Article
Oncology
Yi Wang, Leiming Xia, Jing Lin, Li Gong, Yang Xia, Yang Xu, Liu Liu, Jian Bao, Congshu Zhang, Yuqing Chai, Hongxia Li
Summary: This study explored the therapeutic effect of combining thioridazine (THZ) with carboplatin (CBP) on metastatic triple-negative breast cancer (TNBC) cells and cancer stem cells (CSCs). The results demonstrated that the combination therapy inhibited cell proliferation, induced cell apoptosis, suppressed tumorigenesis and metastasis, and reduced tumor burden. This combination therapy may serve as a potential strategy for TNBC treatment.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Biochemical Research Methods
Rui Zhang, Ling-yi Zhao, Chen-yang Zhao, Ming Wang, Si-rui Liu, Jian-chu Li, Rui-na Zhao, Ruo-jiao Wang, Fang Yang, Lei Zhu, Xu-jin He, Chang-hui Li, Yu-xin Jiang, Meng Yang
Summary: The study utilized a handheld dual-modal PA/US imaging system to examine benign and malignant breast nodules, revealing significant differences in the distribution of PA signals between the two. Both quantitative and semi-quantitative analyses showed promising diagnostic potential for breast cancer, highlighting the clinical utility of PA parameters in diagnosis.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Multidisciplinary Sciences
Jiayu Wang, Tao Sun, Quchang Ouyang, Yiqun Han, Binghe Xu
Summary: This study investigated the safety and preliminary efficacy of TQB2450, an anti-PD-L1 antibody, combined with anlotinib, a multi-kinase inhibitor, in advanced TNBC. The results showed that the combination therapy of TQB2450 and anlotinib as a chemotherapy-free treatment demonstrated promising efficacy with a manageable safety profile for previously treated advanced TNBC patients.
Review
Pharmacology & Pharmacy
Hitesh Kumar, Rachna M. Kumar, Devanjali Bhattacharjee, Preethi Somanna, Vikas Jain
Summary: This article discusses the role of Nrf2 in the development of drug resistance, angiogenesis, cancer stem cell generation, and metastasis in breast cancer. Therapeutic strategies utilizing Nrf2 signaling cascades are also discussed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Oceane Campion, Jessica Thevenard Devy, Clotilde Billottet, Christophe Schneider, Nicolas Etique, Jean-William Dupuy, Anne-Aurelie Raymond, Camille Boulagnon Rombi, Marie Meunier, El-Hadi Djermoune, Elodie Lelievre, Amandine Wahart, Camille Bour, Cathy Hachet, Stefano Cairo, Andreas Bikfalvi, Stephane Dedieu, Jerome Devy
Summary: The inhibition of LRP-1 in MDA-MB-231 tumors led to a 60% growth delay due to morphological and functional vascular differences, confirmed by angiogenic models. In vitro, the secretome of LRP-1-repressed cells restrained HUVECs' angiogenic capabilities. Proteomic analysis revealed that LRP-1 supports tumor growth and angiogenesis through regulation of TGF-beta signaling and the plasminogen/plasmin system.
Article
Pharmacology & Pharmacy
Lutan Zhou, Ronghua Yin, Na Gao, Huifang Sun, Dingyuan Chen, Ying Cai, Lin Ren, Lian Yang, Zhili Zuo, Hongbin Zhang, Jinhua Zhao
Summary: nHG and its derivatives extracted from sea cucumber demonstrate the ability to inhibit heparanase activity and show inhibitory effects on various cancer-related cells and angiogenesis. In addition, they exhibit practical antimetastatic effects in a metastatic mouse model.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xiang-Yu Guo, Tian-Tian Liu, Wen-Jie Zhu, Hai-Ting Liu, Guo-Hao Zhang, Lin Song, Rui-Nan Zhao, Xu Chen, Peng Gao
Summary: This study reveals the tumor-suppressor role of circKDM4B in breast cancer, especially in inhibiting tumor growth, metastasis, and angiogenesis, making it a potential therapeutic target for breast cancer progression.
Article
Oncology
Jennifer Xiao, Habib Rahbar, Daniel S. Hippe, Mara H. Rendi, Elizabeth U. Parker, Neal Shekar, Michael Hirano, Kevin J. Cheung, Savannah C. Partridge
Summary: The study evaluated the association of breast cancer features on dynamic contrast-enhanced MRI with MVD, a marker for angiogenesis. Lesions with high MVD levels showed higher peak SER and WF, and some radiomics texture features were promising in predicting increased MVD. DCE-MRI can non-invasively assess breast cancer angiogenesis, which could help optimize treatments based on tumor biology.
