Review
Oncology
Mohammed I. Quraishi
Summary: Precision oncology utilizes molecular profiling to guide therapeutic interventions, and radiomic analysis can depict molecular mechanisms and correlate with genetic alterations. Combining these two approaches can be beneficial in the management of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
K. A. Kanta, Adrien Laville, Elie Rassy, Radouane EL Ayachi, Patricia Pautier, Mouhamadou Bachir, Sophie Bockel, Samir Achkar, Sophie Espenel, Amandine Maulard, Philippe Morice, Christine Haie-Meder, Roger Sun, Cyrus Chargari
Summary: The study reports the experience of using IGABT in the treatment of locally advanced cervical cancer spreading to adjacent organs. The analysis of cases shows that IGABT has a good local control effect in treating these advanced tumors. The dose and patient performance are associated with survival rates and fistula formation.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Alina Emiliana Sturdza, Richard Poetter, Michael Kossmeier, Kathrin Kirchheiner, Umesh Mahantshetty, Christine Haie-Meder, Jacob Christian Lindegaard, Ina Jurgenliemk-Schulz, Li Tee Tan, Peter Hoskin, Erik van Limbergen, Charles Gillham, Barbara Segedin, Ekkasit Tharavichitkul, Elena Villafranca Iturre, Lars Ulrik Fokdal, Stephan Polterauer, Christian Kirisits, Kari Tanderup
Summary: This study developed a nomogram for predicting overall survival in patients with locally advanced cervical cancer based on data from 720 patients. The nomogram included factors such as age, tumor characteristics, and treatment regimens, and showed promising calibration and discrimination in predicting 60-month survival.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Mame Daro Faye, Mariana Petruccelli Araujo, Michel D. Wissing, Khalid Alrabiah, Lucy Gilbert, Xing Zeng, Luis Souhami, Joanne Alfieri
Summary: This retrospective study compared the effects of two-dimensional-brachytherapy (2D-BT) and three-dimensional-image-guided adaptive BT (3D-IGABT) on locally advanced cervical cancer (LACC) patients. The results showed that 3D-IGABT significantly reduced the occurrence of late toxicities compared to 2D-BT. There were no significant differences in disease control or survival outcomes between the two groups.
Article
Oncology
Richard Potter, Kari Tanderup, Maximilian Paul Schmid, Ina Jurgenliemk-Schulz, Christine Haie-Meder, Lars Ulrik Fokdal, Alina Emiliana Sturdza, Peter Hoskin, Umesh Mahantshetty, Barbara Segedin, Kjersti Bruheim, Fleur Huang, Bhavana Rai, Rachel Cooper, Elzbieta Van der Steen-Banasik, Erik Van Limbergen, Bradley Rumwell Pieters, Li-Tee Tan, Remi Abubakar Nout, Astrid Agatha Catharina De Leeuw, Robin Ristl, Primoz Petric, Nicole Nesvacil, Kathrin Kirchheiner, Christian Kirisits, Jacob Christian Lindegaard
Summary: The EMBRACE-I study demonstrated that chemoradiotherapy and MRI-guided adaptive brachytherapy resulted in effective and stable long-term local control in patients with locally advanced cervical cancer, with limited severe morbidity.
Article
Oncology
Stefan Ecker, Christian Kirisits, Maximilian Schmid, Johannes Knoth, Gerd Heilemann, Astrid De Leeuw, Alina Sturdza, Kathrin Kirchheiner, Nina Jensen, Remi Nout, Ina Juergenliemk-Schulz, Richard Poetter, Sofia Spampinato, Kari Tanderup, Nicole Eder-Nesvacil
Summary: This study aims to develop a novel decision-support system in radiation oncology that incorporates clinical, treatment, and outcome data from a clinical trial on magnetic resonance image-guided adaptive brachytherapy for locally advanced cervical cancer. The developed system, EviGUIDE, combines dosimetric information, patient and treatment characteristics, tumor control probability (TCP) and normal tissue complication probability (NTCP) models to predict treatment outcomes. EviGUIDE provides visual representation of the clinical impact of different treatment plans and feedback on achievable doses based on a large reference population.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Fei Li, Dan Shi, Mingwei Bu, Shuangchen Lu, Hongfu Zhao
Summary: Through a systematic review, four-dimensional brachytherapy shows good local control and late toxicity in cervical cancer patients. The probit model reveals the dose-response relationship between the HR-CTV D90 value and the local control probability.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Umesh Mahantshetty, Richard Poetter, Sushil Beriwal, Surbhi Grover, Gurram Lavanya, Bhavana Rai, Primoz Petric, Kari Tanderup, Heloisa Carvalho, Neamat Hegazy, Sandy Mohamed, Tatsuya Ohno, Napapat Amornwichet
Summary: This article discusses the use of CT imaging in Image Guided Adaptive Brachytherapy for cervical cancer and proposes recommendations for CT-based target contouring to improve contouring accuracy with available CT, US, and MRI.
