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Biochemistry & Molecular Biology
Ziling Wang, Lu Wang, Rong Jiang, Chang Li, Xiongbin Chen, Hanxianzhi Xiao, Jiying Hou, Ling Hu, Caihong Huang, Yaping Wang
Summary: The study revealed that ginsenoside Rg1 can prevent MSCs from entering senescence state by activating the NRF2 and AKT pathways, enhancing cell antioxidant capacity. This discovery provides new therapeutic targets for preventing cell senescence.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
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Cell & Tissue Engineering
Lan Luo, Chen Yan, Naoki Fuchi, Yukinobu Kodama, Xu Zhang, Goto Shinji, Kiyonori Miura, Hitoshi Sasaki, Tao-Sheng Li
Summary: The study explored the hypothesis that altered secretion of extracellular vesicles (EVs) from mesenchymal stem cells (MSCs) triggered radiation-induced heart disease. Results indicated that EVs from irradiated MSCs exhibited changed miRNA profiles and harmful effects on heart cells.
STEM CELL RESEARCH & THERAPY
(2021)
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Cell & Tissue Engineering
Matteo Mazzella, Keegan Walker, Christina Cormier, Michael Kapanowski, Albi Ishmakej, Azeem Saifee, Yashvardhan Govind, G. Rasul Chaudhry
Summary: This study investigated the self-renewal mechanism of primitive (p) MSCs and found that the Wnt pathway is associated with self-renewal potential, while senescence is linked to the TGF beta pathway. Transcriptomic and MNase-seq analysis revealed distinct gene expressions and nucleosome occupancies in pMSCs grown in xeno-free and fetal bovine serum medium, providing insights into the complex molecular mechanisms governing the self-renewal and senescence of MSCs.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Multidisciplinary Sciences
Tae Woo Kim, Da-Won Hong, Sung Hee Hong
Summary: In this study, a novel benzothiazole derivative PB01 was shown to have antitumor effects in radiation-resistant human NSCLC cells by inducing cell death and inhibiting epithelial-to-mesenchymal transition. The mechanism involved induction of reactive oxygen species, ER stress, and activation of the ATR axis, suggesting that PB01 treatment could overcome radio-resistance during NSCLC radiotherapy.
SCIENTIFIC REPORTS
(2021)
Review
Cell & Tissue Engineering
Zirui Guan, Jiaxin Zhang, Nan Jiang, Mingyan Tian, Hongyong Wang, Bing Liang
Summary: This study aims to assess the quality of evidence for mesenchymal stem cell (MSC) treatment in rodent models of radiation-induced oral complications and determine whether MSCs can improve the therapeutic effect of radiation-induced oral mucositis. The results suggest that MSCs are effective in treating radiation-induced xerostomia and oral mucositis in animal models.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Linshan Xu, Yuyang Wang, Jianping Wang, Jianglong Zhai, Li Ren, Guoying Zhu
Summary: Cellular senescence and its associated secretory phenotype (SASP) are considered potential therapeutic targets for aging-related diseases. Inducing cellular senescence in osteocyte-like cells led to increased expression of senescence and SASP markers, disrupting the differentiation potential of bone marrow mesenchymal stem cells (BMSCs) through paracrine signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Savita Verma, Ajaswrata Dutta, Akshu Dahiya, Namita Kalra
Summary: The study found that Quercetin-3-Rutinoside (Q-3-R) can protect against radiation-induced lung injury by regulating NF-Kappa B/TGF-beta 1 signaling pathway, scavenging free radicals, preventing perivascular infiltration, and prolonged inflammatory cascade. This may have potential therapeutic effects on lung damage caused by planned or unplanned radiation exposure.
Article
Biochemistry & Molecular Biology
T. Iwata, N. Mizuno, S. Ishida, M. Kajiya, T. Nagahara, E. Kaneda-Ikeda, M. Yoshioka, S. Munenaga, K. Ouhara, T. Fujita, H. Kawaguchi, H. Kurihara
Summary: Mesenchymal stem cell (MSC) transplantation is an effective therapy for periodontal regeneration, but senescence is inevitable for MSCs. This study identified GATA6 and SOX11 as regulatory transcription factors for cell senescence by affecting the Wnt and BMP signaling pathways.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biology
David Murray, Razmik Mirzayans
Summary: The cellular response to genotoxic and/or oxidative stress caused by agents such as ionizing radiation exhibits a nonlinear relationship, with p53 playing a key role in coordinating these responses. In solid tumor-derived cell lines, moderate doses of radiation primarily invoke a dose-dependent cytostatic response.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hae-Ran Park, Yeo-Jin Choi, Jee-Young Kim, In-Gyu Kim, Uhee Jung
Summary: DLX2 is involved in cancer stemness, radioresistance, migration, invasion, and tumorigenic capability in surviving NSCLC cancer cells following fractionated irradiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Xuan Wang, Tianwei He, Lei He, Bu Yang, Zhongyu Liu, Mao Pang, Peigen Xie, Liangming Zhang, Limin Rong
Summary: The study demonstrates that melatonin enhances the hypertrophic differentiation of MSC-derived chondrocytes through the Wnt signaling pathway, increasing chondrocyte cell volume and type X collagen expression while decreasing type II collagen expression.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Pharmacology & Pharmacy
Divya Adiga, Samatha Bhat, Sanjiban Chakrabarty, Shama Prasada Kabekkodu
Summary: DOC2B inhibits the Wnt/beta-catenin pathway by enhancing CTNNB1 destruction complex components expression and promoting CTNNB1 degradation. It perturbs CTNNB1 translocation and interaction with transcription factors independently of GSK3beta. The activation of DOC2B-DKK1-senescence-Wnt/beta-catenin-EMT signaling crosstalk may provide a novel approach to restrain malignant behaviors in cervical cancer.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Fenglei Chen, Shan Wang, Chenying Zeng, Su'an Tang, Huimin Gu, Ziming Wang, Jinteng Li, Pei Feng, Yunhui Zhang, Peng Wang, Yanfeng Wu, Huiyong Shen
Summary: This study reveals that circSERPINE2 plays a regulatory role in stem cell senescence and has therapeutic potential in alleviating aging-related disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Zijun Deng, Weiwei Wang, Xun Xu, Yan Nie, Yue Liu, Oliver E. C. Gould, Nan Ma, Andreas Lendlein
Summary: The use of a PDA-coated substrate can reduce oxidative stress and cellular senescence in stem cell expansion, while promoting proliferation rate. PDA also helps suppress the expression of senescence-associated inflammatory components, while maintaining stem cell characteristics and differentiation potential.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Cell Biology
Lulu Su, Yinping Dong, Yueying Wang, Yuquan Wang, Bowen Guan, Yanhua Lu, Jing Wu, Xiaochun Wang, Deguan Li, Aimin Meng, Feiyue Fan
Summary: The study suggests that ionizing radiation may induce macrophage senescence, leading to sustained high secretion of SASP in pulmonary macrophages, which may stimulate a fibrotic phenotype in pulmonary fibroblasts.
CELL DEATH & DISEASE
(2021)