Review
Immunology
Yong-Wei Huang, Xiao-Shuang Yin, Zong-Ping Li
Summary: The novel systemic immune-inflammation index (SII) has been associated with clinical outcomes in stroke patients, showing significant correlations with poor outcomes, mortality, and hemorrhagic transformation, but no impact on recanalization. Patients with high SII levels are more likely to experience adverse outcomes and death in stroke cases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Multidisciplinary Sciences
Teshager Weldegiorgis Abate, Balew Zeleke, Ashenafi Genanew, Bidiru Weldegiorgis Abate
Summary: In Ethiopia, the burden of stroke mainly comes from hemorrhagic and ischemic stroke, with modifiable risk factors including hypertension, alcohol consumption, and dyslipidemia. More than 90% of stroke patients had one or more modifiable risk factors, making them major public health issues in Ethiopia. Targeted modification of these risk factors on a population, community, or individual level is crucial for stroke prevention strategies to reduce the burden of stroke.
Article
Rheumatology
Michele Iudici, Matthias Jarlborg, Kim Lauper, Ulf Mueller-Ladner, Vanessa Smith, Yannick Allanore, Alexandra Balbir-Gurman, Andrea Doria, Paolo Airo, Ulrich A. Walker, Valeria Riccieri, Madelon C. Vonk, Armando Gabrielli, Anna-Maria Hoffmann-Vold, Gabriella Szucs, Thierry Martin, Oliver Distler, Delphine S. Courvoisier
Summary: The objective of this study was to assess the extent of ineligibility and determine the reasons for it in SSc patients included in the EUSTAR database. The study found that the representativeness of patients in SSc-RCTs varies greatly, and is more influenced by treatment and safety factors rather than demographic criteria.
Review
Cardiac & Cardiovascular Systems
Zhen Ye, Tingyi Hu, Jin Wang, Ruoyi Xiao, Xibei Liao, Mengsi Liu, Zhen Sun
Summary: The study suggests that the systemic immune-inflammation index (SII) may be a potential biomarker for the development of cardiovascular disease (CVD), as elevated SII is associated with an increased risk of CVD. However, the quality of evidence from current studies is generally low, and further well-designed research is needed to determine the optimal cutoff value and identify the population that would benefit from SII assessment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Martin Ackah, Cynthia Osei Yeboah, Louise Ameyaw
Summary: This study aims to systematically review and meta-analyze the risk factors for in-hospital stroke mortality in sub-Saharan Africa, in order to provide targeted research. The pooled 30-day in-hospital stroke mortality rate will be analyzed, with meta-regression used to assess associated factors, as well as subgroup and sensitivity analyses conducted for further insights.
Review
Immunology
Marko Sternak, Anton Glasnovic, Paula Josic, Dominik Romic, Srecko Gajovic
Summary: This study analyzed the effect of splenectomy as a preclinical intervention in murine models of ischemic stroke. The results showed that splenectomy reduced the ischemic lesion volumes and improved neurological deficit scores. Despite limitations related to bias, study heterogeneity, and potential publication bias, this meta-analysis suggests that the spleen and its functional cell populations are promising targets for the therapeutic modulation of post-stroke inflammation.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Medicine, General & Internal
Rami Z. Morsi, Yuan Zhang, Julian Carrion-Penagos, Harsh Desai, Elie Tannous, Sachin Kothari, Assem M. Khamis, Andrea J. Darzi, Ammar Tarabichi, Reena Bastin, Layal Hneiny, Sonam Thind, Elisheva Coleman, James R. Brorson, Scott Mendelson, Ali Mansour, Shyam Prabhakaran, Tareq Kass-Hout
Summary: This article presents the current published guidelines and meta-analyses comparing endovascular thrombectomy (EVT) alone versus EVT with bridging intravenous thrombolysis (IVT), suggesting that EVT alone is non-inferior to EVT with bridging thrombolysis in achieving favourable functional outcome. The study aims to systematically update the evidence, perform a meta-analysis of randomized trials, and conduct an economic evaluation comparing both strategies.
Article
Rheumatology
Yehuda Wexler, Udi Nussinovitch
Summary: Systemic sclerosis (SSc) patients exhibit a significant increase in QTc duration, but the absolute prolongation is not extreme and there is no significant correlation with underlying traits. However, substantial heterogeneity between studies highlights the need for further large prospective observational studies to validate this finding.
