Review
Biochemistry & Molecular Biology
Louise Idalgo Vasques, Cristina Wohlke Vendruscolo, Gislaine Ricci Leonardi
Summary: The topical application of vitamin C and its derivatives in skincare is essential, but there is still a lack of scientific data regarding their efficacy, especially in vivo. Studies on the stability, safety, adverse reactions, and efficacy with standardized parameters and a relevant number of subjects are necessary for better understanding their effects.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Antonius T. Otten, Arno R. Bourgonje, Vera Peters, Behrooz Z. Alizadeh, Gerard Dijkstra, Hermie J. M. Harmsen
Summary: High-dose vitamin C supplementation can modulate the composition of gut microbiota in healthy individuals, leading to beneficial shifts in bacterial populations.
Article
Biochemistry & Molecular Biology
Anitra C. Carr, Emma Vlasiuk, Masuma Zawari, Amy Scott-Thomas, Malina Storer, Michael Maze, Stephen T. Chambers
Summary: This study aimed to investigate the impact of vitamin C supplementation on patients with community-acquired pneumonia (CAP). The study found that patients had low vitamin C levels, which were inversely associated with the inflammatory marker C-reactive protein. After vitamin C supplementation, patients' vitamin C levels were increased, and there were trends towards shorter hospital stays and time to clinical stability.
Article
Plant Sciences
Boitshepo L. Pulela, Martin M. Maboko, Puffy Soundy, Stephen O. Amoo
Summary: This study evaluated the nutritional and phytochemical contents of soilless-grown cantaloupe and honeydew sweet melon cultivars at harvest and postharvest. It found that orange-fleshed cultivars had higher vitamin C and beta-carotene concentrations, as well as higher mineral element content. Postharvest storage duration affected the total phenolics content and total soluble solid content.
Article
Nutrition & Dietetics
Anitra C. Carr, Jens Lykkesfeldt
Summary: The study examines the relationship between vitamin C dose and concentration, specifically in relation to age and smoking status. It found that while vitamin C intake was similar across age groups, older individuals had significantly lower circulating vitamin C concentrations. This effect was more pronounced in non-smokers and suggests that older individuals may be more sensitive to low vitamin C intake, possibly due to the effects of long-term smoking and increased chronic disease prevalence.
Article
Food Science & Technology
Abdullah AlSaleh, Mohammed Shahid, Eman Farid, Khalid Bindayna
Summary: This study aims to investigate the effects of ascorbic acid and nicotinamide on Panton-Valentine Leukocidin (PVL) cytotoxicity and granulocyte viability. The results demonstrate that ascorbic acid and nicotinamide can reduce PVL cytotoxicity and maintain cell viability. Further research is needed to explore the potential of these antioxidants in attenuating PVL cytotoxicity in PVL-related diseases.
Review
Pharmacology & Pharmacy
Burton Dunlap, G. Taylor Patterson, Sandeep Kumar, Sagar Vyavahare, Samarth Mishra, Carlos Isales, Sadanand Fulzele
Summary: 14% of US adults have been diagnosed with or show symptoms of osteoarthritis, with incidence gradually increasing over the past 30 years. The aging population and obesity prevalence exacerbate the situation. Research on antioxidant supplementation, particularly vitamin C, for treating osteoarthritis is controversial and further randomized controlled trials in humans are urgently needed.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Multidisciplinary Sciences
Abebe Yimer, Sirawdink Fikereyesus Forsido, Getachew Addis, Abebe Ayelign
Summary: This study aimed to determine the phytochemical content of wild edible plants in Southwest Ethiopia. The results showed that Solanum nigrum and Cleome gynandra contain abundant levels of total phenols and flavonoids, while Vigna membranacea leaf is a good source of vitamin C and beta-carotene. These wild edible plants provide a natural supply of dietary antioxidants to prevent oxidative stress.
Article
Chemistry, Applied
Fengtian Wu, Fangming Yan, Ling Wu, Caihong Zhang, Rong Zeng, Yijia Sun, Xiuping Liu, Chunna Cui, Peng Wang
Summary: The vitamin C/glycerol reduction system can convert cheap CuO to active copper species, promoting the C-N coupling reaction, and provide a simple and cost-effective approach for the preparation of N-arylation products.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Berna Genc, Melike Karaman
Summary: This study found that ascorbic acid can reduce oxidative stress caused by excessive iron intake by altering antioxidant enzyme activities, MDA, and GSH levels. Further studies are needed to elucidate the effect of ascorbic acid on different mechanisms.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Nutrition & Dietetics
Francesca Gori, Jacopo Fumagalli, Caterina Lonati, Riccardo Caccialanza, Alberto Zanella, Giacomo Grasselli
Summary: Ischemia/reperfusion (I/R) injury is a significant factor in graft dysfunction and rejection after transplantation. Ascorbic Acid (AA) has potential as a therapeutic option for reducing I/R damage in solid organ transplantation due to its various biological functions, including antioxidant activity and modulation of apoptosis and inflammation. However, the therapeutic potential of AA, as well as the optimal dosage, timing, and combination with other antioxidants, remains controversial.
