Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective

From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century

(2015) Matthias Blüher et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Role of the rs6923761 Gene Variant in Glucagon-Like Peptide 1 Receptor Gene on Cardiovascular Risk Factors and Weight Loss after Biliopancreatic Diversion Surgery

(2014) Daniel Antonio de Luis et al.   ANNALS OF NUTRITION AND METABOLISM

Is There a Paradox in Obesity?

(2014) Akankasha Goyal et al.   Cardiology in Review

On the Evolutionary Origins of Obesity: A New Hypothesis

(2014) Dyan Sellayah et al.   ENDOCRINOLOGY

MECHANISMS IN ENDOCRINOLOGY: Are metabolically healthy obese individuals really healthy?

(2014) Matthias Blüher   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Diet Effects in Gut Microbiome and Obesity

(2014) Jia Chen et al.   JOURNAL OF FOOD SCIENCE

Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5 and OLFM4 genes with obesity-related traits among Portuguese children

(2014) David Albuquerque et al.   JOURNAL OF HUMAN GENETICS

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Healthy obese versus unhealthy lean: the obesity paradox

(2014) Carl J. Lavie et al.   Nature Reviews Endocrinology

Associations of Genetic Risk Score with Obesity and Related Traits and the Modifying Effect of Physical Activity in a Chinese Han Population

(2014) Jingwen Zhu et al.   PLoS One

Replication of 6 Obesity Genes in a Meta-Analysis of Genome-Wide Association Studies from Diverse Ancestries

(2014) Li-Jun Tan et al.   PLoS One

Weight Loss after Gastric Bypass Is Associated with a Variant at 15q26.1

(2013) Ida J. Hatoum et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Obesidad monogénica humana: papel del sistema leptina-melanocortina en la regulación de la ingesta de alimentos y el peso corporal en humanos

(2013) E. González Jiménez et al.   Anales del Sistema Sanitario De Navarra

Replication of Established Common Genetic Variants for Adult BMI and Childhood Obesity in Greek Adolescents: The TEENAGE Study

(2013) Ioanna Ntalla et al.   ANNALS OF HUMAN GENETICS

The genetics of human obesity

(2013) Qianghua Xia et al.   Annals of the New York Academy of Sciences

Next-Generation Sequencing Platforms

(2013) Elaine R. Mardis   Annual Review of Analytical Chemistry

Evolutionary Perspectives on the Obesity Epidemic: Adaptive, Maladaptive, and Neutral Viewpoints

(2013) John R. Speakman   Annual Review of Nutrition

Surgical interventions for obesity and metabolic disease

(2013) Lan Vu et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Paternal obesity is associated with IGF2hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort

(2013) Adelheid Soubry et al.   BMC Medicine

Targeting the Circulating MicroRNA Signature of Obesity

(2013) F. J. Ortega et al.   CLINICAL CHEMISTRY

Gut bacterial microbiota and obesity

(2013) M. Million et al.   CLINICAL MICROBIOLOGY AND INFECTION

Highly Sensitive Diagnosis of 43 Monogenic Forms of Diabetes or Obesity Through One-Step PCR-Based Enrichment in Combination With Next-Generation Sequencing

(2013) A. Bonnefond et al.   DIABETES CARE

A genome-wide methylation study on obesity

(2013) Xiaojing Xu et al.   Epigenetics

Challenges in pharmacogenetics

(2013) Ingolf Cascorbi et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Interface between Pharmacotherapy and Genes in Human Obesity

(2013) Annalouise O'Connor et al.   HUMAN HEREDITY

Newborns of obese parents have altered DNA methylation patterns at imprinted genes

(2013) A Soubry et al.   INTERNATIONAL JOURNAL OF OBESITY

Finding the missing heritability in pediatric obesity: the contribution of genome-wide complex trait analysis

(2013) C H Llewellyn et al.   INTERNATIONAL JOURNAL OF OBESITY

Genome-wide Association of Single-Nucleotide Polymorphisms With Weight Loss Outcomes After Roux-en-Y Gastric Bypass Surgery

(2013) Erica S. Rinella et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The rs9939609 Polymorphism in theFTOGene Is Associated with Fat and Fiber Intakes in Patients with Type 2 Diabetes