CLINICAL RHEUMATOLOGY
(2022)
Article
Ophthalmology
Peizeng Yang, Zhenyu Zhong, Liping Du, Fuzhen Li, Zhijun Chen, Ying Zhu, Wanyun Zhang, Fanfan Huang, Xingsheng Ye, Guannan Su, Aize Kijlstra
Summary: Approximately one third of uveitis patients in this nationwide survey have an associated systemic disease, with VKH, BD, AS, and JIA being the most frequent entities seen in China.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Bruno Kusznir Vitturi, Alfredo Montecucco, Alborz Rahmani, Guglielmo Dini, Paolo Durando
Summary: This study conducted the first systematic review with meta-analysis to investigate the occupational risk factors of Multiple Sclerosis. It found that agricultural workers, offshore workers, hairdressers, individuals exposed to toxic fumes from oil wells, low-frequency magnetic fields, and pesticides had an increased likelihood of being diagnosed with MS, which could potentially influence public policies and calls for future research in this area.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Clinical Neurology
Xinyu Wang, Yanan Huang, Yanru Chen, Tingting Yang, Wenli Su, Xiaoli Chen, Fanghong Yan, Lin Han, Yuxia Ma
Summary: This study conducted a systematic review and meta-analysis on the relationship between body mass index (BMI) and the risk of stroke. The results showed that the underweight group had a lower risk, while the overweight or obese group had a higher risk. Lowering BMI can be used as a preventive measure against stroke.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Katelijn M. Blok, Joost van Rosmalen, Nura Tebayna, Joost Smolders, Beatrijs Wokke, Janet de Beukelaar
Summary: Predictors of disease activity in primary progressive multiple sclerosis (PPMS) are age and follow-up duration, highlighting the need for long-term monitoring of young patients to evaluate potential treatment benefits.
FRONTIERS IN NEUROLOGY
(2023)
Article
Rheumatology
Xianyong Yin, Kwangwoo Kim, Hiroyuki Suetsugu, So-Young Bang, Leilei Wen, Masaru Koido, Eunji Ha, Lu Liu, Yuma Sakamoto, Sungsin Jo, Rui-Xue Leng, Nao Otomo, Viktoryia Laurynenka, Young-Chang Kwon, Yujun Sheng, Nobuhiko Sugano, Mi Yeong Hwang, Weiran Li, Masaya Mukai, Kyungheon Yoon, Minglong Cai, Kazuyoshi Ishigaki, Won Tae Chung, He Huang, Daisuke Takahashi, Shin-Seok Lee, Mengwei Wang, Kohei Karino, Seung-Cheol Shim, Xiaodong Zheng, Tomoya Miyamura, Young Mo Kang, Dongqing Ye, Junichi Nakamura, Chang-Hee Suh, Yuanjia Tang, Goro Motomura, Yong-Beom Park, Huihua Ding, Takeshi Kuroda, Jung-Yoon Choe, Chengxu Li, Hiroaki Niiro, Youngho Park, Changbing Shen, Takeshi Miyamoto, Ga-Young Ahn, Wenmin Fei, Tsutomu Takeuchi, Jung-Min Shin, Keke Li, Yasushi Kawaguchi, Yeon-Kyung Lee, Yongfei Wang, Koichi Amano, Dae Jin Park, Wanling Yang, Yoshifumi Tada, Ken Yamaji, Masato Shimizu, Takashi Atsumi, Akari Suzuki, Takayuki Sumida, Yukinori Okada, Koichi Matsuda, Keitaro Matsuo, Yuta Kochi, Leah C. Kottyan, Matthew T. Weirauch, Sreeja Parameswaran, Shruti Eswar, Hanan Salim, Xiaoting Chen, Kazuhiko Yamamoto, John B. Harley, Koichiro Ohmura, Tae-Hwan Kim, Sen Yang, Takuaki Yamamoto, Bong-Jo Kim, Nan Shen, Shiro Ikegawa, Hye-Soon Lee, Xuejun Zhang, Chikashi Terao, Yong Cui, Sang-Cheol Bae
Summary: This study conducted the largest genome-wide meta-analysis for SLE in East Asian populations, identifying 46 novel loci and prioritizing putative causal variants using Bayesian statistical approach. The findings highlight the power of large-scale genetic discovery in shedding light on the genetic and biological understandings of SLE.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Nutrition & Dietetics
Eirini D. Basdeki, Anastasios Kollias, Panagiota Mitrou, Christiana Tsirimiagkou, Marios K. Georgakis, Antonios Chatzigeorgiou, Antonios Argyris, Kalliopi Karatzi, Yannis Manios, Petros P. Sfikakis, Athanase D. Protogerou
Summary: Our study found inconsistency in population characteristics and methodology among RCTs, which may have led to the lack of significant associations between different levels of daily sodium intake and systemic inflammation levels in humans. Suggestions for future RCTs include focusing on young healthy participants, having three arms of daily sodium intake levels, and an adequate intervention duration of 14 days.
Article
Environmental Sciences
Chao Tang, Qing-Ru Li, Yan-Mei Mao, Yuan-Rui Xia, Heng-Sheng Guo, Jun-Ping Wang, Zong-Wen Shuai, Dong-Qing Ye
Summary: The study found through meta-analysis that only PM10 in the air is related to MS, while other pollutants are not. There was no publication bias, and the stability analysis results suggest that PM10 is associated with the disease MS.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
