Article
Plant Sciences
Yunfeng Zhou, Mingzhu Yan, Ruile Pan, Zhi Wang, Xue Tao, Chenchen Li, Tianji Xia, Xinmin Liu, Qi Chang
Summary: Radix Polygalae (RP) demonstrated remarkable antidepressant activity in behavioral despair mice and chronic restraint stress (CRS)-induced rats, possibly by promoting autophagy and inhibiting neuroinflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Chen-Chen Li, Fan Ye, Chen-Xi Xu, Qi Chang, Xin-Min Liu, Rui-Le Pan
Summary: This study demonstrates that Radix Polygalae extract (RPE) can modulate colonic dysfunction in rats subjected to chronic restraint stress (CRS) through its effects on gut microbiota, inflammation, metabolites and enzymes, and tight junction proteins.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wu Zeng, An Guo Wu, Xiao-Gang Zhou, Imran Khan, Rui Long Zhang, Hang Hong Lo, Li Qun Qu, Lin Lin Song, Xiao Yun Yun, Hui Miao Wang, Juan Chen, Jerome P. L. Ng, Fang Ren, Si Yu Yuan, Lu Yu, Yong Tang, Guo Xin Huang, Vincent Kam Wai Wong, Sookja Kim Chung, Simon Wing Fai Mok, Da Lian Qin, Hua Lin Sun, Liang Liu, W. L. Wendy Hsiao, Betty Yuen Kwan Law
Summary: With the increase in human lifespan, population aging has become a major global issue. Aging is an irreversible progressive process that affects humans through various factors. Traditional herbal plants have been widely used for anti-aging and modulation of aging-related symptoms due to their safety and polypharmacological potency.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Juan Li, Bin Zou, Xiao-Yu Cheng, Xin-He Yang, Jia Li, Chun-Hui Zhao, Rui-Xia Ma, Ji-Xiang Tian, Yao Yao
Summary: This study found that total saikosaponins (TS) could ameliorate cognitive dysfunction in Alzheimer's disease (AD) by activating nuclear factor 2 (Nrf2) and downregulating the expression of beta-secretase 1 (BACE1), reducing the generation of amyloid-beta (A beta) and senile plaque deposition. TS also enhanced autophagy, inhibited the activation of nuclear factor-kappa B (NF-kappa B), and improved synaptic loss and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Tao Long, Xue Chen, Yue Zhang, Yu-Jia Zhou, Yan-Ni He, Yun-Fei Zhu, Hai-Jun Fu, Lu Yu, Chong-Lin Yu, Betty Yuen-Kwan Law, Jian-Ming Wu, Da-Lian Qin, An-Guo Wu, Xiao-Gang Zhou
Summary: This study explores the therapeutic potential of Radix Stellariae, a traditional Chinese medicine, in treating Alzheimer's disease (AD), and demonstrates that it effectively diminishes AD-associated protein expression and related impairments by inducing autophagy. The key active constituent, Dichotomine B, is shown to mitigate AD pathology.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Tomoharu Kuboyama, Seiya Kominato, Misaki Nagumo, Chihiro Tohda
Summary: The study focused on evaluating herbal medicine constituents that induce M2 predominance for the treatment of SCI. Polygalae Radix (PR) was found to induce M2 predominance in microglia, improve motor function in SCI model mice, and showed potential for protecting against axonal degeneration in the injured spinal cord.
