Article
Pharmacology & Pharmacy
Christelle Sanchez, Kathrin Hemmer, Natascha Kroemmelbein, Bernd Seilheimer, Jean-Emile Dubuc, Christophe Antoine, Yves Henrotin
Summary: Through experiments, it was found that Ze14 may reduce the expression and activation of MMP13, increase the production of CCN1, and promote the production of type II collagen and aggrecan in human OA chondrocytes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Cristina Duarte-Olivenza, Juan Antonio Montero, Carlos Ignacio Lorda-Diez
Summary: The study revealed the dual and opposite effects of berberine on the growth and differentiation of skeletal progenitors, showing an inhibitory or promoting effect on chondrogenesis depending on the stage of culture. Furthermore, berberine may be involved in cartilage differentiation through transcriptional influence on DNA methyltransferase genes, suggesting the potential role of epigenetic factors in its effects. These findings have important implications for the clinical use of berberine in the treatment of cartilage degenerative diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Chemistry, Physical
Arjan Atwal, Tina P. Dale, Martyn Snow, Nicholas R. Forsyth, Pooya Davoodi
Summary: The impairment of articular cartilage poses challenges, but recent advancements in regenerative medicine, particularly the use of injectable hydrogels, offer promising prospects for cartilage regeneration. Hydrogels can mimic the characteristics of native cartilage and provide minimally invasive delivery of bioactive agents to the damaged site, accelerating cartilage healing and modulating inflammation.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Genetics & Heredity
Tugba Semerci Sevimli, Murat Sevimli, Emilia Qomi Ekenel, Burcugul Altug Tasa, Merve Nur Soykan, Zilif Demir Gucluer, Ulukan Inan, Onur Uysal, Sibel Gunes Bagis, Fatih Cemrek, Ayla Eker Sariboyaci
Summary: This study investigated the differences in exosomal microRNA-127-5p expression profiles between hAT-MSCs and hSF-MSCs during chondrogenesis for cartilage regeneration treatment. Differentiation of hAT-MSCs, hSF-MSCs, and hfCCs was induced, and staining was performed to detect chondrogenic differentiation. Exosomes from differentiated cells were isolated, and expression of microRNA-127-5p was measured by qRT-PCR. Higher levels of microRNA-127-5p expression were found in hAT-MSCs exosomes compared to hSF-MSCs, suggesting hAT-MSCs are better sources for stimulating chondrogenesis and regenerative therapy of cartilage-related pathologies. hAT-MSCs exosomes are rich in microRNA-127-5p and can be a significant candidate for cartilage regeneration treatments.
Review
Cell Biology
Jingliang Gu, Wu Rao, Shaochuan Huo, Tianyou Fan, Minlei Qiu, Haixia Zhu, Deta Chen, Xiaoping Sheng
Summary: Osteoarthritis (OA) is a common musculoskeletal disease that is characterized by progressive loss of articular cartilage and other pathological changes. Non-coding RNAs (ncRNAs), especially miRNAs and lncRNAs, play vital roles in regulating cartilage homeostasis and the progression of OA. Changes in ncRNA expression levels can promote or decelerate OA progression through distinct molecular mechanisms. The potential of ncRNAs as diagnostic biomarkers, prognostic indicators, and therapeutic targets for OA has been emphasized.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Rheumatology
Alejandro Rodriguez Ruiz, Margo Tuerlings, Ankita Das, Rodrigo Coutinho de Almeida, H. Eka D. Suchiman, Rob G. H. H. Nelissen, Yolande F. M. Ramos, Ingrid Meulenbelt
Summary: This study determined the role of TNFRSF11B overexpression in the development of OA and found that it may act as a direct driving factor for the transition of chondrocytes to osteoblasts in lesioned OA cartilage, independent of the OPG/RANK/RANKL pathway commonly seen in bone remodeling.
Review
Chemistry, Medicinal
Jhi Biau Foo, Qi Hao Looi, Chee Wun How, Sau Har Lee, Maimonah Eissa Al-Masawa, Pei Pei Chong, Jia Xian Law
Summary: Exosomes are small extracellular vesicles secreted by cells for intercellular communication, with miRNAs being a promising therapeutic factor for cartilage regeneration. They can promote chondrocyte proliferation and matrix secretion, reduce scar tissue formation, and decrease inflammation, but the optimization of exosome therapy for cartilage injuries is still lacking.
