Disintegrin-like Protein Strategy to Inhibit Aggressive Triple-Negative Breast Cancer

Potential of uPAR, αvβ6 Integrin, and Tissue Factor as Targets for Molecular Imaging of Oral Squamous Cell Carcinoma: Evaluation of Nine Targets in Primary Tumors and Metastases by Immunohistochemistry

(2023) Mads Lawaetz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Combination of Immune Checkpoint Blockade with Tumor Vessel Normalization as a Promising Therapeutic Strategy for Breast Cancer: An Overview of Preclinical and Clinical Studies

(2023) Ombretta Melaiu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrin Targeting Enhances the Antimelanoma Effect of Annexin V in Mice

(2023) Jingyi Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recent Advances with Precision Medicine Treatment for Breast Cancer including Triple-Negative Sub-Type

(2023) Md Abdus Subhan et al.   Cancers

Alternagin-C, an alpha2beta1 integrin ligand, attenuates collagen-based adhesion, stimulating the metastasis suppressor 1 expression in triple-negative breast tumor cells

(2022) Milene Nóbrega de Oliveira Moritz et al.   TOXICON

Targeting Integrins for Cancer Therapy - Disappointments and Opportunities

(2022) Cecilia Bergonzini et al.   Frontiers in Cell and Developmental Biology

Pharmacological and In Silico Analysis of Oat Avenanthramides as EGFR Inhibitors: Effects on EGF-Induced Lung Cancer Cell Growth and Migration

(2022) Lorenza Trabalzini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer

(2021) Archis Bagati et al.   CANCER CELL

Hydromethanolic root and aerial part extracts from Echium arenarium Guss suppress proliferation and induce apoptosis of multiple myeloma cells through mitochondrial pathway

(2021) Inès Limam et al.   ENVIRONMENTAL TOXICOLOGY

RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving Field

(2021) Beatrice S. Ludwig et al.   Cancers

Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer

(2021) Fatema Tuz Zahra et al.   Cancers

Overview on the Different Patterns of Tumor Vascularization

(2021) Domenico Ribatti et al.   Cells

RIPK1 is a negative mediator in Aquaporin 1-driven triple-negative breast carcinoma progression and metastasis

(2021) Zhuming Yin et al.   npj Breast Cancer

Inhibition of triple negative breast cancer metastasis and invasiveness by novel drugs that target epithelial to mesenchymal transition

(2021) Elizabeth Garcia et al.   Scientific Reports

Breast Cancer Drug Resistance: Overcoming the Challenge by Capitalizing on MicroRNA and Tumor Microenvironment Interplay

(2021) Giulia Cosentino et al.   Cancers

Nano-Strategies Targeting the Integrin αvβ3 Network for Cancer Therapy

(2021) Tsai-Mu Cheng et al.   Cells

Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment

(2021) Wuzhen Chen et al.   Biomarker Research

Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction

(2021) Ariana A. Vasconcelos et al.   Frontiers in Molecular Biosciences

Olea europaea L. cv. Chetoui leaf and stem hydromethanolic extracts suppress proliferation and promote apoptosis via caspase signaling on human multiple myeloma cells

(2020) Inès Limam et al.   European Journal of Integrative Medicine

Tumor cell–organized fibronectin maintenance of a dormant breast cancer population

(2020) Lauren E. Barney et al.   Science Advances

Preclinical studies of a novel snake venom-derived recombinant disintegrin with antitumor activity: A review

(2020) Axel H. Schönthal et al.   BIOCHEMICAL PHARMACOLOGY

Alternagin-C (ALT-C), a disintegrin-like protein, attenuates alpha2beta1 integrin and VEGF receptor 2 signaling resulting in angiogenesis inhibition

(2020) Patty K. dos Santos et al.   BIOCHIMIE

A collagen Vα1-derived fragment inhibits FGF-2 induced-angiogenesis by modulating endothelial cells plasticity through its heparin-binding site