Article
Food Science & Technology
Valentina Cecarini, Massimiliano Cuccioloni, Yadong Zheng, Laura Bonfili, Chunmei Gong, Mauro Angeletti, Pedro Mena, Daniele Del Rio, Anna Maria Eleuteri
Summary: The study investigates how phenyl-gamma-valerolactone metabolites modulate cellular proteolysis by inhibiting proteasomes, upregulating autophagy, and inhibiting cathepsin B activity, resulting in reduced amyloid-beta (1-42) peptides. The findings suggest that these metabolites have neuroprotective effects by regulating intracellular proteolysis and could be potential targets for AD preventive and therapeutic strategies.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Psychiatry
Ning Jiang, Shanshan Wei, Yiwen Zhang, Wenlu He, Haiyue Pei, Hong Huang, Qiong Wang, Xinmin Liu
Summary: Radix Polygalae, also known as Yuanzhi in China, is a famous Chinese herb with neuroprotective effects which can be used to treat a variety of CNS disorders. Its mechanisms of action include antioxidant effects, anti-inflammatory effects, neurogenesis, plasticity improvement, HPA axis regulation, neurotransmitter release, and receptor activation. Further research is needed to fully understand its pharmacological effects.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Gaeul Han, Junhyuk Choi, Seung-Yun Cha, Byung Il Kim, Hee Kyung Kho, Maeng-Jin Jang, Mi Ae Kim, Sungho Maeng, Heeok Hong
Summary: Postmenopausal syndrome is characterized by symptoms caused by decreased female hormones after mid-40s, leading to cognitive decline and depressive symptoms. Radix Polygalae, when administered orally in a mouse model of estrogen depletion, showed improvements in memory, reduced depression-related behaviors, and potential neuroprotective effects without increasing serum estradiol levels. These results suggest the possible benefits of Radix Polygalae as a supplement to prevent postmenopausal depression and cognitive decline.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Nutrition & Dietetics
Seong-Lae Jo, Hyun Yang, Sang R. Lee, Jun H. Heo, Hye-Won Lee, Eui-Ju Hong
Summary: This study focuses on the relationship between neurodegenerative diseases and energy metabolism, using Curcumae radix extract in cells and animal models. The results show that Curcumae radix can reduce neurodegenerative markers and influence cellular glycolysis and mitochondrial function.
Article
Biochemistry & Molecular Biology
Manuela Leri, Andrea Bertolini, Massimo Stefani, Monica Bucciantini
Summary: The study demonstrates that olive oil polyphenols, particularly oleuropein aglycone and hydroxytyrosol, synergistically activate the autophagic flux to protect against Aβ (1-42) oligomer-induced cell damage, reduce ROS production, and improve mitochondrial function, potentially providing a promising strategy to combat neurodegeneration associated with aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Batbayar Tumurbaatar, Anna Fracassi, Pietro Scaduto, Jutatip Guptarak, Randall Woltjer, Daniel Jupiter, Giulio Taglialatela
Summary: This study investigates the association of autophagy with cognitive integrity in individuals with Alzheimer's disease neuropathology but without dementia. The results suggest that preserved autophagy may protect against cognitive decline in these individuals.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Tsz Yan Fung, Ashok Iyaswamy, Sravan G. Sreenivasmurthy, Senthilkumar Krishnamoorthi, Xin-Jie Guan, Zhou Zhu, Cheng-Fu Su, Jia Liu, Yuxuan Kan, Yuan Zhang, Hoi Leong Xavier Wong, Min Li
Summary: This article reviews the role of Klotho in Alzheimer's disease (AD), including its effect on promoting amyloid-beta clearance and inducing autophagy for the clearance of toxic proteins through regulating the autophagy lysosomal pathway. The results of multiple studies suggest that targeting Klotho could be a potential therapeutic strategy in AD treatment.
Article
Chemistry, Medicinal
Haiyu Zhang, Xinmei Xie, Junzhuo Shi, Qian Zhao, Dongmei Luo, Jiaojiao Hao, Yunfeng Zhou, Guang Han, Xiaobin Pang
Summary: The present study confirmed the cognition-enhancing effect of 3, 14, 19-Triacetyl andrographolide (ADA) on learning and memory deficits in 3 x Tg-AD mice. ADA improves synaptic plasticity and cognitive function mainly through inducing autophagy and promoting the degradation process.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Xing Jun Jiang, Yan Qing Wu, Rong Ma, Yan Min Chang, Lu Lu Li, Jia Hui Zhu, Gong Ping Liu, Gang Li
Summary: This study found that overexpression of PINK1 can promote the degradation of accumulated tau proteins in patients with AD, improving cognitive abilities and rescuing damaged neurons and synapses. Furthermore, PINK1 also improves mitochondrial dysfunction caused by tau proteins. This suggests that PINK1 may be a potential target for AD treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)