Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia

Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules

(2015) Lanfranco Leo et al.   Cell Reports

Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease

(2014) Kurt R. Brunden et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons

(2014) S. Havlicek et al.   HUMAN MOLECULAR GENETICS

Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A

(2014) Peng-Peng Zhu et al.   HUMAN MOLECULAR GENETICS

The tubulin code: Molecular components, readout mechanisms, and functions

(2014) Carsten Janke   JOURNAL OF CELL BIOLOGY

Brain-Penetrant, Orally Bioavailable Microtubule-Stabilizing Small Molecules Are Potential Candidate Therapeutics for Alzheimer’s Disease and Related Tauopathies

(2014) Kevin Lou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pathogenic Mutation of Spastin Has Gain-of-Function Effects on Microtubule Dynamics

(2014) J. M. Solowska et al.   JOURNAL OF NEUROSCIENCE

Ensembl 2015

(2014) Fiona Cunningham et al.   NUCLEIC ACIDS RESEARCH

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

(2014) Hans Zempel et al.   TRENDS IN NEUROSCIENCES

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia

(2014) Y. Fan et al.   Biology Open

Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms

(2013) John K. Fink   ACTA NEUROPATHOLOGICA

Neurodegenerative Disease Phenotypes in Carriers of MAPT p.A152T, A Risk Factor for Frontotemporal Dementia Spectrum Disorders and Alzheimer Disease

(2013) Suzee E. Lee et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

(2013) Hans Zempel et al.   EMBO JOURNAL

It cuts two ways: microtubule loss during Alzheimer disease

(2013) Daphney C Jean et al.   EMBO JOURNAL

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice

(2013) Meaghan Morris et al.   NEUROBIOLOGY OF AGING

Loss of Spastin Function Results in Disease-Specific Axonal Defects in Human Pluripotent Stem Cell-Based Models of Hereditary Spastic Paraplegia

(2013) Kyle R. Denton et al.   STEM CELLS

Deciphering Alzheimer Disease

(2013) D. Selkoe et al.   Cold Spring Harbor Perspectives in Medicine

Notch signalling in adult neurons: a potential target for microtubule stabilization

(2013) Sara Anna Bonini et al.   Therapeutic Advances in Neurological Disorders

Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice

(2012) C. Fassier et al.   Disease Models & Mechanisms

The Endocannabinoid, Anandamide, Augments Notch-1 Signaling in Cultured Cortical Neurons Exposed to Amyloid-β and in the Cortex of Aged Rats

(2012) Riffat Tanveer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The neurological and ophthalmological manifestations of SPG4-related hereditary spastic paraplegia

(2012) Grant Guthrie et al.   JOURNAL OF NEUROLOGY

The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

(2012) B. Zhang et al.   JOURNAL OF NEUROSCIENCE

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Transcriptional and Post-Transcriptional Regulation of SPAST, the Gene Most Frequently Mutated in Hereditary Spastic Paraplegia

(2012) Brian J. Henson et al.   PLoS One

Spastin's Microtubule-Binding Properties and Comparison to Katanin

(2012) Thomas Eckert et al.   PLoS One

Normal Spastin Gene Dosage Is Specifically Required for Axon Regeneration

(2012) Michelle C. Stone et al.   Cell Reports

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

(2011) Xiaoyu Li et al.   EMBO JOURNAL

Loss ofDrosophila melanogaster p21-activated kinase 3Suppresses Defects in Synapse Structure and Function Caused byspastinMutations

(2011) Emily F. Ozdowski et al.   GENETICS

Microtubule Affinity Regulating Kinase Activity in Living Neurons Was Examined by a Genetically Encoded Fluorescence Resonance Energy Transfer/Fluorescence Lifetime Imaging-based Biosensor

(2011) Thomas Timm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

(2011) Dennis W. Dickson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Microtubule-Severing ATPase Spastin in Glioblastoma: Increased Expression in Human Glioblastoma Cell Lines and Inverse Roles in Cell Motility and Proliferation

(2011) Eduarda Dráberová et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Linking Amyloid-ß and Tau: Amyloid-ß Induced Synaptic Dysfunction via Local Wreckage of the Neuronal Cytoskeleton

(2011) Hans Zempel et al.   Neurodegenerative Diseases

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

A Family of Protein-Deglutamylating Enzymes Associated with Neurodegeneration

(2010) Krzysztof Rogowski et al.   CELL

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia

(2010) R. Butler et al.   Disease Models & Mechanisms

Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia

(2010) J. M. Solowska et al.   HUMAN MOLECULAR GENETICS

Inhibition of Cell Migration and Cell Division Correlates with Distinct Effects of Microtubule Inhibiting Drugs

(2010) Hailing Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tubulin polyglutamylation stimulates spastin-mediated microtubule severing

(2010) Benjamin Lacroix et al.   JOURNAL OF CELL BIOLOGY

Amyloid   Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation

(2010) H.-Y. Wu et al.   JOURNAL OF NEUROSCIENCE

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Acetylation of Microtubules Influences Their Sensitivity to Severing by Katanin in Neurons and Fibroblasts

(2010) H. Sudo et al.   JOURNAL OF NEUROSCIENCE

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease

(2010) H.N. Dawson et al.   NEUROSCIENCE

Pleiotropic effects of spastin on neurite growth depending on expression levels

(2009) Elena Riano et al.   JOURNAL OF NEUROCHEMISTRY

Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients

(2009) Paul R. Kasher et al.   JOURNAL OF NEUROCHEMISTRY

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases

(2009) Yang Yu et al.   JOURNAL OF NEUROCHEMISTRY

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Expansion of mutation spectrum, determination of mutation cluster regions and predictive structural classification of SPAST mutations in hereditary spastic paraplegia

(2008) Moneef Shoukier et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Quantitative and Functional Analyses of Spastin in the Nervous System: Implications for Hereditary Spastic Paraplegia

(2008) J. M. Solowska et al.   JOURNAL OF NEUROSCIENCE

Microtubule stabilizing effect of notch activation in primary cortical neurons

(2008) G. Ferrari-Toninelli et al.   NEUROSCIENCE