Article
Medicine, General & Internal
Choong-Kyun Noh, Eunyoung Lee, Bumhee Park, Sun Gyo Lim, Sung Jae Shin, Kee Myung Lee, Gil Ho Lee
Summary: This study investigated the long-term effect of Helicobacter pylori eradication on the prevention of metachronous gastric neoplasm after endoscopic submucosal dissection (ESD) of gastric adenoma. The results showed that eradication of H. pylori did not increase the risk of metachronous gastric neoplasm after ESD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Cheol Min Shin, Nayoung Kim, Hyuk Yoon, Yoon Jin Choi, Ji Hyun Park, Young Soo Park, Dong Ho Lee
Summary: This study investigated the potential of MOS methylation as a predictor for metachronous recurrence after endoscopic resection of gastric neoplasms. The results showed that high levels of MOS methylation were associated with an increased risk of metachronous recurrence, while OLGA or OLGIM stages were not predictive of the risk. Further validation studies are needed to confirm the usefulness of MOS methylation.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Donghoon Kang, Chul-Hyun Lim, Jin Su Kim, Yu Kyung Cho, Jae Myung Park, Myung-Gyu Choi
Summary: Autoimmune gastritis (AIG) is associated with an increased risk of metachronous gastric neoplasms (MGN) after endoscopic resection (ER). Positive anti-parietal cell antibody (APCA) test results have clinical implications for predicting MGN. Proper monitoring and management are essential in AIG patients for early detection and treatment of recurrent lesions.
Article
Oncology
Haruhisa Suzuki, Satoru Nonaka, Iruru Maetani, Takahisa Matsuda, Seiichiro Abe, Shigetaka Yoshinaga, Ichiro Oda, Yukinori Yamagata, Takaki Yoshikawa, Yutaka Saito
Summary: This study explores the features of patients with metachronous gastric cancer (MGC) with possible lymph node metastasis (LNM) after endoscopic submucosal dissection (ESD) and Helicobacter pylori (H. pylori) eradication. It is found that MGCs are more common in the posterior wall of the stomach and lower body mass index (BMI) may be associated with the development of MGCs with possible LNM.
Letter
Gastroenterology & Hepatology
Mohsen Karbalaei, Masoud Keikha
Summary: Eradication of H. pylori significantly reduces the risk of metachronous gastric cancer after endoscopic resection in the East Asian population. However, factors such as increasing age, severe atrophy in the corpus and antrum, and intestinal metaplasia may increase the risk of metachronous gastric cancer in H. pylori eradicated patients.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Oncology
Toshio Watanabe, Yuji Nadatani, Wataru Suda, Akira Higashimori, Koji Otani, Shusei Fukunaga, Shuhei Hosomi, Fumio Tanaka, Yasuaki Nagami, Koichi Taira, Tetsuya Tanigawa, Geicho Nakatsu, Masahira Hattori, Yasuhiro Fujiwara
Summary: The gastric microbiome, aside from H. pylori, plays a role in the tumorigenesis of gastric cancer. Patients with early GC who undergo endoscopic submucosal dissection have a high risk of developing metachronous GC even after successful H. pylori eradication. H. pylori eradication partially restores microbial diversity in these patients, but dysbiosis may persist long after eradication and be involved in the development of both primary and metachronous GC.
Article
Gastroenterology & Hepatology
Rieko Nakata, Yasuaki Nagami, Atsushi Hashimoto, Taishi Sakai, Masaki Ominami, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Mizuki Ohira, Koichi Taira, Hirokazu Yamagami, Tetsuya Tanigawa, Toshio Watanabe, Yasuhiro Fujiwara
Summary: This study showed that successful eradication of H. pylori can prevent metachronous gastric cancer after endoscopic submucosal dissection for early gastric cancer. Persistent H. pylori infection may increase the risk of metachronous gastric cancer.
