Evidence against dopamine D1/D2 receptor heteromers

CrossTalk opposing view: Weighing the evidence for class A GPCR dimers, the jury is still out

(2014) Nevin A. Lambert et al.   JOURNAL OF PHYSIOLOGY-LONDON

D1R/GluN1 complexes in the striatum integrate dopamine and glutamate signalling to control synaptic plasticity and cocaine-induced responses

(2014) E Cahill et al.   MOLECULAR PSYCHIATRY

SKF-83959 is not a highly-biased functionally selective D1 dopamine receptor ligand with activity at phospholipase C

(2014) Sang-Min Lee et al.   NEUROPHARMACOLOGY

Viral over-expression of D1 dopamine receptors in the prefrontal cortex increase high-risk behaviors in adults: Comparison with adolescents

(2014) Kai C. Sonntag et al.   PSYCHOPHARMACOLOGY

Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation

(2013) P Trifilieff et al.   MOLECULAR PSYCHIATRY

Heteromeric Dopamine Receptor Signaling Complexes: Emerging Neurobiology and Disease Relevance

(2013) Melissa L Perreault et al.   NEUROPSYCHOPHARMACOLOGY

Building a better hormone therapy? How understanding the rapid effects of sex steroid hormones could lead to new therapeutics for age-related memory decline.

(2012) Karyn M. Frick   BEHAVIORAL NEUROSCIENCE

Deciphering biased-agonism complexity reveals a new active AT1 receptor entity

(2012) Aude Saulière et al.   Nature Chemical Biology

Reduced striatal dopamine D1–D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats

(2012) M.L. Perreault et al.   NEUROSCIENCE

Dopamine D1–D2 Receptor Heteromer in Dual Phenotype GABA/Glutamate-Coexpressing Striatal Medium Spiny Neurons: Regulation of BDNF, GAD67 and VGLUT1/2

(2012) Melissa L. Perreault et al.   PLoS One

Loss of Thr286 phosphorylation disrupts synaptic CaMKIIα targeting, NMDAR activity and behavior in pre-adolescent mice

(2011) Richard M. Gustin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

CODA-RET reveals functional selectivity as a result of GPCR heteromerization

(2011) Eneko Urizar et al.   Nature Chemical Biology

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

The Dopamine D1–D2 Receptor Heteromer in Striatal Medium Spiny Neurons: Evidence for a Third Distinct Neuronal Pathway in Basal Ganglia

(2011) Melissa L. Perreault et al.   Frontiers in Neuroanatomy

Activation of phosphatidylinositol-linked D1-like receptors increases spontaneous glutamate release in rat somatosensory cortical neurons in vitro

(2010) Hong-Yuan Chu et al.   BRAIN RESEARCH

The Dopamine D1-D2 Receptor Heteromer Localizes in Dynorphin/Enkephalin Neurons

(2010) Melissa L. Perreault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for a Distinct D1Like Dopamine Receptor that Couples to Activation of Phosphoinositide Metabolism in Brain

(2010) Ashiwel S. Undie et al.   JOURNAL OF NEUROCHEMISTRY

Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant-like effects

(2010) Lin Pei et al.   NATURE MEDICINE

What is the degree of segregation between striatonigral and striatopallidal projections?

(2010) Jesus Bertran-Gonzalez   Frontiers in Neuroanatomy

Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms

(2009) Ahmed Hasbi et al.   CURRENT OPINION IN PHARMACOLOGY

Activation of Phosphatidylinositol-Linked Novel D1 Dopamine Receptors Inhibits High-Voltage-Activated Ca2+ Currents in Primary Cultured Striatal Neurons

(2009) Li-Qun Ma et al.   JOURNAL OF NEUROPHYSIOLOGY

Activation of Phosphatidylinositol-Linked D1-Like Receptor Modulates FGF-2 Expression in Astrocytes via IP3-Dependent Ca2+ Signaling

(2009) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Calcium Signaling by Dopamine D5 Receptor and D5-D2 Receptor Hetero-Oligomers Occurs by a Mechanism Distinct from That for Dopamine D1-D2 Receptor Hetero-Oligomers

(2009) C. H. So et al.   MOLECULAR PHARMACOLOGY

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

(2009) Yang Han et al.   Nature Chemical Biology

Building a new conceptual framework for receptor heteromers

(2009) Sergi Ferré et al.   Nature Chemical Biology

Phosphatidylinositol-linked novel D1 dopamine receptor facilitates long-term depression in rat hippocampal CA1 synapses

(2009) Jue Liu et al.   NEUROPHARMACOLOGY

Activation of calcium/calmodulin-dependent protein kinase IIα in the striatum by the heteromeric D1-D2 dopamine receptor complex

(2009) J. Ng et al.   NEUROSCIENCE

Striatal Medium-Sized Spiny Neurons: Identification by Nuclear Staining and Study of Neuronal Subpopulations in BAC Transgenic Mice

(2009) Miriam Matamales et al.   PLoS One

Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth

(2009) Ahmed Hasbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dopamine D2 receptors form higher order oligomers at physiological expression levels

(2008) Wen Guo et al.   EMBO JOURNAL

Drd1a-tdTomato BAC Transgenic Mice for Simultaneous Visualization of Medium Spiny Neurons in the Direct and Indirect Pathways of the Basal Ganglia

(2008) J. A. Shuen et al.   JOURNAL OF NEUROSCIENCE

Opposing Patterns of Signaling Activation in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol

(2008) J. Bertran-Gonzalez et al.   JOURNAL OF NEUROSCIENCE

D5 Dopamine Receptors are Required for Dopaminergic Activation of Phospholipase C

(2008) A. Sahu et al.   MOLECULAR PHARMACOLOGY

GPCR monomers and oligomers: it takes all kinds

(2008) Vsevolod V. Gurevich et al.   TRENDS IN NEUROSCIENCES