Article
Neurosciences
Lauren Wagner, Megan Banchik, Nana J. Okada, Nicole McDonald, Shafali S. Jeste, Susan Y. Bookheimer, Shulamite A. Green, Mirella Dapretto
Summary: Despite growing evidence, it remains unclear how alterations in thalamic functional connectivity emerge early in human development in autism spectrum disorder (ASD). In this study, researchers investigated the thalamocortical functional connectivity in infants at high and typical familial likelihood for ASD. The findings suggest that ASD may be characterized by early differences in thalamic gating, which could underlie atypical sensory processing and attention to social vs. nonsocial stimuli observed in ASD.
Article
Neurosciences
Haotian Qian, Dongxue Qin, Shouliang Qi, Yueyang Teng, Chen Li, Yudong Yao, Jianlin Wu
Summary: This study explores the neural mechanism of cognitive impairment in Type 2 diabetes mellitus (T2DM). Using imaging biomarkers, dysfunctional brain connections were identified to distinguish between T2DM patients with cognitive impairment and those with normal cognition. The study found that a small number of dysfunctional connections, mainly related to Default Mode Network (DMN) and long-distance links, can predict T2DM and T2DM-induced cognitive impairment.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Zi-Min Cao, Yi-Chao Chen, Guo-Yun Liu, Xu Wang, An-Qi Shi, Lu-Fan Xu, Zhi-Jun Li, Jian-Wei Huo, Ya-Nan Zhang, Ni Liu, Chao-Qun Yan, Jun Wang
Summary: This study investigated the altered functional connectivity in brain regions of migraine patients using data-driven and regions of interest approaches. The findings suggest that patients with migraine exhibit abnormalities in the functional connectivity of the bilateral thalamus, which may serve as a mechanism for the development of migraine.
Article
Geriatrics & Gerontology
Ang Xiao, Hai-Jun Li, Qiu-Yu Li, Rong-Bin Liang, Hui-Ye Shu, Qian-Min Ge, Xu-Lin Liao, Yi-Cong Pan, Jie-Li Wu, Ting Su, Li-Juan Zhang, Qiong Zhou, Yi Shao
Summary: This study investigated changes in functional connectivity (FC) in AMD patients using resting-state functional magnetic resonance imaging (rs-fMRI). The results showed abnormalities in FC in several specific cerebral regions in AMD patients compared to healthy controls.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Jinjin Long, Fengmei Lu, Xiaonan Guo, Yajing Pang, Shanshan Yang, Heng Chen, Bifang He
Summary: This study proposed a dual-segment method for thalamus functional parcellation based on resting-state fMRI data, which subdivided the thalamus into two sub-regions connecting high-level cognitive cortical regions and low-level sensory cortical areas. The functional connectivity strength between thalamus sub-regions and the corresponding cortical regions using the dual-segment method was higher and showed better classification ability for distinguishing subjects with autism spectrum disorder from healthy controls compared to the traditional winner-takes-all method. This new method offers insights into the functions of thalamus sub-regions in neuroscience studies.
NEUROSCIENCE LETTERS
(2021)
Article
Clinical Neurology
Shangpei Wang, Huanhuan Cai, Zong Cao, Chuan Li, Tong Wu, Fangcheng Xu, Yinfeng Qian, Xianwen Chen, Yongqiang Yu
Summary: This study found alterations in both static and dynamic functional connectivity between the thalamus and cortical areas in Parkinson's disease patients with freezing of gait. These changes were associated with the severity of freezing of gait symptoms.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Stefano Delli Pizzi, Piero Chiacchiaretta, Carlo Sestieri, Antonio Ferretti, Maria Giulia Tullo, Stefania Della Penna, Giovanni Martinotti, Marco Onofrj, Leor Roseman, Christopher Timmermann, David J. Nutt, Robin L. Carhart-Harris, Stefano L. Sensi
Summary: The study found that LSD intake selectively changes the functional connectivity between the thalamus and cortex, including the ventral complex, pulvinar, and non-specific nuclei. These nuclei showed increased functional coupling with sensory cortices and parts of the associative cortex dense in serotonin type 2A receptors. LSD also affected the subcortical connectivity.
