The Immunomodulatory and Neuroprotective Effects of Mesenchymal Stem Cells (MSCs) in Experimental Autoimmune Encephalomyelitis (EAE): A Model of Multiple Sclerosis (MS)

Essential Role of CD8+CD122+ Regulatory T Cells in the Recovery from Experimental Autoimmune Encephalomyelitis

(2014) Y.-H. Lee et al.   JOURNAL OF IMMUNOLOGY

Swift Entry of Myelin-Specific T Lymphocytes into the Central Nervous System in Spontaneous Autoimmune Encephalomyelitis

(2014) G. C. Furtado et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Th1 Cells Facilitate the Entry of Th17 Cells to the Central Nervous System during Experimental Autoimmune Encephalomyelitis

(2014) R. A. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Dopaminergic differentiation of neural progenitors derived from placental mesenchymal stem cells in the brains of Parkinson's disease model rats and alleviation of asymmetric rotational behavior

(2012) Saeyoung Park et al.   BRAIN RESEARCH

Transplantation of Placenta-Derived Mesenchymal Stem Cells in the EAE Mouse Model of MS

(2012) Yonit Fisher-Shoval et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Senescence-associated intrinsic mechanisms of osteoblast dysfunctions

(2011) Moustapha Kassem et al.   AGING CELL

Human Mesenchymal Stem Cells Are Susceptible to Lysis by CD8+ T Cells and NK Cells

(2011) Meindert J. Crop et al.   CELL TRANSPLANTATION

Variable behavior and complications of autologous bone marrow mesenchymal stem cells transplanted in experimental autoimmune encephalomyelitis

(2011) Nikolaos Grigoriadis et al.   EXPERIMENTAL NEUROLOGY

Immunological Aspects of Allogeneic and Autologous Mesenchymal Stem Cell Therapies

(2011) M.J. Hoogduijn et al.   HUMAN GENE THERAPY

Scientists Probe Strategies to Repair Neuron Damage in Multiple Sclerosis

(2011) Bridget M. Kuehn   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Immunoregulatory function of bone marrow mesenchymal stem cells in EAE depends on their differentiation state and secretion of PGE2

(2011) Mariola Matysiak et al.   JOURNAL OF NEUROIMMUNOLOGY

Long-Lasting Inhibitory Effects of Fetal Liver Mesenchymal Stem Cells on T-Lymphocyte Proliferation

(2011) Massimo Giuliani et al.   PLoS One

Human Endometrial-Derived Mesenchymal Stem Cells Suppress Inflammation in the Central Nervous System of EAE Mice

(2011) J. P. S. Peron et al.   Stem Cell Reviews and Reports

Immunosuppressive Properties of Mesenchymal Stem Cells

(2011) Mohamed Abumaree et al.   Stem Cell Reviews and Reports

Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells

(2010) Amber Wilson et al.   BMC GENOMICS

Immunogenicity and Immunomodulatory Properties of Umbilical Cord Lining Mesenchymal Stem Cells

(2010) Tobias Deuse et al.   CELL TRANSPLANTATION

Isolation of Mesenchymal Stem Cells with Neurogenic Potential from the Mesoderm of the Amniotic Membrane

(2010) Yu-Jen Chang et al.   CELLS TISSUES ORGANS

Mesenchymal stromal cells transiently alter the inflammatory milieu post-transplant to delay graft-versus-host disease

(2010) M. E. Christensen et al.   HAEMATOLOGICA

Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions

(2010) K. Schallmoser et al.   HAEMATOLOGICA

Age-related changes in osteogenic stem cells in mice

(2010) R.J. Bergman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The role of dendritic cells in CNS autoimmunity

(2010) Alla L. Zozulya et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Human Mesenchymal Stem Cells Infiltrate the Spinal Cord, Reduce Demyelination, and Localize to White Matter Lesions in Experimental Autoimmune Encephalomyelitis

(2010) David Gordon et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Immunomodulatory Properties of Mesenchymal Stem Cells Derived from Dental Pulp and Dental Follicle are Susceptible to Activation by Toll-Like Receptor Agonists

(2010) Sergej Tomic et al.   STEM CELLS AND DEVELOPMENT

Survival and Neuronal Differentiation of Mesenchymal Stem Cells Transplanted into the Rodent Brain Are Dependent upon Microenvironment

