Review
Oncology
Christof Kaltenmeier, Richard L. Simmons, Samer Tohme, Hamza O. Yazdani
Summary: Neutrophil Extracellular Traps (NETs) play a crucial role in cancer progression, particularly in promoting premetastatic niche formation, interacting with circulating cancer cells, and facilitating epithelial to mesenchymal transition during cancer metastasis. Targeting NETs may offer potential treatment options to impede tumor progression.
Review
Oncology
Urszula Demkow
Summary: This review focuses on the pro-tumorigenic action of neutrophil extracellular traps (NETs), which are found in various human and animal tumors. NETs play a crucial role in tumor development by awakening dormant cancer cells, regulating the tumor microenvironment, and enhancing tumor aggressiveness. Understanding the crosstalk between cancer and NETs can lead to novel therapeutic interventions to block cancer evasion mechanisms and prevent metastatic spread.
Review
Oncology
Yue Chen, Haoyue Hu, Songtao Tan, Qionglan Dong, Xue Fan, Yi Wang, Huan Zhang, Jun He
Summary: This review discusses the role of neutrophil extracellular traps (NETs) in cancer. Research has found that NETs are closely associated with cancer progression, metastasis, and cancer-associated thrombosis. The article summarizes the current understanding of NET formation and explores the potential applications of NETs in cancer therapy.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Biochemical Research Methods
Junho Lee, Donggu Lee, Sean Lawler, Yangjin Kim
Summary: This study investigates the mutual interactions between tumor cells and neutrophils in facilitating tumor invasion through a mathematical model. The model shows that tumor-associated neutrophils can enhance tumor cell invasion by secreting neutrophil elastase, reproducing major experimental observations and making important predictions for future experiments.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Review
Oncology
Wentao Zhong, Qianyu Wang, Xiaofei Shen, Junfeng Du
Summary: Neutrophil extracellular traps (NETs) are web-like structures composed of DNA, histones, and granule proteins released by neutrophils. They play an important role in innate immunity against pathogenic bacteria. Recent studies have shown that NETs are also involved in the progression of sterile inflammation and have been implicated in the development of cancer, particularly metastasis. Targeting NETs may be a promising treatment strategy for various types of cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Dakai Yang, Jing Liu
Summary: Neutrophil Extracellular Traps (NETs) are essential for host defense and have implications in diseases such as cancer, particularly in metastasis. Researchers are working on strategies targeting NETs in pre-clinical models and facing challenging questions in the field.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Lianghan Zhu, Zhaoting Li, Ning Liu, Honghao Sun, Yixin Wang, Minjie Sun
Summary: The study explores a protein delivery strategy using poly amino acid conjugated with polyethylene glycol (PAAP) to prevent liver metastasis by degrading chromatin and disassembling NET-DNA. This approach not only suppresses tumor growth by degrading intracellular chromatin, but also prevents liver metastasis by disassembling NET-NDA, providing potential new inspiration for patients with metastatic colon and breast cancer.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Editorial Material
Oncology
Phei Er Saw, Jianing Chen, Erwei Song
Summary: Neutrophil extracellular traps (NETs) are involved in both infection control and tumor metastasis. The study by Mousset et al. published in Cancer Cell reveals that chemotherapy-induced inflammation promotes NETosis in malignant tumors, leading to chemoresistance. This finding highlights the potential of targeting inflammatory NETs for cancer treatment.
Article
Oncology
Wei-Wei Wang, Lipei Wu, Wenying Lu, Wei Chen, Wenhui Yan, Chunrun Qi, Shihai Xuan, Anquan Shang
Summary: The study demonstrates that LPS-induced formation of NETs promotes the development and metastasis of colorectal cancer, involving the TLR9 and mitogen-activated protein kinase signaling pathway.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Oncology
Hao Zhang, Yanghanzhao Wang, Mengdi Qu, Wenqian Li, Dan Wu, Juan P. P. Cata, Changhong Miao
Summary: Sepsis is a life-threatening condition characterized by dysfunction of the immune system and multiple organ failure due to exaggerated response to infection. Endothelial dysfunction is a hallmark of sepsis. Excessive neutrophil activation and release of neutrophil extracellular traps (NETs) contribute to endothelial cell pro-inflammatory and pro-coagulant phenotype, leading to compromised microcirculation, tissue hypoperfusion, and organ failure.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Remo Poto, Leonardo Cristinziano, Luca Modestino, Amato de Paulis, Gianni Marone, Stefania Loffredo, Maria Rosaria Galdiero, Gilda Varricchi
Summary: Human neutrophils play a significant role in the host response against pathogens, and recent research has revealed their functional plasticity and involvement in cancer and angiogenesis. Neutrophils release angiogenic factors and form NETs, which promote tumor growth and metastasis through various mechanisms. Understanding the functions of NETs in cancer and angiogenesis could be important for early diagnosis, prevention, and treatment of tumors.