Review
Chemistry, Medicinal
Gollahalli Shivashankar Prajwal, Naveen Jeyaraman, Krishna Kanth, Madhan Jeyaraman, Sathish Muthu, Sree Naga Sowndary Rajendran, Ramya Lakshmi Rajendran, Manish Khanna, Eun Jung Oh, Kang Young Choi, Ho Yun Chung, Byeong-Cheol Ahn, Prakash Gangadaran
Summary: Tissue engineering and regenerative medicine provide a new approach for treating musculoskeletal diseases, utilizing MSCs and growth factors to improve the regenerative environment. However, the selection of MSCs source and the long-term and short-term effects of MSCs treatment remain uncertain.
Article
Chemistry, Multidisciplinary
Sirong Shi, Tianyu Chen, Weitong Lu, Yang Chen, Dexuan Xiao, Yunfeng Lin
Summary: This study presents a novel therapeutic strategy for osteoarthritis (OA) treatment by synthesizing tetrahedral framework nucleic acids (tFNAs) carrying miR-124 (T-miR3). T-miR3 efficiently prevents OA progression by inhibiting chondrocyte apoptosis, smoothing cartilage surfaces, suppressing extracellular matrix degradation, and increasing synovial thickness.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Judit Vago, Roland Takacs, Patrik Kovacs, Tibor Hajdu, Daan R. van der Veen, Csaba Matta
Summary: The unique structure and composition of articular cartilage are critical for its function, but they can be disrupted by degeneration or trauma. The low regenerative capacity of the tissue limits its healing response, leading to inflammation and reduced quality of life. Tissue engineering approaches that generate new cartilage can address these limitations by considering the biomechanical microenvironment and entraining the molecular circadian clockwork. This review highlights the importance of the biomechanical microenvironment in advancing cartilage tissue engineering interventions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Weiping Lin, Zhengmeng Yang, Liu Shi, Haixing Wang, Qi Pan, Xiaoting Zhang, Peng Zhang, Sien Lin, Gang Li
Summary: This study aimed to evaluate the efficacy of intra-articular delivery of peripheral blood derived mesenchymal stromal cells (PB-MSCs) on the progression of trauma-induced osteoarthritis (OA) in mice. The results showed that PB-MSCs administration significantly reduced subchondral bone volume, improved degeneration of articular cartilage, and reduced the expression of catabolic marker MMP13 in articular cartilage. Additionally, injected PB-MSCs differentiated into chondrocytes in situ and reduced inflammation levels in the peripheral sera of mice.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Anna Nakamura, Daiki Murata, Ryota Fujimoto, Sakura Tamaki, Sanae Nagata, Makoto Ikeya, Junya Toguchida, Koichi Nakayama
Summary: This study successfully fabricated cartilage constructs for repairing cartilage defects, using scaffold-free Kenzan method and iPSC-derived cells, showing promising tissue function.
Article
Pharmacology & Pharmacy
Claudio Intini, Lia Blokpoel Ferreras, Sarah Casey, James E. Dixon, John P. Gleeson, Fergal J. O'Brien
Summary: A novel miR-activated scaffold was developed to enhance mesenchymal stem/stromal cells (MSC) chondrogenesis and cartilage repair through the delivery of an inhibitor to miR-221. The miR-activated scaffold successfully transfected human MSCs with the miR-221 cargo, promoting an improved cell-mediated chondrogenic response. This innovative scaffold shows promise in improving chondrogenesis and enhancing cartilage defect repair.
