Blocking the Function of Inflammatory Cytokines and Mediators by Using IL-10 and TGF-β: A Potential Biological Immunotherapy for Intervertebral Disc Degeneration in a Beagle Model

Detrimental effects of discectomy on intervertebral disc biology can be decelerated by growth factor treatment during surgery: a large animal organ culture model

(2014) Svenja Illien-Jünger et al.   Spine Journal

Inflammatory Cytokines Associated with Degenerative Disc Disease Control Aggrecanase-1 (ADAMTS-4) Expression in Nucleus Pulposus Cells through MAPK and NF-κB

(2013) Ye Tian et al.   AMERICAN JOURNAL OF PATHOLOGY

A role for TNFα in intervertebral disc degeneration: A non-recoverable catabolic shift

(2013) D. Purmessur et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synergistic Effect of Combined Growth Factors in Porcine Intervertebral Disc Degeneration

(2013) Hongsik Cho et al.   CONNECTIVE TISSUE RESEARCH

Role of cytokines in intervertebral disc degeneration: pain and disc content

(2013) Makarand V. Risbud et al.   Nature Reviews Rheumatology

Degenerative Grade Affects the Responses of Human Nucleus Pulposus Cells to Link-N, CTGF, and TGFβ3

(2012) Rosalyn D. Abbott et al.   JOURNAL OF SPINAL DISORDERS & TECHNIQUES

TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc

(2011) Jianru Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium pentosan polysulfate and sodium pentosan polysulfate may be used to treat intervertebral disc degeneration

(2011) Jia-Guo Zhao et al.   MEDICAL HYPOTHESES

Annulus Fibrosus Cells Interact With Neuron-Like Cells to Modulate Production of Growth Factors and Cytokines in Symptomatic Disc Degeneration

(2011) Hong Joo Moon et al.   SPINE

Degeneration and regeneration of the intervertebral disc: lessons from development

(2010) L. J. Smith et al.   Disease Models & Mechanisms

The Effect of Relative Needle Diameter in Puncture and Sham Injection Animal Models of Degeneration

(2009) Dawn M. Elliott et al.   SPINE

Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration

(2009) S Jane Millward-Sadler et al.   ARTHRITIS RESEARCH & THERAPY

Tissue engineering and the intervertebral disc: the challenges

(2008) Rita Kandel et al.   EUROPEAN SPINE JOURNAL

Future perspectives of cell-based therapy for intervertebral disc disease

(2008) Daisuke Sakai   EUROPEAN SPINE JOURNAL

Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc

(2008) J. A. Hoyland et al.   RHEUMATOLOGY

The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain

(2008) A. J. Freemont   RHEUMATOLOGY

The Action of Resveratrol, a Phytoestrogen Found in Grapes, on the Intervertebral Disc

(2008) Xin Li et al.   SPINE