P450BM3-Axial Mutations: A Gateway to Non-Natural Reactivity

Protein Design: Toward Functional Metalloenzymes

(2014) Fangting Yu et al.   CHEMICAL REVIEWS

Expanding P450 catalytic reaction space through evolution and engineering

(2014) John A McIntosh et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Design of activated serine–containing catalytic triads with atomic-level accuracy

(2014) Sridharan Rajagopalan et al.   Nature Chemical Biology

P450-Catalyzed Intramolecular sp3 C–H Amination with Arylsulfonyl Azide Substrates

(2014) Ritesh Singh et al.   ACS Catalysis

Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo

(2013) John A. McIntosh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic X–H insertion reactions based on carbenoids

(2013) Dennis Gillingham et al.   CHEMICAL SOCIETY REVIEWS

Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future

(2013) Manfred T. Reetz   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Dual Anchoring Strategy for the Localization and Activation of Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology

(2013) Jeremy M. Zimbron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Precision is essential for efficient catalysis in an evolved Kemp eliminase

(2013) Rebecca Blomberg et al.   NATURE

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

(2013) Pedro S Coelho et al.   Nature Chemical Biology

Biocatalytic retrosynthesis

(2013) Nicholas J Turner et al.   Nature Chemical Biology

Evolution of a designed retro-aldolase leads to complete active site remodeling

(2013) Lars Giger et al.   Nature Chemical Biology

Iron Porphyrin-Catalyzed Three-Component Reaction of Ethyl Diazoacetate with Aliphatic Amines and β,γ-Unsaturated α-Keto Esters

(2013) Chaoqun Ma et al.   ORGANIC LETTERS

Iron(IV)hydroxide pKa and the Role of Thiolate Ligation in C-H Bond Activation by Cytochrome P450

(2013) T. H. Yosca et al.   SCIENCE

Cytochrome P450-catalyzed insertion of carbenoids into N–H bonds

(2013) Z. Jane Wang et al.   Chemical Science

Artificial Metalloenzymes and Metallopeptide Catalysts for Organic Synthesis

(2013) Jared C. Lewis   ACS Catalysis

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

(2012) P. S. Coelho et al.   SCIENCE

Biotinylated Rh(III) Complexes in Engineered Streptavidin for Accelerated Asymmetric C-H Activation

(2012) T. K. Hyster et al.   SCIENCE

Tuning P450 Enzymes as Oxidation Catalysts

(2012) Rudi Fasan   ACS Catalysis

Merging the best of two worlds: artificial metalloenzymes for enantioselective catalysis

(2011) Mark R. Ringenberg et al.   CHEMICAL COMMUNICATIONS

P450BM3(CYP102A1): connecting the dots

(2011) Christopher J. C. Whitehouse et al.   CHEMICAL SOCIETY REVIEWS

Bioinspired Catalyst Design and Artificial Metalloenzymes

(2011) Peter J. Deuss et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enzymatic functionalization of carbon–hydrogen bonds

(2010) Jared C. Lewis et al.   CHEMICAL SOCIETY REVIEWS

Switching from an Esterase to a Hydroxynitrile Lyase Mechanism Requires Only Two Amino Acid Substitutions

(2010) Santosh Kumar Padhi et al.   CHEMISTRY & BIOLOGY

Design strategies for the creation of artificial metalloenzymes

(2010) Tillmann Heinisch et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation Kinetics

(2010) J. Rittle et al.   SCIENCE

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

(2010) J. B. Siegel et al.   SCIENCE

Converting an Esterase into an Epoxide Hydrolase

(2009) Helge Jochens et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron-Catalyzed Cyclopropanation with Trifluoroethylamine Hydrochloride and Olefins in Aqueous Media: In Situ Generation of Trifluoromethyl Diazomethane

(2009) Bill Morandi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Two Site-Directed Mutations Are Required for the Conversion of a Sugar Dehydratase into an Aminotransferase§

(2009) Paul D. Cook et al.   BIOCHEMISTRY

Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes

(2009) Paul R. Ortiz de Montellano   CHEMICAL REVIEWS

Directed evolution drives the next generation of biocatalysts

(2009) Nicholas J Turner   Nature Chemical Biology

“Restoration” of Glutathione Transferase Activity By Single-site Mutation of The Yeast Prion Protein Ure2

(2008) Zai-Rong Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Recent applications of biocatalysis in developing green chemistry for chemical synthesis at the industrial scale

(2007) Ningqing Ran et al.   GREEN CHEMISTRY