Article
Multidisciplinary Sciences
Minsu Jang, Rackhyun Park, Ayane Yamamoto, Yea-In Park, Yeonjeong Park, Siyun Lee, Junsoo Park
Summary: A study has found that an inhibitor called compound C can effectively inhibit the replication of the human coronavirus OC43 strain. This finding suggests that compound C may be a potential drug candidate for COVID-19.
Article
Biochemistry & Molecular Biology
Mina Jang, Shuta Hara, Gun-Hee Kim, Seung Min Kim, Sangkeun Son, Mincheol Kwon, In-Ja Ryoo, Hyemin Seo, Min Jung Kim, Nam-Doo Kim, Nak-Kyun Soung, Yong Tae Kwon, Bo Yeon Kim, Hiroyuki Osada, Jae-Hyuk Jang, Sung-Kyun Ko, Jong Seog Ahn
Summary: The study demonstrates a novel autophagy enhancer, dutomycin (DTM), that induces autophagy and eventually apoptosis by activating serine protease inhibitor B6 (SERPINB6). The inhibitory effects of DTM on SERPINB6 function were confirmed, and this research provides new insights for future studies on the relationship between cancer and autophagy.
ACS CHEMICAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jingwen Ma, Yan Teng, Youming Huang, Xiaohua Tao, Yibin Fan
Summary: This article discusses the characteristics of photoaging and the protective role of autophagy in skin cells damaged by UV radiation. Autophagy is a crucial cellular process that clears or recycles damaged components in cells, playing a key role in cell survival and adaptive responses.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yen-Tze Liu, Hsin-Yu Ho, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: Platyphyllenone can induce both autophagy and apoptosis in oral cancer cells by regulating multiple signaling pathways, providing a potential therapeutic option for chemoprevention against oral cancer proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Shuo Yang, Long Wang, Yuesong Wu, Anguo Wu, Feihong Huang, Xiaoqin Tang, Fahsai Kantawong, Songyot Anuchapreeda, Dalian Qin, Qibing Mei, Jianping Chen, Xinwu Huang, Chunxiang Zhang, Jianming Wu
Summary: This review discusses the controversy surrounding the role of apoptosis in platelet production. While some researchers believe that apoptosis is necessary for platelet generation, others argue that it is dispensable or even inhibited. The review also explores why there are conflicting conclusions regarding the role of apoptosis in thrombopoiesis and attempts to uncover the truth behind this mystery. By examining the relationship between apoptosis, megakaryocytopoiesis, and thrombopoiesis, the review provides comprehensive insights into the possible pathological mechanisms of platelet disorders caused by abnormal apoptosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Elizaveta Belyaeva, Nina Loginova, Brett A. Schroeder, Ian S. Goldlust, Arbind Acharya, Sandeep Kumar, Peter Timashev, Ilya Ulasov
Summary: The balance between cell death and cell survival involves the breakdown and removal of unnecessary or harmful materials in a controlled manner. Autophagy, initiated by various stresses, is a well-regulated process with specific genes and proteins. Targeting autophagy shows promise as an anti-tumor therapy, but its effects on different tumor cells remain unclear. This review investigates autophagy as a potential therapeutic target for aggressive sarcomas.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Hongyan Xi, Shuo Wang, Beibei Wang, Xuelan Hong, Xueping Liu, Meichao Li, Ruxia Shen, Qixiu Dong
Summary: Autophagy and apoptosis are important cellular processes that are closely connected and mutually regulated. The balance between autophagy and apoptosis is crucial for cell functionality and survival. Disruption of this balance can lead to disease, particularly tumor formation.