Article
Surgery
Eunwoo Lee, Sang Gyun Kim, Bokyung Kim, Jue Lie Kim, Jung Kim, Hyunsoo Chung, Soo-Jeong Cho
Summary: This study aimed to clarify the long-term clinical outcomes and risk factors of metachronous gastric neoplasm (MGN) 5 years after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). The study found that male sex, severe intestinal metaplasia, tumor-positive lateral margin, <5 mm lateral safety margin, and synchronous adenoma were positive predictive factors for MGN after 5 years post-ESD. In addition, successful eradication of Helicobacter pylori was a negative predictive factor for MGN.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Medicine, General & Internal
Shan-Shan Xu, Ning-Li Chai, Xiao-Wei Tang, En-Qiang Linghu, Sha-Sha Wang, Bao Li
Summary: This study analyzed the characteristics, risk factors, treatment, and follow-up outcomes of patients with metachronous gastric neoplasms (MGN) following curative endoscopic submucosal dissection (ESD). It found that initial multiplicity was the sole independent risk factor of MGN, and patients with MGN had significantly lower disease-specific survival rate compared to those without MGN. Regular and long-term surveillance endoscopy may be beneficial for patients with initial multiple neoplasms.
CHINESE MEDICAL JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Sandra Baile-Maxia, Carolina Mangas-Sanjuan, Uri Ladabaum, Cesare Hassan, Matthew D. Rutter, Michael Bretthauer, Licia Medina-Prado, Noelia Sala-Miquel, Oscar Murcia Pomares, Pedro Zapater, Rodrigo Jover
Summary: This study aimed to assess the association between HRA characteristics and the outcomes of CRC or AAs surveillance. The study found that adenomas larger than 20mm, high-grade dysplasia (HGD), and adenomas with villous component were associated with higher risk of metachronous CRC. However, multiplicity of adenomas did not seem to be significantly associated with higher CRC risk in the near term.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ryosuke Ikeda, Kingo Hirasawa, Chiko Sato, Atsushi Sawada, Masafumi Nishio, Takehide Fukuchi, Ryosuke Kobayashi, Makomo Makazu, Hiroaki Kaneko, Shin Maeda
Summary: Patients with primary early gastric cancer who underwent Helicobacter pylori eradication and endoscopic submucosal dissection showed favorable treatment outcomes with smaller tumor sizes and flat/depressed features. Despite similar treatment outcomes, the eradication group had a significantly higher incidence of metachronous cancer.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Oncology
Motohiro Hirao, Chikatoshi Katada, Tetsuji Yokoyama, Tomonori Yano, Haruhisa Suzuki, Yasuaki Furue, Keiko Yamamoto, Hisashi Doyama, Tomoyuki Koike, Masashi Tamaoki, Noboru Kawata, Yoshiro Kawahara, Atsushi Katagiri, Takashi Ogata, Takenori Yamanouchi, Hirofumi Kiyokawa, Hirofumi Kawakubo, Maki Konno, Hideki Ishikawa, Akira Yokoyama, Manabu Muto
Summary: This study aimed to evaluate the risk factors for developing metachronous primary gastric cancer after endoscopic resection for esophageal squamous cell carcinoma. The study found that severe gastric atrophy and macrocytosis were closely associated with the development of metachronous primary gastric cancer. In particular, macrocytosis was considered an important predictor.
Article
Pharmacology & Pharmacy
Jianping Cheng, Chanjuan Fan, Kun Huang, Lili Zhai, Hui Wang, Dongling Xie, Yong Cai, Zhen Li, Qixuan Bai, Pan Wang, Haiou Ding
Summary: This study compared the efficacy and safety of high-dose ilaprazole-amoxicillin dual therapy (HT) with bismuth quadruple therapy (BQT) as an initial treatment for H. pylori infection. The results showed that the 14-day HT treatment demonstrated better efficacy in H. pylori eradication and improved safety and compliance compared to BQT.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biology
Anca Negovan, Andreea-Raluca Szoke, Simona Mocan, Claudia Banescu
Summary: This study investigated the impact of clinicopathological parameters on Helicobacter pylori status, finding that severe endoscopic lesions were more frequent in H. pylori-infected group, while there was no difference in the distribution of premalignant gastric lesions. Anemia and dyslipidemia were independently associated with H. pylori-positive biopsies.