Article
Biochemistry & Molecular Biology
Wenyuan Zhu, Siqi Yang, Delan Meng, Qingsong Wang, Jianguo Ji
Summary: Increased neutrophil extracellular traps (NETs) formation contributes to the metastasis of colorectal cancer (CRC). This study found that neutrophils from CRC patients have enhanced NETs formation capacity and increased NETs positively correlate with CRC progression. Quantitative proteomic analysis identified decreased secreted protein acidic and rich in cysteine (SPARC) as a key factor in driving massive NETs formation, with integrin alpha 5 beta 1 being the hub protein of NETs-tumor cell interaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Zeyu Jiang, Xiangwu Chen, Yang Lin, Qian Li, Xinxin Nie, Guixiang Xu, Cancan Yu, Xinke Zhang, Yuxia Luan
Summary: A B7-H4 checkpoint-based photodynamic nanodrug combined with NETs-degrading enzyme DNase I is designed for treating immune-cold triple-negative breast cancer (TNBC). This synergistic approach enables cascade amplification of B7-H4 target-based outcomes and disrupts NETs-mediated metastasis, providing a potent strategy to reinvigorate the antitumor immune response and enhance the efficacy of TNBC immunotherapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Medicine, Research & Experimental
Tong Zhu, Xiaoming Zou, Chunfa Yang, Liangliang Li, Bing Wang, Rong Li, Hongxuan Li, Zhangxuan Xu, Di Huang, Qingyun Wu
Summary: Neutrophil extracellular traps (NETs) in gastric cancer (GC) are associated with tumor progression, metastasis risk, and tumor microenvironment. The study found that NETs formation is affected by the tumor microenvironment and may exacerbate GC progression through promoting epithelial-mesenchymal transition (EMT). Hence, targeting NETs may be therapeutically beneficial in GC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Zhengze Lu, Yang Long, Jiaxin Li, Kebai Ren, Wei Zhao, Xuhui Wang, Chunyu Xia, Yashi Wang, Man Li, Zhirong Zhang, Qin He
Summary: The developed LA/DOX NP can inhibit inflammatory cell recruitment in the liver and lungs through multiple mechanisms, block NF-kappa B and STAT3 signaling pathways, thereby shutting down inflammatory feed-forward loops, providing a new therapeutic strategy for breast cancer and its metastasis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Multidisciplinary Sciences
Pasquale Piccolo, Rosa Ferriero, Anna Barbato, Sergio Attanasio, Marcello Monti, Claudia Perna, Florie Borel, Patrizia Annunziata, Annamaria Carissimo, Rossella De Cegli, Luca Quagliata, Luigi M. Terracciano, Chantal Housset, Jeffrey H. Teckman, Christian Mueller, Nicola Brunetti-Pierri
Summary: AAT deficiency is caused by pathogenic variants in the SERPINA1 gene, with the Z allele encoding for Z alpha 1-antitrypsin leading to hepatotoxic polymers. The up-regulation of miR-34b/c in PiZ mouse livers is correlated to intrahepatic ATZ, and its expression is dependent on JNK phosphorylation on Ser574. Deletion of miR-34b/c in PiZ mice results in early liver fibrosis and increased signaling of platelet-derived growth factor.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Francesca Iommelli, Viviana De Rosa, Cristina Terlizzi, Rosa Fonti, Rosa Camerlingo, Maria Patrizia Stoppelli, C. Allison Stewart, Lauren Averett Byers, David Piwnica-Worms, Silvana Del Vecchio
Summary: Notch1 and EGFR are two different surface receptors in cancer cells, with high levels of active Notch1 leading to resistance to EGFR inhibitors by regulating the promoter activity of the EGFR gene and causing a reversible shift of driver dependence from EGFR to Notch1.
