Article
Biology
Dario Huesler, Pia Stauffer, Bernhard Keller, Desiree Boeck, Thomas Steiner, Anne Ostrzinski, Simone Vormittag, Bianca Striednig, A. Leoni Swart, Francois Letourneur, Sandra Maass, Doerte Becher, Wolfgang Eisenreich, Martin Pilhofer, Hubert Hilbi
Summary: This study investigates the interaction between Legionella pneumophila and lipid droplets (LDs) in the amoeba Dictyostelium discoideum. The researchers find that the fusion GTPase Sey1, the T4SS of L. pneumophila, and the Ran GTPase activator LegG1 all promote the interaction between LDs and the LCV. In addition, Sey1 and the L. pneumophila fatty acid transporter FadL are implicated in fatty acid metabolism and intracellular growth of the bacteria.
Review
Immunology
Tatiana M. Clemente, Rajendra K. Angara, Stacey D. Gilk
Summary: Obligate intracellular pathogens can either reside freely in the host cell cytoplasm or be confined in a membrane-bound vacuole. The pathogens in membrane-bound vacuoles are protected from the innate immune system and antimicrobial drugs, but they face challenges such as obtaining membrane components, maintaining a suitable microenvironment, acquiring essential nutrients from the host cell, and manipulating the host cell through a specialized secretion system.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
S. Di Cataldo, A. Cevidanes, C. Ulloa-Contreras, E. Hidalgo-Hermoso, V Gargano, I Sacristan, N. Sallaberry-Pincheira, D. Penaloza-Madrid, D. Gonzalez-Acuna, C. Napolitano, J. Vianna, G. Acosta-Jamett, D. Vicari, J. Millan
Summary: A study on Anaplasma platys and Ehrlichia canis in free-ranging dogs and foxes in Chile found that A. platys was present in all six bioclimatic regions, while E. canis was not detected in any samples. Dogs infested with Rhipicephalus sanguineus ticks were more prone to Anaplasma spp. infection, with higher DNA prevalence in juvenile dogs compared to adults, but higher seroprevalence in adults. The overall prevalence of A. platys DNA was higher in dogs than in foxes, possibly due to lower tick infestations in foxes.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Biotechnology & Applied Microbiology
Matthew L. Aardema, Nina Bates, Qiana E. Archer, Friederike D. von Loewenich
Summary: This study examines the genetic diversity and population dynamics of the tick-vectored bacterium Anaplasma phagocytophilum in Europe, specifically focusing on the evolution of host specialization. The results demonstrate that the specialized ecotype infecting roe deer evolved from a generalist ancestor after the last glacial maximum. The study also shows a close correlation between changes in the population of the host and the bacterium, suggesting a co-evolutionary relationship between the two. Additionally, the findings highlight the importance of understanding the evolution of host range diversity and its implications for human and veterinary health.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Immunology
Jennifer Roeder, Pascal Felgner, Michael Hensel
Summary: Salmonella enterica Typhimurium obtains nutrients required for rapid proliferation by forming Salmonella-induced filaments and expressing nutrient uptake systems, adapting uniquely to different host cell nutrient conditions. This leads to improved nutrient supply and bacterial proliferation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Livia Perles, Heitor M. Herrera, Wanessa T. G. Barreto, Gabriel C. de Macedo, Ana C. Calchi, Rosangela Z. Machado, Marcos R. Andre
Summary: This study used multi-locus sequencing to characterize Ehrlichia and Anaplasma in coati's blood samples in Midwestern Brazil. The results identified a putative novel Anaplasmataceae agent, 'Candidatus Ehrlichia dumleri', and an Anaplasma sp. closely related to 'Candidatus Anaplasma brasiliensis'.
Review
Immunology
Lupeng Li, Mary S. Dickinson, Jorn Coers, Edward A. Miao
Summary: Pathogenic microbes invade the human body, triggering a host immune response. Host-adapted pathogens use virulence strategies to overcome host defense mechanisms, shaping the evolution of the host's immune response. Pyroptosis, a lytic form of cell death, plays a crucial role in combating intracellular bacterial infection by eliminating replicative niches and modulating the immune system. This review explores the role of pyroptosis in neutrophils and intestinal epithelial cells, its regulatory mechanisms involving autophagy and interferon-inducible GTPases, and the differential response to host-adapted pathogens and environmental microbes.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Microbiology
Maria Laura Felix, Sebastian Munoz-Leal, Luis Andres Carvalho, Diego Queirolo, Susana Remesar, Maria Teresa Armua-Fernandez, Jose Manuel Venzal
Summary: Human ehrlichiosis in Uruguay is poorly documented. A study revealed the presence of a new rickettsial organism, Candidatus Ehrlichia pampeana, in Haemaphysalis juxtakochi and a gray brocket deer through molecular detection. The potential pathogenicity of this new Ehrlichia for humans remains unknown, but some eco-epidemiological factors suggest possible risks to human health.