Article
Chemistry, Medicinal
Chih-Wei Fu, Han-En Tsai, Wei-Sheng Chen, Tzu-Ting Chang, Chia-Ling Chen, Pei-Wen Hsiao, Wen-Shan Li
Summary: Our study reports the synthesis and evaluation of a series of cell-permeable and N- versus O-selective sialyltransferase inhibitors. Among them, FCW34 and FCW66 were shown to effectively inhibit cell migration, with FCW34 also demonstrating inhibitory effects on tumor growth, angiogenesis, and cancer cell metastasis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Medicine, General & Internal
Klaudia Katarzyna Brogowska, Monika Zajkowska, Barbara Mroczko
Summary: Breast cancer is the most common and lethal malignancy in women. Its development is influenced by factors such as age, genetic mutations, and body weight. Currently, there is a lack of sensitive and specific screening tests, but researchers are exploring new diagnostic biomarkers. The VEGF family of proteins and their receptors play a significant role in the pathogenesis of breast cancer and could potentially be used as diagnostic biomarkers and therapeutic targets.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Luchang Wang, Kaijiong Zhang, Jia Feng, Dongsheng Wang, Jinbo Liu
Summary: Breast cancer is a common and deadly disease for women, affecting their quality of life. Platelets, fragments derived from megakaryocytes, have been a focus of tumor researchers due to their anticoagulant function. They play a crucial role in tumor angiogenesis, vascular integrity, tumor microenvironment, tumor cell proliferation, metastasis, and cancer treatment. This review provides a better understanding of the role of platelets in these processes.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ines Limam, Mohamed Abdelkarim, Mohamed El Ayeb, Michel Crepin, Naziha Marrakchi, Melanie Di Benedetto
Summary: This study demonstrated that Leb-C derived from the venom of Macrovipera lebetina transmediterrannea snakes disrupted the adhesion, migration, and invasion capabilities of breast cancer cells, as well as the adhesion, migration, and invasion of endothelial cells and fibroblast-growth-factor-2-induced proliferation of endothelial cells. In vivo experiments using nude mice showed that treatment with Leb-C resulted in a significant reduction in xenograft tumor size and tumor angiogenesis. These findings suggest the potential utility of Leb-C for inhibiting aggressive and resistant metastatic breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yan Liang, Chao Qian, Yinghong Xie, Xiang Huang, Junjie Chen, Yanlin Ren, Ziyi Fu, Yongfei Li, Tianyu Zeng, Fan Yang, Jianwei Zhou, Wei Li, Yongmei Yin, Changqing Wang
Summary: This study found that JWA expression is lower in trastuzumab-resistant breast cancers compared to sensitive ones, and overexpression of JWA can inhibit tumor growth and promote apoptosis. Additionally, low JWA expression in trastuzumab-resistant breast cancers is associated with a poor prognosis. JWA negatively regulates CDK12 and is involved in the G1-to-S transition of the cell cycle, suggesting it may be a potential predictive marker and therapeutic target for trastuzumab resistance in breast cancer.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Isabel Quiros-Gonzalez, Michal R. Tomaszewski, Monika A. Golinska, Emma Brown, Laura Ansel-Bollepalli, Lina Hacker, Dominique-Laurent Couturier, Rosa M. Sainz, Sarah E. Bohndiek
Summary: The study suggests that photoacoustic tomography may provide an early indication of response or resistance to antiangiogenic therapy, clearly distinguishing between control, responding, and resistant tumors within just a few weeks of treatment.
Article
Medicine, Research & Experimental
Huan Zeng, Yixuan Hou, Xinyue Zhou, Lei Lang, Haojun Luo, Yan Sun, Xueying Wan, Taixian Yuan, Rui Wang, Yongcan Liu, Rui Tang, Shaojie Cheng, Ming Xu, Manran Liu
Summary: The study revealed that lncSNHG5 and its downstream signaling ZNF281-CCL2/CCL5 in CAFs play a crucial role in the formation of premetastatic niche in breast cancer, thus potentially serving as targets for the diagnosis and treatment of BC metastasis.