Article
Cell Biology
Alessia Varone, Chiara Amoruso, Marcello Monti, Manpreet Patheja, Adelaide Greco, Luigi Auletta, Antonella Zannetti, Daniela Corda
Summary: The research demonstrated that Shp1 plays a crucial role in invadopodia formation by promoting the dephosphorylation of cortactin, thereby reducing melanoma cancer cells' ability to degrade the extracellular matrix. Additionally, the study showed that Shp1 can be considered as a regulator of melanoma cell invasiveness and a potential target for antimetastatic drugs. Glycerophosphoinositol was found to facilitate the localization of Shp1 at invadopodia, leading to impaired invadopodia function and decreased tumor dissemination both in vitro and in an in vivo model of melanomas.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Oncology
Viviana De Rosa, Francesca Iommelli, Cristina Terlizzi, Eleonora Leggiero, Rosa Camerlingo, Giovanna G. Altobelli, Rosa Fonti, Lucio Pastore, Silvana Del Vecchio
Summary: The downregulation of PDK1 enhances cancer cell respiration and promotes apoptosis, making tumors more susceptible to tyrosine kinase inhibitors. PDK1 also drives the formation of macromolecular complexes at the ER-mitochondria interface, indirectly anchoring anti-apoptotic proteins to the mitochondrial membrane.
Article
Pharmacology & Pharmacy
Maria A. Riemma, Ida Cerqua, Barbara Romano, Elena Irollo, Antonio Bertolino, Rosa Camerlingo, Elisabetta Granato, Giuseppina Rea, Stefania Scala, Michela Terlizzi, Giuseppe Spaziano, Rosalinda Sorrentino, Bruno D'Agostino, Fiorentina Roviezzo, Giuseppe Cirino
Summary: This study found that S1P is involved in the EMT process of airway remodeling and plays a role in asthma-related airway dysfunction. Targeting the S1P/TGF-beta axis may hold promise as a therapeutic target for controlling airway dysfunction in asthma.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Iolanda Scognamiglio, Lorenza Cocca, Ilaria Puoti, Francesco Palma, Francesco Ingenito, Cristina Quintavalle, Alessandra Affinito, Giuseppina Roscigno, Silvia Nuzzo, Rosario Vincenzo Chianese, Stefania Belli, Guglielmo Thomas, Timo Schomann, Alan Chan, Maria Patrizia Stoppelli, Gerolama Condorelli
Summary: Research has shown that exosomes derived from triple-negative breast cancer cells can activate normal fibroblasts and transform them into cancer-associated fibroblasts, thereby promoting tumor invasion. These findings highlight the significant role of breast cancer cells in remodeling the tumor microenvironment and contributing to tumor evolution.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Oncology
Marianna Gallo, Marianeve Carotenuto, Daniela Frezzetti, Rosa Camerlingo, Cristin Roma, Francesca Bergantino, Nicola Normanno, Antonella De Luca
Summary: The study demonstrates that EGFR signaling induces significant changes in miRNA expression, including miR-23c, in MSCs and proposes a novel mechanism of action of miR-23c in basal/claudin-low breast cancer cell lines. These findings contribute to our understanding of the role of EGFR in breast cancer progression and the communication between MSCs and tumor cells.
Article
Medicine, Research & Experimental
Agnese Padula, Raffaella Petruzzelli, Sasha A. Philbert, Stephanie J. Church, Federica Esposito, Severo Campione, Marcello Monti, Filomena Capolongo, Claudia Perna, Edoardo Nusco, Hartmut H. Schmidt, Alberto Auricchio, Garth J. S. Cooper, Roman Polishchuk, Pasquale Piccolo
Summary: This study successfully used split intein technology to design a dual AAV vector approach for gene therapy of Wilson disease. The results demonstrated the efficacy of split intein technology in reconstituting full-length human ATP7B protein and improving liver damage and copper homeostasis in ATP7B mice.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2022)
Review
Biochemistry & Molecular Biology
Alberto Servetto, Daniela Esposito, Roberto Ferrara, Diego Signorelli, Stefania Belli, Fabiana Napolitano, Antonio Santaniello, Paola Ciciola, Luigi Formisano, Roberto Bianco
Summary: The RET oncogene is an important therapeutic target in solid malignancies, especially in thyroid cancer and non-small cell lung cancer (NSCLC). Tumors harboring RET fusion genes are particularly sensitive to RET tyrosine kinase inhibitors and exhibit distinct clinical and molecular features compared to RET fusion-negative tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Physics, Multidisciplinary
Silvana Del Vecchio, Cristina Terlizzi, Sara Pellegrino, Giovanna G. Altobelli, Rosa Fonti
Summary: The COVID-19 pandemic has had a significant impact on global health systems and cancer care. Cancer patients who contract COVID-19 are at high risk for severe outcomes, and understanding the determinants of vulnerability in these patients is crucial for clinical benefit. While the mechanisms of SARS-CoV-2 infection have been clarified, the pathways leading to severe manifestations of the disease are still largely unknown. Exploring the intersection between COVID-19 and cancer could provide insights into the pathogenesis of critical illness in COVID-19 patients.
