Article
Cell Biology
Fengfeng Lu, Xin Pan, Wencheng Zhang, Xin Su, Yuying Gu, Hua Qiu, Shengwei Shen, Changcheng Liu, Wei Liu, Xicheng Wang, Zhenzhen Zhan, Zhongmin Liu, Zhiying He
Summary: Cell transplantation is a promising therapeutic strategy for diseases requiring tissue repair, but tracking transplanted cells in recipients is still in early stages. A practical protocol using a 3D technique was developed to dynamically track and evaluate the engraftment of hepatocytes in a liver failure mouse model. This methodology could serve as a referable standard for studying the outcomes of other transplanted cells during preclinical studies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Neurosciences
Huiyong Liu, Sydney Reiter, Xiangyue Zhou, Hanmin Chen, Yibo Ou, Cameron Lenahan, Yue He
Summary: Stroke is the most common type of cerebrovascular disease, with two major zones of injury: the lesion core and the ischemic penumbra. Stem cell therapy has shown potential in reversing the neurological sequelae of ischemic stroke, but technical and ethical challenges need to be overcome before it can become a treatment option.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Xiaoxiong Zou, Yu Xie, Zhongfei Zhang, Zhiming Feng, Jianbang Han, Qian Ouyang, Shiting Hua, Sixian Huang, Cong Li, Zhizheng Liu, Yingqian Cai, Yuxi Zou, Yanping Tang, Haijia Chen, Xiaodan Jiang
Summary: This study revealed that MCPIP-1 knockdown enhances the proliferation, migration, and angiogenic capacity of ECFCs by activating the AKT/m-TOR signaling pathway and promoting cellular trophic factor secretion. Transplantation of MCPIP-1 knockdown ECFCs promotes neovascularization, neurogenesis, and reduces cerebral infarct size in a mouse model of cerebral ischemia, leading to neurological recovery.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Pian Gong, Qi Tian, Yan He, Peibang He, Jianfeng Wang, Yujia Guo, Qingsong Ye, Mingchang Li
Summary: This study found that intracranial transplantation of dental pulp stem cells (DPSCs) can exert significant neuroprotection in ischemic stroke therapy by inhibiting neuronal death/apoptosis. The results of this study suggest that DPSC transplantation can improve neurological dysfunction and brain edema, reduce infarct volume, and increase the number of NeuN-positive cells in the ischemic penumbra.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cell Biology
Guoyang Zhou, Yongjie Wang, Shiqi Gao, Xiongjie Fu, Yang Cao, Yucong Peng, Jianfeng Zhuang, Junwen Hu, Anwen Shao, Lin Wang
Summary: Cell therapy, especially stem cell therapy, is considered a novel and potential therapeutic strategy to improve stroke outcome through mechanisms such as cell differentiation, cell replacement, immunomodulation, neural circuit reconstruction, and protective factor release. Despite promising results from clinical and preclinical studies, some key issues in cell therapy, such as optimal parameters, require further research and exploration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Li Zhou, Huimin Zhu, Xue Bai, Jiagui Huang, Yue Chen, Jun Wen, Xuemei Li, Bowen Wu, Yongjun Tan, Mingfen Tian, Jiangxia Ren, Mengxia Li, Qin Yang
Summary: Ischemic stroke is a major cause of death and disability. Stem cell transplantation has emerged as a potential treatment that offers hope for ischemic stroke patients.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Immunology
Dianhui Zhang, Jiaxin Ren, Yun Luo, Qianyan He, Ruoyu Zhao, Junlei Chang, Yi Yang, Zhen-Ni Guo
Summary: This review discusses the role of T cells in ischemic stroke, including mediators of recruitment, temporal course of infiltration, and mechanisms behind deleterious and beneficial effects. Research indicates conflicting roles of T cells in post-stroke inflammation and as potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Richard W. Davis, Charlotte G. Muse, Heather Eggleston, Micaila Hill, Peter Panizzi
Summary: In this study, the central metabolism of a modified Streptococcus pyogenes was mapped, and it was found that supplementation with myo-inositol increased luminescence while supplementation with glucose or glycine decreased light production. The inhibition of LDH partially restored luminescent signal in the presence of glucose. These findings provide new insights into the responsiveness of S. pyogenes metabolism to acute changes in its local environments and cellular health.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biology
Tobias Boothe, Mario Ivankovic, Markus A. Grohme, M. Andrea Markus, Christian Dullin, Xingbo Xu, Jochen C. Rink
Summary: Content-aware image restoration (CARE) is extended to luminescence imaging to overcome the limitation of longer exposure times, thus improving temporal resolution and throughput. Luminescent reporters, with inherently high signal-to-noise ratio, are powerful labeling tools for microscopy and in vivo imaging in biomedical research. However, the requirement of longer exposure times in luminescence imaging limits its application in high temporal resolution or throughput. This study demonstrates that CARE can significantly reduce the exposure time requirements in luminescence imaging.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Nicholas Omid Daneshvari, Michelle Christina Johansen
Summary: The study found a significant association between ischemic stroke infarct volume and stroke subtypes, with each 5mL increase in infarct volume leading to a change in the risk of different stroke types. Multiple infarcts may be associated with cardioembolic strokes, while a single large-volume infarct may be related to large-artery atherosclerosis.