Article
Microbiology
Sharanjeet Atwal, Suthida Chuenklin, Edward M. Bonder, Juan Flores, Joseph J. Gillespie, Timothy P. Driscoll, Jeanne Salje
Summary: Peptidoglycan (PG) is a crucial component of bacterial cell walls, providing rigidity and shape. Some host-associated bacteria have lost genes for aPBPs while retaining bPBPs, and they build a minimal PG-like structure, potentially improving fitness by evading recognition by the host immune system.
Review
Biochemistry & Molecular Biology
Malte Kellermann, Felix Scharte, Michael Hensel
Summary: Pathogenic intracellular microorganisms manipulate host cells to create niches for survival and replication. This review focuses on the manipulation of organelle compartments by pathogens and highlights the specific interactions of different pathogens with host cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Junghwan Lee, Chang-Hwa Song
Summary: Oxidative stress plays a crucial role in innate immunity against pathogens, with ROS directly attacking pathogens, regulating immune signals, inducing autophagy, and activating inflammation. The production of ROS by pathogens not only affects cell death but also the endoplasmic reticulum and mitochondria. The regulation of host defense mechanisms by ROS and the interaction between microbial pathogen-induced ROS and the ER and mitochondria remain unclear.
Article
Infectious Diseases
Jing Sun, Hong Liu, Xin-Yan Yao, Yu-Qian Zhang, Zhi-Hang Lv, Jian-Wei Shao
Summary: This study collected 1286 adult ticks from different hosts and vegetation in Harbin area, northeastern China, and identified tick-borne Anaplasmataceae bacteria using genetic analysis. The results showed a prevalence of 7.4% among the tick species, with Ixodes persulcatus being the dominant species. Four species of pathogenic bacteria to humans and/or animals were detected, including a new cluster that was identified for the first time in Asia. These findings highlight the genetic diversity of Anaplasmataceae bacteria in ticks and the importance of studying their potential risks to human and animal health.
TICKS AND TICK-BORNE DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Dario Husler, Pia Stauffer, Hubert Hilbi
Summary: Lipid droplets (LDs) are versatile organelles involved in various cellular functions and disease pathogenesis. They are formed at the endoplasmic reticulum and play roles in lipid metabolism, energy storage, membrane trafficking, and cellular signaling. Several intracellular bacterial pathogens interact with LDs to obtain nutrients and establish their replicative niches. This review focuses on the biogenesis, interactions, and functions of LDs as well as their involvement in the lipid metabolism of intracellular bacterial pathogens.
MOLECULAR MICROBIOLOGY
(2023)
Article
Immunology
Minmin Wu, Ran An, Nan Zhou, Ying Chen, Haijian Cai, Qi Yan, Ru Wang, Qingli Luo, Li Yu, Lijian Chen, Jian Du
Summary: IFN-gamma-activated macrophages can inhibit the replication of Toxoplasma gondii less virulent strain and promote the localization of immunity-related GTPases and guanylate-binding proteins through interaction with host autophagy proteins, thus controlling the proliferation of parasites.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Helen Rebecca Davison, Gregory D. D. Hurst, Stefanos Siozios
Summary: We explore the diversity of the genus 'Candidatus Megaira' using Sequence Read Archive and metagenomic assemblies. We identify four 'Ca. Megaira' genomes, including one complete scaffold, and an additional 14 draft genomes from uncategorized environmental metagenome-assembled genomes. Our findings reveal the underestimation of the diversity of 'Ca. Megaira' and suggest a potential for defensive symbiosis in this genus.
