Article
Biochemistry & Molecular Biology
Sonia Di Gaetano, Luciano Pirone, Ioannis Galdadas, Serena Traboni, Alfonso Iadonisi, Emilia Pedone, Michele Saviano, Francesco Luigi Gervasio, Domenica Capasso
Summary: Galectins are soluble proteins involved in cancer progression and disease outcome, making them important targets for therapeutic intervention. Developing small inhibitors to selectively block galectin activity is a promising strategy for cancer therapy. This study designed a novel compound with high binding affinity to galectins and demonstrated its potential anticancer properties, paving the way for further development as an anticancer agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yunlong Si, Yuying Li, Tong Yang, Xumin Li, Gabriela Jaramillo Ayala, Kevin H. Mayo, Guihua Tai, Jiyong Su, Yifa Zhou
Summary: The crystal structure of Gal-14 differs significantly from other galectins, particularly in its unique interaction with carbohydrates and lactose. In addition, Gal-14 exhibits distinctive characteristics in terms of agglutination activity and cellular localization compared to other galectins.
Article
Chemistry, Medicinal
Soroush Ahmadi, Sohrab Rohani
Summary: Researchers successfully co-crystallized Zn-PA with INAM to form a novel crystalline compound Zn-PA-INAM, which exhibits improved solubility and wettability in an aqueous solution. Various analysis methods revealed significant changes in the intermolecular interactions of Zn-PA-INAM compared to Zn-PA, resulting in reduced hydrophobicity of the crystal.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jinghong Xian, Faqian Bu, Yuxi Wang, Fangyi Long, Zhixiong Zhang, Chengyong Wu, Yiran Tao, Ting Wang, Guan Wang
Summary: IC261, an ATP-competitive inhibitor of serine/threonine-specific casein kinase 1 (CK1), has shown inhibitory activity on microtubule polymerization. This study provides a high-resolution crystal structure of tubulin and IC261 complex, revealing the intermolecular interaction and structure-activity relationship. Comparison with tubulin-colchicine complex and molecular docking studies led to the discovery of potential new microtubule inhibitors based on IC261.
Article
Chemistry, Inorganic & Nuclear
Prashant N. Parale, Abhijeet R. Kadam, K. V. Dabre, S. J. Dhoble
Summary: This research investigated a Dy3+, Eu3+ activated/co-activated NaMg(PO3)3 phosphor prepared by the combustion method using urea as a fuel. The phase identification and crystal structure of the synthesized phosphor were examined using XRD and Rietveld refinement. The morphology and elemental analysis of the proposed phosphor were studied with SEM and EDAX. Fourier Transform Infrared Spectroscopy (FTIR) confirmed the vibrational features of the phosphors. The photoluminescence study revealed three simultaneous emission peaks in the visible range, indicating its potential as a candidate for WLEDs and solid state lighting applications.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Wenyue Zheng, Erkang Tian, Zhen Liu, Changhan Zhou, Pei Yang, Keyue Tian, Wen Liao, Juan Li, Changyu Ren
Summary: Angiotensin-converting enzyme inhibitors are drugs used to treat cardiovascular and kidney diseases. Researchers have been focusing on improving the selectivity of these drugs and developing novel ACE inhibitors to reduce their adverse effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Federica Catti, Santos Hernandez Gallego, Monica Benito, Elies Molins, Francisco Marquillas Olondriz
Summary: There is currently no definitive guide for identifying Gaxilose and distinguishing between crystalline forms in the diagnosis of lactose intolerance. Data from various analytical techniques have been collected to provide a full characterization of the compound and a simple method to discriminate between two solid forms.
CARBOHYDRATE RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Botta Bhavani, Nageshwarrao Chanda, Vishal Kotha, Govind Reddy, Pratyay Basak, Ujjwal Pal, Lingamallu Giribabu, Seelam Prasanthkumar
Summary: The development of five donor-acceptor systems based on porphyrin-napthalimide and the study of their morphology, electronic properties, and catalytic behavior were conducted in this research. The Co(ii) substituted D-A system (PN2) showed a well-aligned 1D nanowire with high electrical conductivity, leading to a remarkable photocatalytic hydrogen production rate.