CLINICAL NUTRITION
(2022)
Review
Chemistry, Medicinal
Junren Chen, Gangmin Li, Chen Sun, Fu Peng, Lei Yu, Yan Chen, Yuzhu Tan, Xiaoyu Cao, Yunli Tang, Xiaofang Xie, Cheng Peng
Summary: This paper systematically reviews the natural sources, pharmacological activities, and roles of quercitrin in various diseases, as well as its pharmacokinetics, structure-activity relationship, and toxicity. The underlying molecular mechanisms of quercitrin in treating related diseases and the dose-effect relationships are discussed, along with the need for further high-quality studies to establish its clinical efficacy.
PHYTOTHERAPY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Marcelo Villagran, Jorge Ferreira, Miquel Martorell, Lorena Mardones
Summary: Vitamin C plays a significant role in cancer prevention and treatment, with studies showing its potential benefits in preventing pulmonary and breast cancer, as well as its synergistic effects with pancreatic cancer drugs. However, a Mendelian randomized study did not find an association between vitamin C and cancer prevention. Ongoing research is needed to further explore the therapeutic role of vitamin C in cancer through new phase II and III clinical trials.
Article
Nutrition & Dietetics
Nayef Chahin, Miheret S. Yitayew, Alicia Richards, Brielle Forsthoffer, Jie Xu, Karen D. Hendricks-Munoz
Summary: Little is known about the nutritional needs of premature infants <37 weeks gestation. This study investigated the relationship between infant characteristics, maternal health, and plasma ascorbic acid (AscA) levels in premature infants during postnatal development. The results suggest that prenatal and postnatal factors influence the initial AscA levels, potentially impacting organ health and disease risk. Dietary targets may need to be adjusted for this population.
Article
Chemistry, Physical
Aishanee Sur, Nicholas B. Jernigan, David C. Powers
Summary: The development of homogeneous catalysis is supported by various kinetics experiments. Metal-organic frameworks have gained attention as platforms for site-isolated catalysis. Evaluating the origin of catalytic activity in MOF-promoted reactions is still limited.
Article
Chemistry, Analytical
Aysu Arman, Sener Saglam, Aysem Uzer, Resat Apak
Summary: The study presented a sensitive detection method for nitroaromatic explosives using a GC/MWCNTs/PEI electrode coated with gold nanoparticles. The method successfully detected TNT, DNT, 2,4-DNP, PA, and tetryl in a linear range, with detection limits ranging from 15 μg L-1 to 135 μg L-1. This method was also validated against the reference LC-MS method for analyzing explosives in soil samples.
Article
Chemistry, Analytical
Ziya Can, Busra Keskin, Aysem Uzer, Resat Apak
Summary: Reactive nitrogen species (RNS) can both damage biomacromolecules and participate in cell signaling, as well as defend against certain pathogens. Two novel methods, a spectrophotometric method and a spectrofluorometric method, were developed to detect and study the scavenging of NO radicals. These methods have potential applications in understanding antioxidant activity and could improve selectivity in human health and disease research related to nitric oxide.
Article
Chemistry, Analytical
Tuana Demircioglu, Mehmet Kaplan, Emine Tezgin, Omer Kaan Koc, Selen Durmazel, Aysem Uzer, Resat Apak
Summary: Water and soil pollution, especially caused by explosive residues, is a global environmental problem. This study developed a gold nanoparticles-based colorimetric probe for the detection of nitro-explosives TNT and tetryl. The probe showed high selectivity and sensitivity, and was not interfered by common soil ions and explosive mixtures.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Selen Ayaz, Aysem Uzer, Yusuf Dilgin, Resat Apak
Summary: A novel amperometric method was developed for total antioxidant capacity determination using a copper-neocuproine complex modified electrode in a flow injection system. The electrode exhibited good electrocatalytic activity towards polyphenolic compounds and showed a wide linear range and low detection limit. The method was successfully applied to measure antioxidant capacity in herbal teas, providing results comparable to spectrophotometric methods but with improved precision and sensitivity.
Article
Spectroscopy
Furkan Burak Sen, Nilay Begic, Mustafa Bener, Resat Apak
Summary: In this study, a fluorescent polyethylenimine capped carbon quantum dots (PEI-C-dots) probe was synthesized and used to detect TNT residues. The synthesized PEI-C-dots exhibited high fluorescence quantum yield and low detection limit for TNT. The detection of TNT was not interfered by similar structured explosives, common soil ions, and camouflage agents.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Mustafa Bener, Furkan Burak Sen, Resat Apak
Summary: In this study, a gold nanocluster based turn on fluorescence sensor was developed for the determination of trace residues of 2,4,6-trinitrotoluene (TNT). The proposed sensor relies on the aggregation-induced emission enhancement mechanism, and showed good selectivity towards TNT with a large Stokes shift. It offers a simple, fast, and sensitive method for TNT determination.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Nanoscience & Nanotechnology
Selen Durmazel, Aysem Uzer, Resat Apak
Summary: In this paper, a simple and rapid nanosensing assay was developed using unlabeled gold nanoparticles (AuNPs) and the supramolecular association of NTO with melamine (MEL). The concentration of NTO could be determined by observing color change, even at a sub-femtomolar level. The analytical results showed a linear relationship between the logarithm of NTO concentration and the absorption ratio. The synthesized AuNPs were characterized using various methods, and potential interferences were examined. NTO recovery was also achieved successfully.
