☆ 4.5 Article

The spliced variant of hepatitis B virus protein, HBSP, interacts with Bcl-2/Bcl-xl in vitro and induces apoptosis in HepG2 cells

IUBMB LIFE (2008)

期刊

IUBMB LIFE

卷 60, 期 10, 页码 700-702

出版社

WILEY

DOI: 10.1002/iub.108

关键词

apoptosis; protein function

类别

Biochemistry & Molecular Biology Cell Biology

向作者/读者索取更多资源

Protocol

Reagent

摘要

We have recently reported that the naturally occurring spliced variant of Hepatitis B virus protein, HBSP, displayed proapoptotic activity through its BH3 domain. To investigate whether the BH3 domain in HBSP interacted with Bcl-2 family of proteins, HBSP and Bcl-2 family of proteins were cloned and expressed in our mammalian two-hybrid system. Interaction assays were carried out in HepG2 cells and measured by the activity of the reporter gene product luciferase. Our results indicated that HBSP interacted with Bcl-2/Bcl-x1 in vitro and induced apoptosis in HepG2 cells. (C) 2008 IUBMB.

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Article Cell Biology

C/EBP homologous protein deficiency enhances hematopoietic stem cell function via reducing ATF3/ROS-induced cell apoptosis

Zhencan Shi, Daojun Diao, Yanan Zhao, Ying Luo, Yafei Li, Dingdong Liu, Kai Zhang, Yugang Qiu, Li Yu, Zhangfa Song, Zhenyu Ju

Summary: The research reveals a new role of CHOP in regulating HSCs function and homeostasis by reducing ATF3 and ROS signaling, leading to improved HSCs homeostasis and function.

AGING CELL (2021)

添加到收藏夹

Article Immunology

Donepezil attenuates injury following ischaemic stroke by stimulation of neurogenesis, angiogenesis, and inhibition of inflammation and apoptosis

Arian Madani Neishaboori, Solmaz Nasseri Maleki, Mahdi Saberi Pirouz, Sara Golmohammadi, Donya Nazarinia, Nahid Aboutaleb

Summary: The study demonstrates the neuroprotective effects of donepezil in a rat model of ischaemic stroke, showing significant reduction in infarct size and decreased expression of apoptotic markers and pro-inflammatory mediators. Additionally, treatment with donepezil led to increased levels of brain-derived neurotrophic factor (BDNF) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha) proteins. Overall, donepezil shows potential as a therapeutic agent for attenuating injury following ischaemic stroke through modulation of inflammation and improvement of mitochondrial function, neurogenesis, and angiogenesis.

INFLAMMOPHARMACOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Intracellular FGF1 protects cells from apoptosis through direct interaction with p53

Agata Lampart, Daniel Krowarsch, Martyna Biadun, Vigdis Sorensen, Jakub Szymczyk, Katarzyna Sluzalska, Antoni Wiedlocha, Jacek Otlewski, Malgorzata Zakrzewska

Summary: FGF1 has both extracellular and intracellular activities. This study reveals that intracellular FGF1 can protect cells from apoptosis by directly interacting with p53, but this protective effect is observed only in cells with wild-type p53.

CELLULAR AND MOLECULAR LIFE SCIENCES (2023)

添加到收藏夹

Article Andrology

Hepatitis B virus surface protein induces sperm dysfunction through the activation of a Bcl2/Bax signaling cascade triggering AIF/Endo G-mediated apoptosis

Ting-Ting Han, Ji-Hua Huang, Jiang Gu, Qing-Dong Xie, Ying Zhong, Tian-Hua Huang

Summary: Exposure to HBs can activate the Bax/Bcl2 signaling cascade leading to AIF/Endo G-mediated apoptosis, resulting in sperm DNA fragmentation, sperm injury, and death, ultimately decreasing sperm fertilizing capacity.

ANDROLOGY (2021)

添加到收藏夹

Article Chemistry, Medicinal

Analysis of the Binding Sites on BAX and the Mechanism of BAX Activators through Extensive Molecular Dynamics Simulations

Renxiao Wang, Guoqin Feng, Xiangying Zhang, Yan Li

Summary: This study used cosolvent molecular dynamics simulation to detect potential binding sites on BAX protein and derived possible binding modes of three reported BAX activators. The results identified the trigger, S184, and vMIA sites as the major binding sites on full-length BAX structure. Solvent probes were found to bind more stably to the trigger bottom pocket. The findings provide useful guidance for designing experiments and discovering more effective BAX activators.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2022)

