Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

ATP-dependent and independent functions of Rad54 in genome maintenance

(2011) Sheba Agarwal et al.   JOURNAL OF CELL BIOLOGY

Hsp90 Inhibitor-Mediated Disruption of Chaperone Association of ATR with Hsp90 Sensitizes Cancer Cells to DNA Damage

(2011) K. Ha et al.   MOLECULAR CANCER THERAPEUTICS

Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition

(2011) P. M. Krawczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction

(2010) L Stingl et al.   BRITISH JOURNAL OF CANCER

Implication of Heat Shock Protein 90 (HSP90) in Tumor Angiogenesis: A Molecular Target for Anti-Angiogenic Therapy?

(2010) K. Staufer et al.   CURRENT CANCER DRUG TARGETS

Heat shock proteins in breast cancer progression–A suitable case for treatment?

(2010) Stuart K. Calderwood   INTERNATIONAL JOURNAL OF HYPERTHERMIA

Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study

(2010) Rolf D Issels et al.   LANCET ONCOLOGY

Phosphotyrosine Confers Client Specificity to Hsp90

(2010) Matthias P. Mayer   MOLECULAR CELL

Understanding of the Hsp90 molecular chaperone reaches new heights

(2010) Cara K Vaughan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

(2009) Andrew J. Massey et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Inhibition of heat shock protein 90 sensitizes melanoma cells to thermosensitive ferromagnetic particle-mediated hyperthermia with low Curie temperature

(2009) Aki Ito et al.   CANCER SCIENCE

Radiochemotherapy for Bladder Cancer

(2009) O.J. Ott et al.   CLINICAL ONCOLOGY

Hyperthermia dose-effect relationship in 420 patients with cervical cancer treated with combined radiotherapy and hyperthermia

(2009) Martine Franckena et al.   EUROPEAN JOURNAL OF CANCER

Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery

(2009) P. Oza et al.   GENES & DEVELOPMENT

Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90

(2009) F. A. Dungey et al.   MOLECULAR CANCER THERAPEUTICS

Chromosome-wide Rad51 Spreading and SUMO-H2A.Z-Dependent Chromosome Fixation in Response to a Persistent DNA Double-Strand Break

(2009) Marian Kalocsay et al.   MOLECULAR CELL

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sulforaphane induces DNA double strand breaks predominantly repaired by homologous recombination pathway in human cancer cells

(2008) Emiko Sekine-Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The endless tale of non-homologous end-joining

(2008) Eric Weterings et al.   CELL RESEARCH

Phase I Study of the Poly(ADP-Ribose) Polymerase Inhibitor, AG014699, in Combination with Temozolomide in Patients with Advanced Solid Tumors

(2008) R. Plummer et al.   CLINICAL CANCER RESEARCH

Cytotoxic Nucleoside Analogues: Different Strategies to Improve their Clinical Efficacy

(2008) C. Galmarini et al.   CURRENT MEDICINAL CHEMISTRY

Hyperthermia adds to chemotherapy

(2008) Rolf D. Issels   EUROPEAN JOURNAL OF CANCER

Heat shock proteins: Stress proteins with Janus-like properties in cancer

(2008) Stuart K. Calderwood et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair

(2008) T. T. Koll et al.   MOLECULAR CANCER THERAPEUTICS

Induction of linear tracks of DNA double-strand breaks by α-particle irradiation of cells

(2008) Jan Stap et al.   NATURE METHODS