期刊
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
卷 130, 期 3, 页码 251-257出版社
ELSEVIER
DOI: 10.1016/j.ijfoodmicro.2009.02.003
关键词
Pediocin PA-1; Lactobacillus plantarum; Human Microbiota Associated rats; DGGE
资金
- Danish FOTEK 3 program [3401-44-03-691]
- Danish Bacon and Meat Council
The bacteriocin pediocin PA-1 has potential use as a food biopreservative, and understanding its effect on the commensal gut microbiota is important for assessment of consumer risks associated with the use of biopreservative cultures. Effects of ingested (i) pediocin PA-1 producing Lactobacillus plantarum DDEN 11007, (ii) the plasmid cured pediocin negative L. plantarum DDEN 12305, or (iii) supernatants of either of these two strains on the composition of the intestinal microbiota of Human Microbiota Associated (HMA) rats were examined by selective cultivation and molecular methods. The culturable microbiota was in all treatments dominated by lactic acid bacteria and coliforms and no changes in the rat commensal microbiota were detected after ingestion of either of the two L plantarum strains as determined by both culturable methods and molecular methods (DGGE). Both strains were detected in the faeces after ingestion. Pediocin PA-1 did not mediate changes of the rat microbiota, and a biological assay indicated that the bacteriocin was degraded or inactivated during passage through the intestine. (C) 2009 Elsevier B.V. All rights reserved.
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