The Effect of Glycosaminoglycans (GAGs) on Amyloid Aggregation and Toxicity

Heparin binding confers prion stability and impairs its aggregation

(2014) Tuane C. R. G. Vieira et al.   FASEB JOURNAL

Heparin Promotes the Rapid Fibrillization of a Peptide with Low Intrinsic Amyloidogenicity

(2013) Jillian Madine et al.   BIOCHEMISTRY

The amyloid-cell membrane system. The interplay between the biophysical features of oligomers/fibrils and cell membrane defines amyloid toxicity

(2013) Cristina Cecchi et al.   BIOPHYSICAL CHEMISTRY

New insights into the roles of sulfated glycosaminoglycans in islet amyloid polypeptide amyloidogenesis and cytotoxicity

(2013) Carole Anne De Carufel et al.   BIOPOLYMERS

Misfolding and Amyloid Aggregation of Apomyoglobin

(2013) Clara Iannuzzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glycation Accelerates Fibrillization of the Amyloidogenic W7FW14F Apomyoglobin

(2013) Clara Iannuzzi et al.   PLoS One

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolution of the effects induced by W → F substitutions on the conformation and dynamics of the amyloid-forming apomyoglobin mutant W7FW14F

(2012) Giuseppe Infusini et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation

(2012) Samuel I.A. Cohen et al.   JOURNAL OF MOLECULAR BIOLOGY

Glycosaminoglycans (GAGs) Suppress the Toxicity of HypF-N Prefibrillar Aggregates

(2012) Theodora Saridaki et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid Formation in Heterogeneous Environments: Islet Amyloid Polypeptide Glycosaminoglycan Interactions

(2012) Hui Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

The “CPC Clip Motif”: A Conserved Structural Signature for Heparin-Binding Proteins

(2012) Marc Torrent et al.   PLoS One

Structural transitions and oligomerization along polyalanine fibril formation pathways from computer simulations

(2012) Erin M. Phelps et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Heparin Binds 8 kDa Gelsolin Cross-β-Sheet Oligomers and Accelerates Amyloidogenesis by Hastening Fibril Extension

(2011) James P. Solomon et al.   BIOCHEMISTRY

Sulfated Glycosaminoglycans Accelerate Transthyretin Amyloidogenesis by Quaternary Structural Conversion

(2011) Steve Bourgault et al.   BIOCHEMISTRY

Glycosaminoglycans, Protein Aggregation and Neurodegeneration

(2011) Dulce Papy-Garcia et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Amyloid-β forms fibrils by nucleated conformational conversion of oligomers

(2011) Jiyong Lee et al.   Nature Chemical Biology

Time-resolved small-angle x-ray scattering study of the early stage of amyloid formation of an apomyoglobin mutant

(2011) Maria Grazia Ortore et al.   PHYSICAL REVIEW E

Heparin Induces Harmless Fibril Formation in Amyloidogenic W7FW14F Apomyoglobin and Amyloid Aggregation in Wild-Type Protein In Vitro

(2011) Silvia Vilasi et al.   PLoS One

Alzheimer's Disease: Another Target for Heparin Therapy

(2011) Luigi Bergamaschini et al.   TheScientificWorldJOURNAL

Amyloid fibril protein nomenclature: 2010 recommendations from the nomenclature committee of the International Society of Amyloidosis

(2010) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin

(2010) Jillian Madine et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Inhibition of aggregate formation as therapeutic target in protein misfolding diseases: effect of tetracycline and trehalose

(2010) Ivana Sirangelo et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Modulation of Aβ42 fibrillogenesis by glycosaminoglycan structure

(2010) Juan José Valle-Delgado et al.   FASEB JOURNAL

Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity

(2010) Massimo Stefani   FEBS Journal

Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

(2010) Elina Sandwall et al.   GLYCOBIOLOGY

The Molecular Basis of Distinct Aggregation Pathways of Islet Amyloid Polypeptide

(2010) Lei Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of proteoglycans and glycosaminoglycans in the pathogenesis of Alzheimer's disease and related disorders: Amyloidogenesis and therapeutic strategies-A review

(2010) Toshio Ariga et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A causative link between the structure of aberrant protein oligomers and their toxicity

(2010) Silvia Campioni et al.   Nature Chemical Biology

Identifying the amylome, proteins capable of forming amyloid-like fibrils

(2010) Lukasz Goldschmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Model Discrimination and Mechanistic Interpretation of Kinetic Data in Protein Aggregation Studies

(2009) Joseph P. Bernacki et al.   BIOPHYSICAL JOURNAL

Amyloid Formation by the Model Protein Muscle Acylphosphatase is Accelerated by Heparin and Heparan Sulphate Through a Scaffolding-based Mechanism

(2009) N. Motamedi-Shad et al.   JOURNAL OF BIOCHEMISTRY

Two-dimensional IR spectroscopy and isotope labeling defines the pathway of amyloid formation with residue-specific resolution

(2009) S.-H. Shim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA