Article
Oncology
Shuran Tan, Yuanyuan Chen, Shi Du, Wenhan Li, Pan Liu, Jing Zhao, Ping Yang, Jing Cai, Rui Gao, Zehua Wang
Summary: TIE2-high cervical cancer cells promote tumor angiogenesis by regulating TIE2 and VEGFR2 in endothelial cells via the TIE2-AKT/MAPK signaling pathway.
TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Ping Chen, Tao Wang, Qi Chen
Summary: A new mechanism of Ginkgo biloba leaf extract (GGLE) in inhibiting melanoma cell invasion and angiogenesis was discovered. GGLE inhibited total RNase activities in melanoma cells and suppressed angiogenin synthesis and secretion, resulting in inhibition of tumor cell invasion and tumor-induced angiogenesis.
INTEGRATIVE CANCER THERAPIES
(2023)
Article
Cell Biology
Hong-Yan Chen, Zhao-Yu Zhou, Yan-Lu Luo, Qin Luo, Jiang-Tao Fan
Summary: In endometrial cancer, inhibition of YKL-40 with siYKL-40 effectively suppresses angiogenesis and reduces microvessel density through the VEGF/VEGFR2 and ERK1/2 signaling pathways, leading to inhibition of tumor growth.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Beiying Qiu, Alison Tan, Yu Zhi Tan, Qi-Yin Chen, Hendrik Luesch, Xiaomeng Wang
Summary: Our study demonstrates that Largazole strongly inhibits the viability, proliferation, and tube-forming ability of retinal vascular endothelial cells. It also inhibits vessel outgrowth from choroidal and metatarsal explants, without affecting quiescent vasculature or pericytes coverage. Additionally, Largazole shows cooperative effects with the anti-VEGF drug, Alflibercept, and its mechanism involves downregulation of VEGFR2 and upregulation of the cell cycle inhibitor, p21.
Article
Cell Biology
Charlie Colin-Pierre, Nicolas Berthelemy, Nicolas Belloy, Louis Danoux, Vincent Bardey, Romain Rivet, Solene Mine, Christine Jeanmaire, Francois-Xavier Maquart, Laurent Ramont, Stephane Brezillon
Summary: The study indicates that GPC1 is a key regulator of microvascular endothelial cell angiogenesis induced by VEGF and HGF secreted by KORS. GPC1 may be an interesting target to tackle alopecia in dermatology research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Camille L. Duran, Lucia Borriello, George S. Karagiannis, David Entenberg, Maja H. Oktay, John S. Condeelis
Summary: Metastasis is a major cause of cancer deaths, and targeting the Tie2 receptor in the tumor microenvironment may be an effective anti-metastatic therapy.
Article
Biochemistry & Molecular Biology
Qi He, Zhenfeng Chen, Jieyu Li, Jinlian Liu, Zirui Zuo, Bingqi Lin, Ke Song, Chuyu Zhou, Haipeng Lai, Qiaobing Huang, Xiaohua Guo
Summary: Angiogenesis is an important characteristic of diabetic microangiopathy. Elevated levels of advanced glycation end products (AGEs) in diabetic tissues affect vascular endothelial cell function. This study investigated the control of small ubiquitin-related modifier (SUMO)-mediated VEGFR2 alterations and found that SENP6 plays a critical role in regulating VEGFR2 trafficking from the Golgi to the endothelial cell surface, which is important for pathological angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mei Wang, Chengfei Zhang, Qian Zheng, Zhijie Ma, Min Qi, Guangfu Di, Shizhang Ling, Haojun Xu, Bin Qi, Chengyun Yao, Hongping Xia, Xiaochun Jiang
Summary: Glioblastoma relies on new blood vessel formation, and RhoJ plays a significant role in regulating endothelial cell behavior and tumor angiogenesis. Targeting RhoJ may be an effective therapeutic strategy against GBM.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Amin Izadpanah, Fatemeh Daneshimehr, Kurtis Willingham, Zahra Barabadi, Stephen E. Braun, Aaron Dumont, Ricardo Mostany, Bysani Chandrasekar, Eckhard U. Alt, Reza Izadpanah
Summary: TRAF3IP2 has been identified as a critical regulator of angiogenesis in glioblastoma multiforme (GBM), and targeting TRAF3IP2 could significantly reduce vascularization and inhibit the expression of growth factors, providing a potential therapeutic option for GBM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yao Xiao, Mingliang Li, Teng Ma, Hao Ning, Libo Liu
Summary: AMG232 effectively inhibits glioma angiogenesis by blocking the MDM2-p53 interaction and modulating the p53-RBM4-VEGFR2 pathway, which involves the upregulation of p53 and RBM4, and the downregulation of MDM2 and VEGFR2.
JOURNAL OF CELL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Xiaohua Lu, Mohamed Elbadawi, Sebastian Blatt, Mohamed E. M. Saeed, Xiaolin Xiao, Xiao Ma, Edmond Fleischer, Peer W. Kammerer, Thomas Efferth
Summary: This study investigated a novel VEGFR2 inhibitor, FO-ARS-123, for cancer treatment. The results showed that FO-ARS-123 exhibited strong binding activity with VEGFR2 and inhibited cell proliferation, migration, invasion, as well as angiogenesis in vitro and in vivo.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Kai Li, Ying-ying Liu, Xiao-fei Lv, Zhuo-miao Lin, Ting-ting Zhang, Fei-ran Zhang, Jia-wei Guo, Yu Hong, Xiu Liu, Xiao-chun Lin, Jia-guo Zhou, Qian-qian Wu, Si-jia Liang, Jin-yan Shang
Summary: The study demonstrates that reducing intracellular chloride concentration inhibits angiogenesis by suppressing various cellular processes and oxidative stress-mediated VEGFR2 signaling activation. Modulation of chloride levels may offer a novel therapeutic approach for angiogenic dysfunction-associated diseases.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Mi So Park, A-Yeong Yang, Jae Eun Lee, Seon Kyu Kim, Jae-seok Roe, Min-Seok Park, Myung Jin Oh, Hyun Joo An, Mi-Young Kim
Summary: GALNT3 has been identified as a tumor-suppressor in lung cancer, inhibiting tumor initiation and growth by reducing lung cancer cell self-renewal and preventing the creation of a favorable tumor microenvironment. This is achieved through mechanisms such as suppressing myeloid-derived suppressor cell infiltration and angiogenesis, and regulating the TNFR1-NF Kappa B and cMET-pAKT pathways.
Article
Pharmacology & Pharmacy
Ting Yang, Yi-Xin Jiang, Ye Wu, Dong Lu, Rui Huang, Long-Ling Wang, Shi-Qi Wang, Ying-Yun Guan, Hong Zhang, Xin Luan
Summary: Resibufogenin (RBF) derived from Bufo bufonis exhibits anti-tumor effects by inhibiting angiogenesis on human umbilical vein endothelial cells (HUVECs) and in vivo by disrupting VEGFR2 phosphorylation and downstream pathways. RBF shows promising anti-angiogenic effects without obvious toxicity in vivo, suggesting its potential as an anti-angiogenic agent for angiogenesis-related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chandra Bhushan Prasad, Deepika Singh, Laxmi Kant Pandey, Satyajit Pradhan, Sunita Singh, Gopeshwar Narayan
Summary: The study reveals that VEGFR2 regulates angiogenesis and epithelial-mesenchymal transition in cervical cancer cells through various signaling pathways. Inhibitors targeting VEGFR showed potential in suppressing metastatic events and cancer-induced angiogenesis. Blocking VEGFR2 signaling altered the formation and growth of cervical tumorspheres, suggesting a potential therapeutic strategy for cervical cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Oncology
Lili Chen, Ling Xi, Jie Jiang, Rutie Yin, Pengpeng Qu, Xiuqin Li, Xiaoyun Wan, Yaxia Chen, Dongxiao Hu, Yuyan Mao, Zimin Pan, Xiaodong Cheng, Xinyu Wang, Qingli Li, Danhui Weng, Xi Zhang, Hong Zhang, Quanhong Ping, Xiaomei Liu, Xing Xie, Beihua Kong, Ding Ma, Weiguo Lu
Summary: This study evaluated the efficacy and safety of single-course initial regimens in low-risk gestational trophoblastic neoplasia patients. The results showed that single-course MTX may be a new treatment option, demonstrating similar effectiveness to multi-course MTX and could be considered for low-risk GTN patients.