Article
Engineering, Biomedical
Cooper J. Mellema, Albert A. Montillo
Summary: This study aims to propose new measures of human brain connectivity to address gaps in the existing measures and facilitate the study of brain function, cognitive capacity, and early markers of human disease. Two new measures of functional and effective connectivity are proposed, using machine learning techniques to capture linear and nonlinear aspects of brain associations. The proposed measures demonstrate higher reproducibility and predictive power compared to traditional measures.
JOURNAL OF NEURAL ENGINEERING
(2023)
Review
Neurosciences
Laurentius Huber (Renzo), Emily S. Finn, Yuhui Chai, Rainer Goebel, Ruediger Stirnberg, Tony Stoecker, Sean Marrett, Kamil Uludag, Seong-Gi Kim, SoHyun Han, Peter A. Bandettini, Benedikt A. Poser
Summary: Recent advances in fMRI technology have enabled researchers to study information processing in the cortical layers more effectively, particularly in terms of connectivity. However, layer-fMRI still faces challenges that require more flexible and precise methods to address. This article describes newly developed acquisition methodologies that can provide more comprehensive data for investigating brain network connections.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Psychiatry
Woo-Sung Kim, Jie Shen, Uyanga Tsogt, Soyolsaikhan Odkhuu, Young-Chul Chung
Summary: This study aimed to investigate the functional network of thalamic subregions in patients with treatment-resistant schizophrenia (TRS). The findings revealed differences in functional connectivity within thalamic subregions and cortical networks between TRS patients and healthy controls. Increased connectivity between thalamic subregions and the sensorimotor cortex, frontal medial cortex, and lingual gyrus was also observed, which may be associated with the pathophysiology of TRS.
WORLD JOURNAL OF PSYCHIATRY
(2022)
Article
Neurosciences
Yongxin Li, Jianping Wang, Xiao Wang, Qian Chen, Bing Qin, Jiaxu Chen
Summary: The study investigated alterations in thalamus morphology, functional activity, and connectivity in children with GTCS, finding both increased and decreased connectivity variability in thalamo-cortical networks. The dynamic restructuring of pathways connecting the thalamus suggests implications for understanding the neural mechanisms underlying GTCS in children.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Kylie Isenburg, Thomas M. Morin, Maya L. Rosen, David C. Somers, Chantal E. Stern
Summary: Studies have found that certain brain regions are activated during attentional deployment via long-term memories. We conducted an analysis of task-based functional connectivity to study the communication between these brain regions underlying long-term memory guided attention. Our results showed that different subnetworks, such as default mode, cognitive control, and dorsal attention, contribute differently to long-term memory guided attention, and the connectivity at the network level shifts based on attentional demands. We also found specific nodes within these subnetworks that play a crucial role in facilitating long-term memory guided attention.
Article
Neurosciences
M. Fiona Molloy, Zeynep M. Saygin
Summary: This study used neonatal data to uncover the intrinsic functional brain networks and individual differences. The study found the most individual variability in different networks among neonates, and this variability was not influenced by noise differences or differences from adult networks. Differential gene expression provided a potential explanation for the emergence of these networks and identified potential genes of interest for future research. This study revealed that neonatal connectomes can reveal individual-specific information processing units and has the potential to improve prediction of behavior and future outcomes.
Article
Neurosciences
Guangyuan Zou, Yuezhen Li, Jiayi Liu, Shuqin Zhou, Jing Xu, Lang Qin, Yan Shao, Ping Yao, Hongqiang Sun, Qihong Zou, Jia-Hong Gao
Summary: This study investigated brain functional networks of patients with insomnia disorder and healthy controls, revealing decreased thalamic connectivity in patients with insomnia disorder compared to controls, particularly with regions like the left amygdala and parahippocampal gyrus. Specific brain region connectivity was found to be significantly correlated with sleep misperception index, shedding new light on the neuropathophysiology of insomnia disorder.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Jungtak Park, Karolina Janacsek, Dezso Nemeth, Hyeon-Ae Jeon
Summary: This study used functional magnetic resonance imaging to investigate the whole-brain connectivity involved in statistical learning. The results showed that the activation strength in the superior frontal gyrus and other brain areas were related to statistical learning performance. The activations of the superior frontal network were most correlated with statistical learning performances. The functional connectivity between the superior frontal gyrus and brain regions involved in salience, language, and dorsal attention networks decreased during statistical learning.