Article
Multidisciplinary Sciences
Tian-jiao Song, Xiao-hong Lin, Ping-ting Huang, Yu-qing Chen, Li-min Chen
Summary: Lung cancer is a malignant tumor with high morbidity and mortality rates worldwide. The current chemotherapy for lung cancer is ineffective due to drug resistance. Tripchlorolide (T4), a natural extract, has been found to have immunosuppressive and antitumor effects, making it a potential therapeutic agent for lung cancer. This study investigated the effect of T4 on reducing chemoresistance in lung cancer cells and explored the underlying mechanism. The results showed that T4 can increase the sensitivity of lung cancer cells to cisplatin, a chemotherapy drug, by reducing the expression of AEG-1 protein.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Michael S. Dahabieh, Fan Huang, Christophe Goncalves, Raul Ernesto Flores Gonzalez, Sathyen Prabhu, Alicia Bolt, Erminia Di Pietro, Elie Khoury, John Heath, Zi Yi Xu, Joelle Remy-Sarrazin, Koren K. Mann, Alexandre Orthwein, Francois-Michel Boisvert, Nancy Braverman, Wilson H. Miller, Sonia V. del Rincon
Summary: Promoting autophagy-mediated degradation of specific proteins and organelles can induce apoptosis in cancer cells or sensitize them to therapy. Targeting peroxisome homeostasis through increased pexophagy can enhance sensitivity to treatment, as shown in lymphoma, lung cancer, and melanoma models.
Review
Oncology
Margarita Kamynina, Salome Tskhovrebova, Jawad Fares, Peter Timashev, Anastasia Laevskaya, Ilya Ulasov
Summary: Glioblastoma (GBM) is the most common and aggressive brain tumor with limited therapeutic options. Gene therapies using self-replicating oncolytic viruses may advance GBM treatment. Autophagy in glioblastoma plays a dual role in cell death and survival.
Article
Medicine, General & Internal
Xing Li, Lijiang Gu, Yuhang Chen, Xiaobing Wang, Yibo Mei, Jinlai Zhou, Minghai Ma, Jianbin Ma, Yue Chong, Xinyang Wang, Peng Guo, Dalin He, Jin Zeng
Summary: The study found that the novel 450-nm laser-mediated DVDMS-based photodynamic therapy (PDT) can inhibit and induce apoptosis in gastric cancer cells by producing excessive reactive oxygen species (ROS). Additionally, PDT also promoted apoptosis in gastric cancer cells through the autophagy pathway. Furthermore, the study identified the involvement of the ROS/PI3K/Akt/mTOR pathway in the regulation of PDT-induced autophagy.
Article
Engineering, Biomedical
X. Wei, Z. Tang, H. Wu, X. Zuo, H. Dong, L. Tan, W. Wang, Y. Liu, Z. Wu, L. Shi, N. Wang, X. Li, X. Xiao, Z. Guo
Summary: The study determined the importance of the proper concentration of released magnesium ions for inhibiting osteosarcoma and ensuring biosafety, demonstrating the anti-osteosarcoma effects of magnesium-coated Ti6Al4V scaffolds, which may contribute to further clinical application.
MATERIALS TODAY BIO
(2021)
Article
Cell Biology
Zhuochao Liu, Hongyi Wang, Chuanzhen Hu, Chuanlong Wu, Jun Wang, Fangqiong Hu, Yucheng Fu, Junxiang Wen, Weibin Zhang
Summary: The study demonstrated that atezolizumab can induce mitochondrial-related apoptosis and protective autophagy independently of the immune system, and combining atezolizumab with autophagy inhibitors significantly enhances its cytotoxic effect on osteosarcoma cells.
CELL DEATH & DISEASE
(2021)
Retraction
Chemistry, Multidisciplinary
Laura Fisher
Summary: The study made progress in inhibiting endoplasmic reticulum stress, but for some reasons, the article was eventually retracted.
Article
Medicine, General & Internal
Changqing Ma, Chad E. Storer, Uma Chandran, William A. LaFramboise, Patricia Petrosko, Madison Frank, Douglas J. Hartman, Liron Pantanowitz, Talin Haritunians, Richard D. Head, Ta-Chiang Liu
Summary: Individuals with the ATG16L1 T300A genotype in gastric carcinoma show suppressed EGFR and PPAR pathways, increased tumor apoptosis, and improved overall survival. Genotyping gastric cancer patients may offer additional insights for clinical stratification.