(2013) Thais Steemburgo et al.   Journal of Nutrigenetics and Nutrigenomics

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

(2013) Keri L Monda et al.   NATURE GENETICS

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

(2013) Sonja I Berndt et al.   NATURE GENETICS

The bigger picture of FTO—the first GWAS-identified obesity gene

(2013) Ruth J. F. Loos et al.   Nature Reviews Endocrinology

Obesity-susceptibility loci and the tails of the pediatric BMI distribution

(2013) Jonathan A. Mitchell et al.   Obesity

The missense variation landscape ofFTO,MC4R,andTMEM18in obese children of African Ancestry

(2013) Sandra Deliard et al.   Obesity

NovelLEPRmutations in obese Pakistani children identified by PCR-based enrichment and next generation sequencing

(2013) Sadia Saeed et al.   Obesity

Genetic factors in exercise adoption, adherence and obesity

(2013) M. P. Herring et al.   Obesity Reviews

Association of FTO Polymorphisms with Obesity and Obesity-Related Outcomes in Portuguese Children

(2013) David Albuquerque et al.   PLoS One

Contribution of Common Genetic Variants to Obesity and Obesity-Related Traits in Mexican Children and Adults

(2013) Paola León-Mimila et al.   PLoS One

Overview of Epidemiology and Contribution of Obesity to Cardiovascular Disease

(2013) Marjorie Bastien et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Genetic modifiers of obesity and bariatric surgery outcomes

(2013) MFS Samantha Sevilla et al.   Seminars in Pediatric Surgery

A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study

(2013) Ulrike Peters et al.   PLoS Genetics

A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue

(2013) Tina Rönn et al.   PLoS Genetics

Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry

(2013) Shafqat Ahmad et al.   PLoS Genetics

The lactase persistence -13910C>T polymorphism shows indication of association with abdominal obesity among Portuguese children

(2012) David Albuquerque et al.   ACTA PAEDIATRICA

Attenuation of the Effect of the FTO rs9939609 Polymorphism on Total and Central Body Fat by Physical Activity in Adolescents

(2012) Jonatan R. Ruiz   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

Genetic determinants of common obesity and their value in prediction

(2012) Ruth J.F. Loos   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Leptin and leptin receptor-related monogenic obesity

(2012) Beatrice Dubern et al.   BIOCHIMIE

Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low

(2012) Carolina Ortega-Azorín et al.   Cardiovascular Diabetology

Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study

(2012) D. Dlouha et al.   CLINICA CHIMICA ACTA

MicroRNAs in Insulin Resistance and Obesity

(2012) Michael D. Williams et al.   Experimental Diabetes Research

Genome wide analysis reveals association of a FTO gene variant with epigenetic changes

(2012) Markus Sällman Almén et al.   GENOMICS

Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia

(2012) Kazuhiro Nakayama et al.   HUMAN GENETICS

Promoter methylation of serotonin transporter gene is associated with obesity measures: a monozygotic twin study

(2012) J Zhao et al.   INTERNATIONAL JOURNAL OF OBESITY

Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children

(2012) M Sällman Almén et al.   INTERNATIONAL JOURNAL OF OBESITY

Circulating miRNA Profiles in Patients with Metabolic Syndrome

(2012) Dwi Setyowati Karolina et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Amerindians show no association of PC-1 gene Gln121 allele and obesity: a thrifty gene population genetics

(2012) Diego Rey et al.   MOLECULAR BIOLOGY REPORTS

Meta-analysis identifies common variants associated with body mass index in east Asians

(2012) Wanqing Wen et al.   NATURE GENETICS

A genome-wide association meta-analysis identifies new childhood obesity loci

(2012)   NATURE GENETICS

Sugar-Sweetened Beverages and Genetic Risk of Obesity

(2012) Qibin Qi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The impact of intronic single nucleotide polymorphisms and ethnic diversity for studies on the obesity geneFTO

(2012) J. A. Jacobsson et al.   Obesity Reviews

DNA Methylation Patterns in Cord Blood DNA and Body Size in Childhood

(2012) Caroline L. Relton et al.   PLoS One

Association of the European Lactase Persistence Variant (LCT-13910 C>T Polymorphism) with Obesity in the Canary Islands

(2012) Ricardo Almon et al.   PLoS One

Association between Common Polymorphism near the MC4R Gene and Obesity Risk: A Systematic Review and Meta-Analysis

(2012) Bo Xi et al.   PLoS One

Beyond the fourth wave of genome-wide obesity association studies

(2012) C H Sandholt et al.   Nutrition & Diabetes

Diet induced epigenetic changes and their implications for health

(2011) J. A. McKay et al.   Acta Physiologica

Association of the FTO rs9939609 polymorphism with obesity in Roma/Gypsy population

