Article
Biochemistry & Molecular Biology
Javier Quero, Nerea Jimenez-Moreno, Irene Esparza, Jesus Osada, Elena Cerrada, Carmen Ancin-Azpilicueta, Maria Jesus Rodriguez-Yoldi
Summary: Grape stem extracts rich in polyphenols have antiproliferative effects on cancer cells through apoptosis cell death and modulation of ROS levels. Additionally, these extracts exhibit antioxidant effects on intestinal cells, offering potential protection against diseases related to oxidative stress. The bioactive compounds in grape extracts could be utilized as bio-functional food ingredients for disease prevention and improving human health.
Article
Food Science & Technology
Raiyan Mahbub, Nidhish Francis, Christopher L. Blanchard, Abishek B. Santhakumar
Summary: The study found that chickpea hull phenolic extracts (CHPE) can alleviate oxidative stress and inflammation by increasing the activity of antioxidant enzymes and reducing the production of inflammatory markers. The results suggest that CHPE may have potential as a treatment for chronic inflammation.
Article
Plant Sciences
Marzieh Moeenfard, Maria Joao Pena, Pedro Barata, Raquel Soares, Raquel Costa
Summary: The study found that both raw and roasted date seed polyphenols extracts can inhibit angiogenesis features, possess antioxidant activity, and show potential anti-angiogenic properties.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Food Science & Technology
Danijel D. Milincic, Nemanja S. Stanisavljevic, Aleksandar Z. Kostic, Svetlana Sokovic Bajic, Milan O. Kojic, Uros M. Gasic, Miroljub B. Barac, Sladjana P. Stanojevic, Zivoslav Lj Tesic, Mirjana B. Pesic
Summary: Grape pomace from the indigenous red grape variety Prokupac is rich in phenolic compounds with strong antioxidant properties, making it a valuable resource for the food and pharmaceutical industry. The presence of flavan-3-ols, phenolic acids, and anthocyanins contribute to the high antioxidant activity observed in the grape pomace.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Elena Morosan, Magdalena Mititelu, Doina Draganescu, Dumitru Lupuliasa, Emma Adriana Ozon, Oana Karampelas, Cerasela Elena Gird, Corina Arama, Marilena Viorica Hovanet, Adina Magdalena Musuc, Ana Corina Ionita
Summary: This study aims to investigate the antioxidant activity of a new pharmaceutical product containing natural antioxidants extracted from plant raw materials. Experimental results show significant antioxidant potential in both the analyzed plant extractive solutions and the final product.
APPLIED SCIENCES-BASEL
(2021)
Article
Food Science & Technology
Yao Zhang, Chengzhi Lv, Juan Sun, Xinjie Song, Nyasha Makaza, Yuanfeng Wu
Summary: The antioxidant activity of broccoli extracts and its purified compounds were investigated, showing that they can protect cells from oxidative stress through increasing total antioxidant capacity and activities of antioxidant enzymes, and decreasing oxidative damage. Additionally, the expression of Nrf2 and related antioxidant enzymes were increased by broccoli extracts. Overall, broccoli extracts showed better antioxidant effects than the purified compound SF, with polyphenols and PSF playing key roles in the protection against oxidative stress.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Food Science & Technology
Maria Julia Martinez, Adriana Balbina Andreu, Luciana Barbini
Summary: Hepatocellular carcinoma (HCC) is a common and deadly tumor. Late diagnosis and treatment delay contribute to poor prognosis. Polyphenols from potatoes have antioxidant properties and cytotoxic effects on HCC cells, making them a potential treatment option.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Pedro Ferreira-Santos, Antonio Nogueira, Cristina M. R. Rocha, Cristina Pereira Wilson, Jose A. Teixeira, Claudia Botelho
Summary: The bioavailability and toxicological effects of S. nigra extracts, specifically from flower and berry, were found to differ significantly, with the berry extract showing better antioxidative effects post-digestion and lower cytotoxicity. These findings suggest the potential of S. nigra by-product compounds as functional food ingredients or bio-therapeutic agents.