Article
Engineering, Biomedical
Ying-Ying Bai, Lishan Wang, Xin-Gui Peng, Yuan-Cheng Wang, Di Chang, Shuyan Zheng, Jie Ding, Cong Li, Shenghong Ju
Article
Neurosciences
Ying-Ying Bai, Xin-Gui Peng, Li-Shan Wang, Zi-Hui Li, Yuan-Cheng Wang, Chun-Qiang Lu, Jie Ding, Pei-Cheng Li, Zhen Zhao, Sheng-Hong Ju
CNS NEUROSCIENCE & THERAPEUTICS
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ying Cui, Yun Jiao, Hua-Jun Chen, Jie Ding, Bing Luo, Cheng-Yu Peng, Sheng-Hong Ju, Gao-Jun Teng
EUROPEAN RADIOLOGY
(2015)
Article
Biochemical Research Methods
Jie Ding, Chao Wang, Pei-Cheng Li, Zhen Zhao, Cheng Qian, Cong-Xiao Wang, Yu Cai, Gao-Jun Teng
JOURNAL OF FLUORESCENCE
(2016)
Article
Neurosciences
Jie Ding, Zhen Zhao, Chao Wang, Cong-Xiao Wang, Pei-Cheng Li, Cheng Qian, Gao-Jun Teng
Article
Oncology
Fang Nie, Jian Yang, Song Wen, Yan-Li An, Jie Ding, Sheng-Hong Ju, Zhen Zhao, Hua-Jun Chen, Xin-Gui Peng, Stephen T. C. Wong, Hong Zhao, Gao-Jun Teng
Article
Neurosciences
Pei-Cheng Li, Yun Jiao, Jie Ding, Yu-Chen Chen, Ying Cui, Cheng Qian, Xiang-Yu Yang, Sheng-Hong Ju, Hong-Hong Yao, Gao-Jun Teng
CNS NEUROSCIENCE & THERAPEUTICS
(2015)
Article
Endocrinology & Metabolism
Yu-Chen Chen, Yun Jiao, Ying Cui, Song-An Shang, Jie Ding, Yuan Feng, Wen Song, Sheng-Hong Ju, Gao-Jun Teng
Article
Radiology, Nuclear Medicine & Medical Imaging
Hua-Jun Chen, Xi-Qi Zhu, Hao Shu, Ming Yang, Yi Zhang, Jie Ding, Yu Wang, Gao-Jun Teng
EUROPEAN JOURNAL OF RADIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Wenwen Lv, Jie Ding, Jiangbo Hu, Chao Wang, Leyi Xu, Ming Fang, Liudi Yuan
MOLECULAR BIOLOGY REPORTS
(2009)
Article
Biotechnology & Applied Microbiology
Juanli Duan, Jinlai Dong, Tiantian Zhang, Zhenyi Su, Jie Ding, Yu Zhang, Xiaohua Mao
Article
Multidisciplinary Sciences
Yi Zhang, Shufeng Fan, Yuyu Yao, Jie Ding, Yu Wang, Zhen Zhao, Lei Liao, Peicheng Li, Fengchao Zang, Gao-Jun Teng
Article
Multidisciplinary Sciences
Ying Zhang, Leilei Wang, Lingling Wang, Ning Wu, Zhi Zhou, Linsheng Song
Article
Multidisciplinary Sciences
Cheng Qian, Pei-Cheng Li, Yun Jiao, Hong-Hong Yao, Yu-Chen Chen, Jian Yang, Jie Ding, Xiang-Yu Yang, Gao-Jun Teng