An insight into antagonist binding and induced conformational dynamics of class B GPCR corticotropin-releasing factor receptor 1

Exploration of the antagonist CP-376395 escape pathway for the corticotropin-releasing factor receptor 1 by random acceleration molecular dynamics simulations

(2014) Qifeng Bai et al.   Molecular BioSystems

Molecular Dynamics Simulations of the Adenosine A2a Receptor: Structural Stability, Sampling, and Convergence

(2013) Hui Wen Ng et al.   Journal of Chemical Information and Modeling

Structure of class B GPCR corticotropin-releasing factor receptor 1

(2013) Kaspar Hollenstein et al.   NATURE

Structure of the human smoothened receptor bound to an antitumour agent

(2013) Chong Wang et al.   NATURE

Structure of the human glucagon class B G-protein-coupled receptor

(2013) Fai Yiu Siu et al.   NATURE

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Antagonist binding and induced conformational dynamics of GPCR A2Aadenosine receptor

(2013) Xueqin Pang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Insights into the structure of class B GPCRs

(2013) Kaspar Hollenstein et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies

(2012) S. Vohra et al.   Journal of the Royal Society Interface

Molecular basis for negative regulation of the glucagon receptor

(2012) C. M. Koth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Dynamics Simulations Reveal Insights into Key Structural Elements of Adenosine Receptors

(2011) David Rodríguez et al.   BIOCHEMISTRY

G Protein- and Agonist-Bound Serotonin 5-HT2AReceptor Model Activated by Steered Molecular Dynamics Simulations

(2011) Vignir Ísberg et al.   Journal of Chemical Information and Modeling

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Structure and function of an irreversible agonist-β2 adrenoceptor complex

(2011) Daniel M. Rosenbaum et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal Structure of the PAC1R Extracellular Domain Unifies a Consensus Fold for Hormone Recognition by Class B G-Protein Coupled Receptors

(2011) Shiva Kumar et al.   PLoS One

Diversity and modularity of G protein-coupled receptor structures

(2011) Vsevolod Katritch et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Progress in corticotropin-releasing factor-1 antagonist development

(2010) Eric P. Zorrilla et al.   DRUG DISCOVERY TODAY

Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism

(2010) Ernst ter Haar et al.   STRUCTURE

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Identification of two distinct inactive conformations of the  2-adrenergic receptor reconciles structural and biochemical observations

(2009) R. O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1

(2008) Augen A. Pioszak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain

(2008) Steffen Runge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

2-Aryloxy-4-alkylaminopyridines: Discovery of Novel Corticotropin-Releasing Factor 1 Antagonists

(2008) Yuhpyng L. Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric Ligands for the Corticotropin Releasing Factor Type 1 Receptor Modulate Conformational States Involved in Receptor Activation

(2008) S. R. J. Hoare et al.   MOLECULAR PHARMACOLOGY

Structure of a β1-adrenergic G-protein-coupled receptor

(2008) Tony Warne et al.   NATURE

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular recognition of parathyroid hormone by its G protein-coupled receptor

(2008) Augen A. Pioszak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE