Article
Chemistry, Multidisciplinary
Tianyi Wang, Huali Lei, Xiang Li, Nailin Yang, Cheng Ma, Guangqiang Li, Xiang Gao, Jun Ge, Zhuang Liu, Liang Cheng, Gang Chen
Summary: Intracerebral hemorrhage (ICH) is a significant cause of morbidity and mortality worldwide, and surgery remains the most effective way to remove ICH. However, surgery brings potential risks such as brain tissue damage, post-operative infection, and difficulty in removing deep hematoma, which are the main problems in the surgical treatment of ICH.
Article
Chemistry, Multidisciplinary
Adriana Zelenakova, Jaroslava Szucsova, Lubos Nagy, Vladimir Girman, Vladimir Zelenak, Veronika Huntosova
Summary: In this study, a drug delivery composite (DDC) consisting of ordered mesoporous silica, iron oxide magnetic nanoparticles (Fe2O3), and the drug naproxen (Napro) was prepared. The results reveal the suppression of the Brownian relaxation process and indicate the potential application of the composite as a drug nanocarrier for magnetic-targeted drug delivery.
Article
Chemistry, Multidisciplinary
Xiaoyu Wang, Qing Ma, Chaochao Wen, Tao Gong, Jing Li, Wenting Liang, Meining Li, Yuyao Wang, Rui Guo
Summary: The novel nano-drug carrier constructed in this study showed good stability and blood compatibility, successfully loaded a hydrophobic anti-cancer drug, and demonstrated excellent liver cancer targeting therapy efficacy.
Article
Chemistry, Multidisciplinary
Peng Guo, Sara Busatto, Jing Huang, Golnaz Morad, Marsha A. Moses
Summary: The developed magnetic extrusion method offers a facile and scaled-up approach for preparing exosome mimetics (EMs) with similar properties and functions as native exosomes, overcoming manufacturing challenges. Additionally, engineered EMs demonstrate efficient drug delivery capabilities and tumor growth inhibition, showing promise as a biological nanomedicine for cancer drug delivery.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Jonas Schwan, Simon Markert, Sabine Rosenfeldt, Dirk Schueler, Frank Mickoleit, Anna S. Schenk
Summary: To ensure the potential applications of magnetic iron oxide nanoparticles in vitro/in vivo, their stability in different physiological fluids needs to be guaranteed. This study investigates the colloidal stabilities of commercial nanoparticles with different coatings and demonstrates that stability can be evaluated and quantified by determining the intensity-weighted average of particle sizes (Z-value). This simple quality criterion can also serve as an indicator for protein corona formation.
Article
Biochemistry & Molecular Biology
R. Shiji, Manu M. Joseph, Anitha Sen, K. Raveendran Pillai, Bs Unnikrishnan, T. T. Sreelekha
Summary: This study modified superparamagnetic iron oxide nanoparticles (SPIONs) using an eco-friendly substance extracted from pomegranate fruit peel, which resulted in tumor-targeted accumulation and improved biocompatibility. By attaching an anticancer drug to the modified nanoparticles, the drug could be selectively released in tumor cells, leading to improved tumor reduction and survival benefits. The modified nanoparticles also exhibited remarkable contrast in magnetic resonance imaging (MRI) for targeted tumor therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Kheireddine El-Boubbou, Rizwan Ali, Sulaiman Al-Humaid, Alshaimaa Alhallaj, O. M. Lemine, Mohamed Boudjelal, Abdulmohsen AlKushi
Summary: This work focuses on the fabrication and characterization of iron oxide mesoporous magnetic nanostructures (IO-MMNs), which showed high surface areas, large pore volumes, small sizes, good crystallinity, and biocompatibility. The drug-loaded IO-MMNs demonstrated significant inhibition of breast and colon cancer cells with minimal toxicity towards normal cells. These results suggest the potential use of IO-MMNs as effective drug delivery agents in cancer theranostics.
Article
Pharmacology & Pharmacy
Keristina Wagdi K. Amin, Mohamed M. Abdelghafour, Viktoria Hornok, Tamas Kiss, Diana Szabo, Laszlo Rovo, Laszlo Janovak
Summary: In this study, a stable and targeted polymeric drug delivery system with good magnetic response was developed. The system can encapsulate therapeutic agents with hydroxyl and/or amino functional groups. The release experiments showed that the free drug had a rapid release profile, while the conjugated drug had a prolonged release profile. The use of magnetic nanoparticles and PVA-SA can enable precise targeting and control of release rate, reducing unwanted side effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Indresh Kumar, Rashmi Nayak, Lal Babu Chaudhary, Vashist Narayan Pandey, Sheo K. Mishra, Narendra Kumar Singh, Abhishek Srivastava, Surendra Prasad, Radhey Mohan Naik
Summary: In this study, iron nanoparticles in the alpha-Fe2O3 phase were successfully synthesized using L-ascorbic acid as a reducing agent. The synthesized nanoparticles exhibited good morphology and stability, and showed promising biological adaptability against human carcinoma A549 lung cancer cells.