(2011) Soňa Mačeková et al.   AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY

Architecture of energy balance traits in emerging lines of the Collaborative Cross

(2011) Wendy Foulds Mathes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

rs9939609 in the FTO Gene is Associated with Obesity but not with Several Biochemical Parameters in Sardinian Obese Children

(2011) Patrizia Zavattari et al.   ANNALS OF HUMAN GENETICS

Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1Ais associated with BMI in Tongans

(2011) Sean Myles et al.   BMC Medical Genetics

Obesity related methylation changes in DNA of peripheral blood leukocytes

(2011) Xiaoling Wang et al.   BMC Medicine

Epigenetic Gene Promoter Methylation at Birth Is Associated With Child's Later Adiposity

(2011) K. M. Godfrey et al.   DIABETES

Educational paper

(2011) Carsten Bergmann   EUROPEAN JOURNAL OF PEDIATRICS

The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents

(2011) D M Hallman et al.   INTERNATIONAL JOURNAL OF OBESITY

Heritability of the Weight Loss Response to Gastric Bypass Surgery

(2011) Ida J. Hatoum et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Differential miRNA Expression in Omental Adipose Tissue and in the Circulation of Obese Patients Identifies Novel Metabolic Biomarkers

(2011) H. M. Heneghan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The global obesity pandemic: shaped by global drivers and local environments

(2011) Boyd A Swinburn et al.   LANCET

National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants

(2011) Mariel M Finucane et al.   LANCET

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Genome partitioning of genetic variation for complex traits using common SNPs

(2011) Jian Yang et al.   NATURE GENETICS

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

(2011) Tuomas O Kilpeläinen et al.   NATURE GENETICS

FTO Risk Haplotype Among Early Onset and Severe Obesity Cases in a Population of Western Spain

(2011) Juan R. González et al.   Obesity

High Allelic Burden of Four Obesity SNPs Is Associated With Poorer Weight Loss Outcomes Following Gastric Bypass Surgery

(2011) Christopher D. Still et al.   Obesity

Role of BMI-Associated Loci Identified in GWAS Meta-Analyses in the Context of Common Childhood Obesity in European Americans

(2011) Jianhua Zhao et al.   Obesity

Ciliopathies: an expanding disease spectrum

(2011) Aoife M. Waters et al.   PEDIATRIC NEPHROLOGY

Molecular genetic studies of complex phenotypes

(2011) Ali J. Marian   Translational Research

Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity

(2011) Pernille Keller et al.   BMC Endocrine Disorders

Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development

(2011) Ulla Sovio et al.   PLoS Genetics

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

(2011) Tuomas O. Kilpeläinen et al.   PLOS MEDICINE

Interação entre gene e nutriente e sua associação à obesidade e ao diabetes melito

(2010) Thais Steemburgo et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

The obesity-associated Fto gene is a transcriptional coactivator

(2010) Qiong Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children

(2010) Hongyun Fang et al.   BMC Medical Genetics

From monogenic to polygenic obesity: recent advances

(2010) Anke Hinney et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Fine mapping of the association with obesity at the FTO locus in African-derived populations

(2010) Mohamed T. Hassanein et al.   HUMAN MOLECULAR GENETICS

Physical Activity and Weight Gain Prevention

(2010) I-Min Lee   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

High-fat diet leads to a decreased methylation of theMc4r gene in the obese BFMI and the lean B6 mouse lines

(2010) S. Widiker et al.   JOURNAL OF APPLIED GENETICS

Evidences on three relevant obesogenes: MC4R, FTO and PPARγ. Approaches for personalized nutrition

(2010) Cristina Razquin et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Crystal structure of the FTO protein reveals basis for its substrate specificity

(2010) Zhifu Han et al.   NATURE

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

(2010) Iris M Heid et al.   NATURE GENETICS

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

Association of the LCT-13910C>T Polymorphism With Obesity and Its Modulation by Dairy Products in a Mediterranean Population

(2010) Dolores Corella et al.   Obesity

MiRNA Expression Profile of Human Subcutaneous Adipose and during Adipocyte Differentiation

(2010) Francisco J. Ortega et al.   PLoS One

The genetics of obesity: FTO leads the way

(2010) Katherine A. Fawcett et al.   TRENDS IN GENETICS

Asociación de polimorfismos en el gen FTO con la obesidad mórbida en la población extremeña