Review
Biochemistry & Molecular Biology
Imre Hegedus, Kitti Andreidesz, Jozsef L. Szentpeteri, Zoltan Kaleta, Laszlo Szabo, Krisztian Szigeti, Balizs Gulyas, Parasuraman Padmanabhan, Ferenc Budan, Domokos Mathe
Summary: This article emphasizes the importance of nutritional interventions in maintaining or restoring human health, with grapes being recognized as a beneficial source of polyphenols that enhance human health. The review provides detailed information on the molecular mechanisms and biological activities of polyphenol molecules in grapes, highlighting their potential roles in diabetes, cancer, viral infections, vascular protection, and neuroprotection. Furthermore, the article explores the therapeutic applications of polyphenols derived from grapes and their byproducts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Nadia Calabriso, Marika Massaro, Egeria Scoditti, Tiziano Verri, Amilcare Barca, Carmela Gerardi, Giovanna Giovinazzo, Maria Annunziata Carluccio
Summary: The study shows that polyphenolic extract from grape pomace can effectively alleviate inflammatory response in enterocyte-like cells and improve vascular function by inhibiting NF-kappa B activity and reducing intracellular ROS levels.
Article
Biochemistry & Molecular Biology
Young Sook Kim, Heung Joo Yuk, Dong Seon Kim
Summary: Ethanol extracts of JGT showed higher antioxidant activity and total phenolic and flavonoid contents compared to water extracts. JGT-E contained more active compounds and was more effective in protecting against oxidative stress-induced cell death, suggesting it could be a potential treatment for muscle aging and loss.
Article
Chemistry, Medicinal
Karolina Jakubczyk, Agnieszka Lukomska, Sylwester Czaplicki, Anna Wajs-Bonikowska, Izabela Gutowska, Norbert Czapla, Malgorzata Tanska, Katarzyna Janda-Milczarek
Summary: Goutweed, a common perennial plant with various nutrients, has antioxidant effects. Research has shown that goutweed leaf extracts have positive effects on oxidative stress in cells and increase the activity of antioxidant enzymes.
Article
Chemistry, Multidisciplinary
Elena Gerasimova, Elena Salimgareeva, Olga Shabunina, Alexander Ermoshin, Anastasya Peshkova, Alla Ivanova
Summary: This study investigated the antioxidant properties of extracts from the red grape pomace and their potential economic return. The effects of extraction parameters on antioxidant capacity and polyphenolic compound content were studied, showing that the red grape pomace is a valuable source of natural antioxidants.
Article
Biochemistry & Molecular Biology
Julen Diaz-Ramirez, Senda Basasoro, Kizkitza Gonzalez, Arantxa Eceiza, Alona Retegi, Nagore Gabilondo
Summary: This study successfully utilized grape pomace agricultural waste to prepare antioxidant Pickering emulsions. Rod-like bacterial cellulose nanocrystals with lengths up to 1.5 μm and widths of 5-30 nm were obtained through enzymatic hydrolysis. The polyphenolic extract obtained through ultrasound-assisted hydroalcoholic solvent extraction showed excellent antioxidant properties. The combination of nanocellulose and polyphenolic extract improved the colloidal stability and antioxidant activity of the emulsions.
Article
Chemistry, Applied
Susana Ferreyra, Ruben Bottini, Ariel Fontana
Summary: This study investigates the stability of PCs in grape canes extracts under different storage temperatures and light conditions. The composition of PCs was analyzed every two weeks using LC-DAD-FLD. Stilbenes initially accounted for 87% of total PCs. Storage at -20 and 5 degrees C resulted in a reduction of 8% and 6% in PCs, respectively. Higher temperatures and light exposure accelerated the degradation of certain PCs, such as (+)-catechin and (-)-epicatechin. trans-piceatannol was particularly sensitive to temperature increase, while the degradation of trans-resveratrol and epsilon-viniferin was mostly catalyzed by light.