ADVANCED THERAPEUTICS
(2023)
Article
Immunology
Fei Cao, Yang Chen, Xing Wang, Li-Min Wu, Mei Tian, Han-Yu Li, Hai-Bo Si, Bin Shen
Summary: MicroRNAs have received significant attention in recent years for their potential role in osteoarthritis pathogenesis. A study on rats showed that intra-articular injections of miR-140-5p can effectively alleviate early-stage OA progression by modulating various biological processes and pathways. In particular, multiple injections of miR-140-5p demonstrated better therapeutic effects compared to single injections in alleviating early-stage OA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Ji-Yun Ko, Jeong-Won Park, Juyoung Kim, Gun-Il Im
Summary: The study demonstrated that ASC spheroids have better in vitro and in vivo survival and chondrogenic potential, exerting greater regenerative effects for articular cartilage, and arresting the progression of surgically induced OA better than ASCs in single-cell suspension through a paracrine mode of action.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Surgery
Zi-Bo Yang, Pei-Hui Wu, Ping-Kwan Wong, Zhi-Yu Huang, Ming Fu, Wei-Ming Liao, Ai-Shan He, Yan Kang
JOURNAL OF INVESTIGATIVE SURGERY
(2018)
Article
Medicine, Research & Experimental
Fangang Meng, Zhiwen Li, Zhiqi Zhang, Zibo Yang, Yan Kang, Xiaoyi Zhao, Dianbo Long, Shu Hu, Minghui Gu, Suiwen He, Peihui Wu, Zongkun Chang, Aishan He, Weiming Liao
Article
Cell Biology
Guping Mao, Shu Hu, Ziji Zhang, Peihui Wu, Xiaoyi Zhao, Ruifu Lin, Weiming Liao, Yan Kang
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2018)
Article
Surgery
Peihui Wu, Qiaoli Liu, Ming Fu, Zhiqi Zhang, Suiwen He, Weiming Liao, Yan Kang
JOURNAL OF INVESTIGATIVE SURGERY
(2019)
Article
Orthopedics
Zhiqi Zhang, Can Liu, Zhiwen Li, Peihui Wu, Shu Hu, Weiming Liao
JOURNAL OF KNEE SURGERY
(2020)
Article
Medicine, Research & Experimental
Shu Hu, Guping Mao, Ziji Zhang, Peihui Wu, Xingzhao Wen, Weiming Liao, Zhiqi Zhang
Review
Rehabilitation
Siqi Tang, Xiaoshuai Wang, Peihui Wu, Peiqi Wu, Jiaming Yang, Zefeng Du, Shaoyu Liu, Fuxin Wei
Article
Rheumatology
Hao Sun, Xingzhao Wen, Hongyi Li, Peihui Wu, Minghui Gu, Xiaoyi Zhao, Ziji Zhang, Shu Hu, Guping Mao, Ruofan Ma, Weiming Liao, Zhiqi Zhang
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Proceedings Paper
Biochemical Research Methods
Chulan Chen, Peihui Wu, Linli Zheng, Yuanping Liu, Xiaoyan Zhang, Yukai Song
2019 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM)
(2019)
Article
Medicine, General & Internal
Lin-Li Zheng, Yang-Yang Lin, Xiao-Yan Zhang, Qian-Hui Ling, Wei-Ming Liao, Pei-Hui Wu
CHINESE MEDICAL JOURNAL
(2019)
Article
Cell Biology
Guping Mao, Peihui Wu, Ziji Zhang, Zhiqi Zhang, Weiming Liao, Yukang Li, Yan Kang
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2017)
Article
Orthopedics
Zhiqi Zhang, Peihui Wu, Zhiyu Huang, Baoxi Yu, Hong Sun, Ming Fu, Yan Kang, Weiming Liao
JOURNAL OF ORTHOPAEDICS
(2017)
Article
Medicine, General & Internal
Pei-Hui Wu, Zhi-Qi Zhang, Ming-Hui Gu, Xiao-Yi Zhao, Yan Kang, Wei-Ming Liao, Ming Fu
CHINESE MEDICAL JOURNAL
(2017)
Article
Orthopedics
Yu Baoxi, Fu Ming, Zhang Zhiqi, Wu Peihui, Huang Zhiyu, Sun Hong
JOURNAL OF ORTHOPAEDICS
(2017)
Article
Cell Biology
Hao Sun, Zhiyu Huang, Peihui Wu, Zongkun Chang, Weiming Liao, Zhiqi Zhang
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)