Article
Biochemistry & Molecular Biology
Lihua Sun, Hui Tian, Songguo Xue, Hongjuan Ye, Xue Xue, Rongxiang Wang, Yu Liu, Caixia Zhang, Qiuju Chen, Shaorong Gao
Summary: A hormone-sensitive signaling pathway in ovarian cells has been identified as a potential target for better treatment of infertility-associated complications. The study found a strong connection between the exposure to human chorionic gonadotropin (hCG) and the expression of a signaling protein associated with blood vessels in ovarian cells, offering new insights into the prevention and management of ovarian hyperstimulation syndrome (OHSS).
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Zhe Qing, Hanfei Huang, Shikun Yang, Jie Lin, Zhong Zeng, Jian Duan, Bo Yuan, Tingfeng Ming
Summary: The study demonstrates that LSECs cultured under hypoxic conditions can maintain fenestrae and promote proliferation through the SENP1/HIF-1α/VEGF signaling axis, thereby adapting to the hypoxic environment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Mariko Miyashita-Ishiwata, Malak El Sabeh, Lauren D. Reschke, Sadia Afrin, Mostafa A. Borahay
Summary: This study reveals an aberrant response of leiomyoma cells to hypoxia, characterized by increased cell proliferation and secretion of angiogenic factors. This abnormal response may contribute to the development and growth of leiomyoma.
Article
Biochemistry & Molecular Biology
Joon Seok Lee, Hyun Geun Cho, Jeong Yeop Ryu, Eun Jung Oh, Hyun Mi Kim, Suin Kwak, Seok-Jong Lee, Jongmin Lee, Sang Yub Lee, Seung Huh, Ji Yoon Kim, Ho Yun Chung
Summary: This study analyzed the effects of hypoxia on angiogenesis in arteriovenous malformation (AVM) patients and normal tissues. The results showed that AVM ECs exhibited higher angiogenesis capacity and expression of angiogenesis-related genes under hypoxic conditions. These findings provide a foundation for the development of AVM treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anesthesiology
Marlene E. Da Vitoria Lobo, Nick Weir, Lydia Hardowar, Yara Al Ojaimi, Ryan Madden, Alex Gibson, Samuel M. Bestall, Masanori Hirashima, Chris B. Schaffer, Lucy F. Donaldson, David O. Bates, Richard Philip Hulse
Summary: Neuropathic pain, such as in diabetes, may result from reduced blood flow and vascularity in the dorsal horn, leading to hypersensitivity and pain response. Increased hypoxia in dorsal horn neurons, activated by hypoxic signaling, contributes to the development of pain. Inhibiting carbonic anhydrase activity can alleviate hypoxia-induced pain behaviors.
Article
Cell Biology
Marina Katsman, Aviva Azriel, Guy Horev, Yitzhak Reizel, Ben-Zion Levi
Summary: The study reveals the crucial role of N-VEGF as an autoregulatory arm of VEGF-A in angiogenesis and cell survival under hypoxic conditions.
Article
Biochemistry & Molecular Biology
Miron Tokarski, Aneta Cierzniak, Dagmara Baczynska
Summary: This study investigates the effect of chemically-induced hypoxia on the expression of miRNA molecules in human endothelial cells and identifies several miRNAs that may affect the HGFA-HGF-c-Met signaling pathway. The findings shed new light on the role of miRNAs in hypoxia and highlight the importance of specific miRNAs in regulating this signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Cell Biology
Ming-Jen Hsu, Han-Kun Chen, Jin-Cherng Lien, Yu-Han Huang, Shiu-Wen Huang
Summary: This study evaluated the anti-angiogenic properties of a new naphthoquinone derivative, PPE8, and explored its mechanisms of action. The results showed that PPE8 reduced proliferation, migration, invasion, and tube formation in human umbilical vein endothelial cells (HUVECs) induced by VEGF-A. It also inhibited micro vessel sprouting and angiogenesis in vivo. Additionally, PPE8 suppressed phosphorylation of VEGFR-2, Src, FAK, ERK1/2, and AKT in HUVECs exposed to VEGF-A, and exhibited significant decline in xenograft tumor growth. These findings suggest that PPE8 may target VEGF-A-VEGFR-2 signaling to reduce angiogenesis, making it a potential drug candidate for angiogenesis-related diseases.
