期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 60, 期 2, 页码 242-255出版社
WILEY
DOI: 10.1002/mnfr.201500605
关键词
Azoxymethane; dextran sulphate sodium; Chemoprevention; Colitis-associated colorectal cancer; Oleuropein; Th17 response
资金
- Spanish government (MICIIN) [SAF2009-10059-C03-01]
- Spanish government (FEDER) [SAF2009-10059-C03-01]
- Universitat de Valencia
ScopeThe main phenolic secoiridoid oleuropein and active constituent from olive tree (Olea europaea, Oleaceae), has demonstrated anti-inflammatory properties in intestinal inflammation and anti-tumoral effects in different cancer cells. In this study, we evaluated the chemoprevention of oleuropein in a model of azoxymethane (AOM)/Dextran sulfate sodium (DSS)-induced colorectal cancer (CRC) in C57BL/6 mice and the modulatory effect on the Th17 response in DSS acute colitis. Methods and resultsOleuropein protected from AOM/DSS-induced CRC by improving clinical symptoms, disease activity index score as well as suppressed the growth and multiplicity of colonic tumors. Treatment with oleuropein reduced intestinal IL-6, IFN-, TNF-, and IL-17A concentration, and decreased cyclooxygenase-2, Bax and proliferating cell nuclear antigen protein expression. Western blot analysis also showed a markedly downregulation of CRC-related pathways as nuclear factor-B (NF-B), Wnt/-catenin, phosphatidylinositol-3-kinase (P3IK)/Akt, and signal transducer and activators of transcription (STAT)3. In DSS acute model, oleuropein inhibited Th17 response, by decreasing CD4(+)Rort(+) IL-17(+) IFN-(+) T-cell subsets in the lamina propria, as well as IL-17A and IFN- expression. ConclusionOleuropein as a dietary supplementation could be a promising protective agent against colitis-associated CRC.
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