Article
Medicine, General & Internal
Young Sin Cho, Su Youn Nam, Hee Seok Moon, Tae Ho Kim, Sung Eun Kim, Jin Tae Jung
Summary: This study evaluated the effect of Helicobacter pylori eradication on the recurrence rate of gastric hyperplastic polyps after endoscopic resection, and found that successful eradication of H. pylori can reduce the risk of recurrence.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Yonghoon Choi, Soo In Choi, Nayoung Kim, Ryoung Hee Nam, Jae Young Jang, Hee Young Na, Cheol Min Shin, Dong Ho Lee, Huitae Min, Yeon-Ran Kim, Yeong-Jae Seok
Summary: This study aimed to investigate the response of rat colon to a high-fat diet (HFD) and the effect of Clostridium butyricum on HFD-induced intestinal inflammation and production of short-chain fatty acids (SCFAs) according to sex. The results showed that HFD significantly increased inflammation scores and fat proportions. Clostridium butyricum improved HFD-induced colonic inflammation, increased SCFA production, and enhanced the expression of tight junction proteins. These effects were more pronounced in male rats, showing a sex difference.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Hyeong Ho Jo, Nayoung Kim, Hyeon Jeong Oh, Du Hyun Song, Yonghoon Choi, Jaehyung Park, Jongchan Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Hye Seung Lee, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung Ho Kim, Ji-Won Kim, Jin Won Kim, Keun-Wook Lee, Won Chang, Ji Hoon Park, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim, Soyeon Ahn
Summary: This study examined the proportion and characteristics of mixed carcinoma in gastric cancer patients and found that mixed carcinoma is associated with lymph node metastasis. It is more common to see submucosal invasion in early gastric cancer, but less likely to have venous invasion and distant metastasis in advanced gastric cancer.
Article
Gastroenterology & Hepatology
Du Hyun Song, Nayoung Kim, Hyeong Ho Jo, Sangbin Kim, Yonghoon Choi, Hyeon Jeong Oh, Hye Seung Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, So Hyun Kang, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung Ho Kim, Ji-Won Kim, Keun-Wook Lee, Won Chang, Ji Hoon Park, Jin Won Kim, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim, Soyeon Ahn, Young-Joon Surh
Summary: This study aimed to identify risk factors for synchronous multiple gastric cancer (SMGC). Data from 14,603 patients with gastric cancer were analyzed, and the incidence of SMGC was found to be 4.04%, which was associated with male sex, age ≥65 years, and early gastric cancer. Unlike single gastric cancer, SMGC had a high survival rate.
Article
Gastroenterology & Hepatology
Sang Bin Kim, Nayoung Kim, Jaehyung Park, In-Chang Hwang, Seon Hee Lim, Du Hyun Song, Yonghoon Choi, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Soyeon Ahn
Summary: This study investigated the association between Helicobacter pylori (HP) infection and coronary heart disease (CHD). The results showed that HP eradication prevented CHD, but the effect varied based on age and sex.
Article
Oncology
Eun Hyo Jin, Kyungdo Han, Cheol Min Shin, Dong Ho Lee, Seung Joo Kang, Joo Hyun Lim, Yoon Jin Choi
Summary: This study investigated the correlation between alcohol consumption in the young population and the risk of early-onset colorectal cancer (CRC). It found that moderate and heavy drinkers had a higher risk of early-onset CRC compared to light drinkers. Furthermore, there was a dose-response relationship between drinking frequency and early-onset CRC risk.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Kichul Yoon, Cheol Min Shin, Kyungdo Han, Jin Hyung Jung, Eun Hyo Jin, Joo Hyun Lim, Seung Joo Kang, Yoon Jin Choi, Dong Ho Lee
Summary: This study used the Korean National Health Insurance Service database to investigate the association between insomnia and the risk of various cancers. The results showed that insomnia was associated with an increased or decreased risk of certain cancers depending on age, cancer type, and sex.
