Article
Public, Environmental & Occupational Health
Ju Eun Seol, Jeongseon Kim, Bong-Hwa Lee, Dae-Yong Hwang, Jinyoung Jeong, Hun-Jae Lee, Yoon-Ok Ahn, Jung Eun Lee, Dong-Hyun Kim
Summary: This study found that alcohol intake increased the risk of colorectal cancer in East Asian populations, and there may be an interaction between ALDH2 gene and methyl diets, where a low methyl diet increased the risk of CRC among individuals with the ALDH2 A allele.
PUBLIC HEALTH NUTRITION
(2021)
Article
Oncology
Chang Kyun Choi, Min-Ho Shin, Sang-Hee Cho, Hye-Yeon Kim, Wei Zheng, Jirong Long, Sun-Seog Kweon
Summary: This study found that the ALDH2 rs671 genotype related to alcohol consumption was associated with a reduced risk of colorectal cancer in men, especially among regular drinkers. However, the ADH1B rs1229984 genotype showed no significant association with colorectal cancer risk. The combined genotype with the highest genetically predicted alcohol consumption was associated with a higher risk for colorectal cancer.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Ting-Gang Chang, Ting-Ting Yen, Chia-Yi Wei, Tzu-Hung Hsiao, I-Chieh Chen
Summary: This study aimed to evaluate the associations of ADH1B rs1229984 and ALDH2 rs671 with the risks of alcohol-related disorder and cancer. The results showed significant additive and synergic risks of these genetic variants for alcohol-related disorders and cancer. It is recommended to advise high-risk individuals carrying these variants to reduce alcohol consumption as a preventive measure.
Article
Oncology
Senbang Yao, Chen Gan, Tao Wang, Qianqian Zhang, Mingjun Zhang, Huaidong Cheng
Summary: High expression of ALDH2 is associated with better prognosis in gastric cancer patients. ALDH2 may cooperate with other genes to inhibit gastric cancer progression by regulating multiple signaling pathways and chemical carcinogenesis. Therefore, ALDH2 may serve as a prognostic marker and a potential therapeutic target for patients with gastric cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Substance Abuse
Seung Joo Kang, Cheol Min Shin, Joohon Sung, Nayoung Kim
Summary: ALDH2 polymorphism affects the risk of gastric cancer, especially in moderate to heavy drinkers. Individuals with inactive ALDH2 who consume moderate to heavy amounts of alcohol are more susceptible to gastric cancer than non-drinkers or light drinkers.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Oncology
Chang Kyun Choi, Jungho Yang, Sun-Seog Kweon, Sang-Hee Cho, Hye-Yeon Kim, Eun Myung, Min-Ho Shin
Summary: In Eastern Asians, ALDH2 rs671 polymorphisms are associated with esophageal cancer, which may be linked to acetaldehyde accumulation. The study found that in men, the risk of esophageal cancer was higher with GA and AA genotypes, while in women, the risk was higher with GA and AA genotypes as well. Additionally, in men, the association between ALDH2 polymorphisms and esophageal cancer was influenced by alcohol consumption.
Review
Pharmacology & Pharmacy
Hong Zhang, Liwu Fu
Summary: ALDH2 plays a crucial role in tumorigenesis and progression, with the ALDH2*2 polymorphism associated with tumor development. This study summarizes the essential functions and potential mechanisms of ALDH2 in cancer. Therefore, ALDH2 is considered a potential therapeutic target for cancer treatment.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Nutrition & Dietetics
Mari Sugimoto, Hiroki Tabata, Hideyoshi Kaga, Yuki Someya, Saori Kakehi, Abulaiti Abudurezake, Hitoshi Naito, Naoaki Ito, Huicong Shi, Hikaru Otsuka, Futaba Umemura, Yasuyo Yoshizawa, Ryuzo Kawamori, Hirotaka Watada, Yoshifumi Tamura
Summary: This study investigated the effects of the ALDH2 genotype on dietary patterns (DPs) and the mediating role of alcohol intake in elderly adults. The results showed significant associations between the ALDH2 genotype and several DPs, but most of the associations were mediated by alcohol intake.
