Wrestling with stress: Roles of protein SUMOylation and deSUMOylation in cell stress response

Whole-Genome Sequencing Uncovers the Genetic Basis of Chronic Mountain Sickness in Andean Highlanders

(2013) Dan Zhou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia

(2013) Chun Guo et al.   EMBO JOURNAL

SUMO wrestling with Drp1 at mitochondria

(2013) Caroline A Anderson et al.   EMBO JOURNAL

A SUMO protease for stress protection

(2013) Alison Schuldt   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Senp1 Is Essential for Desumoylating Sumo1-Modified Proteins but Dispensable for Sumo2 and Sumo3 Deconjugation in the Mouse Embryo

(2013) Prashant Sharma et al.   Cell Reports

Heat shock induces a massive but differential inactivation of SUMO-specific proteases

(2012) Manuel P. Pinto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors

(2012) Masaharu Uno et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein Group Modification and Synergy in the SUMO Pathway as Exemplified in DNA Repair

(2012) Ivan Psakhye et al.   CELL

SENP1 deficiency promotes ER stress-induced apoptosis by increasing XBP1 SUMOylation

(2012) Zhou Jiang et al.   CELL CYCLE

DeSUMOylating isopeptidase: a second class of SUMO protease

(2012) Eun Ju Shin et al.   EMBO REPORTS

Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions

(2012) Sarah Schulz et al.   EMBO REPORTS

Small Ubiquitin-like Modifier (SUMO) Modification of E1 Cys Domain Inhibits E1 Cys Domain Enzymatic Activity

(2012) Khue Truong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Function and regulation of SUMO proteases

(2012) Christopher M. Hickey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An Upregulation of SENP3 After Spinal Cord Injury: Implications for Neuronal Apoptosis

(2012) Haixiang Wei et al.   NEUROCHEMICAL RESEARCH

SUMOylation in carcinogenesis

(2011) Kira Bettermann et al.   CANCER LETTERS

Development of Small Molecule Inhibitors and Probes of Human SUMO Deconjugating Proteases

(2011) Victoria E. Albrow et al.   CHEMISTRY & BIOLOGY

All the Little Pieces

(2011) Makhosazane Zungu et al.   CIRCULATION JOURNAL

Cost of disorders of the brain in Europe 2010

(2011) Anders Gustavsson et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The SUMO E3-ligase PIAS1 couples reactive oxygen species-dependent JNK activation to oxidative cell death

(2011) Beatriz B. Leitao et al.   FASEB JOURNAL

Swapping Small Ubiquitin-like Modifier (SUMO) Isoform Specificity of SUMO Proteases SENP6 and SENP7

(2011) Kamela O. Alegre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Dynamics and Mechanism of SUMO Chain Deconjugation by SUMO-specific Proteases

(2011) Miklós Békés et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced SUMOylation and SENP-1 Protein Levels following Oxygen and Glucose Deprivation in Neurones

(2011) Helena Cimarosti et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Analysis of Oxygen/Glucose-Deprivation-Induced Changes in SUMO3 Conjugation Using SILAC-Based Quantitative Proteomics

(2011) Wei Yang et al.   JOURNAL OF PROTEOME RESEARCH

The SUMO-specific isopeptidase SENP2 associates dynamically with nuclear pore complexes through interactions with karyopherins and the Nup107-160 nucleoporin subcomplex

(2011) Jacqueline Goeres et al.   MOLECULAR BIOLOGY OF THE CELL

NF-κB Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress

(2011) Moon Hee Lee et al.   MOLECULAR CELL

Elevated Global SUMOylation in Ubc9 Transgenic Mice Protects Their Brains against Focal Cerebral Ischemic Damage

(2011) Yang-ja Lee et al.   PLoS One

Crosstalk between JNK and SUMO Signaling Pathways: deSUMOylation Is Protective against H2O2-Induced Cell Injury

(2011) Marco Feligioni et al.   PLoS One

Distribution and paralogue specificity of mammalian deSUMOylating enzymes

(2010) Nagamalleswari Kolli et al.   BIOCHEMICAL JOURNAL

Mechanisms, regulation and consequences of protein SUMOylation

(2010) Kevin A. Wilkinson et al.   BIOCHEMICAL JOURNAL

Targets and consequences of protein SUMOylation in neurons

(2010) Kevin A. Wilkinson et al.   BRAIN RESEARCH REVIEWS

Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3

(2010) Mei-Ling Kuo et al.   CELL CYCLE

Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90

(2010) Shan Yan et al.   EMBO JOURNAL

Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and Angiogenesis

(2010) Ying Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SUMO protease SENP6 is a direct regulator of PML nuclear bodies

(2010) Neil Hattersley et al.   MOLECULAR BIOLOGY OF THE CELL

SUMO-Specific Protease 2 Is Essential for Suppression of Polycomb Group Protein-Mediated Gene Silencing during Embryonic Development

(2010) Xunlei Kang et al.   MOLECULAR CELL

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition

(2010) Jaclyn R. Gareau et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

Characterization of SENP7, a SUMO-2/3-specific isopeptidase

(2009) Lin Nan Shen et al.   BIOCHEMICAL JOURNAL

PIAS proteins: pleiotropic interactors associated with SUMO

(2009) Miia M. Rytinki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation

(2009) Chao Huang et al.   EMBO JOURNAL

Mitochondrial outer-membrane permeabilization and remodelling in apoptosis

(2009) Alexis Jourdain et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Translocation of SenP5 from the Nucleoli to the Mitochondria Modulates DRP1-dependent Fission during Mitosis

(2009) Rodolfo Zunino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMOylation participates in induction of ischemic tolerance

(2009) Yang ja Lee et al.   JOURNAL OF NEUROCHEMISTRY

System-Wide Changes to SUMO Modifications in Response to Heat Shock

(2009) F. Golebiowski et al.   Science Signaling

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Small Ubiquitin-Like Modifier Proteases OVERLY TOLERANT TO SALT1 and -2 Regulate Salt Stress Responses in Arabidopsis

(2008) L. Conti et al.   PLANT CELL

Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation

(2007) Zheng Xu et al.   FASEB JOURNAL