Article
Nanoscience & Nanotechnology
Di Wu, Yong Hou, Zhiqin Chu, Qiang Wei, Wei Hong, Yuan Lin
Summary: Cells rely on receptor-ligand binding to connect and communicate with the external environment. Understanding the interaction between receptors and ligands is crucial for comprehending cellular biology. Recent evidence suggests that the mobility of ligands at the cell-ECM interface affects cell adhesion and spreading, but the underlying mechanism is unclear. This modeling investigation reveals a biphasic relationship between adhesion and ligand diffusivity, with peak spreading observed at intermediate ligand mobility. The aggregation of ligands and the kinetics of bond association/dissociation play a role in determining this peak position.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Xinqing Pang, Weiqi Li, Lan Chang, Julien E. Gautrot, Wen Wang, Helena S. Azevedo
Summary: The extracellular matrix component hyaluronic acid plays a crucial role in regulating endothelial cell behavior. Immobilized HA enhances cell spreading and migration, facilitates cell alignment and elongation under laminar flow conditions, potentially drives directional migration, and accelerates the assembly of focal adhesions. Studying the effects of immobilized HA provides new insights into its role in regulating the behavior of endothelial cells.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Cell Biology
Xinyi Ren, Xiaopu Guo, Zihan Liang, Renxian Guo, Shaohui Liang, Han Liu
Summary: Cell migration is a complex process that involves the coordination of various cellular components. In this study, we discovered a novel interaction between IQGAP1 and Hax1, which plays a significant role in focal adhesion turnover and directional cell migration. Our findings suggest that Hax1 acts as a link between dynamic focal adhesions and IQGAP1, facilitating efficient cell migration. Perturbation of the IQGAP1/Hax1 interaction impairs focal adhesion turnover and inhibits directional cell migration.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Chemistry, Multidisciplinary
Seungkuk Ahn, Upnishad Sharma, Krishna Chaitanya Kasuba, Nico Strohmeyer, Daniel J. J. Muller
Summary: This study introduces a simple and scalable method to engineer biomimetic 3D fibrillar fibronectin matrices and characterizes how fibroblasts sense and adhere to these matrices. The findings demonstrate that fibroblasts accelerate adhesion initiation and strengthening to fibrillar fibronectin matrices compared to globular fibronectin. This immediate sensing and adhesion to fibrillar fibronectin also guide migration speed, persistency, and proliferation range in fibroblasts.
Article
Oncology
Ha Hyung Moon, Nina-Naomi Kreis, Alexandra Friemel, Susanne Roth, Dorothea Schulte, Christine Solbach, Frank Louwen, Juping Yuan, Andreas Ritter
Summary: The microtubule cytoskeleton regulator MCAK plays a critical role in cell motility and migration by affecting the dynamics of actin-MT cytoskeleton and FA turnover, potentially promoting malignant progression and metastasis of tumor cells.
Article
Cell Biology
Nour Zaimia, Joelle Obeid, Annie Varrault, Julia Sabatier, Christophe Broca, Patrick Gilon, Safia Costes, Gyslaine Bertrand, Magalie A. Ravier
Summary: Glucagon-like peptide 1 (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIPR) receptors play important roles in glucose homeostasis. This study highlights the distinct roles of ARRB2 in regulating GLP-1R and GIPR signaling, as well as the potential consequences of its decreased expression in pathological conditions such as diabetes.
Review
Biochemistry & Molecular Biology
Abdulrahman G. Alharbi, Andrew B. Tobin, Graeme Milligan
Summary: FFA1 and FFA4, two G protein-coupled receptors activated by long chain fatty acids, have crucial roles in mediating various biological functions in the body. Recent studies have highlighted the importance of understanding the interactions between beta-arrestins and GRKs with FFA1 and FFA4, suggesting the need to consider these interactions when studying the functions of FFA1 and FFA4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Chikahiro Imashiro, Byungjun Kang, Yunam Lee, Youn-Hoo Hwang, Seonghun Im, Dae-Eun Kim, Kenjiro Takemura, Hyungsuk Lee
Summary: Collective cell migration is critical in various physiological and pathological processes, and this study investigated the effect of propagating acoustic waves on such migration behavior. The research found that cell migration was enhanced at a critical wave intensity but suppressed at higher intensities. The observed increased migration was potentially due to cell orientation alignment and thicker actin bundles indicative of higher traction force in response to the acoustic stimulation.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Multidisciplinary Sciences
W. Tucker Shelton, S. Madison Thomas, Hunter R. Alexander, C. Evan Thomes, Daniel E. Conway, Adi D. Dubash
Summary: Desmosomes play a central role in cell-cell extracellular adhesion and also regulate biological processes such as proliferation, differentiation, apoptosis, and migration. The study found that the desmosomal protein Dsg2 controls cell-matrix adhesion through Rap1 GTPase, influencing cell spreading and focal adhesion protein phosphorylation. These findings provide insight into non-canonical effects of cadherins on cell spreading mechanisms.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Emmet A. Francis, Volkmar Heinrich
Summary: The dynamic interplay between cell adhesion and protrusion is crucial for cell motility. Traditional mathematical models often consider passive cell adhesion as the primary driving force for cell spreading, but this is inconsistent with experimental results. In contrast, a protrusive zipper model agrees well with experimental findings and can reproduce the observed correlation between antibody density and maximum cell-substrate contact area. This integrative experimental/computational approach reveals that phagocytic spreading is driven by cellular protrusion and is limited by the density of adhesion sites.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuqi Zhang, Yizeng Li, Keyata N. Thompson, Konstantin Stoletov, Qinling Yuan, Kaustav Bera, Se Jong Lee, Runchen Zhao, Alexander Kiepas, Yao Wang, Panagiotis Mistriotis, Selma A. Serra, John D. Lewis, Miguel A. Valverde, Stuart S. Martin, Sean X. Sun, Konstantinos Konstantopoulos
Summary: Cell migration plays a crucial role in various physiological processes, including cancer metastasis. This study reveals the polarization of NHE1 and SWELL1 at different regions of migrating cells, which is important for cell volume regulation and directional migration. The findings also highlight the physiological significance of the Osmotic Engine Model in cell migration and cancer metastasis.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Michael F. Staddon, Michael P. Murrell, Shiladitya Banerjee
Summary: The coordinated and cooperative motion of cells plays a crucial role in embryonic development, tissue morphogenesis, wound healing, and cancer invasion. By developing a predictive cellular vertex model, we can understand the relative roles of substrate rigidity, tissue mechanics, and active cell properties in collective cell motion. Our model predicts that the cooperation of cell crawling and tissue pressure drives faster spreading, with the spreading rate being sensitive to the mechanical properties of the tissue.
