期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 15, 期 11, 页码 19791-19815出版社
MDPI
DOI: 10.3390/ijms151119791
关键词
angiogenesis; HIF-1 alpha; HIF-2 alpha; hypoxia; tissue engineering; wound healing
资金
- Netherlands Institute for Regenerative Medicine (NIRM)
In patients with chronic wounds, autologous tissue repair is often not sufficient to heal the wound. These patients might benefit from regenerative medicine or the implantation of a tissue-engineered scaffold. Both wound healing and tissue engineering is dependent on the formation of a microvascular network. This process is highly regulated by hypoxia and the transcription factors hypoxia-inducible factors-1 alpha ( HIF-1 alpha) and -2 alpha ( HIF-2 alpha). Even though much is known about the function of HIF-1 alpha in wound healing, knowledge about the function of HIF-2 alpha in wound healing is lacking. This review focuses on the function of HIF-1 alpha and HIF-2 alpha in microvascular network formation, wound healing, and therapy strategies.
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