FRONTIERS OF MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Po-Hsun Chen, Chih-Yang Lin, Ting-Chang Chang, Jason K. Eshraghian, Yu-Ting Chao, Wei D. Lu, Simon M. Sze
Summary: Resistive random-access memory (RRAM) crossbar arrays have shown great potential for neuromorphic computing, in-memory computing, and high-density storage-class memory applications, but leakage currents through parasitic sneak paths remain a major obstacle. The use of inherent selectors native to switching, such as niobium oxide (NbOx), can help reduce sneak path currents without sacrificing structural simplicity. Experimental results demonstrate abnormal phenomena in the reset process, and the switching behaviors of NbOx devices make them attractive candidates for future memory and in-memory computing applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Yang Hu, Kuan Jiang, Dongli Wang, Shengyu Yao, Linwei Lu, Huan Wang, Jie Song, Jianfen Zhou, Xingyan Fan, Yong Wang, Weiyue Lu, Jian Wang, Gang Wei
Summary: In this study, a lipoplex was designed to address the unmet demands on intranasal siRNA delivery to the brain for treatment of glioma. The lipoplex exhibited a stable core-shell structure and could be selectively internalized along with cell debris by glioma cells via active macropinocytosis. This lipoplex improved the gene delivery efficiency of intranasal administration and was promising in the perspective of selectively silencing disease-related genes in intracranial tumor.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Electrical & Electronic
Yuting Wu, Xinxin Wang, Wei D. Lu
Summary: Memristive devices have rich dynamics due to internal state variables determining conductance, which may serve as building blocks for biofaithful neuromorphic systems; these devices can be utilized in compute-in-memory architectures to process temporal data efficiently, implementing synaptic and neuronal functions effectively.
SEMICONDUCTOR SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xuan Zhao, Ruowei Yi, Lei Zheng, Ya Liu, Zhiyun Li, Leiying Zeng, Yanbin Shen, Wei Lu, Liwei Chen
Summary: Prelithiation using lithium-carbon microspheres passivated with a monolayer of octadecylphosphonic acid is demonstrated as an effective strategy to improve the Coulombic efficiency and cycle life of lithium-ion batteries. By supplementing lithium source into the battery, excessive delithiation and destructive phase transformation can be avoided, resulting in higher initial discharge capacity and increased capacity retention after cycles. This work provides a practical approach for developing high energy density and long cycle life LIBs.
Article
Spectroscopy
Fengye Chen, Chen Sun, Zengqi Yue, Yuqing Zhang, Weijie Xu, Sahar Shabbir, Long Zou, Weiguo Lu, Wei Wang, Zhenwei Xie, Lanyun Zhou, Yan Lu, Jin Yu
Summary: Raman spectroscopy shows promise for detecting ovarian cancer, but faces challenges in distinguishing between cancer, cyst, and normal samples. The study found distinct behaviors in the Raman spectra of the three types of samples, which were further visualized in a high dimensional space.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Engineering, Environmental
Peipei Su, Haitao Zhang, Lipeng Yang, Chunxian Xing, Shanshan Pan, Wei Lu, Suojiang Zhang
Summary: This study systematically investigates the effects of conductive additives on the rheological and electrochemical properties of suspension electrodes. The results show that different additives have different percolation thresholds and inflection points. The 1.5 wt.% KB-based suspension exhibits superior cycle and rate performances.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Instruments & Instrumentation
Qing Li, Ting He, Kun Zhang, Yunlong Xiao, Ke Deng, Jinshui Miao, Ning Li, Wenjuan Wang, Wei Lu
Summary: In this study, InGaAs/InP avalanche photodetectors with various guard ring structures were investigated. It was found that deeper guard rings are more effective in preventing edge breakdown and reducing surface electric field. The results also showed that guard rings can inhibit edge breakdown.
