Roles of zinc ions and structural polymorphism of β-amyloid in the development of Alzheimer’s disease

Mitochondrial superoxide: a key player in Alzheimer's disease

(2016) Cynthia A. Massaad et al.   Aging-US

A role for cyclooxygenase-1 in β-amyloid-induced neuroinflammation

(2016) Eduardo Candelario-Jalil   Aging-US

Cyclooxygenase-1 null mice show reduced neuroinflammation in response to β-amyloid

(2016) Sang-Ho Choi et al.   Aging-US

Phosphorylation of amyloid beta (Aβ) peptides – A trigger for formation of toxic aggregates in Alzheimer's disease

(2016) Sathish Kumar et al.   Aging-US

ZINC-INDUCED DIMERS OF CHEMICALLY MODIFIED A β- ARE POSSIBLE AGGREGATION SEEDS

(2014) Sergey A. Kozin et al.   Alzheimers & Dementia

Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies

(2014) Tiernan T. O’Malley et al.   BIOCHEMICAL JOURNAL

Phosphorylation of Ser8 promotes zinc-induced dimerization of the amyloid-β metal-binding domain

(2014) Alexandra A. Kulikova et al.   Molecular BioSystems

Dual effects of familial Alzheimer's disease mutations (D7H, D7N, and H6R) on amyloid β peptide: Correlation dynamics and zinc binding

(2014) Liang Xu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Early intraneuronal accumulation and increased aggregation of phosphorylated Abeta in a mouse model of Alzheimer’s disease

(2013) Sathish Kumar et al.   ACTA NEUROPATHOLOGICA

Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn23Iowa mutation

(2013) Silvia Fossati et al.   BIOCHEMICAL JOURNAL

ESI-MS identification of the minimal zinc-binding center in natural isoforms of β-amyloid domain 1–16

(2013) I. A. Popov et al.   MOLECULAR BIOLOGY

Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity

(2013) Luisa Diomede et al.   NEUROBIOLOGY OF DISEASE

Peripherally Applied Synthetic Peptide isoAsp7-Aβ(1-42) Triggers Cerebral β-Amyloidosis

(2013) S. A. Kozin et al.   NEUROTOXICITY RESEARCH

Isomerization of Asp7 leads to increased toxic effect of amyloid-β42 on human neuronal cells

(2013) V A Mitkevich et al.   Cell Death & Disease

Post-translational modifications induce significant yet not extreme changes to protein structure

(2012) Fuxiao Xin et al.   BIOINFORMATICS

NMR Solution Structure of Rat Aβ(1–16): Toward Understanding the Mechanism of Rats' Resistance to Alzheimer's Disease

(2012) Andrey N. Istrate et al.   BIOPHYSICAL JOURNAL

Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers

(2012) Daniela Kaden et al.   EMBO Molecular Medicine

Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environment

(2012) Kirill D. Nadezhdin et al.   FEBS LETTERS

Proteinopathies, neurodegenerative disorders with protein aggregation-based pathology

(2012) T. A. Shelkovnikova et al.   MOLECULAR BIOLOGY

Amyloid-Beta (Aβ) D7H Mutation Increases Oligomeric Aβ42 and Alters Properties of Aβ-Zinc/Copper Assemblies

(2012) Wei-Ting Chen et al.   PLoS One

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Capabilities of MS for Analytical Quantitative Determination of the Ratio of α- and βAsp7 Isoforms of the Amyloid-β Peptide in Binary Mixtures

(2011) Maria I. Indeykina et al.   ANALYTICAL CHEMISTRY

Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders

(2011) Mathias Jucker et al.   ANNALS OF NEUROLOGY

A Kinetic Aggregation Assay Allowing Selective and Sensitive Amyloid-β Quantification in Cells and Tissues

(2011) Deguo Du et al.   BIOCHEMISTRY

Amyloid deposits: Protection against toxic protein species?