Article
Biochemistry & Molecular Biology
Fei Fei, Mingfeng Zhang, Somayeh S. Tarighat, Eun Ji Joo, Lu Yang, Nora Heisterkamp
Summary: Galectin-1 and Galectin-3 have a complicated joint contribution to BCP-ALL survival, with stromal Galectin-3 playing an important role in maintaining BCP-ALL fitness during chemotherapy exposure, while stromal Galectin-1 does not significantly contribute to drug resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Outi Keina''nen, Samantha M. Sarrett, Samantha Delaney, Cindy Rodriguez, Eric J. Dayts, Emily Capone, Frederic Sauniere, Rodolfo Ippoliti, Gianluca Sala, Stefano Iacobelli, Brian M. Zeglis
Summary: Galectin-3 binding protein (Gal-3BP) is a glycoprotein overexpressed and secreted by several cancers, and has been identified as a marker for tumor progression and poor prognosis in various cancer types. In this study, a pair of Gal-3BP-targeting radioimmunoconjugates for Zr-89-immunoPET were developed and evaluated. The results suggest that these probes could be clinically useful for imaging Gal-3BP-expressing malignancies and identifying patients likely to respond to Gal-3BP-targeted therapeutics.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Medicinal
Li Xu, Richard A. Hartz, Brett R. Beno, Kaushik Ghosh, Jinal K. Shukla, Amit Kumar, Dipal Patel, Narasimharaju Kalidindi, Nadine Lemos, Shashyendra Singh Gautam, Anoop Kumar, Bruce A. Ellsworth, Devang Shah, Harinath Sale, Dong Cheng, Alicia Regueiro-Ren
Summary: Galectin-3 is involved in cancer, inflammation, and fibrosis, and tetrahydropyran-based Galectin-3 inhibitors have been discovered as potentially valuable disease-modifying agents. Further research on these inhibitors could lead to new therapeutic options for related conditions.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Engineering, Electrical & Electronic
Shengmin Luo, Yajuan Zhang, Qiang Wang, Tao Que, Yang Lu, Yiting Shan, Hongqing Zhou
Summary: 0.75CaTi(1-x)( Zn1/3Nb2/3) O-x(3)-0.25SmAlO(3) ( CT(1-x)ZN(x)SA) ( 0 <= x <= 0.09) ceramics were synthesized, and the effects of ( Zn1/3Nb2/3)(4+) co-substitution on the structure and dielectric properties were investigated. Moderate amounts of ( Zn1/3Nb2/3)(4+) substitution effectively improved the densification, dielectric properties, flexural strength, and lowered the sintering temperature, while excessive substitution deteriorated the overall performance.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Zhengwen He, Rongjin Huang, Kaiyao Zhou, Ye Liu, Shibin Guo, Yuzhu Song, Zhongnan Guo, Shuxian Hu, Lunhua He, Qingzhen Huang, Laifeng Li, Jingyan Zhang, Shouguo Wang, Jiangang Guo, Xianran Xing, Jun Chen
Summary: LaCoSi, the first 111 Co-based superconductor, exhibits a similar structure and band characteristics to LiFeAs, potentially providing a direction for the discovery of new Co-based superconducting compounds.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Ali Khademi, Ahmad Amiri, Farzaneh Fadaei Tirani, Kurt Schenk-Joss
Summary: Water splitting is a promising method for storing renewable energies and two water-soluble octahedral cobalt (III) complexes were synthesized and characterized for their electrocatalytic water splitting activity. The performance of the complexes in aqueous solutions was attributed to their flat ligands, electroactivity of the metal center and carboxamide ligands, as well as the ability to provide different reduction pathways during the reduction process.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Article
Biochemical Research Methods
Shuang Wang, Tao Song, Shugang Zhang, Mingjian Jiang, Zhiqiang Wei, Zhen Li
Summary: This article proposes a deep learning-based model for molecule generation and optimization, which generates and optimizes molecules by gradually adding substructures. Experimental results show that the model is able to generate valid and novel molecules, and effectively improves the properties of molecules.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Biochemistry & Molecular Biology
Yunlong Si, Shiqiong Feng, Jin Gao, Yue Wang, Zhongyu Zhang, Yue Meng, Yifa Zhou, Guihua Tai, Jiyong Su
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2016)
Article
Chemistry, Physical
Yunlong Si, Ye Yuan, Yue Wang, Jin Gao, Yanbo Hu, Shiqiong Feng, Jiyong Su
Article
Biochemistry & Molecular Biology
Jiyong Su, Karl Forchhammer
Article
Biochemistry & Molecular Biology
Jiyong Su, Christine Schlicker, Karl Forchhammer
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Jiyong Su, Linlin Cui, Yunlong Si, Chenyang Song, Yuying Li, Tong Yang, Hao Wang, Kevin H. Mayo, Guihua Tai, Yifa Zhou
BIOSCIENCE REPORTS
(2018)
Review
Biochemistry & Molecular Biology
Jiyong Su
Article
Biochemistry & Molecular Biology
Yunlong Si, Xing Wang, Guosong Yang, Tong Yang, Yuying Li, Gabriela Jaramillo Ayala, Xumin Li, Hao Wang, Jiyong Su
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Yunlong Si, Yuying Li, Tong Yang, Xumin Li, Gabriela Jaramillo Ayala, Kevin H. Mayo, Guihua Tai, Jiyong Su, Yifa Zhou
Summary: The crystal structure of Gal-14 differs significantly from other galectins, particularly in its unique interaction with carbohydrates and lactose. In addition, Gal-14 exhibits distinctive characteristics in terms of agglutination activity and cellular localization compared to other galectins.
Article
Biochemistry & Molecular Biology
Yunlong Si, Yue Wang, Jin Gao, Chenyang Song, Shiqiong Feng, Yifa Zhou, Guihua Tai, Jiyong Su
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)