Article
Oncology
Yoon Jin Choi, Kyungdo Han, Eun Hyo Jin, Joo Hyun Lim, Cheol Min Shin, Dong Ho Lee
Summary: Allergic diseases, such as allergic rhinitis, asthma, and atopic dermatitis, were found to reduce the risk of gastrointestinal (GI) cancers, including esophageal, stomach, colorectal, and liver cancers. This inverse association suggests that allergic diseases may have a protective effect against GI cancers, possibly through enhanced immune defenses and reduced inflammation. This finding has important implications for the prevention and treatment of GI cancers.
Review
Gastroenterology & Hepatology
Chung Hyun Tae, Ju Yup Lee, Moon Kyung Joo, Chan Hyuk Park, Eun Jeong Gong, Cheol Min Shin, Hyun Lim, Hyuk Soon Choi, Miyoung Choi, Sang Hoon Kim, Chul-Hyun Lim, Jeong-Sik Byeon, Ki-Nam Shim, Geun Am Song, Moon Sung Lee, Jong-Jae Park, Oh Young Lee
Summary: With an aging population, the use of nasogastric tubes for enteral nutrition in patients with swallowing difficulties is increasing. However, long-term use of nasogastric tubes leads to complications and reduced quality of life. Percutaneous endoscopic gastrostomy (PEG) is an alternative method that involves the percutaneous placement of a tube into the stomach for long-term enteral nutrition. This paper presents the first Korean clinical guideline for PEG, providing evidence-based recommendations for indications, timing, methods, and management of PEG.
CLINICAL ENDOSCOPY
(2023)
Editorial Material
Gastroenterology & Hepatology
Eun Jeong Gong, Hye-Kyung Jung
Summary: This article is related to the papers by Gong et al. To access these articles, visit and.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Eun Hyo Jin, Yoon Jin Choi, Joo Hyun Lim, Cheol Min Shin, Kyungdo Han, Dong Ho Lee
Summary: Active control of metabolic syndrome (MetS) can reduce the risk of colorectal cancer (CRC). Individuals who recover from MetS have a lower risk of CRC compared to those with persistent MetS. Resolving high blood pressure, abdominal obesity, and blood sugar levels can prevent CRC, while normalizing lipid profile does not independently decrease CRC risk. Therefore, controlling MetS is crucial for CRC prevention.
JOURNAL OF CLINICAL MEDICINE
(2023)
Correction
Oncology
Tae-Han Kim, In-Ho Kim, Seung Joo Kang, Miyoung Choi, Baek-Hui Kim, Bang Wool Eom, Bum Jun Kim, Byung-Hoon Min, Chang In Choi, Cheol Min Shin, Chung Hyun Tae, Chung Sik Gong, Dong Jin Kim, Arthur Eung-Hyuck Cho, Eun Jeong Gong, Geum Jong Song, Hyeon-Su Im, Hye Seong Ahn, Hyun Lim, Hyung-Don Kim, Jae-Joon Kim, Jeong Il Yu, Jeong Won Lee, Ji Yeon Park, Jwa Hoon Kim, Kyoung Doo Song, Minkyu Jung, Mi Ran Jung, Sang-Yong Son, Shin-Hoo Park, Soo Jin Kim, Sung Hak Lee, Tae-Yong Kim, Woo Kyun Bae, Woong Sub Koom, Yeseob Jee, Yoo Min Kim, Yoonjin Kwak, Young Suk Park, Hye Sook Han, Su Youn Nam, Seong-Ho Kong
JOURNAL OF GASTRIC CANCER
(2023)