Article
Nanoscience & Nanotechnology
Julia Joseph, Kang Zi Khor, Emmanuel Jairaj Moses, Vuanghao Lim, Mohd Yusmaidie Aziz, Nozlena Abdul Samad
Summary: The study demonstrated the anticancer activities of Vernonia amygdalina leaf extracts and silver nanoparticles on human breast cancer cells, reducing cell viability through inducing apoptosis and causing DNA damage. Further research is needed to understand the mechanism of action of these substances.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Energy & Fuels
Sepideh Shahriary, Farzaneh Tafvizi, Parvin Khodarahmi, Masoud Shaabanzadeh
Summary: The study found that green-synthesized CuO nanoparticles have potential in treating cisplatin-resistant ovarian cancer cells. The results showed that these synthesized nanoparticles could induce apoptosis in cancer cells and have minimal toxicity on normal cells. Therefore, biogenic synthesized CuO nanoparticles could be further studied as a potential approach for cancer treatment.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Multidisciplinary Sciences
Aliya Yousaf, Muhammad Waseem, Aneela Javed, Sofia Baig, Bushra Ismail, Ayesha Baig, Irum Shahzadi, Shamyla Nawazish, Iftikhar Zaman
Summary: This study synthesized silver nanoparticles using Taxus wallichiana leaf extract and evaluated their antibacterial and anticancer properties. The nanoparticles showed significant antibacterial activity against Salmonella typhi and Staphylococcus aureus, as well as cytotoxic activity against U251 brain cancer cells.
Article
Biotechnology & Applied Microbiology
Dhanyakumara Shivapoojar Basavarajappa, Raju Suresh Kumar, Abdulrahman I. Almansour, Bidhayak Chakraborty, Meghashyama Prabhakara Bhat, Shashiraj Kariyellappa Nagaraja, Halaswamy Hiremath, Karthikeyan Perumal, Sreenivasa Nayaka
Summary: This study successfully synthesized silver nanoparticles using Passiflora vitifolia leaf extract as reducing and capping agent. The synthesized nanoparticles showed stability, polydispersity, and demonstrated antimicrobial, antioxidant, and anticancer activities. These findings suggest the potential biomedical applications of this nanomaterial.
BIOCHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
C. S. Madhu, K. S. Balaji, J. Shankar, S. N. Sunil Gowda, A. C. Sharada
Summary: Silver nanoparticles were successfully synthesized using a green mediated approach aided by the fruit extract of Praecitrullus fistulosus, and their biological properties were evaluated. The synthesized nanoparticles showed antibacterial activity, dye degradation properties, cytotoxic potential against cancer cells, and angiosuppressive activity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Environmental
Dinesh Babu Manikandan, Arun Sridhar, Rajkumar Krishnasamy Sekar, Balaji Perumalsamy, Srinivasan Veeran, Manikandan Arumugam, Parthiban Karuppaiah, Thirumurugan Ramasamy
Summary: The study demonstrated the green fabrication of silver nanoparticles using a leaf extract of Ocimum Americanum, showcasing their potential applications in antibacterial, anticancer, and photocatalytic dye degradation. The nanoparticles showed high stability, biocompatibility, and multifunctionality, making them a promising candidate for therapeutic and catalytic purposes.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Huda Mahdi Younis, Hanaa Ali Hussein, Fatin L. Khaphi, Zahra Kadhum Saeed
Summary: The research successfully synthesized gold and silver nanoparticles using teak extract and studied their anticancer and antimicrobial activities. The results showed that silver nanoparticles exhibited significant anticancer activity against liver cancer, while gold nanoparticles showed significant antibacterial and antifungal activity against various bacteria and fungi.
Article
Nanoscience & Nanotechnology
Shakeel Ahmad Khan, Sammia Shahid, Amber Ayaz, Jawaher Alkahtani, Mohamed S. Elshikh, Tauheeda Riaz
Summary: NiO nanoparticles coated with plant molecules synthesized using plant extract demonstrated superior antibacterial and anticancer performance, excellent antioxidant activity, and biocompatibility.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Polymer Science
Nabil A. Alhakamy, Usama A. Fahmy, Shaimaa M. Badr Eldin, Osama A. A. Ahmed, Hibah M. Aldawsari, Solomon Z. Okbazghi, Mohamed A. Alfaleh, Wesam H. Abdulaal, Abdulmohsin J. Alamoudi, Fatma M. Mady
Summary: This study demonstrates that incorporating quercetin, scorpion venom peptides, and Phospholipon(R) 90H into a nano-based delivery platform improves the cellular uptake and antiproliferative efficacy of quercetin, showing potential as a therapeutic approach for the treatment of breast cancer.