RADIOTHERAPY AND ONCOLOGY
(2021)
Review
Oncology
Alina Emiliana Sturdza, Johannes Knoth
Summary: Image-guided brachytherapy is an effective method for treating locally advanced cervical cancer, allowing for precise targeting and minimal harm to organs at risk.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Oncology
Umesh Mahantshetty, Lavanya Gurram, Sabheen Bushra, Yogesh Ghadi, Dheera Aravindakshan, John Paul, Vinod Hande, Avinash Pilar, Supriya Chopra, Jaya Ghosh, T. S. Shylasree, Palak Popat, Nilesh Sable, Amita Maheswari, Sudeep Gupta
Summary: The study evaluated the feasibility and safety of SA-MF, HDR IGABT for cervical cancer. The results showed promising dosimetric parameters and clinical outcomes in 95% of patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Shanshan Song, Dongmei Han, Ning Zhang, Zhuang Mao, Xin Guo, Guanghui Cheng
Summary: This study retrospectively compared the clinical and toxicity outcomes for cervical cancer of two adaptive brachytherapy (IGABT) fractions versus one IGABT fraction in one application. The results showed that the treatment strategy of two continuous IGABT every other day in one application can shorten the overall treatment time, reduce medical costs, and is safe and effective.
RADIATION ONCOLOGY
(2023)
Editorial Material
Oncology
Maheetha Bharadwaj, Mounica Vallurupalli, Franklin W. Huang
Summary: The article calls for improving access to precision oncology therapies in lower- and middle-income countries, highlighting lack of diagnostic ability, trained providers, and drug availability as significant barriers to cancer care delivery. It draws upon lessons from international efforts in oncology and infectious disease to make this urgent call to action.
Review
Oncology
Federica Di Nicolantonio, Pietro Paolo Vitiello, Silvia Marsoni, Salvatore Siena, Josep Tabernero, Livio Trusolino, Rene Bernards, Alberto Bardelli
Summary: Progress in precision medicine for colorectal cancer has been slower compared to other solid tumor types, but novel targeted therapy strategies based on tumor biology are emerging due to better translational models. The availability of patient-derived CRC models and in vitro/in vivo analyses has led to significant advances in the field over the past decade. Successful personalized treatment in CRC now involves considering the intrinsic biology of CRC cells in addition to molecular profiles of individual tumors.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Review
Medicine, General & Internal
Anders Edsjo, Louise Holmquist, Birgit Geoerger, Frederique Nowak, Georgy Gomon, Catherine Alix-Panabieres, Carolin Ploeger, Ulrik Lassen, Christophe Le Tourneau, Janne Lehtio, Patrick A. Ott, Andreas von Deimling, Stefan Froehling, Emile Voest, Frederick Klauschen, Rodrigo Dienstmann, Aisha Alshibany, Lillian L. Siu, Albrecht Stenzinger
Summary: Precision cancer medicine requires the involvement and commitment of many stakeholders and can be improved through advancements in molecular diagnostics and clinical trial concepts. Adaptive profiling strategies and early detection approaches are becoming routine in patient management. Collaborative efforts and multicentric networks are crucial in implementing precision oncology in practice.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Mark N. Pernik, Cylaina E. Bird, Jeffrey Traylor, Diana D. Shi, Timothy E. Richardson, Samuel K. McBrayer, Kalil G. Abdullah
Summary: The emergence of patient-derived cancer organoid (PDO) models, which closely recapitulate parental tumor tissue, provides a promising approach in cancer research. PDOs can efficiently retain tumor-specific properties and enhance precision oncologic care for patients compared to traditional cell lines and xenograft models. This review highlights the advantages of PDOs in cancer modeling and potential clinical applications.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Letter
Urology & Nephrology
Nicholas G. Zaorsky, Daniel E. Spratt, Pierre Blanchard
Article
Otorhinolaryngology
Li Wang, Shichao Han, Jinming Zhu, Xiaochun Wang, Yuting Li, Zeming Wang, Eric Lin, Xiaofang Wang, David P. Molkentine, Pierre Blanchard, Yining Yang, Ruiping Zhang, Narayan Sahoo, Michael Gillin, Xiaorong Ronald Zhu, Xiaodong Zhang, Jeffrey N. Myers, Steven J. Frank
