The prostaglandin D2 receptor CRTH2 regulates accumulation of group 2 innate lymphoid cells in the inflamed lung

Group 2 innate lymphoid cells and CD4+T cells cooperate to mediate type 2 immune response in mice

(2014) L. Y. Drake et al.   ALLERGY

Discontinued drug projects in the respiratory therapeutic area during 2012

(2014) Noel J C Snell   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

(2014) Christopher J. Oliphant et al.   IMMUNITY

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

(2014) Luzheng Xue et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type 2 Innate Lymphoid Cells Drive CD4+ Th2 Cell Responses

(2014) A. S. Mirchandani et al.   JOURNAL OF IMMUNOLOGY

Innate lymphoid cells and allergic inflammation

(2013) Brian S Kim et al.   CURRENT OPINION IN IMMUNOLOGY

Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis

(2013) Jinny E. Chang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-9–mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation

(2013) Jan-Eric Turner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TH2, allergy and group 2 innate lymphoid cells

(2013) Paula Licona-Limón et al.   NATURE IMMUNOLOGY

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis

(2013) E. Hams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy and safety of AZD1981, a CRTH2 receptor antagonist, in patients with moderate to severe COPD

(2013) Noel Snell et al.   RESPIRATORY MEDICINE

Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma

(2013) C. Barnig et al.   Science Translational Medicine

TSLP Elicits IL-33-Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

(2013) B. S. Kim et al.   Science Translational Medicine

Innate Lymphoid Cells: Emerging Insights in Development, Lineage Relationships, and Function

(2012) Hergen Spits et al.   Annual Review of Immunology

Innate Lymphoid Cells: Balancing Immunity, Inflammation, and Tissue Repair in the Intestine

(2012) Elia D. Tait Wojno et al.   Cell Host & Microbe

Innate lymphoid cells: critical regulators of allergic inflammation and tissue repair in the lung

(2012) Laurel A Monticelli et al.   CURRENT OPINION IN IMMUNOLOGY

Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459

(2012) D. Singh et al.   EUROPEAN RESPIRATORY JOURNAL

Lung Natural Helper Cells Are a Critical Source of Th2 Cell-Type Cytokines in Protease Allergen-Induced Airway Inflammation

(2012) Timotheus Y.F. Halim et al.   IMMUNITY

Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients

(2012) William W. Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Update on the Development of Antagonists of Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2). From Lead Optimization to Clinical Proof-of-Concept in Asthma and Allergic Rhinitis

(2012) Roy Pettipher et al.   JOURNAL OF MEDICINAL CHEMISTRY

A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma

(2011) N. Barnes et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Innate Th2-type immune responses and the natural helper cell, a newly identified lymphocyte population

(2011) Shigeo Koyasu et al.   Current Opinion in Allergy and Clinical Immunology

SPICE: Exploration and analysis of post-cytometric complex multivariate datasets

(2011) Mario Roederer et al.   CYTOMETRY PART A

Innate IL-13–producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity

(2011) Jillian L. Barlow et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-33-Responsive Lineage-CD25+CD44hi Lymphoid Cells Mediate Innate Type 2 Immunity and Allergic Inflammation in the Lungs

(2011) K. R. Bartemes et al.   JOURNAL OF IMMUNOLOGY

Nuocytes: expanding the innate cell repertoire in type-2 immunity

(2011) Jillian L. Barlow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161

(2011) Jenny M Mjösberg et al.   NATURE IMMUNOLOGY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages

(2008) Benjamin J. Marsland et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-4-Promoted T Helper 2 Responses Enhance Nippostrongylus brasiliensis-Induced Pulmonary Pathology

(2008) H. Mearns et al.   INFECTION AND IMMUNITY

Hookworm-Induced Persistent Changes to the Immunological Environment of the Lung

(2008) J. J. Reece et al.   INFECTION AND IMMUNITY

The roles of the prostaglandin D2 receptors DP1 and CRTH2 in promoting allergic responses

(2007) R Pettipher   BRITISH JOURNAL OF PHARMACOLOGY