Article
Chemistry, Multidisciplinary
Leena V. Hublikar, Sharanabasava V. Ganachari, Veerabhadragouda B. Patil
Summary: Averrhoa bilimbi leaf extract was used as a reducing agent to synthesize silver nanoparticles (AgNPs), which showed stability and controlled release. The synthesized nanoparticles were characterized as spherical and monodispersed using UV-visible, FT-IR spectroscopies, XRD, and SEM analyses. These bio-synthesized AB-AgNPs demonstrated effective cytotoxicity against lung cancer (A549 cell line) and breast cancer (MCF7 cell line), with optimized conditions. The IC50 values for A549 and MCF7 cells were found to be 49.52 g mL(-1) and 78.40 g mL(-1), respectively. Thus, the green synthesis of AB-AgNPs holds promise as a potential anticancer agent.
NANOSCALE ADVANCES
(2023)
Article
Oncology
Katerina Spyridopoulou, Georgios Aindelis, Aglaia Pappa, Katerina Chlichlia
Summary: Colorectal cancer is a major health problem with high mortality rates and prevalence, requiring innovative treatment approaches. Biogenic selenium nanoparticles, synthesized by a probiotic microorganism, have the potential to induce apoptotic and immunogenic cell death in colon cancer cell lines. The nanoparticles showed promising results in inhibiting colon cancer cell growth and inducing pro-apoptotic and immunogenic cell death markers, suggesting they could be an efficient strategy for destroying tumor cells.
Article
Biochemical Research Methods
Amr H. Hashem, Salem S. Salem
Summary: This study successfully biosynthesized SeNPs using aqueous extract of Urtica dioica leaf, showing excellent antimicrobial activity and promising anticancer activity. SeNPs exhibited inhibitory activity against various bacteria and fungi, with minimal cytotoxicity towards cancerous cells.
BIOTECHNOLOGY JOURNAL
(2022)
Article
Environmental Sciences
H. Joy Prabu, Rintu Varghese, I. Johnson, S. John Sundaram, A. Dhayal Raj, Rajakrishnan Rajagopal, Palaniselvam Kuppusamy, Rengasamy Sathya, K. Kaviyarasu
Summary: Metal nanoparticles synthesized by the green synthesis approach have demonstrated biocompatibility and eco-friendly attributes. A laser-induced bio reduction work using Centella asiatica extract was successfully achieved on copper oxide nanoparticles for the first time. This synthesis technique is simple and effective, allowing for the synthesis of stable copper nanoparticles with different shapes. Various characterization techniques revealed the ability of these nanoparticles to regulate the crystalline nature and morphology of the integrated specimen. Furthermore, the obtained copper oxide nanoparticles have catalytic activity in reducing the absorbance of methylene blue.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Thidarath Rattanaburee, Patpanat Sermmai, Kornthip Tangthana-umrung, Tienthong Thongpanchang, Potchanapond Graidist
Summary: This study investigated the cytotoxicity and anticancer activity of (+/-)-kusunokinin derivatives on various cancer cells. The results showed that (+/-)-TTPG-B exhibited the strongest cytotoxicity on breast cancer and cholangiocarcinoma cells. Both (+/-)-TTPG-A and (+/-)-TTPG-B induced cell cycle arrest and apoptosis, and their effects were superior to (+/-)-kusunokinin.
Article
Pharmacology & Pharmacy
Nida Nayyar Farshori, Mai Mohammad Al-Oqail, Ebtesam Saad Al-Sheddi, Shaza Mohamed Al-Massarani, Quaiser Saquib, Maqsood Ahmed Siddiqui, Rizwan Wahab, Abdulaziz Ali Al-Khedhairy
Summary: In this study, silver nanoparticles were successfully synthesized using a green method and their anticancer effects in human lung adenocarcinoma cells were investigated. The results showed that the synthesized silver nanoparticles can inhibit the growth of cancer cells by inducing apoptosis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Minh Thong Le, Hojun Choi, Hyejeong Lee, Van Chanh Quy Le, Byeongyong Ahn, Chak-Sum Ho, Kwonho Hong, Hyuk Song, Jin-Hoi Kim, Chankyu Park
SCIENTIFIC REPORTS
(2020)
Article
Immunology
Hye-sun Cho, Joori Yum, Andy Lariviere, Nicolas Leveque, Quy Van Chanh Le, ByeongYong Ahn, Hyoim Jeon, Kwonho Hong, Nagasundarapandian Soundrarajan, Jin-Hoi Kim, Charles Bodet, Chankyu Park
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Jin-Hoi Kim
Summary: Several studies have demonstrated the molecular mechanisms involved in the biogenesis and release of exosomes. PtNPs were shown to enhance exosome secretion in A549 cells by inducing oxidative stress and the ceramide pathway. Pre-treatment with NAC could inhibit the PtNPs-induced exosome biogenesis and release.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Min-Kyeung Choi, Minh Thong Le, Hye-Sun Cho, Juyoung Lee, Hyoim Jeon, Se-Yeoun Cha, Manheum Na, Taehoon Chun, Jin-Hoi Kim, Hyuk Song, Chankyu Park
Summary: The study on PG1 transgenic mice showed positive effects in resisting Staphylococcus aureus infection, with reduced lung injury, improved bacteria clearance, and lower inflammation. However, some individuals developed eye problems, indicating the importance of AMP expression regulation and localization to prevent adverse effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Min-Hee Kang, Jin-Hoi Kim
Summary: Exosomes are nanoscale membrane vesicles secreted by cells, which play important roles in intercellular communication and disease diagnosis. Research on exosomes has great potential in biomedical fields, but the underlying biological mechanisms require further exploration.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Correction
Cell Biology
Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Muhammad Qasim, Jin-Hoi Kim
Article
Biochemistry & Molecular Biology
Hye-sun Cho, Munjeong Choi, Yunjung Lee, Hyoim Jeon, Byeongyong Ahn, Nagasundarapandian Soundrarajan, Kwonho Hong, Jin-Hoi Kim, Chankyu Park
Summary: The study found that using broad-spectrum antimicrobial peptide PMAP-36 can effectively isolate high-quality RNA from various bacteria, providing an efficient method for nucleic acid isolation. Additionally, the use of PMAP-36 also successfully isolates high-quality genomic DNA from challenging bacterial strains, offering a new option for microbiome research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Min-Hee Kang, Muhammad Qasim, Khalid Khan, Jin-Hoi Kim
Summary: Extracellular vesicles (EVs) are a diverse group of membrane-bound vesicles that function as messengers between cells. Much remains unknown about their biogenesis, cargo sorting, and potential therapeutic applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Jin-Hoi Kim
Summary: This study demonstrates for the first time that PdNPs stimulate exosome biogenesis and release in THP-1 cells, simultaneously increasing levels of cytokines and chemokines by modulating various physiological processes. These findings offer a rational approach to enhancing exosome production for various therapeutic applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Sangiliyandi Gurunathan, Muhammad Qasim, Min-Hee Kang, Jin-Hoi Kim
Summary: Cancer is the second leading cause of death worldwide, and melatonin has been shown to have oncostatic and anticancer properties by directly affecting carcinogenesis and indirectly disrupting the circadian cycle.
ONCOTARGETS AND THERAPY
(2021)
Article
Immunology
Hansam Cho, Yuyeon Jang, Ki-Hoon Park, Hanul Choi, Aleksandra Nowakowska, Hee-Jung Lee, Minjee Kim, Min-Hee Kang, Jin-Hoi Kim, Ha Youn Shin, Yu-Kyoung Oh, Young Bong Kim
Summary: A recombinant baculoviral vector-based DNA vaccine system against MERS-CoV and SARS-CoV2 was reported, showing high efficacy in preventing viral infections in animal models.
Article
Agriculture, Dairy & Animal Science
S. Youk, M. T. Le, M. Kang, B. Ahn, M. Choi, K. Kim, T. H. Kim, J. H. Kim, C. S. Ho, C. Park
Summary: A high-resolution typing method was developed for swine leukocyte antigen 3 (SLA-3), identifying 21 alleles with four novel ones, although the allelic diversity of SLA-3 was lower compared to SLA-1 and -2. More SLA-3 alleles were observed in Landrace and Yorkshire breeds, with SLA-3*04:01 being the most widely distributed allele across all breeds. This method aids in analyzing major SLA genes from field samples, enhancing understanding of immune responses and genetic makeup.
Review
Agriculture, Dairy & Animal Science
Sangiliyandi Gurunathan, Min-Hee Kang, Hyuk Song, Nam Hyung Kim, Jin-Hoi Kim
Summary: Extracellular vesicles (EVs) are nanosized membrane-enclosed compartments that act as messengers in cell-to-cell communication. They influence the phenotype and function of recipient cells by transferring functional proteins and genetic information. Various types of EVs are present in biological fluids, carrying cargoes such as lipids, proteins, and nucleic acids. EVs associated with the reproductive system play a significant role in regulating physiological events such as gamete maturation, fertilization, and embryo and fetal development.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sangiliyandi Gurunathan, Ah Reum Lee, Jin Hoi Kim
Summary: SARS-CoV-2 has caused a pandemic of COVID-19, and some patients have acquired secondary infections such as black fungus disease. Prompt diagnosis and treatment are necessary to prevent high mortality and morbidity rates. Uncontrolled diabetes and immunosuppression are major risk factors, and the use of steroids can increase the risk of black fungus infection. Novel and effective antimicrobial agents are needed to combat this infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Jin Hoi Kim
Summary: Graphene oxide (GO) stimulates exosome biogenesis and release in human ovarian cancer cells (SKOV3), indicating its potential as a tool for targeting the exosome pathway.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
