Dichloroacetate restores drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation

Using a yeast two-hybrid system to identify FTCD as a new regulator for HIF-1α in HepG2 cells

(2014) Zhenhai Yu et al.   CELLULAR SIGNALLING

Relationship Between 18F-FDG Accumulation and Lactate Dehydrogenase A Expression in Lung Adenocarcinomas

(2014) X. Zhou et al.   JOURNAL OF NUCLEAR MEDICINE

HSP40 Interacts with Pyruvate Kinase M2 and Regulates Glycolysis and Cell Proliferation in Tumor Cells

(2014) Liangqian Huang et al.   PLoS One

Proviral Insertion in Murine Lymphomas 2 (PIM2) Oncogene Phosphorylates Pyruvate Kinase M2 (PKM2) and Promotes Glycolysis in Cancer Cells

(2013) Zhenhai Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Lipolysis by Mercaptoacetate and Etomoxir Specifically Sensitize Drug-Resistant Lung Adenocarcinoma Cell to Paclitaxel

(2013) Jiajin Li et al.   PLoS One

New aspects of the Warburg effect in cancer cell biology

(2012) Steven J. Bensinger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Bicarbonate and dichloroacetate: Evaluating pH altering therapies in a mouse model for metastatic breast cancer

(2011) Ian F Robey et al.   BMC CANCER

Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells

(2011) Y. Zhou et al.   CANCER RESEARCH

Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?

(2011) A Lemarie et al.   ONCOGENE

Glycolysis Inhibition Inactivates ABC Transporters to Restore Drug Sensitivity in Malignant Cells

(2011) Ayako Nakano et al.   PLoS One

Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

(2010) B M Madhok et al.   BRITISH JOURNAL OF CANCER

Dichloroacetate metabolically targeted therapy defeats cytotoxicity of standard anticancer drugs

(2010) Dirk Heshe et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer

(2010) David J. Stewart   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC

(2010) Luke H. Stockwin et al.   INTERNATIONAL JOURNAL OF CANCER

Comparative proteomic analysis of paclitaxel sensitive A549 lung adenocarcinoma cell line and its resistant counterpart A549-Taxol

(2010) Qiang-ling Sun et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Targeting mitochondria for cancer therapy

(2010) Simone Fulda et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacologically Increased Tumor Hypoxia Can Be Measured by 18F-Fluoroazomycin Arabinoside Positron Emission Tomography and Enhances Tumor Response to Hypoxic Cytotoxin PR-104

(2009) R. A. Cairns et al.   CLINICAL CANCER RESEARCH

Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging

(2009) Qiongqiong Zhou et al.   FEBS LETTERS

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER

Correction: Reversal of Multidrug Resistance by Lapatinib

(2008)   CANCER RESEARCH

Dichloroacetate induces apoptosis in endometrial cancer cells

(2008) Jason Y.Y. Wong et al.   GYNECOLOGIC ONCOLOGY

Paclitaxel Induces Vascular Endothelial Growth Factor Expression through Reactive Oxygen Species Production

(2008) Hyun Sun Kim et al.   PHARMACOLOGY

Dichloroacetate (DCA) sensitizes both wild‐type and over expressingBcl‐2prostate cancer cells in vitro to radiation

(2008) Wengang Cao et al.   PROSTATE

Mitochondria in cancer: Not just innocent bystanders

(2008) Christian Frezza et al.   SEMINARS IN CANCER BIOLOGY