Article
Biochemistry & Molecular Biology
Tingting Jiang, Duo Su, Xin Liu, Yan Wang, Linjie Wang
Summary: This study found that FGF11 is enriched in brown adipose tissue of goats and promotes differentiation and thermogenesis in brown adipocytes by promoting UCP1 gene expression through EBF2 binding to the UCP1 promoter.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Frederike Sass, Christian Schlein, Michelle Y. Jaeckstein, Paul Pertzborn, Michaela Schweizer, Thorsten Schinke, Andrea Ballabio, Ludger Scheja, Joerg Heeren, Alexander W. Fischer
Summary: TFEB is identified as a driver of BAT whitening, mediating mitochondrial degradation through the autophagosomal and lysosomal machinery. This study demonstrates that interfering with the mitochondrial degradation machinery can increase mitochondrial mass in classical BAT under human-relevant conditions, but interfering with autophagy may result in accumulation of nonfunctional mitochondria.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Michael S. Kuefner, Erin Stephenson, Mladen Savikj, Heather S. Smallwood, Qingming Dong, Christine Payre, Gerard Lambeau, Edwards A. Park
Summary: The study shows that PLA2G2A enhances adipose tissue thermogenesis through increased substrate delivery and mitochondrial content in BAT, as demonstrated by the metabolic analysis and expression of UCP1 protein.
Review
Biology
Jan Nedergaard, Gabriella von Essen, Barbara Cannon
Summary: This article discusses whether a decrease in UCP1 activity could cause obesity in humans. Studies in mice suggest that the absence of UCP1 leads to obesity. It is still unknown if similar mechanisms exist in humans.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Endocrinology & Metabolism
Xiaomeng Liu, Zhi Zhang, Yajie Song, Hengchang Xie, Meng Dong
Summary: Overweight and obesity have become global problems, with limited effective intervention approaches. Activating brown adipose tissue and browning white adipose tissue can protect against obesity and related metabolic diseases. However, important issues such as the causality between increased brown adipose tissue activity and body weight loss are still unresolved. This review comprehensively summarizes approaches to activating brown adipose tissue and/browning white adipose tissue and discusses the functional mechanisms of small-molecule treatment and brown adipose tissue transplantation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Mingzhu Yan, Suwei Jin, Zhi Wang, Tianji Xia, Yongguang Liu, Qi Chang
Summary: Limonin, a compound found in citrus fruits, has been found to effectively combat obesity by reducing fat mass and body weight gain, and improving fatty liver and hyperlipidemia caused by a high-fat diet. It also promotes the browning of white adipose tissues and prevents the whitening of brown adipose tissue in mice. These effects are associated with the activation of PGC-1 alpha pathway. Overall, limonin shows great potential for regulating energy balance and treating obesity.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Endocrinology & Metabolism
Zijing Wang, Yunfeng Zhen, Yong Tang, Guangyao Song, Huijuan Ma, Hang Zhao
Summary: Maternal calorie restriction during pregnancy may affect the development and thermogenic capacity of brown adipose tissue in offspring, increasing the risk of adult obesity and metabolic disorders. This may be related to impaired fatty acid oxidation.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Biochemistry & Molecular Biology
Iker Gomez-Garcia, Jenifer Trepiana, Alfredo Fernandez-Quintela, Marta Giralt, Maria P. Portillo
Summary: This narrative review examines the sex differences in the effects of cold exposure, feeding pattern, and age on brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning. The findings suggest that females tend to activate thermogenesis earlier in response to cold exposure and exhibit greater sensitivity to overfeeding or energy restriction. Sexual development leads to increased BAT activity, especially in boys, while aging results in a decline in thermogenic capacity, particularly in men. Additionally, females are more susceptible to WAT browning. Further studies are needed to provide valuable information for personalized approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Gabriella von Essen, Erik Lindsund, Elaina M. Maldonado, Petr Zouhar, Barbara Cannon, Jan Nedergaard
Summary: This study examines the possibility of countering obesity by activating brown or beige adipose tissue and UCP1. The findings show that although UCP1 protein may increase, it is not necessarily utilized for diet-induced thermogenesis. Constant activation of UCP1 is required to effectively ameliorate obesity development.
MOLECULAR METABOLISM
(2023)
Article
Physiology
Jaycob D. Warfel, Carrie M. Elks, David S. Bayless, Bolormaa Vandanmagsar, Allison C. Stone, Samuel E. Velasquez, Paola Olivares-Nazar, Robert C. Noland, Sujoy Ghosh, Jingying Zhang, Randall L. Mynatt
Summary: This study aimed to investigate the thermogenic mechanisms in rats lacking Ucp1 gene. The results showed that Ucp1(-/-) rats had decreased body weight and adiposity, and exhibited a decline in core temperature under low temperature conditions. Increased mitochondrial lipid metabolism markers in white adipose tissue and skeletal muscle indicated adaptive responses to UCP1 deficiency. These findings provide novel insights into thermogenic responses and highlight Ucp1(-/-) rats as a valuable model for studying thermogenesis.
Article
Biochemistry & Molecular Biology
Yu-Jen Chen, Chiao-Wei Lin, Yu-Ju Peng, Chao-Wei Huang, Yi-Shan Chien, Tzu-Hsuan Huang, Pei-Xin Liao, Wen-Yuan Yang, Mei-Hui Wang, Harry J. Mersmann, Shinn-Chih Wu, Tai-Yuan Chuang, Yuan-Yu Lin, Wen-Hung Kuo, Shih-Torng Ding
Summary: The role of adiponectin receptors, especially AdipoR1, in cold-induced thermogenesis is still unclear. By studying transgenic mice over-expressing AdipoR1, researchers found that AdipoR1 leads to reduced glucose uptake, enlarged adipocytes, and altered gene expression in cold-acclimated mice, as observed through PET/CT scanning and surface body temperature measurements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Chad C. Doucette, Davide Barteselli, Daniel C. Nguyen, Sophia Blanchard, Mason Pelletier, Devesh Kesharwani, Ed Jachimowicz, Su Su, Michele Karolak, Aaron C. Brown
Summary: In this study, an optogenetic approach was used to activate UCP1-dependent thermogenesis in brown adipocytes. This system allows for precise, chemical free, temporal control of UCP1-dependent thermogenesis, which can contribute to our understanding of brown adipocyte biology and the development of therapies for obesity-related disorders.
Article
Cell Biology
Junnosuke Mae, Kazuki Nagaya, Yuko Okamatsu-Ogura, Ayumi Tsubota, Shinya Matsuoka, Junko Nio-Kobayashi, Kazuhiro Kimura
Summary: This study reveals that brown adipogenesis during postnatal white-to-brown conversion of adipose tissue in Syrian hamsters is regulated by secretory factors from adipocytes and stromal cells. Adipocyte-secreted factors suppress brown adipogenesis, while stromal cell-secreted factors promote brown adipogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Josef Oeckl, Petra Janovska, Katerina Adamcova, Kristina Bardova, Sarah Brunner, Sebastian Dieckmann, Josef Ecker, Tobias Fromme, Jiri Funda, Thomas Gantert, Piero Giansanti, Maria Soledad Hidrobo, Ondrej Kuda, Bernhard Kuster, Yongguo Li, Radek Pohl, Sabine Schmitt, Sabine Schweizer, Hans Zischka, Petr Zouhar, Jan Kopecky, Martin Klingenspor
Summary: We explore different potential sources of UCP1-independent thermogenesis and identify a futile ATP-consuming triglyceride/fatty acid cycle as the main contributor to cellular heat production in brown adipocytes lacking UCP1. We uncover the mechanism on a molecular level and pinpoint the key enzymes involved using pharmacological and genetic interference.