Article
Biochemistry & Molecular Biology
Hsiao-Cheng Tsai, Che-Hong Chen, Daria Mochly-Rosen, Yi-Chen Ethan Li, Min-Huey Chen
Summary: The research indicates that the ALDH2*2 mutation combined with alcohol consumption and chronic exposure to bacterial toxins from periodontal disease increases the risk of dental bone loss. Experimental results show that ALDH2 knockdown leads to loss of proliferation and mineralization capability in osteoblasts.
Article
Urology & Nephrology
Daniel R. Greenberg, Hriday P. Bhambhvani, Satvir S. Basran, Brett P. Salazar, Luis Carl Rios, Sin-Jin Li, Che-Hong Chen, Daria Mochly-Rosen, Michael L. Eisenberg
Summary: This study found an association between alcohol intake and semen parameters among East Asian men carrying the ALDH2*2 allele. Alcohol consumption was associated with significantly lower total and progressive sperm motility in ALDH2*2 carriers. Furthermore, ALDH2 expression in spermatozoa was significantly lower in ALDH2*2 carriers.
JOURNAL OF UROLOGY
(2022)
Review
Public, Environmental & Occupational Health
Carmen S. Ng, Xin Jiong Ong, Minnie Au, Yan Ho Lau, Harley H. Y. Kwok, Jianchao Quan
Summary: Estimating the burden of alcohol-attributable cancer in East Asian populations, taking into account ALDH2 genotype-specific cancer risk and alcohol exposure, it was found that the burden of alcohol-attributable cancer caused by ALDH2 genotype is underestimated.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Oncology
Wojciech Kluzniak, Agata Szymiczek, Amelie Rodrigue, Dominika Wokolorczyk, Bogna Rusak, Klaudia Stempa, Tomasz Huzarski, Jacek Gronwald, Jan Lubinski, Neda Zamani, Shiyu Zhang, Jean-Yves Masson, Steven A. Narod, Cezary Cybulski, Mohammad R. Akbari
Summary: In the Polish population, the low-penetrance BRCA2 p.K3326* variant is associated with increased breast cancer risk only in individuals homozygous for the T allele of the ALDH2 rs10744777 variant, suggesting an interaction between these two variants.
JCO PRECISION ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yi-Chyan Chen, Li-Fang Yang, Ching-Long Lai, Shih-Jiun Yin
Summary: Alcohol sensitivity is influenced by genetic and sociocultural factors, with ALDH2*2 playing a major role in physiological negative responses related to acetaldehyde and providing genetic protection against alcoholism in East Asians.
Review
Cell Biology
Che-Hong Chen, Benjamin R. Kraemer, Daria Mochly-Rosen
Summary: The ALDH2*2 variant is a genetic polymorphism that commonly leads to alcohol flushing reactions and is associated with the largest number of traits in humans. It affects nearly 8% of the world population, especially East Asians. Carriers of the ALDH2*2 variant present alterations in multiple blood biomarkers, clinical measurements, drug prescriptions, dietary habits, and lifestyle behaviors. They are also more susceptible to aldehyde-associated diseases. However, the interaction between alcohol and ALDH2-related pathology and the possible beneficial effects of ALDH2 deficiency are not well understood.
DISEASE MODELS & MECHANISMS
(2022)
Article
Biochemistry & Molecular Biology
Yan Zhang, Zheng Yuan, Jun Chai, Dawei Zhu, Xinsheng Miao, Jiahui Zhou, Xinhua Gu
Summary: This study suggests that ALDH2 may play a protective role in the process of gastric ulcer, by inhibiting oxidative stress, NLRP3 inflammasome activation, and ferroptosis, thus alleviating gastric mucosal damage and inflammation.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Gastroenterology & Hepatology
Jin Hee Noh, Ji Yong Ahn, Jene Choi, Young Soo Park, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Jung Mogg Kim
Summary: This study confirmed the effectiveness and advantages of the RT-PCR detection method in detecting H. pylori infection and verifying CLR resistance. Compared to RUT, RT-PCR more accurately detected H. pylori infection and could verify the presence of CLR resistance through fluorescence melting curve analysis. Due to the high sensitivity and accessibility of the RT-PCR method, it can help clinicians select suitable treatment regimens and improve the eradication rate.