Article
Medicine, Research & Experimental
Ruslan Rust, Rebecca Z. Weber, Melanie Generali, Debora Kehl, Chantal Bodenmann, Daniela Uhr, Debora Wanner, Kathrin J. Zuercher, Hirohide Saito, Simon P. Hoerstrup, Roger M. Nitsch, Christian Tackenberg
Summary: In this study, transgene- and xeno-free neural progenitor cells (NPCs) were generated for potential clinical applications. These cells had stable gene expression, could be expanded, and spontaneously differentiated into mature neurons. This research presents a valuable tool for safe and effective cell therapies for brain injuries.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Behavioral Sciences
Xi Chen, Jing Wang, Liang Ge, Gang Lu, Hailin Wan, Yeqing Jiang, Zhenwei Yao, Gang Deng, Xiaolong Zhang
Summary: This study investigated the relationship between fibrin deposition and no-reflow within microcirculation after thrombolysis in acute ischemic stroke (AIS). The results suggest that fibrin deposition and accumulated red blood cells contribute to microcirculation no-reflow in AIS after thrombolytic therapy.
BRAIN AND BEHAVIOR
(2022)
Review
Clinical Neurology
Tong Zhao, Tongming Zhu, Liqian Xie, Yao Li, Rong Xie, Feng Xu, Hailiang Tang, Jianhong Zhu
Summary: Ischemic stroke is a common cerebrovascular accident with severe neurological deficits. Stem cell transplantation shows promising therapeutic role for ischemic stroke, but its mechanisms are still unclear and further clinical studies are needed.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Hematology
Beth Whittington, Evangelos Tzolos, Rong Bing, Jack Andrews, Christophe Lucatelli, Mark G. Macaskill, Adriana A. S. Tavares, Tim Clark, Nicholas L. Mills, Jennifer Nash, Damini Dey, Piotr J. Slomka, Norman Koglin, Andrew W. Stephens, Edwin J. R. van Beek, Colin Smith, Marc R. Dweck, Michelle C. Williams, William Whiteley, Joanna M. Wardlaw, David E. Newby
Summary: Using F-18-GP1 positron emission tomography and computed tomography angiography, it is possible to identify activated platelets and thrombus noninvasively, which has potential clinical application in establishing the role and origin of thrombus in ischemic stroke.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Wenxiu He, Qiyong Mei, Jie Li, Yuting Zhai, Yiting Chen, Rui Wang, Enhao Lu, Xiao-Yong Zhang, Zhiwen Zhang, Xianyi Sha
Summary: The study presents a novel biomimetic nanoplatform designed to enhance drug delivery to cerebral ischemic lesions, demonstrating superior neuroprotective effects.
Article
Engineering, Biomedical
Ying-Ying Bai, Lishan Wang, Xin-Gui Peng, Yuan-Cheng Wang, Di Chang, Shuyan Zheng, Jie Ding, Cong Li, Shenghong Ju
Article
Biochemical Research Methods
Jie Ding, Chao Wang, Pei-Cheng Li, Zhen Zhao, Cheng Qian, Cong-Xiao Wang, Yu Cai, Gao-Jun Teng
JOURNAL OF FLUORESCENCE
(2016)
Article
Urology & Nephrology
Jie Ding, Chao Wang, Xiaofeng Chang
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2018)
Article
Multidisciplinary Sciences
Junyi Ju, Aiping Chen, Yexuan Deng, Ming Liu, Ying Wang, Yadong Wang, Min Nie, Chao Wang, Hong Ding, Bing Yao, Tao Gui, Xinyu Li, Zhen Xu, Chi Ma, Yong Song, Marc Kvansakul, Ke Zen, Chen-Yu Zhang, Cheng Luo, Ming Fang, David C. S. Huang, C. David Allis, Renxiang Tan, Changjiang Kathy Zeng, Jiwu Wei, Quan Zhao
NATURE COMMUNICATIONS
(2017)
Article
Multidisciplinary Sciences
Cheng Qian, Pei-Cheng Li, Yun Jiao, Hong-Hong Yao, Yu-Chen Chen, Jian Yang, Jie Ding, Xiang-Yu Yang, Gao-Jun Teng
Article
Medicine, Research & Experimental
Chao Wang, Liang Ge, Jianban Wu, Xuan Wang, Liudi Yuan
Article
Engineering, Biomedical
Bo Yin, Chao Wang, Francis Abza
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2020)
Article
Medicine, Research & Experimental
Jie Ding, Yi Zhang, Cong-Xiao Wang, Pei-Cheng Li, Zhen Zhao, Chao Wang, Gao-Jun Teng
Article
Engineering, Biomedical
Lizhen Shen, Mingfang He, Ning Shen, Nasser Yousefi, Chao Wang, Guoqing Liu
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2020)
Article
Computer Science, Interdisciplinary Applications
Chao Wang, Lizhen Shen, Liang Wu
Summary: The electrical response of boron nitride nanocones to 5-Fluorouracil drug was investigated using first-principle density functional theory. The study suggests that BNNCs could be a suitable candidate for 5FU detection and may be used in electronic sensors. Additionally, BNNCs have a short recovery time for desorption of 5FU.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Kaiyu Xue, Yunyun Hu, Shuanglin Gu, Chao Wang, Ren Kong, Wei Xie, Jian Li
Summary: The synapse is a specialized structure regulating neurotransmission, with cell adhesion molecules playing key roles in cell interactions. NRXNs and NLGNs are associated with autism and other neuropsychiatric diseases, with numerous variants identified in previous research. By analyzing protein structures and using risk assessment tools, potential pathological variants were identified for further investigation.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Cell Biology
Yue Zhang, Chao Wang, Xiaoxu Liu, Qian Yang, Hongliang Ji, Mengjun Yang, Manman Xu, Yunyan Zhou, Wei Xie, Zhuojuan Luo, Chengqi Lin
JOURNAL OF MOLECULAR CELL BIOLOGY
(2019)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.