(2020) Tao Jia et al.   MATRIX BIOLOGY

Review of Integrin‐Targeting Biomaterials in Tissue Engineering

(2020) Prachi Dhavalikar et al.   Advanced Healthcare Materials

The Roles of Integrin α5β1 in Human Cancer

(2020) Jianbing Hou et al.   OncoTargets and Therapy

Application of “omics” sciences to the prediction of bone metastases from breast cancer: State of the art

(2020) Marica Gentile et al.   Journal of Bone Oncology

Leucurogin and melanoma therapy

(2019) Meire C. Almeida et al.   TOXICON

Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins

(2019) Cédric Zeltz et al.   SEMINARS IN CANCER BIOLOGY

Alternagin-C, a disintegrin-like protein from Bothrops alternatus venom, attenuates inflammation and angiogenesis and stimulates collagen deposition of sponge-induced fibrovascular tissue in mice

(2019) Luis Fernando Gonçalves Rabelo et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Role of VEGFs in metabolic disorders

(2019) M. di Somma et al.   ANGIOGENESIS

Resistance to Anti-Angiogenic Therapy in Cancer—Alterations to Anti-VEGF Pathway

(2018) Yoshiro Itatani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular alterations in triple-negative breast cancer—the road to new treatment strategies

(2017) Carsten Denkert et al.   LANCET

Exploring the Role of RGD-Recognizing Integrins in Cancer

(2017) Markus Nieberler et al.   Cancers

In situ validation of VEGFR-2 and α v ß 3 integrin as targets for breast lesion characterization

(2016) Josef Ehling et al.   ANGIOGENESIS

MDA-MB-231 breast cancer cells overexpressing single VEGF isoforms display distinct colonisation characteristics

(2015) Melanie Di Benedetto et al.   BRITISH JOURNAL OF CANCER

Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature

(2015) Elena I. Deryugina et al.   MATRIX BIOLOGY

Inhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo

(2014) Liangru W. Contois et al.   ANGIOGENESIS

Inhibition of integrins αv/α5-dependent functions in melanoma cells by an ECD-disintegrin acurhagin-C

(2013) Chun-Ho Shih et al.   MATRIX BIOLOGY

RGD-Based Strategies To Target Alpha(v) Beta(3) Integrin in Cancer Therapy and Diagnosis

(2012) Fabienne Danhier et al.   MOLECULAR PHARMACEUTICS

Invading Basement Membrane Matrix Is Sufficient for MDA-MB-231 Breast Cancer Cells to Develop a Stable In Vivo Metastatic Phenotype

(2011) Mohamed Abdelkarim et al.   PLoS One

Leucurogin, a new recombinant disintegrin cloned from Bothrops leucurus (white-tailed-jararaca) with potent activity upon platelet aggregation and tumor growth

(2011) D.A. Higuchi et al.   TOXICON

Acurhagin-C, an ECD disintegrin, inhibits integrin αvβ3-mediated human endothelial cell functions by inducing apoptosis via caspase-3 activation

(2010) Wen-Jeng Wang   BRITISH JOURNAL OF PHARMACOLOGY

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cooperation between integrin ανβ3 and VEGFR2 in angiogenesis

(2009) Payaningal R. Somanath et al.   ANGIOGENESIS

Leberagin-C, A disintegrin-like/cysteine-rich protein from Macrovipera lebetina transmediterranea venom, inhibits alphavbeta3 integrin-mediated cell adhesion

(2009) Inès Limam et al.   MATRIX BIOLOGY

An integrin αvβ3–c-Src oncogenic unit promotes anchorage-independence and tumor progression

(2009) Jay S Desgrosellier et al.   NATURE MEDICINE

New Symmetrically Esterified m-Bromobenzyl Non-Aminobisphosphonates Inhibited Breast Cancer Growth and Metastases

(2009) Mohamed Abdelkarim et al.   PLoS One