(2010) Guilherme Lepski et al.   TISSUE ENGINEERING PART A

Different Facets of Aging in Human Mesenchymal Stem Cells

(2010) Wolfgang Wagner et al.   TISSUE ENGINEERING PART B-REVIEWS

Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T cell proliferation and collagen-induced arthritis

(2010) Evelien Schurgers et al.   ARTHRITIS RESEARCH & THERAPY

DNA methylation pattern changes upon long-term culture and aging of human mesenchymal stromal cells

(2009) Simone Bork et al.   AGING CELL

Multipotent mesenchymal stem cells from human placenta: critical parameters for isolation and maintenance of stemness after isolation

(2009) Oleg V. Semenov et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Pathogenic CD8+T cells in multiple sclerosis

(2009) Manuel A. Friese et al.   ANNALS OF NEUROLOGY

T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-β

(2009) Luca Durelli et al.   ANNALS OF NEUROLOGY

Effects of human marrow stromal cells on activation of microglial cells and production of inflammatory factors induced by lipopolysaccharide

(2009) Chang Zhou et al.   BRAIN RESEARCH

Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

(2009) Ryang Hwa Lee et al.   Cell Stem Cell

Transplantation of Allogeneic and Xenogeneic Placenta-Derived Cells Reduces Bleomycin-Induced Lung Fibrosis

(2009) Anna Cargnoni et al.   CELL TRANSPLANTATION

Mesenchymal Stem Cells Promote Oligodendroglial Differentiation in Hippocampal Slice Cultures

(2009) Francisco J. Rivera et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Reciprocal effect of mesenchymal stem cell on experimental autoimmune encephalomyelitis is mediated by transforming growth factor-β and interleukin-6

(2009) X.-J. Liu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mesenchymal cells inhibit expansion but not cytotoxicity exerted by gamma-delta T cells

(2009) I. Petrini et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Novel CD8+Treg suppress EAE by TGF-β- and IFN-γ-dependent mechanisms

(2009) Mei-Ling Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mesenchymal stem cells suppress B-cell terminal differentiation

(2009) Sadaki Asari et al.   EXPERIMENTAL HEMATOLOGY

Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis

(2009) Lianhua Bai et al.   GLIA

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Th9 and allergic disease

(2009) Pejman Soroosh et al.   IMMUNOLOGY

IL-9 as a mediator of Th17-driven inflammatory disease

(2009) Elizabeth C. Nowak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Inhibiting CD4 Th17 T Cells in a CC Chemokine Ligand 2-Dependent Manner

(2009) Moutih Rafei et al.   JOURNAL OF IMMUNOLOGY

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

Helminth Antigens Modulate Immune Responses in Cells from Multiple Sclerosis Patients through TLR2-Dependent Mechanisms

(2009) J. Correale et al.   JOURNAL OF IMMUNOLOGY

Comparison of Cytokine Expression in Mesenchymal Stem Cells from Human Placenta, Cord Blood, and Bone Marrow

(2009) Jong Ha Hwang et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Intracerebroventricular Transplantation of Human Mesenchymal Stem Cells Induced to Secrete Neurotrophic Factors Attenuates Clinical Symptoms in a Mouse Model of Multiple Sclerosis

(2009) Yael Barhum et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effectin vivo

(2009) Cristina Lanza et al.   JOURNAL OF NEUROCHEMISTRY

Allogeneic Mesenchymal Stem Cells for Treatment of Experimental Autoimmune Encephalomyelitis

(2009) Moutih Rafei et al.   MOLECULAR THERAPY

In the beginning

(2009) Richard M. Ransohoff   NATURE

Angiogenesis in Differentiated Placental Multipotent Mesenchymal Stromal Cells Is Dependent on Integrin α5β1

(2009) Ming-Yi Lee et al.   PLoS One

Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord, and placenta: Implication in the migration

(2009) Guo Li et al.   PROTEOMICS

Human bone marrow-derived mesenchymal stem cells secrete brain-derived neurotrophic factor which promotes neuronal survival in vitro

(2009) Alastair Wilkins et al.   Stem Cell Research

Adipose-Derived Mesenchymal Stem Cells Ameliorate Chronic Experimental Autoimmune Encephalomyelitis