(2010) Raquel Rodríguez-López et al.   Endocrinologia y Nutricion

Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies

(2009) Shengxu Li et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

FTOgene variation and measures of body mass in an African population

(2009) Branwen J Hennig et al.   BMC Medical Genetics

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

Associations of Gestational Weight Gain With Offspring Body Mass Index and Blood Pressure at 21 Years of Age

(2009) Abdullah A. Mamun et al.   CIRCULATION

MicroRNAs Induced During Adipogenesis that Accelerate Fat Cell Development Are Downregulated in Obesity

(2009) H. Xie et al.   DIABETES

European lactase persistence genotype shows evidence of association with increase in body mass index

(2009) J. Kettunen et al.   HUMAN MOLECULAR GENETICS

The genetic and environmental influences on childhood obesity: a systematic review of twin and adoption studies

(2009) K Silventoinen et al.   INTERNATIONAL JOURNAL OF OBESITY

High fat diet-induced obesity modifies the methylation pattern of leptin promoter in rats

(2009) F. I. Milagro et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

The polymorphisms of UCP1 genes associated with fat metabolism, obesity and diabetes

(2009) Jun-jing Jia et al.   MOLECULAR BIOLOGY REPORTS

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

Maternal Pregestational BMI Is Associated With Methylation of thePPARGC1APromoter in Newborns

(2009) Carolina Gemma et al.   Obesity

The Role of Obesity-associated Loci Identified in Genome-wide Association Studies in the Determination of Pediatric BMI

(2009) Jianhua Zhao et al.   Obesity

Individuality and epigenetics in obesity

(2009) J. Campión et al.   Obesity Reviews

MicroRNA Expression in Human Omental and Subcutaneous Adipose Tissue

(2009) Nora Klöting et al.   PLoS One

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

(2009) Cecilia M. Lindgren et al.   PLoS Genetics

NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium

(2009) Nancy L. Heard-Costa et al.   PLoS Genetics

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

(2009) Chris Church et al.   PLoS Genetics

Epigenetics and the embodiment of race: Developmental origins of US racial disparities in cardiovascular health

(2008) Christopher W. Kuzawa et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Physical Activity and the Association of Common FTO Gene Variants With Body Mass Index and Obesity

(2008) Evadnie Rampersaud et al.   ARCHIVES OF INTERNAL MEDICINE

Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet

(2008) Rieko Takanabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetic mechanisms in mammals

(2008) J. K. Kim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human Obesity: A Heritable Neurobehavioral Disorder That Is Highly Sensitive to Environmental Conditions

(2008) S. O'Rahilly et al.   DIABETES

Common Variation in the Fat Mass and Obesity-Associated (FTO) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population

(2008) Y.-C. Chang et al.   DIABETES

Lessons from Extreme Human Obesity: Monogenic Disorders

(2008) Sayali A. Ranadive et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Thrifty genes for obesity, an attractive but flawed idea and an alternative perspective: the ‘drifty gene’ hypothesis

(2008) J R Speakman   INTERNATIONAL JOURNAL OF OBESITY

Variations in the FTO gene are associated with severe obesity in the Japanese

(2008) Kikuko Hotta et al.   JOURNAL OF HUMAN GENETICS

Common variants near MC4R are associated with fat mass, weight and risk of obesity

(2008) Ruth J F Loos et al.   NATURE GENETICS

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

(2008) John C Chambers et al.   NATURE GENETICS

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS

Linkage disequilibrium — understanding the evolutionary past and mapping the medical future

(2008) Montgomery Slatkin   NATURE REVIEWS GENETICS

Viral AlkB proteins repair RNA damage by oxidative demethylation

(2008) Erwin van den Born et al.   NUCLEIC ACIDS RESEARCH

FTOPolymorphisms Are Associated With Obesity but Not Diabetes Risk in Postmenopausal Women

(2008) Yiqing Song et al.   Obesity

Polymorphisms of theFTOGene Are Associated With Variation in Energy Intake, but not Energy Expenditure

(2008) John R. Speakman et al.   Obesity

Association Analysis of the FTO Gene with Obesity in Children of Caucasian and African Ancestry Reveals a Common Tagging SNP

(2008) Struan F. A. Grant et al.   PLoS One

Persistent epigenetic differences associated with prenatal exposure to famine in humans

(2008) B. T. Heijmans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutritional Control of Reproductive Status in Honeybees via DNA Methylation

(2008) R. Kucharski et al.   SCIENCE