Review
Biochemical Research Methods
Aisling Fleming, Lorenzo Cursi, James A. Behan, Yan Yan, Zengchun Xie, Laurent Adumeau, Kenneth A. Dawson
Summary: This review discusses the fundamental obstacles in designing successful bionanoconstructs and emphasizes the importance of surface architecture and thorough characterization of engineered bionanoconstructs, as well as the significance of population heterogeneity in interpreting in vitro and in vivo results.
BIOCONJUGATE CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Ralf P. Friedrich, Iwona Cicha, Christoph Alexiou
Summary: The use of nanomaterials in regenerative medicine and tissue engineering has become increasingly important, particularly in treating cardiovascular, osteochondral and neurological disorders, as well as aiding organ regeneration and wound healing. Iron oxide nanoparticles (IONPs) play a crucial role in tissue engineering and cell therapy, allowing for non-invasive therapy monitoring and acceleration of regeneration through their magnetic properties and functionalization with bioactive compounds.
Article
Chemistry, Multidisciplinary
York E. Serge-Correales, David Neumeyer, Sajjad Ullah, Robert Mauricot, Qilin Zou, Sidney J. L. Ribeiro, Marc Verelst
Summary: In this study, oleic acid-stabilized ZnGa2O4 nanoparticles were successfully synthesized with controlled size and monodispersity. The size and persistent luminescence of the nanoparticles could be further increased using a seed mediated approach. Surface modification strategies involving poly(acrylic acid) or cysteamine in conjunction with BF4- provided long-term colloidal stability and enhanced persistent luminescence.
Review
Oncology
Zhi Wei Tay, Prashant Chandrasekharan, Benjamin D. Fellows, Irati Rodrigo Arrizabalaga, Elaine Yu, Malini Olivo, Steven M. Conolly
Summary: Magnetic Particle Imaging (MPI) is an emerging imaging technique that provides direct imaging of superparamagnetic iron oxide nanoparticles, showing great potential in cancer diagnosis and therapy monitoring. Different from MRI, MPI offers ideal image contrast with zero background tissue signal, enabling clear visualization of cancer. MPI enhances therapeutic precision and accuracy through magnetic means, contributing to the advancement of cancer imaging and guided therapy.
Article
Chemistry, Physical
B. Lakshmi, Pramod Gopinath
Summary: The modification of Magneto-optic Faraday Rotation (MFR) based on Surface Plasmon Resonance (SPR) of noble metal nanoparticles (NP) has been an exciting field of research. In this study, MFR measurements were conducted in magnetoplasmonic colloidal mixtures and a spectacular plasmonic enhancement of MFR was observed for the first time. The concentration of the participating systems had a strong influence on the Langevin-type MFR patterns, and a mutually dependent optimum concentration was required to achieve MFR enhancement.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Natalia Yudintceva, Ekaterina Lomert, Natalia Mikhailova, Elena Tolkunova, Nikol Agadzhanian, Konstantin Samochernych, Gabriele Multhoff, Grigoriy Timin, Vyacheslav Ryzhov, Vladimir Deriglazov, Anton Mazur, Maxim Shevtsov
Summary: The study demonstrates that MSCs have high migratory capacity towards C6 glioblastoma cells and exhibit tumor-tropism. SPION-labeled MSCs can accumulate in tumor tissues in vivo and enhance the contrast of the tumor through high-field magnetic resonance imaging. Biodistribution studies support the retention of MSCs in glioblastoma.
Article
Chemistry, Multidisciplinary
Lisa Zschiesche, Christina Janko, Bernhard Friedrich, Benjamin Frey, Julia Band, Stefan Lyer, Christoph Alexiou, Harald Unterweger
Summary: Dextran-coated superparamagnetic iron oxide nanoparticles (SPIONDex) of different sizes can be used as contrast agents in magnetic resonance imaging (MRI) without interfering with immune response.
Article
Biotechnology & Applied Microbiology
Bernhard Friedrich, Patrick Vogel, Martin A. Rueckert, Stefan Lyer, Johanna Guenther, Ulrich Wernery, Sunitha Joseph, Judith Mueller, Volker C. Behr, Christoph Alexiou, Rainer Tietze
Summary: This study utilizes a sensitive and adaptable method to detect viral antibodies in camels, using low-cost equipment. It confirms that magnetic nanoparticles can be functionalized with viral proteins, and a fast and reliable measurement can be achieved using COMPASS. This method offers a cost-effective and quickly adaptable approach for detecting viral infections.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hatice Genc, Alessandro Cianciosi, Raphael Lohse, Philipp Stahlhut, Jurgen Groll, Christoph Alexiou, Iwona Cicha, Tomasz Juengst
Summary: This study aimed to develop a suitable hydrogel-based 3D platform for long-term culture of primary endothelial cells (ECs) and fibroblasts. Two hydrogel systems, G1MM and G2LH, were cross-linked using thiol-ene click reaction. The G2LH hydrogel showed better cell- cell interactions, F-actin organization, and collagen and fibronectin production, supporting long-term culture and matrix remodeling.