Article
Oncology
Yanfen Cui, Hui Liu, Zhaosong Wang, He Zhang, Jianfei Tian, Zhiyong Wang, Weijie Song, Hui Guo, Liming Liu, Ruinan Tian, Xiaoyan Zuo, Sixin Ren, Fei Zhang, Ruifang Niu
Summary: High fructose intake is associated with increased risk of multiple cancers. Fructose can enhance the biological function of vascular endothelial cells (VECs) and promote angiogenesis by activating the Akt and Src signaling pathways. It can also upregulate production of reactive oxygen species (ROS) in colorectal cancer cells, indirectly enhancing the function of VECs. These findings have been validated in clinical colorectal cancer tissues and mouse models.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, General & Internal
Yu-Ting Bai, Feng-Jun Xiao, Hua Wang, Ri-Li Ge, Li-Sheng Wang
Summary: The study reveals the regulatory effect of hypoxia on proliferation, migration, and ferroptosis in H9c2 cells, highlighting the protective role of SENP1 upregulation against ferroptosis while promoting proliferation and migration through the regulation of HIF-1 alpha and ACSL4 deSUMOylation. These findings provide a theoretical foundation for novel therapeutics for ischemic heart diseases.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Chemistry, Medicinal
Amirfarbod Yazdanyar, Charles L. Cai, Jacob V. Aranda, Eric Shrier, Kay D. Beharry
Summary: This study found that Eylea is not as effective as Avastin in promoting angiogenesis, although the lower dose of Eylea may be more effective than the higher dose. Additionally, Eylea may promote normal vascular development by regulating the expression of factors such as VEGFR-1 and Notch/Jagged-1.
Article
Genetics & Heredity
Shu Yan, Ji Hu, Jia Li, Pengchao Wang, Yilong Wang, Zhaohui Wang
Summary: PRMT4 is upregulated in ischemic muscles and promotes angiogenesis. It regulates VEGF expression by interacting with YB1. Knockdown of YB1 attenuates PRMT4-mediated angiogenic effects in vitro.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Cell Biology
Aikaterini Gatsiou, Kateryna Sopova, Alexandros Tselepis, Konstantinos Stellos
Summary: Platelets are immune cells known for their haemostatic properties and play a key role in vascular regeneration and angiogenesis by releasing growth factors. The IL-17A/IL-17RA axis selectively induces the release of pro-angiogenic factors from platelets, affecting endothelial cells and driving them towards a pro-angiogenic state.
Article
Biochemistry & Molecular Biology
Qiuling Liu, Tujing Song, Bing Chen, Jingjing Zhang, Wen Li
Summary: Hypoxia is crucial for the development of various disorders, especially hypoxic cerebropathy. The damage to the blood-brain barrier (BBB) caused by hypoxia is well known. This study explored the correlation between endothelial ferroptosis and hypoxia-induced BBB damage using in vivo zebrafish and in vitro bEnd.3 cells. The results showed that hypoxic treatment could induce BBB disruption by down-regulating claudin-5 (CLDN5) expression in both zebrafish cerebrovascular endothelial cells and bEnd.3 cells.
Article
Biotechnology & Applied Microbiology
Rahul Mallick, Erika Gurzeler, Pyry I. Toivanen, Tiina Nieminen, Seppo Yla-Herttuala
Summary: VEGF-B186R127S induces vascular growth in mouse heart by recruiting EPCs. It is a novel therapeutic agent for cardiac therapeutic angiogenesis to rescue myocardial tissue after an ischemic insult.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Meng-Kai Ge, Na Zhang, Li Xia, Cheng Zhang, Shuang-Shu Dong, Zhan-Ming Li, Yan Ji, Min-Hua Zheng, Jing Sun, Guo-Qiang Chen, Shao-Ming Shen
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Yang Wang, Jing Tian, Chao Huang, Jiao Ma, Gaolei Hu, Yalan Chen, Tianshi Wang, Rong Cai, Yong Zuo, Hongsheng Tan, Qiuju Fan, Baijun Dong, Wei Xue, Jing Yi, Guoqiang Chen, Jun Tu, Jinke Cheng
Article
Cell & Tissue Engineering
Jing Chen, Qiong Zhou, Man-Hua Liu, Yun-Sheng Yang, Yin-Qi Wang, Ying Huang, Guo-Qiang Chen
Letter
Oncology
Man-Hua Liu, Xiao-Cui Zhang, Jing Chen, Yun-Sheng Yang, Yin-Qi Wang, Jun-Ke Zheng, Guo-Qiang Chen, Ying Huang
Article
Immunology
Qing Li, Chunlei Feng, Lingyun Li, Guiliang Xu, Haijuan Gu, Shiqiang Li, Dali Li, Mingyao Liu, Shuhua Han, Biao Zheng
Summary: This study demonstrates the important role of Lp-PLA(2) in controlling inflammatory macrophage polarization in autoimmune encephalomyelitis and multiple sclerosis. Lp-PLA(2) affects M1 function through lysophosphatidylcholine-mediated pathways and G2A receptor guidance, which could potentially lead to new therapeutic approaches for MS and other inflammatory disorders.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ping He, Cheng Zhang, Yan Ji, Meng-Kai Ge, Yun Yu, Na Zhang, Shuo Yang, Jian-Xiu Yu, Shao-Ming Shen, Guo-Qiang Chen
Summary: SNHG8, a chromatin-localized lncRNA, interacted and phase separated with histone H1 variants. It showed stronger binding ability to H1 proteins than linker DNA, leading to increased chromatin condensation and epithelial cell differentiation.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Chemistry, Medicinal
Fazhi Yu, Chenyu Zhu, Shuyin Ze, Haojie Wang, Xinyu Yang, Mingyao Liu, Qiong Xie, Weiqiang Lu, Yonghui Wang
Summary: Compound 57 demonstrates potential as a novel A(2A) receptor antagonist in cancer immunotherapy, enhancing T cell activation and inhibiting adenosine levels in the tumor microenvironment.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Zhi Pang, Xinran Dong, Huayun Deng, Chengzhi Wang, Xiaodong Liao, Chunhua Liao, Yahui Liao, Weidong Tian, Jinke Cheng, Guoqiang Chen, Haiying Yi, Lei Huang
Summary: Aberrant overexpression of MUC1 and HER2 is associated with breast cancer, and their concomitant expression leads to worse clinical outcome. In a mouse model, coexpression of Her2 and MUC1-CD promotes mammary tumor development and induces changes in tumor lineage plasticity and downregulation of tricarboxylic acid cycle genes. Furthermore, MUC1 enhances the Her2 signaling pathway by inducing Her2/Egfr dimerization.