EUROPEAN PHYSICAL JOURNAL PLUS
(2022)
Correction
Medicine, Research & Experimental
Iolanda Scognamiglio, Lorenza Cocca, Ilaria Puoti, Francesco Palma, Francesco Ingenito, Cristina Quintavalle, Alessandra Affinito, Giuseppina Roscigno, Silvia Nuzzo, Rosario Vincenzo Chianese, Stefania Belli, Guglielmo Thomas, Timo Schomann, Alan Chan, Maria Patrizia Stoppelli, Gerolama Condorelli
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Environmental Sciences
Luciana Tartaglione, Christopher R. Loeffler, Valentina Miele, Fabio Varriale, Michela Varra, Marcello Monti, Alessia Varone, Dorina Bodi, Astrid Spielmeyer, Samuela Capellacci, Antonella Penna, Carmela Dell'Aversanoa
Summary: Marine toxins have a significant impact on seafood resources and human health. This study focused on screening and identifying bioactive compounds produced by Gambierdiscus balechii, a toxic microalgae species, using liquid chromatography-high resolution mass spectrometry and in vitro cell-based bioassays. The study identified CTX-like and MTX-like toxicity in fractions of the algal extract, and confirmed the presence of a putative I/C-CTX congener. This research has important implications for understanding ciguatera poisoning and developing analytical methods for its detection.
Review
Oncology
Claudia Maria Ascione, Fabiana Napolitano, Daniela Esposito, Alberto Servetto, Stefania Belli, Antonio Santaniello, Sarah Scagliarini, Felice Crocetto, Roberto Bianco, Luigi Formisano
Summary: Bladder cancer is a heterogeneous malignancy and FGFR3 genomic alterations have emerged as potent oncogenic drivers. In this review, the role of FGFR3 in bladder cancer and the state-of-art of anti-FGFR3 treatment are summarized. Additionally, the clinical and molecular features of FGFR3-altered bladder cancers are investigated.
CANCER TREATMENT REVIEWS
(2023)
Article
Oncology
Angel Guerrero-Zotano, Stefania Belli, Christoph Zielinski, Miguel Gil-Gil, Antonio Fernandez-Serra, Manuel Ruiz-Borrego, Eva Maria Ciruelos Gil, Javier Pascual, Montserrat Munoz-Mateu, Begon Bermejo, Mireia Margeli Vila, Antonio Anton, Laura Murillo, Bella Nissenbaum, Yuan Liu, Jesus Herranz, Daniel Fernandez-Garcia, Rosalia Caballero, Jose Antonio Lopez-Guerrero, Roberto Bianco, Luigi Formisano, Nicholas Turner, Miguel Martin
Summary: In patients with hormone receptor-positive (HR+)/HER2- metastatic breast cancer, non-luminal subtype and high CCNE1 expression are associated with resistance to cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) and poor response to treatment. Furthermore, high levels of the Polo-like kinase 1 (PLK1) mRNA indicate resistance to palbociclib, suggesting that PLK1 may play a role in CDK4/6i resistance. These findings highlight the need for validation of these biomarkers and the exploration of PLK1 as a therapeutic target.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Stefania Belli, Daniela Esposito, Alessandra Allotta, Alberto Servetto, Paola Ciciola, Ada Pesapane, Claudia M. Ascione, Fabiana Napolitano, Concetta Di Mauro, Elena Vigliar, Antonino Iaccarino, Carmine De Angelis, Roberto Bianco, Luigi Formisano
Summary: Resistance to ER antagonists in combination with CDK4/6 inhibitors in ER+ breast cancers is associated with up-regulation of MAPK and EMT pathways, with Pak1 playing a pivotal role. Inhibiting Pak1 could be a promising strategy to overcome resistance in these patients.