Article
Oncology
Jordan Eber, Cyrille Blondet, Martin Schmitt, David G. Cox, Claire Vit, Clara Le Fevre, Delphine Antoni, Fabrice Hubele, Georges Noel
Summary: Breast radiotherapy can cause radiation-induced cardiac disease, especially in left breast cancers. A prospective single-center study will be conducted to explore alternative approaches, such as deep inspiration breath hold radiotherapy and intensity modulated radiation therapy, to reduce the risk of myocardial perfusion defects in patients with left breast cancer. The study will use stress and resting myocardial scintigraphy to assess myocardial perfusion and aims to demonstrate the effectiveness of reducing cardiac dose in preventing early and medium-term perfusion disorders.
Review
Oncology
Michela Buglione, Andrea Emanuele Guerini, Andrea Riccardo Filippi, Luigi Spiazzi, Nadia Pasinetti, Alessandro Magli, Cristian Toraci, Paolo Borghetti, Luca Triggiani, Alessandro Alghisi, Gianluca Costantino, Francesco Bertagna, Niccolo Giaj Levra, Ludovica Pegurri, Stefano Maria Magrini
Summary: IMRT is effective in reducing the dose to OARs in mediastinal lymphoma treatment, which decreases the risk of long-term toxicity. However, there is a trade-off as it may increase the risk of SMNs due to increased low dose volumes, highlighting the importance of personalized treatment planning and selecting appropriate techniques for individual patients and disease characteristics.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Kristine Fjellanger, Linda Rossi, Ben J. M. Heijmen, Helge Egil Seime Pettersen, Inger Marie Sandvik, Sebastiaan Breedveld, Turid Husevag Sulen, Liv Bolstad Hysing
Summary: This study compared deep inspiration breath hold (DIBH) with free breathing (FB) in patients with locally advanced non-small cell lung cancer (LA-NSCLC) treated with intensity-modulated radiotherapy (IMRT). DIBH resulted in smaller target volumes and similar target coverage compared to FB. DIBH reduced lung and heart dose, as well as the risk of radiation pneumonitis and 2-year mortality, for a significant number of LA-NSCLC patients. However, the benefits varied among patients and were dependent on tumor location.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Haitham Shaheen, Mohamed S. Zaghloul, Hany Ammar, Bakr Aly, Ehab Hassanin, Soheir Abd-el Mohsen, Soha Ahmed
Summary: Deep inspiration breath-hold (DIBH) is an effective technique to reduce the exposure of normal tissues during radiotherapy for breast cancer and mediastinal Hodgkin lymphoma in children and adolescents. In this study, 49 pediatric and adolescent patients were treated with DIBH and precise radiotherapy, and they all demonstrated good tolerance and compliance. DIBH proved to be feasible, tolerable, and easy to apply, leading to a considerable reduction in radiation dose to normal tissues.
Article
Radiology, Nuclear Medicine & Medical Imaging
Danfang Yan, Lihua Ning, Ying Chen, Shanbao Ke, Huijie Huang, Lihong Wang, Senxiang Yan
Summary: This retrospective cohort study investigated the advantages of the deep inspiration breath-hold (DIBH) technique in postoperative intensity-modulated radiation therapy (IMRT) for thymomas. The results showed that using DIBH can significantly reduce the radiation dose to organs at risk and decrease the incidence of pneumonitis.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Oncology
Loic Vander Veken, Genevieve Van Ooteghem, Ariane Razavi, Sergio Da Rita Quaresma, Eleonore Longton, Carine Kirkove, Benjamin Ledoux, Ad Vandermeulen, Christel Abdel Massih, Pascale Henderickx, Mortimer Gabriels, Celine Delvaux, Faycal Salah, Aude Vaandering, Xavier Geets
Summary: This study compared the effects of mechanically-induced DIBH and SGRT-guided voluntary DIBH in breast radiotherapy. The results showed that mechanically-induced DIBH performed better in protecting and repositioning critical organs while achieving similar target irradiation accuracy as SGRT.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Engineering, Biomedical
Simon K. Goodall, Peter L. Rampant
Summary: ExacTrac Dynamic (ETD) provides a Deep Inspiration Breath Hold (DIBH) workflow for breast patients. The study aimed to determine appropriate imaging parameters, optimal Hounsfield Unit (HU) threshold, and workflow evaluation for DIBH breast treatments using a custom breast DIBH phantom. Parameters of 60 kV and 25mAs were determined appropriate for patient imaging and HU thresholds between -600 HU and -200 HU enabled adequate prepositioning. The study showed that ETD is suitable for clinical implementation during DIBH breast treatments.
PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE
(2023)
Review
Oncology
Chirayu G. Patel, Jennifer Peterson, Marianne Aznar, Yolanda D. Tseng, Scott Lester, Deanna Pafundi, Stella Flampouri, Pranshu Mohindra, Rahul R. Parikh, Raymond Mailhot Vega, Laila Konig, John P. Plastaras, James E. Bates, Pierre Loap, Youlia M. Kirova, Ester Orlandi, Carola Luetgendorf-Caucig, Georgios Ntentas, Bradford Hoppe
Summary: This study systematically reviewed dosimetric studies comparing deep inspiration breath hold (DIBH) with free breathing (FB) in mediastinal lymphoma patients undergoing proton therapy, and found that proton therapy (FB or DIBH) was superior to IMRT-DIBH in reducing doses to the heart, lungs, and breast.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Yongkai Lu, Di Yang, Xiaowei Zhang, Yonggang Teng, Wei Yuan, Yuemei Zhang, Ruixin He, Fengwen Tang, Jie Pang, Bo Han, Ruijuan Chen, Yi Li
Summary: DIBH has shown significant advantages over FB in patients with left-sided breast cancer receiving radiotherapy, reducing heart, left anterior descending branch, and ipsilateral lung doses and volumes, while increasing ipsilateral lung volume.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Anni Young Lundgaard, Danijela Dejanovic, Anne Kiil Berthelsen, Flemming Littrup Andersen, Laura Ann Rechner, Lise Borgwardt, Lisa Lyngsie Hjalgrim, Lena Specht, Maja Vestmo Maraldo
Summary: The prospective study found that for pediatric patients with mediastinal lymphoma, in the DIBH state, lung volume increased while the heart was displaced caudally and separated from the lymphoma. Both anatomical and metabolically active lymphoma volumes appeared different in shape and configuration under the two breathing conditions. The image quality of DIBH PET was equal to FB PET in interpreting and delineating lymphoma lesions.
Article
Engineering, Biomedical
Saber Nankali, Rune Hansen, Esben Worm, Esben S. Yates, Mette Skovhus Thomsen, Birgitte Offersen, Per Rugaard Poulsen
Summary: The study involved ten left-sided breast cancer patients receiving DIBH radiotherapy, using SGRT to guide breath-hold and align chest wall position. Further integration of SGRT with image-guidance may improve treatment accuracy and workflow, although no significant accuracy improvements were shown in scenarios B and C compared to scenario A.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Bruno Speleers, Max Schoepen, Francesca Belosi, Vincent Vakaet, Wilfried De Neve, Pieter Deseyne, Leen Paelinck, Tom Vercauteren, Michael J. Parkes, Tony Lomax, Annick Van Greveling, Alessandra Bolsi, Damien C. Weber, Liv Veldeman, Werner De Gersem
Summary: The use of deep inspiration breath hold and shallow breathing in the prone crawl position significantly reduces doses to the heart and lungs, leading to a decrease in mortality risk for different risk profiles of patients. Deep inspiration breath hold results in significant dose reductions for other organs-at-risk with photon radiotherapy, while minor differences are observed with proton radiotherapy.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Alessandra Vendrame, Cristina Cappelletto, Paola Chiovati, Lorenzo Vinante, Masud Parvej, Angela Caroli, Giovanni Pirrone, Loredana Barresi, Annalisa Drigo, Michele Avanzo
Summary: Deep Bidirectional Long Short-Term Memory (BLSTM) recurrent neural networks were used to predict eligibility for deep inspiration breath-hold (DIBH) radiotherapy treatment in patients with left breast cancer based on analysis of respiratory signals. The BLSTM-RNN accurately classified patients eligible for DIBH, achieving high accuracy, specificity, sensitivity, F1 score, and AUC in the test dataset. This provides promising results for the development of an accurate and robust decision system to assist the radiotherapy team in assigning patients to DIBH.
APPLIED SCIENCES-BASEL
(2023)
Article
Oncology
Gianluca Ferini, Vito Valenti, Anna Viola, Giuseppe Emmanuele Umana, Emanuele Martorana
Summary: Adjuvant radiotherapy may harm the heart in left-sided breast cancer patients. The deep-inspiration-breath-hold technique can limit heart exposure to radiation. Anatomical predictors may aid insiders in treatment decisions and improving practitioner efficiency.
