期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 158, 期 1, 页码 37-44出版社
WILEY
DOI: 10.1111/j.1365-2249.2009.03995.x
关键词
experimental autoimmune encephalomyelitis; mesenchymal stem cells; transforming growth factor-beta; interleukin-6; T-reg; Th17
类别
资金
- Harbin Medical University [060031]
- National 15 Hightech project [2004BA745C]
- Ministry of Education [20050226001]
- Education Department of Heilongjiang Province [11531z16]
- Heilongjiang Provincial Science and Technology [QC07C66]
P>Mesenchymal stem cells (MSCs) have the ability to suppress T cell proliferation and modulate cytokine production. Recently, MSCs have been shown to ameliorate autoimmune diseases such as experimental autoimmune encephalomyelitis (EAE), but in some cases shown to stimulate lymphocyte proliferation. So far, mechanisms through which MSCs modulate immune reactions are still undefined. In this report we demonstrate that MSCs have the capacity for either stimulating or inhibiting myelin basic protein-specific T lymphocytes in a dose-dependent manner and modulate antigen-stimulated T cells to differentiate into either T helper type 17 or regulatory T cells, respectively, via pathways involving transforming growth factor-beta and interleukin-6. These results may lead better utility of MSCs as a treatment for autoimmune disease.
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