添加到收藏夹

Article Chemistry, Inorganic & Nuclear

Portable self-powered photoelectrochemical immunosensor based on Cu3SnS4 nanoflower for ultra-sensitive and real-time detection of human cytochrome c

Xin Zhang, Ling-Hua Jin, Yan-Yan Li, Zi-Zhen Xiao, Yu Feng, Ying-Wu Lin, Ye Zhang

Summary: A self-powered photoelectrochemical (PEC) immunosensor based on Cu3SnS4 nanoflower is constructed for the ultra-sensitive and portable real-time detection of human cytochrome c (Cyt c). The immunosensor shows good reproducibility, high specificity, good storage stability, and excellent detection capability of Cyt c in clinical serum samples. The detection range is from 1 fM to 1000 nM, with an ultra-sensitive detection limit of 0.35 fM.

INORGANIC CHEMISTRY FRONTIERS (2023)

添加到收藏夹

Article Biotechnology & Applied Microbiology

YAP Circular RNA, circYap, Attenuates Cardiac Fibrosis via Binding with Tropomyosin-4 and Gamma-Actin Decreasing Actin Polymerization

Nan Wu, Jindong Xu, William W. Du, Xiangmin Li, Faryal Mehwish Awan, Feiya Li, Sema Misir, Esra Eshaghi, Juanjuan Lyu, Le Zhou, Kaixuan Zeng, Aisha Adil, Sheng Wang, Burton B. Yang

Summary: Cardiac fibrosis is associated with circular RNA circYap, which modulates fibrosis by regulating the interaction between TMP4 and ACTG, potentially serving as a new target for cardiac therapy in the future.

MOLECULAR THERAPY (2021)

添加到收藏夹

Article Immunology

PRKCD as a potential therapeutic target for chronic obstructive pulmonary disease

Siqi Li, Qiong Huang, Dongbo Zhou, Baimei He

Summary: This review discusses the roles and mechanisms of PRKCD in the development of chronic obstructive pulmonary disease (COPD), suggesting that PRKCD contributes to COPD by promoting inflammatory response, apoptosis, mitochondrial dysfunction, and MUC5AC hypersecretion, and highlighting the potential of PRKCD as a therapeutic target for COPD.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

添加到收藏夹

Article Computer Science, Artificial Intelligence

On the design of a similarity function for sparse binary data with application on protein function annotation

Marcelo B. A. Veras, Bishnu Sarker, Sabeur Aridhi, Joao P. P. Gomes, Jose A. F. Macedo, Engelbert Mephu Nguifo, Marie-Dominique Devignes, Malika Smail-Tabbone

Summary: Automatic protein function annotation is crucial for disease understanding and drug design. Similarity functions play an important role in protein function prediction, but there is a lack of specifically designed similarity functions for protein function annotation. This study analyzes the best similarity functions for the task and proposes a new one.

KNOWLEDGE-BASED SYSTEMS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Birinapant selectively enhances immunotoxin-mediated killing of cancer cells conditional on the IAP protein levels within target cells

Antonella Antignani, Maria Teresa Bilotta, Jacob S. Roth, Daniel J. Urban, Min Shen, Matthew D. Hall, David FitzGerald

Summary: A study found that IAPs are a barrier to the efficacy of immunotoxin treatment, which can be overcome with combination treatments that include Smac mimetics.

FASEB JOURNAL (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Immunotherapy of glioblastoma explants induces interferon-γ responses and spatial immune cell rearrangements in tumor center, but not periphery

Tala Shekarian, Carl P. Zinner, Ewelina M. Bartoszek, Wandrille Duchemin, Anna T. Wachnowicz, Sabrina Hogan, Manina M. Etter, Julia Flammer, Chiara Paganetti, Tomas A. Martins, Philip Schmassmann, Steven Zanganeh, Francois Le Goff, Manuele G. Muraro, Marie-Francoise Ritz, Darci Phillips, Salil S. Bhate, Graham L. Barlow, Garry P. Nolan, Christian M. Schuerch, Gregor Hutter

Summary: This study demonstrated that ex vivo immunotherapy of GBM explants can induce an active antitumoral immune response within the tumor center, providing a framework for multidimensional personalized assessment of tumor response to immunotherapy.