Article
Oncology
Lone Hoffmann, ML. Ehmsen, J. Hansen, R. Hansen, MM. Knap, HR. Mortensen, PR. Poulsen, T. Ravkilde, HK. Rose, HH. Schmidt, ES. Worm, DS. Moller
Summary: Deep-inspiration breath-hold (DIBH) during radiotherapy can reduce dose to the lungs and heart, but intra-fractional target shifts may decrease target coverage. This study compared target shifts between planning CT and CBCT scans in DIBH treatments and found that intra-DIBH shifts at the planning CT session are generally smaller than those observed at CBCTpre/post.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Dan Ou, Julien Adam, Ingrid Garberis, Pierre Blanchard, France Nguyen, Antonin Levy, Odile Casiraghi, Philippe Gorphe, Ingrid Breuskin, Francois Janot, Stephane Temam, Jean-Yves Scoazec, Eric Deutsch, Yungan Tao
RADIOTHERAPY AND ONCOLOGY
(2019)
Review
Urology & Nephrology
Charlien Berghen, Maarten Albersen, Pierre Blanchard, Alberto Bossi, Alberto Briganti, Cesare Cozzarini, Karel Decaestecker, Valerie Fonteyne, Karin Haustermans, Steven Joniau, Daryl Lim Joon, Vincent Khoo, Paul L. Nguyen, Piet Ost, Geert Villeirs, Christof Vulsteke, Anthony Zietman, Gert De Meerleer
Review
Radiology, Nuclear Medicine & Medical Imaging
Elaine Johanna Limkin, Pierre Blanchard
BRITISH JOURNAL OF RADIOLOGY
(2019)
Article
Oncology
Cyrus Chargari, Eric Deutsch, Pierre Blanchard, Sebastien Gouy, Helene Martelli, Florent Guerin, Isabelle Dumas, Alberto Bossi, Philippe Morice, Akila N. Viswanathan, Christine Haie-Meder
CA-A CANCER JOURNAL FOR CLINICIANS
(2019)
Review
Medicine, General & Internal
Yu-Pei Chen, Anthony T. C. Chan, Quynh-Thu Le, Pierre Blanchard, Ying Sun, Jun Ma
Article
Oncology
Adnan Elhammali, Pierre Blanchard, Alison Yoder, Zhongxing Liao, Xiadong Zhang, X. Ronald Zhu, Pamela K. Allen, Melenda Jeter, James Welsh, Quynh-Nhu Nguyen
RADIOTHERAPY AND ONCOLOGY
(2019)
Editorial Material
Oncology
Pierre Blanchard, Anne Auperin, Jean-Pierre Pignon
Article
Oncology
Etienne Dauzier, Benjamin Lacas, Pierre Blanchard, Quynh-Thu Le, Christian Simon, Gregory Wolf, Francois Janot, Masatoshi Horiuchi, Jeffrey S. Tobias, James Moon, John Simes, Vinay Deshmane, Jean-Jacques Mazeron, Samir Mehta, Branko Zaktonik, Minoru Tamura, Elizabeth Moyal, Lisa Licitra, Catherine Fortpied, Bruce G. Haffty, Maria Grazia Ghi, Vincent Gregoire, Jonathan Harris, Jean Bourhis, Anne Auperin, Jean-Pierre Pignon
Article
Otorhinolaryngology
Antoine Moya-Plana, David Mangin, Pierre Blanchard, Rais Obongo, Odile Casiraghi, Francois Bidault, Stephane Temam, Caroline Robert, Philippe Gorphe
Summary: The study found that the cN status is not a prognostic factor in patients with resectable head and neck mucosal melanoma. Elective lymph node dissection should not be routinely performed in cN0 patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Letter
Oncology
Pierre Blanchard, Michael J. Zelefsky, Alberto Bossi, Cyrus Chargari, Jean-Marc Cosset
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Arnaud Jannin, Alexandre Escande, Abir Al Ghuzlan, Pierre Blanchard, Dana Hartl, Benjamin Chevalier, Frederic Deschamps, Livia Lamartina, Ludovic Lacroix, Corinne Dupuy, Eric Baudin, Christine Do Cao, Julien Hadoux
Summary: Anaplastic thyroid carcinoma (ATC) is a rare and aggressive form of thyroid cancer with a poor prognosis. Improving the management of this deadly disease involves the use of molecular tests for targeted therapies, fast-track dedicated care pathways, and prompt initiation of treatment. Adjuvant chemo-radiotherapy is recommended for localized disease after surgery, while chemotherapy or targeted therapy combined with decompressive cervical radiotherapy is recommended for locally advanced or metastatic disease.
Review
Oncology
Mario Terlizzi, Elaine Johanna Limkin, Yasmina Moukasse, Pierre Blanchard
Summary: The management of patients with biochemical recurrence after prostatectomy has changed significantly in recent years. Close monitoring of prostate-specific antigen (PSA) and early salvage radiotherapy (RT) have become the standard of care. However, uncertainties remain regarding the management of high-risk patients and the role of imaging.
Article
Oncology
Miet Vandemaele, Marianne Aznar, Pierre Blanchard, Josep M. Borras, Michelle Leech, Ajay Aggarwal, Yolande Lievens
Summary: In order to address the evaluation issue of radiotherapy innovations, the HERO project of ESTRO has initiated the development of a radiotherapy-specific value-based framework. A systematic literature search revealed no widely accepted definition or classification system for radiotherapy innovations. However, the unique properties of radiotherapy interventions can be used to categorize innovations in radiation oncology, but clear terminology denoting radiotherapy-specific characteristics is still needed.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Medicine, General & Internal
C. Petit, P. Blanchard, J. P. Pignon, B. Lueza
SYSTEMATIC REVIEWS
(2019)