Review
Medicine, Research & Experimental
Seyed Sajjad Babaeimarzangou, Himasadat Zaker, Ehsan Soleimannezhadbari, Naeimeh Shamsi Gamchi, Masoud Kazeminia, Shima Tarighi, Homayon Seyedian, Aristidis Tsatsakis, Demetrios A. Spandidos, Denisa Margina
Summary: Zoonotic viral diseases have become a major threat to global public health and economies in recent times. The lack of vaccines and effective antiviral drugs against most of these viruses increases the risk of new outbreaks. This review provides an update on the progress of vaccine development in clinical trials for various zoonotic viruses.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Medicine, General & Internal
Ismail Topal, Mustafa Yasar Ozdamar, Tulin Catakli, Ismail Malkoc, Ahmet Hacimuftuoglu, Charalampos Mamoulakis, Aristidis Tsatsakis, Konstantinos Tsarouhas, Christina Tsitsimpikou, Ali Taghizadehghalehjoughi
Summary: This study aimed to evaluate the renoprotective effects of taxifolin (TXF) in a paracetamol (PAR)-induced nephrotoxicity rat model. The results showed that the levels of blood urea nitrogen, creatinine and malondialdehyde were significantly increased in the PAR group, while the levels of glutathione peroxidase, glutathione reductase and total glutathione were significantly higher in the TXF group. Histopathological examination revealed severe tubular epithelium damage in the PAR group, while the TXF group showed mild dilated/congested blood vessels. These findings suggest that TXF has potential renoprotective effects against PAR-induced nephrotoxicity through its antioxidant activity and should be further investigated.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
K. Yu Maksimovich, R. Yu Dudko, E. I. Shatalova, A. K. Tsakalof, A. M. Tsatsakis, K. S. Golokhvast, E. A. Novikov
Summary: The detrimental environmental consequences caused by intensification of crop cultivation can be prevented through monitoring of specific biological indicators. This study focused on the impact of crop type and cultivation intensity on the community of ground beetles in the forest-steppe of Western Siberia. The ground beetles' community showed a high evenness of species distribution across the agroecosystems. Differences in ground beetle distribution were observed between wheat and corn crops. The use of bioindicators allowed for assessing the environmental sustainability of the agricultural environment and provided insights for ecologically directed correction of agrotechnological operations in agroecosystem management.
ENVIRONMENTAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Daniela-Madalina Ciuca Anghel, Ana-Maria Vlasceanu, Gheorghe Tudor, Anne-Marie Ciobanu, Miriana Stan, Gabriela Viorela Nitescu, Dimitra Florou, Aristidis M. Tsatsakis, Daniela Luiza Baconi
Summary: The aim of our study was to evaluate the differences among different groups of drug users, focusing on hematological, biochemical, urinary, and cardiological aspects. A retrospective study was conducted on 2572 hospitalized patients in Bucharest, Romania from 2015 to 2021. The study group was characterized based on demographic data, personal history/co-morbidities, consumption history, and substitution treatment. The analysis of medical records revealed correlations between GGT levels and alcohol intake as well as contagious diseases, a decrease in MCH and MCHC levels across the entire study group, and correlations between specific cardiological events and certain substance groups. The study provides important information on different types of drug users and supports future research on the chemical structures of consumed compounds.