(2009) Gabriela Constantin et al.   STEM CELLS

Cotransplantation of Placental Mesenchymal Stromal Cells Enhances Single and Double Cord Blood Engraftment in Nonobese Diabetic/Severe Combined Immune Deficient Mice

(2009) Smita D Hiwase et al.   STEM CELLS

The Negative Co-Signaling Molecule B7-H4 Is Expressed by Human Bone Marrow–Derived Mesenchymal Stem Cells and Mediates its T-Cell Modulatory Activity

(2009) Qun Xue et al.   STEM CELLS AND DEVELOPMENT

Immunomodulatory effects of mesenchymal stem cells involved in favoring type 2 T cell subsets

(2009) Xiaoxi Lu et al.   TRANSPLANT IMMUNOLOGY

Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts

(2008) Shuanhu Zhou et al.   AGING CELL

Homogeneity of active demyelinating lesions in established multiple sclerosis

(2008) Esther C. W. Breij et al.   ANNALS OF NEUROLOGY

Human bone marrow mesenchymal stem cells and chondrocytes promote and/or suppress the in vitro proliferation of lymphocytes stimulated by interleukins 2, 7 and 15

(2008) C Bocelli-Tyndall et al.   ANNALS OF THE RHEUMATIC DISEASES

Neuroprotection and Immunomodulation With Mesenchymal Stem Cells in Chronic Experimental Autoimmune Encephalomyelitis

(2008) Ibrahim Kassis et al.   ARCHIVES OF NEUROLOGY

Impact of myelin-specific antigen presenting B cells on T cell activation in multiple sclerosis

(2008) Christopher T. Harp et al.   CLINICAL IMMUNOLOGY

IL-10 suppressor activity andex vivo Tr1 cell function are impaired in multiple sclerosis

(2008) Ivan Martinez-Forero et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adipose-Derived Mesenchymal Stem Cells Alleviate Experimental Colitis by Inhibiting Inflammatory and Autoimmune Responses

(2008) Manuel A. González et al.   GASTROENTEROLOGY

Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti-inflammatory action

(2008) You-Joung Kim et al.   GLIA

Engraftment potential of human placenta-derived mesenchymal stem cells after in utero transplantation in rats

(2008) Chie-Pein Chen et al.   HUMAN REPRODUCTION

Th17 cells in human disease

(2008) Laura A. Tesmer et al.   IMMUNOLOGICAL REVIEWS

T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis

(2008) Chris J. Hedegaard et al.   IMMUNOLOGY

Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE

(2008) Marloes van Zwam et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Overexpression of CNTF in Mesenchymal Stem Cells reduces demyelination and induces clinical recovery in experimental autoimmune encephalomyelitis mice

(2008) Zhengqi Lu et al.   JOURNAL OF NEUROIMMUNOLOGY

Autoantibodies and neurodegeneration in multiple sclerosis

(2008) Tamara Vyshkina et al.   LABORATORY INVESTIGATION

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Environmental factors and multiple sclerosis

(2008) George C Ebers   LANCET NEUROLOGY

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY

Novel therapeutic strategies for multiple sclerosis — a multifaceted adversary

(2008) Rocio S. Lopez-Diego et al.   NATURE REVIEWS DRUG DISCOVERY

Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis

(2008) A. Vercelli et al.   NEUROBIOLOGY OF DISEASE

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses

(2008) H. Ohtaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Trafficking Mechanisms of Multipotent Mesenchymal Stem Cells Derived from Human Bone Marrow and Placenta

(2008) Gary Brooke et al.   STEM CELLS AND DEVELOPMENT

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

(2007) John S. Tzartos et al.   AMERICAN JOURNAL OF PATHOLOGY

Compromised CD4+ CD25highregulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

(2007) Koen Venken et al.   IMMUNOLOGY

Immunomodulation and neuroprotection with mesenchymal bone marrow stem cells (MSCs): A proposed treatment for multiple sclerosis and other neuroimmunological/neurodegenerative diseases

(2007) Dimitrios Karussis et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Allogeneic mesenchymal stem cell and mesenchymal stem cell-differentiated chondrocyte suppress the responses of type II collagen-reactive T cells in rheumatoid arthritis.

(2007) Z. H. Zheng et al.   RHEUMATOLOGY