtained models provide insights into the differences in activity and structural variations. This refinement protocol can be applied to model the orthosteric binding site of ORs and GPCRs with low sequence identity.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Agriculture, Multidisciplinary
Johanna Tiroch, Andreas Dunkel, Sonja Sterneder, Sofie Zehentner, Maik Behrens, Antonella Di Pizio, Jakob P. Ley, Barbara Lieder, Veronika Somoza
Summary: Human gingival fibroblast cells (HGF-1 cells) are an important cell model for studying the response of gingiva to inflammatory stimuli. Recently, it was found that trans-resveratrol can repress the release of interleukin-6 (IL-6), a pro-inflammatory cytokine, in HGF-1 cells stimulated by Porphyromonas gingivalis (Pg-LPS), through the involvement of TAS2R50 bitter taste sensing receptor. This study aims to investigate the association between a compound's bitter taste threshold and its repressing effect on Pg-LPS evoked IL-6 release by HGF-1 cells.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Susanne I. Wudy, Verena K. Mittermeier-Klessinger, Andreas Dunkel, Karin Kleigrewe, Regina Ensenauer, Corinna Dawid, Thomas F. Hofmann
Summary: Amino acids and acylcarnitines are important biomarkers for the body's energy state and can be used to diagnose certain inborn errors of metabolism. This study developed a quantitative high-throughput method to analyze these compounds in serum samples, using minimal amounts of serum and isotopically labeled standards for quantification. The method was successfully validated and applied to serum samples from infants, showing excellent reproducibility and enabling simultaneous profiling of amino acids and acylcarnitines.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Thomas Skurk, Tamara Kraemer, Patrick Marcinek, Agne Malki, Roman Lang, Andreas Dunkel, Tiffany Krautwurst, Thomas F. Hofmann, Dietmar Krautwurst
Summary: Non-nutritive sweeteners (NNS) can help control blood sugar levels in personalized nutrition strategies, but their consumption is associated with person-specific and microbiome-dependent glycemic impairments. Little is known about the effects of NNS on the individual cellular immune system. Recent research has suggested that taste receptors may play a role in immune modulation.
Article
Endocrinology & Metabolism
Felix Sternberg, Christina Sternberg, Andreas Dunkel, Taraneh Beikbaghban, Andras Gregor, Aleksander Szarzynski, Veronika Somoza, Ingrid Walter, Kalina Duszka, Barbara Ko, Elena E. Pohl
Summary: Heart diseases are the leading cause of death worldwide. Ketogenic diets have been used to treat epilepsy, diabetes, and obesity, which are common comorbidities of heart diseases. However, recent reports have linked ketogenic diets based on long-chain triglycerides (LCTs) to cardiac fibrosis and a reduction of heart function in rodents. The effects of LCT and LCT/MCT mix ketogenic diets on cardiac tissue integrity and the plasma metabolome were assessed in mice.
MOLECULAR METABOLISM
(2023)
Article
Food Science & Technology
Daniela Marianne Hartl, Oliver Frank, Corinna Dawid, Thomas Frank Hofmann
Summary: The focus of green chemistry on natural deep eutectic solvents (NADES) is due to their sustainability, low toxicity, and high solute potential. NADES are applied in various fields, including organic chemistry, agriculture, and food industry. In the food industry, NADES can be used for extraction of small molecules, macromolecules, and heavy metals to achieve desired food quality. Additionally, NADES can increase compound yield in Maillard-type model reactions. A food-grade NADES system based on sucrose/D-sorbitol was developed and evaluated for its stability as a reaction medium in terms of temperature and pH. Two Maillard-type model reactions were successfully implemented, producing taste-modulating compounds that exceed their respective thresholds. This newly developed NADES shows great potential as a solvent candidate for a wide range of applications in the food industry.
Article
Agriculture, Multidisciplinary
Christoph Konrad Hofstetter, Andreas Dunkel, Ugo Bussy, Miriam Wimmer, Thomas Kauz, Timo D. Stark, John Didzbalis, Corinna Dawid, Thomas Hofmann
Summary: The unified flavor quantitation method, using ultra-high-performance liquid chromatography tandem mass spectrometry, allows for the simultaneous analysis and quantification of a large number of flavor compounds in a single run. The application to chocolate highlights the potential and feasibility of high-throughput quantitation of key aroma- and taste-active molecules.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
S. Hager, M. Meinardus, T. Hofmann, K. Glas
Summary: Reverse osmosis technology plays a crucial role in water treatment processes, especially in the brewing industry. The efficiency of RO plants depends on accurate hydro chemical predictions of the retentate flow. The importance of saturation limits in sparingly soluble salts cannot be overstated when selecting the maximum achievable fresh water yield.