Review
Medicine, Research & Experimental
Michael Aschner, Anatoly V. Skalny, Viktor A. Gritsenko, Olga L. Kartashova, Abel Santamaria, Joao B. T. Rocha, Demetrios A. Spandidos, Irina P. Zaitseva, Aristidis Tsatsakis, Alexey A. Tinkov
Summary: The aim of this study was to summarize the potential interactive effects between the gut microbiota and advanced glycation end-product (AGE) accumulation and toxicity in the host, and to reveal the mediating effects of the gut microbiota on AGE-related health effects. Existing data demonstrates that dietary AGEs can significantly impact the richness and diversity of the gut microbiota, with specific effects depending on species type and exposure dose. Additionally, the gut microbiota may metabolize dietary AGEs. The characteristics of the gut microbiota, including richness and relative abundance of certain taxa, are closely associated with AGE accumulation in the host organism. In turn, the interplay between AGE toxicity and modulation of the gut microbiota may contribute to aging and diabetes-associated diseases. Bacterial endotoxin lipopolysaccharide appears to mediate the interactions between the gut microbiota and AGE toxicity, specifically through modulation of the receptor for AGE signaling. Therefore, modulation of the gut microbiota using probiotics or other dietary interventions may significantly impact AGE-induced glycative stress and systemic inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vasiliki Karzi, Eren Ozcagli, Manolis N. Tzatzarakis, Elena Vakonaki, Irene Fragkiadoulaki, Aikaterini Kalliantasi, Christina Chalkiadaki, Athanasios Alegakis, Polychronis Stivaktakis, Aikaterini Karzi, Antonios Makrigiannakis, Anca Oana Docea, Daniela Calina, Aristidis Tsatsakis
Summary: Exposure to combined endocrine disruptors can cause DNA damage, as observed in this study using comet and micronuclei assays. The highest level of damage was found in the group exposed to a high-dose mixture of substances, particularly glyphosate. The micronuclei assay results were moderately correlated with exposure period, and all exposure groups showed an increasing trend in micronuclei counts over time.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Aristidis Tsatsakis, Tatiana Oikonomopoulou, Taxiarchis Konstantinos Nikolouzakis, Elena Vakonaki, Manolis Tzatzarakis, Matthaios Flamourakis, Elisavet Renieri, Persefoni Fragkiadaki, Evaggelia Iliaki, Maria Bachlitzanaki, Vasiliki Karzi, Ioanna Katsikantami, Fotios Kakridonis, Eleftheria Hatzidaki, Maria Tolia, Andrey A. Svistunov, Demetrios A. Spandidos, Dragana Nikitovic, John Tsiaoussis, Aikaterini Berdiaki
Summary: Cancer is a major issue in clinical, social, and economic aspects, ranking highest in terms of cause-specific disability-adjusted life years among all human pathologies. The trigger of cancer involves various factors, including genetic predisposition and telomere status, which are DNA structures at the end of chromosomes. However, there is no universal trend in the association between telomere length and cancer, as both short and long telomeres have been linked to high cancer incidence risks. This review aims to present the complex relationship between telomere length and cancer comprehensively.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fotios Tekos, Zoi Skaperda, Periklis Vardakas, Despina Kyriazi, Georgios C. C. Maravelis, Konstantinos Poulas, Ioannis A. A. Taitzoglou, Charitini Nepka, Demetrios Kouretas
Summary: Wine and its by-products, such as grape stems, contain bioactive polyphenolic compounds that can potentially benefit animal and human health. However, there are limited studies on the safety and toxicological risks of these compounds in vivo. This study examined the effects of oral administration of grape stem and wine extracts on redox biomarkers in mice and rats. The results showed that grape stem extract improved redox homeostasis in mice, while wine extract had both beneficial and harmful effects on rat redox status, indicating the complexity of biological systems.
Review
Food Science & Technology
Eleftheria Hatzidaki, Marina Pagkalou, Ioanna Katsikantami, Elena Vakonaki, Matthaios Kavvalakis, Aristidis M. Tsatsakis, Manolis N. Tzatzarakis
Summary: Human milk is the healthiest option for newborns, but infant formula is a valuable alternative in certain circumstances. Ensuring pollutant-free composition, infant formulas are regulated and monitored for safe exposure. While legislation varies across countries, standard policies for protecting vulnerable infants are in place. This article presents current regulations and directives for limiting endocrine-disrupting chemicals and persistent organic pollutants in infant formulas, highlighting the need for limited risk assessment studies to assess the health risks for infants from dietary exposure to pollutants.