Article
Multidisciplinary Sciences
Xue Chen, Yanyan Xu, Qidi Chen, Heng Zhang, Yu Zeng, Yan Geng, Lei Shen, Fubin Li, Lei Chen, Guo-Qiang Chen, Chuanxin Huang, Junling Liu
Summary: PTEN-deficient platelets promote autoimmunity in mouse models through excessive activation of T-FH cells and systemic autoimmune pathology.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Chunyang Yi, Jiacheng He, Dan Huang, Yumiao Zhao, Chan Zhang, Xiyun Ye, Ying Huang, Ruth Nussinov, Junke Zheng, Mingyao Liu, Weiqiang Lu
Summary: Activation of the orphan GPCR GPR132 induces cell differentiation in acute myeloid leukemia (AML) and the natural product 8-gingerol is found to be a potential GPR132 agonist, promoting differentiation and reducing colony formation in AML cell lines.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Ying Chen, Jinyi Zhang, Yuan Weng, Yueming Xu, Weiqiang Lu, Wei Liu, Mingyao Liu, Tian Hua, Gaojie Song
Summary: This study presents the structures of the human adenosine A2B receptor (A2BR) bound to its agonists NECA and BAY60-6583, elucidating the orthosteric binding pockets and their subtle differences. Selectivity is mainly determined by regions extended from the orthosteric pocket, and the key determinants for BAY60-6583's selectivity against A2BR are identified. This study provides a better understanding of ligand selectivity in the adenosine receptor family and offers a structural template for the development of A2BR ligands for related diseases.
Article
Chemistry, Medicinal
Peng He, Juanjuan Feng, Xinting Xia, Yue Sun, Jia He, Tian Guan, Yangrui Peng, Xueli Zhang, Mingyao Liu, Xiufeng Pang, Yihua Chen
Summary: HP661 is a highly effective OXPHOS inhibitor that can inhibit mitochondrial oxygen consumption in high OXPHOS lung cancer cells. It also shows significant sensitivity in MEK inhibitor-resistant lung cancer cells and has therapeutic efficacy against high OXPHOS lung cancer.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Chenyu Zhu, Shuyin Ze, Ronghui Zhou, Xinyu Yang, Haojie Wang, Xiaolei Chai, Meimiao Fang, Mingyao Liu, Yonghui Wang, Weiqiang Lu, Qiong Xie
Summary: Recent studies and clinical evidence have shown that adenosine A2A receptor (A2AR) antagonists have great potential as novel approaches for cancer immunotherapy. Through the screening of a compound library, a pyridinone hit compound with weak A2AR antagonistic activity was identified, and further studies led to the discovery of a series of pyridinone derivatives with strong potency. Compound 38 demonstrated potent A2AR antagonistic activity, good metabolic stability, and excellent oral bioavailability, and also effectively enhanced the activation and killing ability of T cells. In addition, it exhibited excellent in vivo antitumor activity, making it a promising candidate for cancer immunotherapy.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Chenyu Zhu, Shuyin Ze, Ronghui Zhou, Xinyu Yang, Haojie Wang, Xiaolei Chai, Meimiao Fang, Mingyao Liu, Yonghui Wang, Weiqiang Lu, Qiong Xie
Summary: Recent studies and clinical evidence have shown that adenosine A2A receptor (A2AR) antagonists have great potential in cancer immunotherapy. Through screening, compound 38, a pyridinone derivative, was identified as a potent A2AR antagonist with good stability and high bioavailability. Furthermore, compound 38 effectively enhanced the activation of T cells in vitro and demonstrated excellent antitumor activity in vivo, making it a promising candidate for cancer immunotherapy.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Yin-Qi Wang, Yun-Sheng Yang, Jing Chen, Man-Hua Liu, Guo-Qiang Chen, Ying Huang
EXPERIMENTAL CELL RESEARCH
(2020)