INFRARED PHYSICS & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sunyi Wu, Linwei Lu, Jianfen Zhou, Danni Ran, Songli Wang, Qianzhu Xu, Weixia Xu, Jun Wang, Yu Liu, Cao Xie, Zimiao Luo, Weiyue Lu
Summary: In this study, we developed a modified cabazitaxel nanocrystal-loaded liposome targeted to all stages of glioma and demonstrated its therapeutic efficacy in vitro and in a mouse model. The carrier exhibited excellent targeting and barrier-crossing capabilities, effectively killing glioma cells.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Computer Science, Information Systems
Tingting Chen, Xuechen Liu, Ruiwei Feng, Wenzhe Wang, Chunnv Yuan, Weiguo Lu, Haizhen He, Honghao Gao, Haochao Ying, Danny Z. Chen, Jian Wu
Summary: In this study, a new cervical lesion detection method for colposcopic images is proposed, which tackles the challenges posed by the specific characteristics of these images. The method utilizes novel feature enhancing mechanisms and achieves more accurate localization and diagnosis. Experimental results demonstrate the superiority of the proposed method over state-of-the-art models on four widely used metrics.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Optics
Ruixuan Yi, Xutao Zhang, Chen Li, Bijun Zhao, Jing Wang, Zhiwen Li, Xuetao Gan, Li Li, Ziyuan Li, Fanlu Zhang, Liang Fang, Naiyin Wang, Pingping Chen, Wei Lu, Lan Fu, Jianlin Zhao, Hark Hoe Tan, Chennupati Jagadish
Summary: This study demonstrates that III-V semiconductor nanowire (NW) lasers can be used for self-frequency conversion to extend their working wavelengths. Extra visible laser output can be obtained from a GaAs/In(0.16)Ga(0.84)As core/shell NW through the process of second-harmonic generation. In addition, multiple self-frequency-conversion lasing modes are observed in a larger diameter NW laser due to second-harmonic generation and sum-frequency generation.
LIGHT-SCIENCE & APPLICATIONS
(2022)
Article
Optics
Lin Wang, Li Han, Wanlong Guo, Libo Zhang, Chenyu Yao, Zhiqingzi Chen, Yulu Chen, Cheng Guo, Kaixuan Zhang, Chia-Nung Kuo, Chin Shan Lue, Antonio Politano, Huaizhong Xing, Mengjie Jiang, Xianbin Yu, Xiaoshuang Chen, Wei Lu
Summary: This study efficiently integrated and manipulated the optoelectronic properties of topological Dirac semimetal PtSe2 and its van der Waals heterostructures, allowing for high-speed and low-energy photon harvesting. The results showed a significant photoresponse and superb ambient stability.
LIGHT-SCIENCE & APPLICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Huigang Shi, Nan Zong, Shaopeng Li, Jianwen Le, Guangfa Huang, Jiuxiao Li, Jianwei Mao, Weijie Lu
Summary: We observed an interesting phenomenon in a new polycrystalline zirconium alloy where the intensity and attenuation of yield drop behavior increase and decrease, respectively, with increasing strain. This yield discontinuity is attributed to the recombination of climb-dissociated partials introduced by previous strain, and the work hardening or softening stage with increasing or decreasing partial dislocations results in the progressive intensification or attenuation of yield drop, respectively. The anisotropic response of the strain hardening-softening transition leads to relatively higher values of yield drop and increment-decrement transition strain along the rolling direction (-5.5 MPa and -21%, respectively) compared to the transverse direction (-4.6 MPa and -10%, respectively).
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
(2022)
Article
Biochemistry & Molecular Biology
Mengting Wu, Qiongzi Qiu, Qing Zhou, Jia Li, Juze Yang, Chengcai Zheng, Aoran Luo, Xufan Li, Honghe Zhang, Xiaodong Cheng, Weiguo Lu, Pengyuan Liu, Bingjian Lu, Yan Lu
Summary: This study identifies circFBXO7, a novel circRNA, as a tumor suppressor in ovarian cancer. The circFBXO7/miR-96-5p/MTSS1 axis is found to be an important regulator in the Wnt/beta-catenin signaling pathway.
Article
Engineering, Mechanical
Weiping Lu, Wen Cui, Xiaogang Zhang, Yali Zhang, Shu Yang, Jian Pu, Junyan Li, Zhongmin Jin
Summary: The friction and wear behaviors between cartilage replacement materials and articular cartilage are crucial for the function and performance of the replacements. This study investigated the difference between cross-shear motion and reciprocal linear motion on the frictional and wear behaviors of cartilage, as well as the effect of bearing surface roughness. The results showed that there was no significant difference between the two motion types. The water contact angle of the bearing surface affected the friction and wear behaviors for low roughness implants, while the surface roughness of the material affected the behaviors for high roughness implants. PEEK was found to be a suitable material for osteochondral implants.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART J-JOURNAL OF ENGINEERING TRIBOLOGY
(2023)