Article
Engineering, Mechanical
Mattia Serpelloni, Matteo Arricca, Claudia Bonanno, Alberto Salvadori
Summary: Cell responses during spreading and motility are influenced by multiple physics events triggered by extracellular cues, presenting a living system that reorganizes in response to external signals in an unpredictable and reproducible manner, highlighting the need for a multi-physics framework to model cell behavior.
ACTA MECHANICA SINICA
(2021)
Article
Materials Science, Multidisciplinary
Joel Betorz, Gaurav R. Bokil, Shreyas M. Deshpande, Shardool Kulkarni, Daniel R. Araya, Chiara Venturini, Pablo Saez
Summary: In this study, a computational model of cell motility was developed to investigate the mechanisms of cell protrusion, polarization, and retrograde flow. The model was validated through experiments on cell spreading, polarization, and two types of cell migration. Further analysis was done on the effects of chemical and mechanical signals on cell migration, as well as the competition between chemotaxis and durotaxis. The study provides insights into controlling directed cell migration and has implications for tissue and biomedical engineering.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2023)
Article
Multidisciplinary Sciences
X. Chen, Y. Xu, Y. Cheng, S. W. Pang
Summary: This paper examines cell migration in the vertical direction and finds that taller barriers hinder the vertical migration of MC3T3 cells, while grating and arrows in channels promote it. By fabricating barriers with sloped sidewalls of specific heights, the probability of MC3T3 cells climbing and descending increases.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Vsevolod V. Gurevich, Eugenia V. Gurevich
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Biochemistry & Molecular Biology
Andras D. Toth, Susanne Prokop, Pal Gyombolai, Peter Varnai, Andras Balla, Vsevolod V. Gurevich, Laszlo Hunyady, Gabor Turu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Sergey A. Vishnivetskiy, Regina J. Lee, X. Edward Zhou, Andreas Franz, Qiuyi Xu, H. Eric Xu, Vsevolod V. Gurevich
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemical Research Methods
Shih-Chia Tso, Qiuyan Chen, Sergey A. Vishnivetskiy, Vsevolod V. Gurevich, T. M. Iverson, Chad A. Brautigam
ANALYTICAL BIOCHEMISTRY
(2018)
Article
Cell Biology
Whitney M. Cleghorn, Nada Bulus, Seunghyi Kook, Vsevolod V. Gurevich, Roy Zent, Eugenia V. Gurevich
CELLULAR SIGNALLING
(2018)
Review
Biochemistry & Molecular Biology
Qiuyan Chen, Tina M. Iverson, Vsevolod V. Gurevich
TRENDS IN BIOCHEMICAL SCIENCES
(2018)
Review
Pharmacology & Pharmacy
Vsevolod V. Gurevich, EugeniaV. Gurevich
TRENDS IN PHARMACOLOGICAL SCIENCES
(2018)
Article
Neurosciences
Srimal Samaranayake, Xiufeng Song, Sergey A. Vishnivetskiy, Jeannie Chen, Eugenia V. Gurevich, Vsevolod V. Gurevich
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Editorial Material
Biochemistry & Molecular Biology
Vsevolod V. Gurevich, Eugenia Gurevich
Meeting Abstract
Ophthalmology
Sergey Vishnivetskiy, Lori S. Sullivan, Sara J. Bowne, Stephen P. Daiger, Eugenia Gurevich, Vsevolod V. Gurevich
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)
Meeting Abstract
Ophthalmology
Srimal Aminda Samaranayake, Sergey A. Vishnivetskiy, Kimberly C. Thibeault, Eugenia Gurevich, Vsevolod V. Gurevich
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)
Meeting Abstract
Ophthalmology
Vsevolod V. Gurevich, Ned Van Eps, Sergey Vishnivetskiy, Luwi Shamambo, Nicole A. Perry, Wayne L. Hubbell
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)
Article
Ophthalmology
Sergey A. Vishnivetskiy, Lori S. Sullivan, Sara J. Bowne, Stephen P. Daiger, Eugenia V. Gurevich, Vsevolod V. Gurevich
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)
Meeting Abstract
Ophthalmology
Lori S. Sullivan, Sara J. Bowne, Kaylie Webb-Jones, John R. Heckenlively, Daniel C. Koboldt, Yumei Li, Rui Chen, Vsevolod Gurevich, David G. Birch, Stephen P. Daiger
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Article
Cell Biology
Lizzy Wanka, Stefanie Babilon, Kerstin Burkert, Karin Moerl, Vsevolod V. Gurevich, Annette G. Beck-Sickinger
CELLULAR SIGNALLING
(2017)