期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 59, 期 6, 页码 1213-1216出版社
WILEY
DOI: 10.1002/mnfr.201400842
关键词
Alcohol; Dopamine metabolism; Hydroxytyrosol; Tyrosol; Wine
资金
- Fondo de Investigacion Sanitaria-ISCIII-FEDER [FIS PI081913, RTA RD12/0028/0009]
- ISCIII-FIS-CAIBER [CAI08/01/0024]
- CIBEROBN [CB06/03/0028]
- Generalitat de Catalunya [AGAUR2014SGR680]
- ISCIII Rio Hortega [CM12/00085, CM13/00016]
In humans, urinary hydroxytyrosol (OHTyr) concentrations have been associated to alcohol and wine consumption. To explore the role of wine components on promoting an endogenous OHTyr generation we performed a cross-over, double-blind, randomized controlled clinical trial (n = 28 healthy volunteers). Ethanol (wine and vodka), dealcoholized wine, and placebo were administered. Alcohol, dealcoholized wine, and particularly wine promoted a de novo OHTyr generation in vivo in humans. Potential OHTyr precursors (tyrosine, tyrosol, tyramine) were investigated in rats. Tyrosol was metabolized to OHTyr. Collating both studies, it is postulated that an increased Tyr bioavailability, a shift to a reductive pathway in dopamine and tyramine oxidative metabolism, and the biotransformation of Tyr to OHTyr were mechanisms involved in the OHTyr endogenous generation.
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