MICROBIAL GENOMICS
(2023)
Article
Materials Science, Biomaterials
Donald C. Aduba, Seon-Sook An, Gretchen S. Selders, W. Andrew Yeudall, Gary L. Bowlin, Todd Kitten, Hu Yang
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2019)
Article
Materials Science, Biomaterials
Donald C. Aduba, Seon-Sook An, Gretchen S. Selders, W. Andrew Yeudall, Gary L. Bowlin, Todd Kitten, Hu Yang
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2019)
Correction
Biochemistry & Molecular Biology
Cuiping Jiang, Zitong Qi, Hengbo Jia, Yilei Huang, Yunbo Wang, Wenli Zhang, Zimei Wu, Hu Yang, Jianping Liu
Article
Pharmacology & Pharmacy
Quan Yuan, W. Andrew Yeudall, Eunmee Lee, Hu Yang
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Nanoscience & Nanotechnology
Juan Wang, Boxuan Li, Ximing Pu, Xingming Wang, Remy C. Cooper, Qin Gui, Hu Yang
ACS APPLIED MATERIALS & INTERFACES
(2020)
Review
Pharmacology & Pharmacy
Weiqi Jiao, Hu Yang, Zimei Wu, Jianping Liu, Wenli Zhang
EXPERT OPINION ON DRUG DELIVERY
(2020)
Article
Chemistry, Multidisciplinary
Shani L. Levit, Hu Yang, Christina Tang
Article
Biochemistry & Molecular Biology
Juan Wang, Remy C. Cooper, Hu Yang
Article
Engineering, Biomedical
Boxuan Li, Juan Wang, Qin Gui, Hu Yang
BIOACTIVE MATERIALS
(2020)
Article
Biochemistry & Molecular Biology
Shani L. Levit, Narendar Reddy Gade, Thomas D. Roper, Hu Yang, Christina Tang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Applied
Da Huang, Kristoffer Valerie, Hu Yang
Summary: Clickable polymers, especially brush polymers formed by the conjugation of polyethylene glycol (PEG) to clickable polymers, have gained attention in the biomedical field for their ability to carry various functional moieties and enhance drug delivery systems. Recently, a clickable brush polymer PEAMO-g-PEG was developed, which exhibited excellent water solubility, biocompatibility, and flexibility for coupling therapeutic drugs. A novel polymeric drug delivery platform was developed using this technology, resulting in improved survival in brain cancer therapy.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Lei Xu, Xiaoxuan Wang, Honglan Shi, Bin Hua, Joel Gerald Burken, Xingmao Ma, Hu Yang, John J. Yang
Summary: This study investigated the effects of different nanoparticles on lettuce grown in soil and found that the co-interactions of nanoparticles can affect their accumulation and distribution in plants. Additionally, the size of nanoparticles varied between roots and shoots, possibly as a result of the dissolution of nanoparticles in the rhizosphere or the formation of transformed nanoparticles.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Aneel R. Bhagwani, Mehboob Ali, Bryce Piper, Mingjun Liu, Jaylen Hudson, Neil Kelly, Srimathi Bogamuwa, Hu Yang, James D. Londino, Joseph S. Bednash, Daniela Farkas, Rama K. Mallampalli, Mark R. Nicolls, John J. Ryan, A. A. Roger Thompson, Stephen Y. Chan, Delphine Gomez, Elena A. Goncharova, Laszlo Farkas
Summary: Pulmonary arterial hypertension (PAH) is characterized by pathogenic and abnormal endothelial cells (ECs), potentially resulting from clonal selection. This study explores the role of p53 and toll-like receptor 3 (TLR3) in clonal expansion and pulmonary hypertension (PH) through regulation of bone morphogenetic protein (BMPR2) signaling. The findings suggest that a p53/TLR3/IRF3 axis regulates BMPR2 expression and signaling in ECs, offering a potential therapeutic target for PH.
Article
Chemistry, Medicinal
Juan Wang, Boxuan Li, Jing Tang, Li Qiu, Xin Qiao, Na Xu, Hu Yang
Summary: The first-of-its-kind ionic liquid antiglaucoma drug candidate, [Pilo-OEG]Cl, demonstrates enhanced stability, corneal permeability, and biocompatibility compared to traditional drugs, making it a promising candidate for antiglaucoma therapy.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2022)
Article
Materials Science, Biomaterials
Boxuan Li, Juan Wang, Qin Gui, Hu Yang
JOURNAL OF MATERIALS CHEMISTRY B
(2020)