(2011) Sebastian Treusch et al.   CELL CYCLE

Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease

(2011) Sathish Kumar et al.   EMBO JOURNAL

Folding stability of amyloid-β 40 monomer is an important determinant of the nucleation kinetics in fibrillization

(2011) Chun-Lun Ni et al.   FASEB JOURNAL

Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis

(2011) Jason A. Bailey et al.   GENE

Soluble A  Seeds Are Potent Inducers of Cerebral  -Amyloid Deposition

(2011) F. Langer et al.   JOURNAL OF NEUROSCIENCE

Zinc-induced dimerization of the amyloid-β metal-binding domain 1–16 is mediated by residues 11–14

(2011) Sergey A. Kozin et al.   Molecular BioSystems

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioluminescence imaging of A  deposition in bigenic mouse models of Alzheimer's disease

(2011) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prions

(2011) D. W. Colby et al.   Cold Spring Harbor Perspectives in Biology

Neuropathology of the recessive A673V APP mutation: Alzheimer disease with distinctive features

(2010) Giorgio Giaccone et al.   ACTA NEUROPATHOLOGICA

Molecular pathology of human prion disease

(2010) Jonathan D. F. Wadsworth et al.   ACTA NEUROPATHOLOGICA

Pathways linking Aβ and tau pathologies: Figure 1

(2010) Frank M. LaFerla   BIOCHEMICAL SOCIETY TRANSACTIONS

Minimal Zn 2+ Binding Site of Amyloid- β

(2010) Philipp O. Tsvetkov et al.   BIOPHYSICAL JOURNAL

Effects of the English (H6R) and Tottori (D7N) Familial Alzheimer Disease Mutations on Amyloid β-Protein Assembly and Toxicity

(2010) Kenjiro Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optimization of the methods for small peptide solution structure determination by NMR spectroscopy

(2010) A. N. Istrate et al.   MOLECULAR BIOLOGY

Amyloid-β Oligomers: Possible Roles as Key Neurotoxins in Alzheimer's Disease

(2010) Alex L. Lublin et al.   MOUNT SINAI JOURNAL OF MEDICINE

Initiation and propagation of neurodegeneration

(2010) Christian Haass   NATURE MEDICINE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Zinc ions promote Alzheimer A  aggregation via population shift of polymorphic states

(2010) Y. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripherally Applied A -Containing Inoculates Induce Cerebral  -Amyloidosis

(2010) Y. S. Eisele et al.   SCIENCE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Signaling effect of amyloid-β42 on the processing of AβPP

(2009) Massimo Tabaton et al.   EXPERIMENTAL NEUROLOGY

A Role for Synaptic Zinc in Activity-Dependent A  Oligomer Formation and Accumulation at Excitatory Synapses

(2009) A. Deshpande et al.   JOURNAL OF NEUROSCIENCE

Mutations in amyloid precursor protein affect its interactions with presenilin/γ-secretase

(2009) Lauren Herl et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

Induction of cerebral  -amyloidosis: Intracerebral versus systemic A  inoculation

(2009) Y. S. Eisele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis

(2009) G. Di Fede et al.   SCIENCE

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Isomerization of the Asp7 Residue Results in Zinc‐Induced Oligomerization of Alzheimer’s Disease Amyloid β(1–16) Peptide

(2008) Philipp O. Tsvetkov et al.   CHEMBIOCHEM

Structural features of the Cu(ii) complex with the rat Aβ(1–28) fragment

(2008) Elena Gaggelli et al.   CHEMICAL COMMUNICATIONS

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide

(2008) Peter Faller et al.   DALTON TRANSACTIONS

The AβCs of Aβ-cleaving Proteases

(2008) Malcolm A. Leissring   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

(2008) Stephan Schilling et al.   NATURE MEDICINE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Molecular polymorphism of Aβ in Alzheimer's disease

(2008) Harry LeVine et al.   NEUROBIOLOGY OF AGING

Modulation of ???A???-type K+ current by rodent and human forms of amyloid ?? protein

(2008) Talitha L. Kerrigan et al.   NEUROREPORT

Zinc at glutamatergic synapses

(2008) P. Paoletti et al.   NEUROSCIENCE

Amyloid Oligomer Conformation in a Group of Natively Folded Proteins

(2008) Yuji Yoshiike et al.   PLoS One