SCIENCE ADVANCES (2022)

添加到收藏夹

Article Cell Biology

SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment

Chien-Ting Wu, Peter Lidsky, Yinghong Xiao, Ivan T. Lee, Ran Cheng, Tsuguhisa Nakayama, Sizun Jiang, Janos Demeter, Romina J. Bevacqua, Charles A. Chang, Robert L. Whitener, Anna K. Stalder, Bokai Zhu, Han Chen, Yury Goltsev, Alexandar Tzankov, Jayakar Nayak, Garry P. Nolan, Matthias S. Matter, Raul Andino, Peter K. Jackson

Summary: There is evidence suggesting a complex relationship between COVID-19 and diabetes, with SARS-CoV-2 being able to directly induce beta cell killing and this effect being rescued by NRP1 inhibition.

CELL METABOLISM (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Effects of Malate Ringer's solution on myocardial injury in sepsis and enforcement effects of TPP@PAMAM-MR

Lei Tan, Han She, Jie Zheng, Xiaoyong Peng, Ningke Guo, Bindan Zhang, Yue Sun, Chunhua Ma, Shenglian Xu, Daiqin Bao, Yuanqun Zhou, Qinghui Li, Qingxiang Mao, Liangming Liu, Yi Hu, Tao Li

Summary: The study found that Malate Ringer's solution (MR) has a protective effect on myocardial injury after sepsis. MR can improve the function and morphology of cardiomyocyte mitochondria and inhibit cardiomyocyte apoptosis. Compared with Lactate Ringer's solution, MR has a better resuscitation effect.

JOURNAL OF TRANSLATIONAL MEDICINE (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Post-stroke administration of H2 relaxin reduces functional deficits, neuronal apoptosis and immune cell infiltration into the mouse brain

Shirley H. T. Truong, Benjamin Bonnici, Samoda Rupasinghe, Barbara K. Kemp-Harper, Chrishan S. Samuel, Brad R. S. Broughton

Summary: Brain inflammation and apoptosis contribute to neuronal damage and loss following ischaemic stroke, leading to cognitive and functional disability. H2-relaxin, a hormone with anti-inflammatory and anti-apoptotic effects, shows potential as a therapeutic for stroke. This study investigated the effects of post-stroke administration of H2-relaxin and found that it improved motor function and decreased apoptosis in a dose-dependent manner.

PHARMACOLOGICAL RESEARCH (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Spatially resolved transcriptomic profiling of ovarian aging in mice

Jennifer E. Russ, Mary E. Haywood, Sydney L. Lane, William B. Schoolcraft, Mandy G. Katz-Jaffe

Summary: This study used spatial transcriptomics to analyze the transcriptomic landscape of ovaries from young and aged mice. Significant transcriptomic changes were observed between young and aged samples, including distinct granulosa cell populations and the absence of an oocyte sub-cluster in aged mouse ovaries.

ISCIENCE (2022)

添加到收藏夹

Article Food Science & Technology

Isolation of peanut protein aggregates using aqueous extraction processing combined with membrane separation

Junjun Liu, Wenbin Zhang, Pengfei Li, Zhumao Jiang, Ruijin Yang

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2020)

添加到收藏夹

Review Food Science & Technology

Technology innovations for food security in Singapore: A case study of future food systems for an increasingly natural resource-scarce world

Wai Kit Mok, Yong Xing Tan, Wei Ning Chen

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2020)

添加到收藏夹

Article Food Science & Technology

Effects of submerged liquid fermentation of Bacillus subtilis WX-17 using okara as sole nutrient source on the composition of a potential probiotic beverage

Wai Kit Mok, Yong Xing Tan, Xiao Mei Lyu, Wei Ning Chen

FOOD SCIENCE & NUTRITION (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

In Vitro Evaluation of Enriched Brewers' Spent Grains UsingBacillus subtilisWX-17 as Potential Functional Food Ingredients

Yong Xing Tan, Wai Kit Mok, Wei Ning Chen

Summary: In this study, fermented BSG using Bacillus subtilis WX-17 was found to have higher nutritional components such as amino acids, fatty acids, and Vitamin K(2)MK7. Additionally, higher amounts of short-chain fatty acids were produced after fermentation. The fermentation also had different effects on gut microbiota composition, demonstrating the potential of utilizing BSG as functional food ingredients through microbial fermentation.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2021)

添加到收藏夹

Review Food Science & Technology

Bioactive peptides from food fermentation: A comprehensive review of their sources, bioactivities, applications, and future development

Kong Fei Chai, Amanda Ying Hui Voo, Wei Ning Chen

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2020)

添加到收藏夹

Article Plant Sciences

Functional Attributes and Anticancer Potentialities of Chico (Pachycereus Weberi) and Jiotilla (Escontria Chiotilla) Fruits Extract

Luisaldo Sandate-Flores, Eduardo Romero-Esquivel, Jose Rodriguez-Rodriguez, Magdalena Rostro-Alanis, Elda M. Melchor-Martinez, Carlos Castillo-Zacarias, Patricia Reyna Ontiveros, Marcos Fredy Morales Celaya, Wei-Ning Chen, Hafiz M. N. Iqbal, Roberto Parra-Saldivar

PLANTS-BASEL (2020)

添加到收藏夹

Article Agriculture, Multidisciplinary

Enhancement of the Isomerization Activity and Thermostability of Cellobiose 2-Epimerase from Caldicellulosiruptor saccharolyticus by Exchange of a Flexible Loop

Lu Wang, Jiali Gu, Yinghui Feng, Mingming Wang, Yanjun Tong, Yingjie Liu, Xiaomei Lyu, Ruijin Yang

Summary: This study aimed to optimize the catalytic performances of CEs by flexible loop exchange, resulting in mutants with improved isomerization activity and thermostability. Molecular dynamics simulations showed that loop exchange enlarged the entrance of the active site for substrate binding and benefited proton transfer. This work demonstrated the importance of the flexible loop surrounding the active site in determining the isomerization activity and thermostability of CEs.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

添加到收藏夹

Article Agriculture, Dairy & Animal Science

Screening of a Bacillus subtilis strain producing both nattokinase and milk-clotting enzyme and its application in fermented milk with thrombolytic activity

Xuan Zhang, Yanjun Tong, Jing Wang, Xiaomei Lyu, Ruijin Yang

Summary: The study demonstrated that milk fermented by Bacillus subtilis JNFE0126 has potential as a novel functional food in preventing thrombosis-related cardiovascular diseases, showing promising thrombolytic and milk-clotting activities with good sensory acceptance.

JOURNAL OF DAIRY SCIENCE (2021)

添加到收藏夹

Article Food Science & Technology

Administration of xylo-oligosaccharides improves depressive-like behaviour in mice caused by chronic unpredictable mild stress by altering microbiota composition

Xiangling Shu, Yanjun Tong, Ruijin Yang

Summary: This study investigated the modulatory effects of XOS on emotions and behaviors in a mouse model of chronic stress-induced depression. The results showed that XOS could improve depressive-like behavior by modulating neurotransmitters and gut microbiota. These findings suggest that XOS has the potential to be used as a prebiotic for mood disorders.

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2022)

添加到收藏夹

Article Agriculture, Multidisciplinary

Radio frequency as an innovative method to produce low-fat French fries

Cheng Zhang, Xiaomei Lyu, Wei Zhao, Ruijin Yang

Summary: This study used RF technology to prepare low-fat French fries and found that moderate RF treatment can reduce the oil content of fries without altering their texture, providing new possibilities for the development of low-fat fried foods.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2022)

添加到收藏夹

Article Agriculture, Multidisciplinary

Highly efficient isolation and purification of high-purity tea saponins from industrial camellia oil production by porous polymeric adsorbents

Mingming Wang, Qiqi Chen, Xiao Hua, Ruijin Yang

Summary: In this study, an innovative and sustainable strategy using highly-porous polymeric adsorbents was developed for the efficient purification of tea saponin (TS). The proposed method enabled the direct isolation of high-purity TS from industrial camellia oil production, with a high recovery ratio. This methodology shows promising potential for industrial-scale purification.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2023)

添加到收藏夹

Article Agriculture, Multidisciplinary

Acid-induced conformation regulation of peanut polysaccharide and its effect on stability and digestibility of oil-in-water emulsion

Jianfen Ye, Xiao Hua, Xingfeng Shao, Ruijin Yang

Summary: The acidification of peanut polysaccharide at pH 3.0 led to the formation of a stable gel structure for preparing oil-in-water emulsions, which exhibited resistance to digestion and maintained a strong structure. This emulsion showed promising potential as a cholesterol-free and low-fat salad dressing substitute.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Chitosan/casein based microparticles with a bilayer shell-core structure for oral delivery of nattokinase

Xuan Zhang, Xiaomei Lyu, Yanjun Tong, Jing Wang, Jianfen Ye, Ruijin Yang

FOOD & FUNCTION (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Potential novel nutritional beverage using submerged fermentation with Bacillus subtilis WX-17 on brewers' spent grains

Yong Xing Tan, Wai Kit Mok, Wei Ning Chen

HELIYON (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Dual Extraction of Crustacean and Fungal Chitosan from a SingleMucor circinelloidesFermentation

Yun Nian Tan, Pei Pei Lee, Wei Ning Chen

FERMENTATION-BASEL (2020)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.