Article
Gastroenterology & Hepatology
Yonghoon Choi, Soo In Choi, Nayoung Kim, Ryoung Hee Nam, Jae Young Jang, Hee Young Na, Cheol Min Shin, Dong Ho Lee, Huitae Min, Yeon-Ran Kim, Yeong-Jae Seok
Summary: This study aimed to investigate the response of rat colon to a high-fat diet (HFD) and the effect of Clostridium butyricum on HFD-induced intestinal inflammation and production of short-chain fatty acids (SCFAs) according to sex. The results showed that HFD significantly increased inflammation scores and fat proportions. Clostridium butyricum improved HFD-induced colonic inflammation, increased SCFA production, and enhanced the expression of tight junction proteins. These effects were more pronounced in male rats, showing a sex difference.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Du Hyun Song, Nayoung Kim, Hyeong Ho Jo, Sangbin Kim, Yonghoon Choi, Hyeon Jeong Oh, Hye Seung Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, So Hyun Kang, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung Ho Kim, Ji-Won Kim, Keun-Wook Lee, Won Chang, Ji Hoon Park, Jin Won Kim, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim, Soyeon Ahn, Young-Joon Surh
Summary: This study aimed to identify risk factors for synchronous multiple gastric cancer (SMGC). Data from 14,603 patients with gastric cancer were analyzed, and the incidence of SMGC was found to be 4.04%, which was associated with male sex, age ≥65 years, and early gastric cancer. Unlike single gastric cancer, SMGC had a high survival rate.
Article
Gastroenterology & Hepatology
Sang Bin Kim, Nayoung Kim, Jaehyung Park, In-Chang Hwang, Seon Hee Lim, Du Hyun Song, Yonghoon Choi, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Soyeon Ahn
Summary: This study investigated the association between Helicobacter pylori (HP) infection and coronary heart disease (CHD). The results showed that HP eradication prevented CHD, but the effect varied based on age and sex.
Article
Oncology
Eun Hyo Jin, Kyungdo Han, Cheol Min Shin, Dong Ho Lee, Seung Joo Kang, Joo Hyun Lim, Yoon Jin Choi
Summary: This study investigated the correlation between alcohol consumption in the young population and the risk of early-onset colorectal cancer (CRC). It found that moderate and heavy drinkers had a higher risk of early-onset CRC compared to light drinkers. Furthermore, there was a dose-response relationship between drinking frequency and early-onset CRC risk.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Psychiatry
Sujeong Han, Jun-Young Lee, Sung-il Cho, Dae Jong Oh, Dae Hyun Yoon
Summary: Using the group-based trajectory model, our study aimed to identify distinct trajectories of cognitive function and investigate demographic factors that act as risk factors for cognitive decline. The study found that cognitive function trajectories among adults over 40 years of age were heterogeneous, with four trajectories identified: high, medium, low, and rapid decline. Older age, male gender, low educational level, bad dietary habits, diabetes mellitus, technical worker occupation, and lower income increased the likelihood of cognitive function decline.
PSYCHIATRY INVESTIGATION
(2023)
Article
Health Care Sciences & Services
Jaeyoung Ha, Jungmi Park, Sangyi Lee, Jeong Lee, Jin-Young Choi, Junhyoung Kim, Sung-il Cho, Gyeong-Suk Jeon
Summary: This study investigated the predictors of habitual use of wearable health devices among middle-aged individuals with risk factors for metabolic syndrome (MetS). The results showed that performance expectancy was the core variable explaining habitual use, which was influenced by health motivation, effort expectancy, and risk perception. The study highlights the importance of meeting users' performance expectations and promoting health motivation to induce habitual use behaviors.
JMIR FORMATIVE RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Eun Jeong Gong, Hye-Kyung Jung, Bora Lee, Jitaek Hong, Jong Wook Kim, Cheol Min Shin, Young Hoon Youn, Kwang Jae Lee
Summary: This study investigated the impact of long-term proton pump inhibitor (PPI) use on metachronous gastric cancer in high-risk patients who underwent endoscopic resection of gastric neoplasms after Helicobacter pylori eradication. The results showed that long-term PPI use was associated with an increased risk of metachronous gastric cancer. These findings remained robust after sensitivity analysis and propensity score-matched analysis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Substance Abuse
Heewon Kang, Eunsil Cheon, Jaeyoung Ha, Sung-il Cho
Summary: This study analyzed the impact of tobacco retailer density on the prevalence of cigarette and electronic nicotine delivery system (ENDS) use. It highlights the importance of using spatial methods in developing and evaluating retail-based policies.