Review
Medicine, Research & Experimental
Sheng-Fan Wang, Shiuan Chen, Ling-Ming Tseng, Hsin-Chen Lee
EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Article
Medicine, General & Internal
Tzu-Ting Huang, Ling-Ming Tseng, Ji-Lin Chen, Pei-Yi Chu, Chia-Han Lee, Chun-Teng Huang, Wan-Lun Wang, Ka-Yi Lau, Mei-Fang Tseng, Yuan-Ya Chang, Tzu-Yi Chiang, Yune-Fang Ueng, Hsin-Chen Lee, Ming-Shen Dai, Chun-Yu Liu
Article
Oncology
I-Han Wang, Tzu-Ting Huang, Ji-Lin Chen, Li-Wei Chu, Yueh-Hsin Ping, Kai-Wen Hsu, Kuo-Hung Huang, Wen-Liang Fang, Hsin-Chen Lee, Chian-Feng Chen, Chen-Chung Liao, Rong-Hong Hsieh, Tien-Shun Yeh
Article
Medicine, General & Internal
Abdul Aziz Mohamed Yusoff, Siti Zulaikha Nashwa Mohd Khair, Siti Muslihah Abd Radzak, Zamzuri Idris, Hsin-Chen Lee
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2020)
Article
Cell Biology
Mei-Chun Chen, Li-Lin Hsu, Sheng-Fan Wang, Chih-Yi Hsu, Hsin-Chen Lee, Ling-Ming Tseng
Article
Clinical Neurology
Shih-Pin Chen, Yi-An Chang, Chih-Hung Chou, Chi-Chang Juan, Hsin-Chen Lee, Luen-Kui Chen, Pei-Chun Wu, Yen-Feng Wang, Jong-Ling Fuh, Jiing-Feng Lirng, Anne Ducros, Hsien-Da Huang, Shuu-Jiun Wang
Summary: This study identified a panel of miRNAs that distinguished patients with RCVS from controls, with let-7a-5p, let-7b-5p, and let-7f-5p showing higher abundance in patients with ictal migraine. Target prediction and pathway analysis suggested their involvement in RCVS pathogenesis, which was confirmed in vitro. MiR-130a-3p was associated with disruption of the blood-brain barrier and increased permeability in a human BBB model.
ANNALS OF NEUROLOGY
(2021)
Article
Oncology
Chun-Yu Liu, Tzu-Ting Huang, Ji-Lin Chen, Pei-Yi Chu, Chia-Han Lee, Hsin-Chen Lee, Yu-Hsuan Lee, Yuan-Ya Chang, Shung-Haur Yang, Jeng-Kai Jiang, Wei-Shone Chen, Yee Chao, Hao-Wei Teng
Summary: High expression of KMO in CRC is associated with higher metastasis and poorer survival rates. Knockdown of KMO reduces the expression of cancer stem cell markers and the invasion abilities of CRC cells, while inhibition of KMO enzymatic activity suppresses CRC cell motility.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mei-Chun Chen, Li-Lin Hsu, Sheng-Fan Wang, Yi-Ling Pan, Jeng-Fan Lo, Tien-Shun Yeh, Ling-Ming Tseng, Hsin-Chen Lee
Summary: This study revealed that activation of the integrated stress response (ISR) through salubrinal under glucose deprivation conditions increased cancer cell death by upregulating xCT and inducing mitochondrial oxidative stress.
Article
Oncology
Sheng-Fan Wang, Yuh-Lih Chang, Yen-Dun Tzeng, Chun-Ling Wu, Yuan-Zhong Wang, Ling-Ming Tseng, Shiuan Chen, Hsin-Chen Lee
Summary: The study highlights the association between mitochondrial alterations and AI resistance in breast cancer patients, indicating that changes in mitochondrial function could impact patient prognosis. Induction of drug resistance in breast cancer cells through mitochondrial stress adaptation, possibly due to the activation of the AREG-ER alpha loop signaling, suggest potential treatment targets for overcoming AI resistance.