Article
Biochemistry & Molecular Biology
Betul Danisman, Betul Cicek, Serkan Yildirim, Ismail Bolat, Deniz Kantar, Kirill S. Golokhvast, Dragana Nikitovic, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: This study aimed to investigate the impact of carnosic acid (CA) on indomethacin (IND)-induced gastric ulceration. The results showed that CA pretreatment attenuated both gross morphological lesions and histopathological alterations induced by IND, and it achieved gastroprotective effects by reducing oxidative stress and suppressing inflammation.
Article
Health Care Sciences & Services
Betul Cicek, Ahmet Hacimuftuoglu, Yesim Yeni, Betul Danisman, Mustafa Ozkaraca, Behzad Mokhtare, Mecit Kantarci, Marios Spanakis, Dragana Nikitovic, Georgios Lazopoulos, Konstantinos Tsarouhas, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: This research evaluated the cardioprotective properties of chlorogenic acid (CGA) in doxorubicin (DOX)-induced cardiotoxicity and identified one of the possible mechanisms for its protective effects. The study found that CGA ameliorated oxidative stress and cardiomyocyte apoptosis by upregulating the Nrf2/HO-1-dependent pathway and downregulating dityrosine (DT) expression. These findings suggest that CGA may be cardioprotective, particularly in patients receiving DOX-based chemotherapy.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Environmental Sciences
Cigdem Sevim, Erol Akpinar, Emrah Hicazi Aksu, Ali Dogan Omur, Serkan Yildirim, Mehtap Kara, Ismail Bolat, Aristides Tsatsakis, Robin Mesnage, Kirill S. S. Golokhvast, Sevgi Karabulut Uzuncakmak, Rabia Nilufer Ersoylu
Summary: The study aimed to investigate the positive effects of probiotic Saccharomyces boulardii on the male reproductive system under low dose neonicotinoid pesticide exposure conditions. Acetamiprid and imidacloprid caused degeneration and necrosis of spermatocytes, severe edema of the intertubular region, and hyperemia. This was accompanied by increased oxidative stress and apoptosis. Saccharomyces boulardii supplementation mitigated these toxic effects.
Article
Environmental Sciences
Paraskevi-Maria Nechalioti, Thomas Karampatzakis, Robin Mesnage, Michael N. Antoniou, Mariam Ibragim, Aristidis Tsatsakis, Anca Oana Docea, Charitini Nepka, Demetrios Kouretas
Summary: The wide-scale emergence of glyphosate-resistant weeds has caused an increase in the application of herbicide mixtures containing glyphosate plus dicamba or glyphosate plus 2,4-D. This raises concerns about the environmental and health risks from exposure to a mixture of herbicide active ingredients. The study evaluated the hepatotoxic effects of perinatal exposure to glyphosate alone or in combination with 2,4-D and dicamba on Wistar rats. The findings highlight the importance of assessing the combined effects of chemical pollutants at safe individual doses.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Betul Cicek, Betul Danisman, Serkan Yildirim, Neslihan Yuce, Dragana Nikitovic, Ismail Bolat, Mehmet Kuzucu, Ertugrul Ceyran, Ebru Bardas, Kirill S. Golokhvast, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Summary: SN berry extract has protective effects against IND-induced gastric ulcers in rats by reducing oxidative damage and inflammation in the gastric mucosa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Yuliya V. Ryabova, Ilzira A. Minigalieva, Marina P. Sutunkova, Svetlana V. Klinova, Alexandra K. Tsaplina, Irene E. Valamina, Ekaterina M. Petrunina, Aristides M. Tsatsakis, Charalampos Mamoulakis, Kostas Stylianou, Sergey V. Kuzmin, Larisa I. Privalova, Boris A. Katsnelson
Summary: This study found that chronic diseases of the urogenital tract can develop under the effects of chemical hazards in the working environment, particularly from nanosized particles generated in industrial processes. The researchers studied the nephrotoxicity of element oxide nanoparticles through animal experiments, and found that these nanoparticles had a toxic effect on the kidneys and caused changes in kidney function and histological structure. The results of this study are important for the early diagnosis of occupational and nonoccupational nephropathies.
