Article
Clinical Neurology
Takenori Yamaguchi
Summary: This article provides a brief overview of the research conducted at the National Cerebral and Cardiovascular Center in Japan, including intravenous thrombolysis and dual antiplatelet therapy. The author also discusses the Stroke and Cardiovascular Disease Control Act, which aims to improve primary prevention, acute treatment, rehabilitation, and secondary prevention of stroke for the Japanese population.
Article
Public, Environmental & Occupational Health
Maryam Masoomi, Seyedehmahboobeh Hosseinikolbadi, Fahimeh Saeed, Vandad Sharifi, Amir Hossein Jalali Nadoushan, Sheikh Shoib
Summary: Suicide and suicide attempt have a significant impact on a portion of the general population, but the stigma surrounding this issue remains a problem, particularly in lower-income countries like Iran. Help-seeking for suicidal individuals is low in Iran due to fear of stigma associated with loss of faith, severe mental illness, and unacceptable sexual relationships. Public stigma poses a greater obstacle to accessing care for suicidal thoughts or attempts, leading many individuals to miss out on support programs. This article addresses the challenges of public stigma in Iranian society and proposes culturally appropriate strategies to improve the situation.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Family Studies
Catherine A. LaBrenz, Saltanat Childress, Erica D. Robinson, Margaret Lloyd Sieger, Jessica Ontiberos
Summary: This study examines the relationship between family preservation, family support, and basic need service utilization and child removal among families with substantiated cases of maltreatment.
CHILD ABUSE & NEGLECT
(2022)
Article
Family Studies
Luciana C. Assini-Meytin, Keith L. Kaufman, Ben Mathews, Donald A. Palmer, Maggie Ingram, Elizabeth J. Letourneau
Summary: This study analyzed 74 organizational documents from four major US youth-serving organizations to assess current measures in preventing and responding to child sexual abuse. The organizations collectively implement hundreds of measures categorized under eight themes, providing a starting point for discussions on core elements needed to keep children safe in such settings.
CHILD ABUSE & NEGLECT
(2021)
Article
Biochemistry & Molecular Biology
Luis Reza Herrera, Ronnesha A. Johnson, Kathleen McGlynn, Zane A. Gibbs, Anthony J. Davis, Angelique W. Whitehurst
Summary: Tumor-induced expression of meiotic genes, particularly HORMAD1, is associated with reduced patient survival and increased genomic instability. HORMAD1 plays a critical role in protecting stalled DNA replication forks and preventing DNA strand degradation. Loss of HORMAD1 leads to increased DNA breaks and chromosomal defects, exacerbated by induction of replication stress.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Matthew C. J. Yip, Sichen Shao
Summary: This article discusses the advancements in our mechanistic understanding of detecting and rescuing stalled ribosomal complexes in eukaryotes, including selectively detecting rare aberrant translational complexes, processing heterogeneous components, eliminating problematic RNA and nascent proteins through quality control pathways, and ensuring nascent proteome integrity through fail-safe mechanisms.
TRENDS IN BIOCHEMICAL SCIENCES
(2021)
Article
Infectious Diseases
Jeremiah Chakaya, Mishal Khan, Francine Ntoumi, Eleni Aklillu, Razia Fatima, Peter Mwaba, Nathan Kapata, Sayoki Mfinanga, Seyed Ehtesham Hasnain, Patrick D. M. C. Katoto, Andre N. H. Bulabula, Nadia A. Sam-Agudu, Jean B. Nachega, Simon Tiberi, Timothy D. McHugh, Ibrahim Abubakar, Alimuddin Zumla
Summary: The global TB report for October 2020 highlights slow progress in TB control efforts and the need to ramp up screening and diagnostic test services. Key drivers of TB, including undernutrition, poverty, diabetes, tobacco smoking, and household air pollution, must be addressed to achieve WHO 2035 TB care and prevention targets. Global focus is needed on the development of new vaccines for TB using new technological methods.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Computer Science, Interdisciplinary Applications
Huan Sun, Haiyan Wang, Sonja Steffensen
Summary: This paper studies a new reward and punishment mechanism to enhance prevention efficiency of the health system and individuals. The findings show that the mechanism can motivate all participants to make decisions according to the government's requirements and has a positive network externality. Furthermore, the effectiveness of the mechanism is proven regardless of the availability of information on individuals' prevention efforts.