Article
Nanoscience & Nanotechnology
Harald Unterweger, Christina Janko, Tamara Folk, Iwona Cicha, Noemi Kovacs, Gyula Gyebnar, Ildiko Horvath, Domokos Mathe, Kang H. Zheng, Bram F. Coolen, Erik Stroes, Janos Szebeni, Christoph Alexiou, Laszlo Dezsi, Stefan Lyer
Summary: This study compared a new iron oxide-based contrast agent, SPIONDex, with conventional contrast agents ferucarbotran and ferumoxytol. The results demonstrate that SPIONDex has better biocompatibility and immunocompatibility, and does not trigger allergic reactions. In a rat model, SPIONDex showed liver imaging properties comparable to the other two agents but with faster clearance. These findings suggest that SPIONDex is a promising candidate for further clinical translation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Bernhard Friedrich, Rainer Tietze, Michaela Duemig, Alexandru Sover, Marius-Andrei Boca, Eveline Schreiber, Julia Band, Christina Janko, Sven Krappmann, Christoph Alexiou, Stefan Lyer
Summary: Magnetic nanoparticles have been successfully utilized for rapid sample preparation and separation of pathogens, such as Candida albicans, for diagnostic purposes. By functionalizing the nanoparticles with a suitable peptide, the magnetic separation method ensures selective enrichment of the target microorganism without compromising the integrity of human blood cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Physical
Jonas Dinter, Ralf. P. P. Friedrich, Hai Yang, Christian Pilarsky, Harald Mangge, Marina Poettler, Christina Janko, Christoph Alexiou, Stefan Lyer
Summary: Pancreatic ductal adenocarcinoma is a difficult-to-treat cancer with poor long-term survival rates. In this study, a 3D cell culture model of human pancreatic ductal adenocarcinoma was used to investigate the potential use of superparamagnetic iron oxide nanoparticles (SPIONs) as a drug delivery system for the chemotherapeutic agent mitoxantrone (MTO). The results showed that MTO-loaded SPIONs induced cell death in tumor spheroids, with increased uptake in spheroids with a SMAD4 mutation. This suggests that MTO-loaded SPIONs could be a promising approach for treating pancreatic ductal adenocarcinomas.
Article
Nanoscience & Nanotechnology
Sebastian Lotter, Lukas Brand, Vahid Jamali, Maximilian Schaefer, Helene M. M. Loos, Harald Unterweger, Sandra Greiner, Jens Kirchner, Christoph Alexiou, Dietmar Drummer, Georg Fischer, Andrea Buettner, Robert Schober
Summary: Synthetic Molecular Communication (SMC) has experienced continuous growth and is considered a novel and revolutionary communication paradigm. The feedback from theoretical and experimental studies has shaped its vision, with experimental research being crucial for its practical applications. This comprehensive survey focuses on experimental research, categorizing existing works and identifying research gaps.
IEEE NANOTECHNOLOGY MAGAZINE
(2023)
Article
Biotechnology & Applied Microbiology
Jerome Grenier, Bertrand David, Clement Journe, Iwona Cicha, Didier Letourneur, Herve Duval
Summary: In this study, researchers combined porous polysaccharide-based hydrogel scaffolds with a bioreactor-type perfusion device to provide biological and mechanical stimuli for in vitro cell culture. They found that cells organized into spheroids with a diameter of 30-100 μm and were not affected by hypoxia under the perfusion rate of 10 mL/min. These findings are important for future applications in organoid research.
BIOENGINEERING-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Amani Remmo, Frank Wiekhorst, Olaf Kosch, Stefan Lyer, Harald Unterweger, Harald Kratz, Norbert Loewa
Summary: Magnetic particle imaging (MPI) is an imaging technique that quantitatively determines the three-dimensional distribution of magnetic nanoparticles (MNPs) used as tracers in biological systems. Magnetic particle spectroscopy (MPS) is a zero-dimensional counterpart of MPI without spatial coding but with higher sensitivity. MPS is typically used to qualitatively evaluate the MPI capability of tracer systems based on measured harmonic spectra. In this study, we investigated the correlation between three characteristic MPS parameters and the achievable MPI resolution using a two-voxel analysis of data from the system function acquisition in Lissajous scanning MPI. We evaluated nine different tracer systems, determined their MPI capability and resolution based on MPS measurements, and compared the results with MPI phantom measurements.
Article
Biochemistry & Molecular Biology
Hatice Genc, Bernhard Friedrich, Christoph Alexiou, Krzysztof Pietryga, Iwona Cicha, Timothy E. L. Douglas
Summary: This study evaluates the ability of whey protein isolate (WPI) hydrogels to support the growth of endothelial cells. The results demonstrate the good compatibility of WPI hydrogels with endothelial cells, which is expected to promote vascularization and improve implant outcomes.