Article
Oncology
Sheng-Fan Wang, Yuh-Lih Chang, Wen-Liang Fang, Anna Fen-Yau Li, Chian-Feng Chen, Tien-Shun Yeh, Giun-Yi Hung, Kuo-Hung Huang, Hsin-Chen Lee
Summary: This study investigates the role of growth differentiation factor 15 (GDF15) in chemoresistance of gastric cancer. The results demonstrate that GDF15 serum levels can serve as a valuable biomarker for predicting prognosis in gastric cancer. Additionally, GDF15 upregulation is associated with cisplatin resistance in gastric cancer cells by increasing intracellular glutathione (GSH) content and antioxidant activities.
Review
Endocrinology & Metabolism
Sheng-Fan Wang, Yi-Sheng Lin, Wan-Yu Yeh, Yuh-Lih Chang, Chern-En Chiang, Chen-Huan Chen, Ling-Ming Tseng, Hsin-Chen Lee, Chun-Yu Liu, Hao-Min Cheng
Summary: This study summarizes the clinical effects of antiresorptive agents in patients with early breast cancer receiving endocrine therapy. The results show that antiresorptive agents have significant clinical benefits on disease recurrence and locoregional recurrence in these patients. However, there is a potential risk of osteonecrosis of the jaw with the use of these agents.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Oncology
Sheng-Fan Wang, Kuan-Wei Huang, Yueh-Ching Chou, Hsin-Chen Lee, Po-Kuei Wu, Wei-Ming Chen, Giun-Yi Hung, Yuh-Lih Chang
Summary: Taiwanese patients receiving high-dose methotrexate (HD-MTX) treatment often experience severe hepatotoxicity, which affects subsequent treatment. Co-administration of proton pump inhibitors (PPIs), trimethoprim-sulfamethoxazole (TMP-SMX), or non-steroidal anti-inflammatory drugs (NSAIDs) with MTX can lead to drug-drug interactions. However, limited real-world analyses have been conducted on the effects of these co-medications and other potential risk factors on HD-MTX-mediated acute hepatotoxicity in patients with osteogenic sarcoma (OGS) in East Asia.
Review
Cell Biology
Sheng-Fan Wang, Ling-Ming Tseng, Hsin-Chen Lee
Summary: Dysregulating cellular metabolism is an emerging cancer hallmark, and mitochondria play a crucial role in cancer progression. This review discusses the alterations in mitochondrial DNA and dynamics in cancer, as well as the regulatory mechanisms of mitochondrial dysfunction-mediated retrograde signaling pathways. It also explores the impact of mitochondria on immune regulation and the potential of targeting mitochondria and metabolism for cancer immunotherapy.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sheng-Fan Wang, Yuh-Lih Chang, Ting-Yu Liu, Kuo-Hung Huang, Wen-Liang Fang, Anna Fen-Yau Li, Tien-Shun Yeh, Giun-Yi Hung, Hsin-Chen Lee
Summary: This study found that high expression of GDF15 protein may increase disease recurrence in adjuvant chemotherapy-treated gastric cancer patients. Additionally, treatment with mitochondrial inhibitors can upregulate GDF15 and enhance cisplatin insensitivity in human gastric cancer cells. Mechanistically, the activating transcription factor 4-C/EBP homologous protein pathway plays a crucial role in the heightened manifestation of GDF15. This research reveals that mitochondrial dysfunction enhances cisplatin insensitivity through GDF15 upregulation.
Article
Allergy
Vincent Yi-Fong Su, Szu-Wen Ko, Yuh-Lih Chang, Yueh-Ching Chou, Hsin-Chen Lee, Kuang-Yao Yang, Kun-Ta Chou, Chia-Chen Hsu
Summary: This study found that cardioselective beta-blockers, ARBs, and DHP CCB therapies may lower the risk of acute exacerbation in patients with ACO.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2022)