ACS APPLIED NANO MATERIALS
(2022)
Editorial Material
Chemistry, Analytical
Mustafa Soylak, Resat Apak
Summary: This special issue of Analytical Letters features selected articles from the Third International Congress of Environmental Chemistry (EnviroChem 2021), in which the authors have expanded upon their conference papers and included their latest experimental results. EnviroChem 2021 aimed to promote and disseminate knowledge on various topics and technologies related to Environmental Chemistry. All articles have undergone the standard review process.
ANALYTICAL LETTERS
(2023)
Review
Chemistry, Analytical
Resat Apak, Aysem Uzer, Sener Saglam, Aysu Arman
Summary: Explosive detection technologies play a critical role in national security, and there is a demand for improved sensitivity and selectivity in current detection techniques. Electrochemical devices combined with nanomaterials offer a simpler, cheaper, and faster way to obtain targeted analytical information. This review focuses on providing information related to MIPs and nanomaterial-based electrochemical sensors.
Article
Spectroscopy
Herbert Cirrus Kaboggoza, Burcu Bekdeser, Resat Apak
Summary: A fluorescent gold nanocluster was used to determine the peroxyl radical scavenging activity of antioxidants. The addition of glutathione enhanced the fluorescence intensity of the gold nanoclusters, while antioxidants reduced the decline in fluorescence intensity caused by peroxyl radical attack. This method provides a simple and selective estimation of peroxyl radical scavenging activity in complex matrices.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Multidisciplinary
Ayse Nur Onem, Kevser Sozgen Baskan, Resat Apak
Summary: In this study, a gold nanoparticle (AuNP)-decorated and multiwalled carbon nanotube (MWCNT)-Nafion-modified glassy carbon electrode (GCE/AuNP/MWCNT-Nafion) was developed to assess the preventive effect of antioxidants on oxidative DNA damage. The electrochemical method relied on two phenomena: (i) reactive species (RS) produced by dissolved oxygen in the presence of copper(II) partially damaged the DNA immobilized on the electrode surface, and (ii) antioxidant compounds prevented this damage by scavenging the formed RS. The DNA protective ability of various antioxidant compounds was evaluated, with quercetin showing the highest antioxidant effect.
Article
Chemistry, Multidisciplinary
Asli Neslihan Avan, Sema Demirci-Cekic, Resat Apak
Summary: Immobilization of biological enzymes using magnetic nanoparticles as support materials enables cost reduction and reusability. In this study, three different oxidase enzymes were successfully immobilized on MNPs, and colorimetric nanobiosensors were developed for the determination of biologically important substrates. The immobilized enzymes showed no loss of affinity for the substrate, and the system exhibited wide linear concentration ranges and low detection limits, with the ability to be reused multiple times.
Article
Nanoscience & Nanotechnology
Omer Kaan Koc, Aysem Uzer, Resat Apak
Summary: Oxygen- and nitrogen-heteroatom-doped carbon dots were prepared for the selective and sensitive determination of picric acid. The fluorescence of the carbon dots was selectively quenched by picric acid through ground-state interaction. The detection limits for picric acid were 12.5 pM (by emission measurement) and 0.9 nM (by absorption measurement). Smartphone-assisted fluorometric detection of picric acid was also achieved by incorporating the carbon dots into a polymer composite film.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Aysu Arman, Sener Saglam, Aysem Uzer, Resat Apak
Summary: This work presents a novel sensor electrode for electrocatalytic reduction of nitro-aromatic explosives (NAEs) by combining electrochemically reduced graphene nanosheets (GNSs) with a poly-caffeic acid (pCAF) film-modified glassy carbon electrode (GCE). The sensor showed high performance for TNT detection and could accurately determine various NAEs. The optimized electrode demonstrated resistance to interference effects and satisfactory results in real samples.
Article
Nanoscience & Nanotechnology
Omer Kaan Koc, Aysem Uzer, Resat Apak
Summary: Oxygen- and nitrogen-heteroatom-doped carbon dots were prepared for the selective and sensitive determination of picric acid, and their fluorescence properties were characterized. The results showed that these carbon dots can selectively detect picric acid in the presence of other explosives.
ACS APPLIED MATERIALS & INTERFACES
(2023)