MOLECULAR METABOLISM
(2022)
Article
Food Science & Technology
Kuiliang Zhang, Juan Sun, Mingcong Fan, Haifeng Qian, Hao Ying, Yan Li, Li Wang
Summary: Activation and recruitment of brown adipose tissue are effective for treating obesity and related diseases. Functional ingredients in wholegrains positively affect the activity of brown adipocytes and browning of white adipocytes, contributing to the control of obesity and energy metabolism.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Physiology
Dana S. Hutchinson, Nadine Brew, Teresa Vu, Jon Merlin, Nadia Hale, David W. Walker, Flora Y. Wong
JOURNAL OF APPLIED PHYSIOLOGY
(2018)
Article
Physiology
Saori Mukaida, Masaaki Sato, Anette Oberg, Nodi Dehvari, Jessica M. Olsen, Martina Kocan, Michelle Louise Halls, Jon Merlin, Anna L. Sandstrom, Robert Csikasz, Bronwyn Anne Evans, Roger James Summers, Ana Sabine Hutchinson, Tore Bengtsson
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Article
Oncology
Anna Ostrovskaya, Caroline Hick, Dana S. Hutchinson, Brett W. Stringer, Peter J. Wookey, Denise Wootten, Patrick M. Sexton, Sebastian G. B. Furness
Review
Pharmacology & Pharmacy
Bronwyn A. Evans, Jon Merlin, Tore Bengtsson, Dana S. Hutchinson
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Review
Pharmacology & Pharmacy
Ling Yeong Chia, Bronwyn A. Evans, Saori Mukaida, Tore Bengtsson, Dana S. Hutchinson, Masaaki Sato
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Jai Rautela, Laura F. Dagley, Carolina C. de Oliveira, Iona S. Schuster, Soroor Hediyeh-Zadeh, Rebecca B. Delconte, Joseph Cursons, Robert Hennessy, Dana S. Hutchinson, Craig Harrison, Badia Kita, Eric Vivier, Andrew I. Webb, Mariapia A. Degli-Esposti, Melissa J. Davis, Nicholas D. Huntington, Fernando Souza-Fonseca-Guimaraes
Article
Endocrinology & Metabolism
Jessica M. Olsen, Alice Aslund, Muhammad Hamza Bokhari, Dana S. Hutchinson, Tore Bengtsson
MOLECULAR METABOLISM
(2019)
Article
Pharmacology & Pharmacy
Nodi Dehvari, Masaaki Sato, Muhammad Hamza Bokhari, Anastasia Kalinovich, Seungmin Ham, Jie Gao, Huong T. M. Nguyen, Lynda Whiting, Saori Mukaida, Jon Merlin, Ling Yeong Chia, Denise Wootten, Roger J. Summers, Bronwyn A. Evans, Tore Bengtsson, Dana S. Hutchinson
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2020)
Article
Pharmacology & Pharmacy
Sarah K. Walsh, Christopher Lipina, Sheng Y. Ang, Masaaki Sato, Ling Yeong Chia, Martina Kocan, Dana S. Hutchinson, Roger J. Summers, Cherry L. Wainwright
Summary: Emerging evidence suggests that G protein coupled receptor 55 (GPR55) may influence adrenoceptor function in the cardiovascular system. This study found that GPR55 and alpha(1A)-AR do not form heteromers, but interact at the signaling level to modulate the function of alpha(1A)-AR in the cardiovascular system.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Navista Sri Octa Ujiantari, Seungmin Ham, Chisae Nagiri, Wataru Shihoya, Osamu Nureki, Dana Sabine Hutchinson, Daniela Schuster
Summary: This study utilized virtual screening and in vitro assays to confirm the biological activity of predicted β(3)-AR agonists. Several compounds showed activity against both human and mouse β(3)-AR.
MOLECULAR INFORMATICS
(2022)
Article
Endocrinology & Metabolism
Darren M. Riddy, Helene L. Kammoun, Andrew J. Murphy, Sanja Bosnyak-Gladovic, Rocio De la Fuente Gonzalez, Jon Merlin, Mark Ziemann, Stewart Fabb, Tracie L. Pierce, Natalie Diepenhorst, Patricia Rueda, Assam El-Osta, Jean-Francois Gautier, Nicolas Venteclef, William N. Charman, Arthur Christopoulos, Patrick M. Sexton, Roger J. Summers, Mark A. Febbraio, Philippe Delerive, Christopher J. Langmead
Summary: Studies on GPR21 in both humans and mice indicate that GPR21 may play a role in glucose homeostasis and monocyte migration regulated by MCP-1/CCL2-CCR2 signaling pathway. However, results from Gpr21 knockout mice with bone marrow transplantation and high-fat feeding suggest limited overlap in the mechanisms involved in monocyte-driven inflammation and glucose homeostasis.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Pharmacology & Pharmacy
Peishen Zhao, Tin T. Truong, Jon Merlin, Patrick M. Sexton, Denise Wootten
Summary: This study investigates the kinetics of GLP-1R activation and cAMP production mediated by peptide agonists. The results reveal a positive correlation between peptide agonist dissociation kinetics and the onset, duration, and conformational change of receptor-G protein coupling and cAMP signaling. These findings advance the understanding of molecular events that link GLP-1R ligand binding to intracellular signaling and have implications for the agonist action at other related class B1 GPCRs.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Bui San Thai, Ling Yeong Chia, Anh T. N. Nguyen, Chengxue Qin, Rebecca H. Ritchie, Dana S. Hutchinson, Andrew Kompa, Paul J. White, Lauren T. May
Summary: Heart failure remains a significant cause of morbidity and mortality worldwide. Current treatment options have limitations, leading to many patients progressing to advanced stages. Exploration of novel therapeutics targeting G protein-coupled receptors (GPCRs) has shown promise, but efficacy and unwanted effects remain as challenges.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)