Review
Forestry
Hae-ryoung Chun, Yoon-Young Choi, Inhyung Cho, Hee-kyoung Nam, Geonwoo Kim, Sujin Park, Sung-il Cho
Summary: Research on forest therapy and health outcomes is lacking and lacks a unified set of health indicators. Information about the natural therapeutic elements of forests and forest therapy programs is not sufficient. This systematic review summarizes the health outcomes of forest therapy from 2010 to 2021 and provides insights into the natural therapeutic elements, forest therapy sites, characteristics, and health outcomes. The analysis of 29 articles shows that walking and physical activity are the most common forest therapy interventions, which can improve overall sentiment condition and reduce depression, enhance psychological well-being, alleviate stress, and improve cardiovascular and endocrine systems. Walking, five-senses stimulation, physical activities, and meditation have positive psychological and physiological effects. The findings of this review can guide the planning and implementation of forest therapy programs.
Article
Substance Abuse
Hana Kim, Heewon Kang, Jinyoung Choi, Sung-il Cho
Summary: This study investigated the trend in household secondhand smoke (SHS) exposure and found that parental education level plays a significant role. Adolescents with low-educated parents are at higher risk of household SHS exposure.
TOBACCO INDUCED DISEASES
(2023)
Article
Health Care Sciences & Services
Junhyoung Kim, Jin-Young Choi, Hana Kim, Taeksang Lee, Jaeyoung Ha, Sangyi Lee, Jungmi Park, Gyeong-Suk Jeon, Sung-il Cho
Summary: This study uses various models of wrist-worn wearables and a novel time-series clustering method to analyze wearable data and determine different physical activity patterns. The results show a significant association between age and physical activity patterns.
JMIR MHEALTH AND UHEALTH
(2023)
Article
Public, Environmental & Occupational Health
Heewon Kang, Sung-il Cho
Summary: This paper proposes an epidemiological model that combines conventional measures and tobacco endgame policies, and identifies insufficient research and control on the vector and environment components by both types of measures.
JOURNAL OF PREVENTIVE MEDICINE & PUBLIC HEALTH
(2023)
Review
Medicine, General & Internal
Hyo-Joon Yang, Seung In Seo, Jin Lee, Cheal Wung Huh, Joon Sung Kim, Jun Chul Park, Hyunki Kim, Hakdong Shin, Cheol Min Shin, Chan Hyuk Park, Sang Kil Lee
Summary: Significant translational research advances have been made in the upper gastrointestinal (GI) research field in recent years. Endoscopic evaluation is a reasonable option for acquiring upper GI tissue for research purposes with minimal risk. The optimal number of biopsy samples and sample storage is crucial and might influence results. Few reports have been published on methods for sample collection from endoscopic biopsies. This review provides a protocol for collecting study samples for upper GI research, including microbiome, DNA, RNA, protein, single-cell RNA sequencing, and organoid culture, through a comprehensive literature review. Different methods and sample sizes are recommended for different types of analysis.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Correction
Oncology
Tae-Han Kim, In-Ho Kim, Seung Joo Kang, Miyoung Choi, Baek-Hui Kim, Bang Wool Eom, Bum Jun Kim, Byung-Hoon Min, Chang In Choi, Cheol Min Shin, Chung Hyun Tae, Chung Sik Gong, Dong Jin Kim, Arthur Eung-Hyuck Cho, Eun Jeong Gong, Geum Jong Song, Hyeon-Su Im, Hye Seong Ahn, Hyun Lim, Hyung-Don Kim, Jae-Joon Kim, Jeong Il Yu, Jeong Won Lee, Ji Yeon Park, Jwa Hoon Kim, Kyoung Doo Song, Minkyu Jung, Mi Ran Jung, Sang-Yong Son, Shin-Hoo Park, Soo Jin Kim, Sung Hak Lee, Tae-Yong Kim, Woo Kyun Bae, Woong Sub Koom, Yeseob Jee, Yoo Min Kim, Yoonjin Kwak, Young Suk Park, Hye Sook Han, Su Youn Nam, Seong-Ho Kong
JOURNAL OF GASTRIC CANCER
(2023)