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Otorhinolaryngology
Antoine Schernberg, Charles Canova, Pierre Blanchard, Philippe Gorphe, Ingrid Breuskin, Haitham Mirghani, Antoine Moya-Plana, Francois Janot, Francois Bidault, Cyrus Chargari, Sara Bellefqih, Amandine Ruffier, Caroline Even, France Nguyen, Stephane Temam, Yungan Tao
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Otorhinolaryngology
Philippe Gorphe, Younes Chekkoury Idrissi, Yungan Tao, Antoine Moya-Plana, Odile Casiraghi, Francois Janot, Pierre Blanchard, Haitham Mirghani, Stephane Temam
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Oncology
Amy C. Moreno, Steven J. Frank, Adam S. Garden, David I. Rosenthal, Clifton D. Fuller, Gary B. Gunn, Jay P. Reddy, William H. Morrison, Tyler D. Williamson, Emma B. Holliday, Jack Phan, Pierre Blanchard
Review
Oncology
Gargi Kothari, Piet Ost, Patrick Cheung, Pierre Blanchard, Alison C. Tree, Nicholas J. van As, Simon S. Lo, Drew Moghanaki, Andrew Loblaw, Shankar Siva
CURRENT ONCOLOGY REPORTS
(2019)
Meeting Abstract
Oncology
A. Ruffier-Loubiere, Y. G. Tao, F. NGuyen, A. Moya-Plana, C. Even, C. Berthold, O. Casiraghi, S. Temam, P. Blanchard
RADIOTHERAPY AND ONCOLOGY
(2019)
Article
Oncology
Adnan Elhammali, Pierre Blanchard, Alison Yoder, Zhongxing Liao, Xiadong Zhang, X. Ronald Zhu, Pamela K. Allen, Melenda Jeter, James Welsh, Quynh-Nhu Nguyen
RADIOTHERAPY AND ONCOLOGY
(2019)
Article
Oncology
Etienne Dauzier, Benjamin Lacas, Pierre Blanchard, Quynh-Thu Le, Christian Simon, Gregory Wolf, Francois Janot, Masatoshi Horiuchi, Jeffrey S. Tobias, James Moon, John Simes, Vinay Deshmane, Jean-Jacques Mazeron, Samir Mehta, Branko Zaktonik, Minoru Tamura, Elizabeth Moyal, Lisa Licitra, Catherine Fortpied, Bruce G. Haffty, Maria Grazia Ghi, Vincent Gregoire, Jonathan Harris, Jean Bourhis, Anne Auperin, Jean-Pierre Pignon
Article
Otorhinolaryngology
Antoine Moya-Plana, David Mangin, Pierre Blanchard, Rais Obongo, Odile Casiraghi, Francois Bidault, Stephane Temam, Caroline Robert, Philippe Gorphe
Summary: The study found that the cN status is not a prognostic factor in patients with resectable head and neck mucosal melanoma. Elective lymph node dissection should not be routinely performed in cN0 patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Letter
Oncology
Pierre Blanchard, Michael J. Zelefsky, Alberto Bossi, Cyrus Chargari, Jean-Marc Cosset
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Arnaud Jannin, Alexandre Escande, Abir Al Ghuzlan, Pierre Blanchard, Dana Hartl, Benjamin Chevalier, Frederic Deschamps, Livia Lamartina, Ludovic Lacroix, Corinne Dupuy, Eric Baudin, Christine Do Cao, Julien Hadoux
Summary: Anaplastic thyroid carcinoma (ATC) is a rare and aggressive form of thyroid cancer with a poor prognosis. Improving the management of this deadly disease involves the use of molecular tests for targeted therapies, fast-track dedicated care pathways, and prompt initiation of treatment. Adjuvant chemo-radiotherapy is recommended for localized disease after surgery, while chemotherapy or targeted therapy combined with decompressive cervical radiotherapy is recommended for locally advanced or metastatic disease.
Review
Oncology
Mario Terlizzi, Elaine Johanna Limkin, Yasmina Moukasse, Pierre Blanchard
Summary: The management of patients with biochemical recurrence after prostatectomy has changed significantly in recent years. Close monitoring of prostate-specific antigen (PSA) and early salvage radiotherapy (RT) have become the standard of care. However, uncertainties remain regarding the management of high-risk patients and the role of imaging.
Article
Oncology
Miet Vandemaele, Marianne Aznar, Pierre Blanchard, Josep M. Borras, Michelle Leech, Ajay Aggarwal, Yolande Lievens
Summary: In order to address the evaluation issue of radiotherapy innovations, the HERO project of ESTRO has initiated the development of a radiotherapy-specific value-based framework. A systematic literature search revealed no widely accepted definition or classification system for radiotherapy innovations. However, the unique properties of radiotherapy interventions can be used to categorize innovations in radiation oncology, but clear terminology denoting radiotherapy-specific characteristics is still needed.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)