COMPUTERS & INDUSTRIAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Daniel Solvie, Apoorva Baluapuri, Leonie Uhl, Daniel Fleischhauer, Theresa Endres, Dimitrios Papadopoulos, Amel Aziba, Abdallah Gaballa, Ivan Mikicic, Ekaterina Isaakova, Celeste Giansanti, Jennifer Jansen, Marvin Jungblut, Teresa Klein, Christina Schuelein-Voelk, Hans Maric, Soeren Doose, Markus Sauer, Petra Beli, Andreas Rosenwald, Matthias Dobbelstein, Elmar Wolf, Martin Eilers
Summary: The study reveals that MYC proteins in tumor cells form multimers in response to perturbations in transcription elongation, mRNA splicing, or inhibition of the proteasome. This multimerization process leads to changes in the MYC interactome and accumulation of MYC at stalled replication forks, affecting DNA double strand break formation.
Article
Geosciences, Multidisciplinary
Ross N. Mitchell, Uwe Kirscher
Summary: This study analyzes observational constraints on the Precambrian length of day and finds that the day length stalled at about 19 h for about 1 billion years during the mid-Proterozoic. It suggests that the accelerative torque of atmospheric thermal tides from solar energy balanced the decelerative torque of lunar oceanic tides, temporarily stabilizing Earth's rotation. This stalling coincides with a period of relatively limited biological evolution known as the boring billion.
Review
Oncology
Dana Moldovanu, Harry J. de Koning, Carlijn M. van der Aalst
Summary: Randomized-controlled trials have shown that low-dose computed tomography screening can reduce lung cancer mortality, but evidence on integrating smoking cessation support is lacking. Combining lung cancer screening with smoking cessation can significantly reduce mortality risk. Multi-modality interventions delivered by clinicians may be the most successful in influencing smoking behavior.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Shriya Deshmukh, Adam Ptack, Brian Krug, Nada Jabado
Summary: The discovery of 'oncohistones' in various cancers has revealed their role in promoting genome-wide epigenetic perturbations through altered post-translational modifications on key lysine residues of the H3 tail. These changes disrupt the distribution of opposing chromatin marks, ultimately driving tumorigenesis by maintaining a progenitor state at the expense of differentiation.
Article
Genetics & Heredity
Yanfei Wei, Guanzhang Li, Jing Feng, Fan Wu, Zheng Zhao, Zhaoshi Bao, Wei Zhang, Xiaodong Su, Jiuyi Li, Xueling Qi, Zejun Duan, Yunqiu Zhang, Sandra Ferreyra Vega, Asgeir Store Jakola, Yingyu Sun, Helena Caren, Tao Jiang, Xiaolong Fan
Summary: All IDH-mutant gliomas resemble early stages of oligodendrocyte lineage and are stalled in oligodendrocyte differentiation due to blocked myelination program. These findings provide a framework for accommodating the biological features and therapy development of IDH-mutant gliomas.
Article
Dermatology
Marc Wittlich, Stephan Westerhausen, Benjamin Strehl, Helmut Versteeg, Wiho Stoeppelmann
Summary: A UVR exposure database has been developed and validated to protect millions of workers worldwide. The database includes data from over 250 occupations and 650 activities, providing high-quality information for studying the effects of UVR exposure on the human body.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Surgery
Dih-Dih Huang, Nathan R. Manley, Richard H. Lewis, Peter E. Fischer, Arianna Magnotti, Samantha Davis, Martin A. Croce, Louis J. Magnotti
Summary: This study examines patterns of firearm-related deaths in the US and their correlation with population size. The study reveals that while homicides constitute the majority of firearm-related deaths in metropolitan areas, suicides account for a disproportionate number in smaller urban areas. The rate of firearm-related suicides has significantly increased between 1999 and 2016, emphasizing the need for better prevention efforts and public health policies.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
