Article
Oncology
Veronica Finisguerra, Tereza Dvorakova, Matteo Formenti, Pierre Van Meerbeeck, Lionel Mignion, Bernard Gallez, Benoit J. van den Eynde
Summary: Despite limitations in certain tumor types and patients, immunotherapies have achieved revolutionary success in cancer treatment. However, the efficacy of immunotherapies is dependent on the viability and functionality of tumor antigen-specific CD8 T cells within the immunosuppressive tumor microenvironment, where oxygen levels are often low. This study reveals that the antidiabetic drug metformin can improve CD8 T cell fitness in hypoxia, increasing their proliferation and cytokine production, and enhancing their infiltration and survival in hypoxic tumor areas. This presents a promising strategy to overcome resistance to immunotherapy in hypoxic and immunosuppressive tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Praveen D. Chatani, Frank J. Lowery, Neilesh B. Parikh, Kyle J. Hitscherich, Rami Yossef, Victoria Hill, Jared J. Gartner, Biman Paria, Maria Florentin, Satyajit Ray, Alakesh Bera, Maria Parkhust, Paul Robbins, Sri Krishna, Steven A. Rosenberg
Summary: By analyzing the single-cell transcriptomic states of neoantigen-specific T-cell clonotypes, researchers identified dysfunction markers on the cell surface that can best identify the transcriptional states enriched with antitumor T-cells. They developed an efficient method to capture neoantigen-reactive T-cell receptors (TCRs) directly from resected human tumors. The isolation of TIL(TP) TCRs showed a high correlation with single-cell transcriptomic signatures for neoantigen-reactive TCRs, making it a cost-effective strategy using widely available resources.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
MacLean S. Hall, Jamie K. Teer, Xiaoqing Yu, Holly Branthoover, Sebastian Snedal, Madeline Rodriguez-Valentin, Luz Nagle, Ellen Scott, Ben Schachner, Patrick Innamarato, Amy M. Hall, Jamie Blauvelt, Carolyn J. Rich, Allison D. Richards, Jake Ceccarelli, T. J. Langer, Sean J. Yoder, Matthew S. Beatty, Cheryl A. Cox, Jane L. Messina, Daniel Abate-Daga, James J. Mule, John E. Mullinax, Amod A. Sarnaik, Shari Pilon-Thomas
Summary: This study highlights the importance of neoantigen-specific CD4(+)T cells within tumor-infiltrating lymphocytes (TILs) as a potent source of tumor-specific effectors. The findings suggest that these CD4(+)T cells play a significant role in antitumor immunity and should be included in future adoptive cell therapy (ACT) protocols to improve treatment efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Eric T. Ahrens, Brooke M. Helfer, Charles F. O'Hanlon, Deanne R. Lister, Julie L. Bykowski, Karen Messer, Benjamin Leach, Jiawen Chen, Hongyan Xu, Gregory A. Daniels, Ezra E. W. Cohen
Summary: This study describes the use of a non-invasive biomarker to assay the apoptotic cell fraction after cell therapy infusion in a patient with head and neck squamous cell carcinoma. The results showed that the survival of the cell therapy product varies per patient, and a non-invasive assay of apoptotic cell fraction could provide insight into response and non-response mechanisms.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Binglin Wang, Yi Wang, Xiaofan Sun, Guoliang Deng, Wei Huang, Xingxin Wu, Yanghong Gu, Zhigang Tian, Zhimin Fan, Qiang Xu, Hongqi Chen, Yang Sun
Summary: This study revealed that CXCR6 is exclusively expressed on intratumoral CD8(+) T cells, which are more immunocompetent and possess stronger antitumor activity. Additionally, CXCR6 may serve as a biomarker for tumor immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Emily J. Lelliott, Kelly M. Ramsbottom, Mark R. Dowling, Carolyn Shembrey, Tahereh Noori, Conor J. Kearney, Jessica Michie, Ian A. Parish, Margaret A. Jordan, Alan G. Baxter, Neil D. Young, Amelia J. Brennan, Jane Oliaro
Summary: NKG7 enhances the cytotoxic activity of CD8+ T cells by promoting immune synapse efficiency. Its deficiency reduces the ability of CD8+ T cells to degranulate and kill target cells while increasing the secretion of inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Wei Shi, Mackenzie Fijardo, Jeff P. Bruce, Jie Su, Wei Xu, Rachel Bell, Pierre-Antoine Bissey, Angela B. Y. Hui, John Waldron, Trevor J. Pugh, Kenneth W. Yip, Fei-Fei Liu
Summary: This study reveals the prognostic significance of CD8+ tumor-infiltrating lymphocytes (TILs) in naso-pharyngeal cancer (NPC) and suggests the potential of utilizing CD8+ lymphocytes for immunotherapy.
CLINICAL CANCER RESEARCH
(2022)
Editorial Material
Oncology
Werner Held, Daniel E. Speiser
Summary: Adoptive cell immunotherapy using in vitro expanded autologous tumor-infiltrating lymphocytes shows potential for durable remission in certain cancers, but complete and long-lasting control of metastatic melanoma requires tumor-specific CD8(+) T cells with stem-cell-like properties.
Article
Immunology
Kaili Liao, Qijun Yang, Yuhan Xu, Yingcheng He, Jingyi Wang, Zimeng Li, Chengfeng Wu, Jialing Hu, Xiaozhong Wang
Summary: This study identified specific marker genes for CD8+ T cell subsets in colon cancer and constructed a prognostic evaluation model. The model was able to predict the prognosis and drug response of patients with colon cancer. The study found that certain genes had high mutation rates in specific risk groups, and patients in the high-risk group had lower drug response rates.
CLINICAL IMMUNOLOGY
(2023)
Article
Oncology
Jennifer Wilkinson Carlisle, Caroline S. Jansen, Maria Andrea Cardenas, Ewelina Sobierajska, Adriana Moon Reyes, Rachel Greenwald, Luke Del Balzo, Nataliya Prokhnevska, Omer Kucuk, Bradley C. Carthon, Patrick Connor Mullane, Adeboye Osunkoya, Deborah Baumgarten, Fares Hosseinzadeh, Scott Wilkinson, Ross Lake, Adam G. Sowalsky, Yuan Liu, Viraj A. Master, Mehmet A. Bilen, Haydn Kissick
Summary: This study identifies potential immunological biomarkers that can predict therapeutic response in patients with advanced renal cell carcinoma (RCC). Assessing changes in T cells in the peripheral blood and tumor microenvironment, the researchers found that patients with the highest increase in specific activated T cells had the best antitumor immune response and clinical benefit.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Aubrey S. Smith, Hannah M. Knochelmann, Megan M. Wyatt, Guillermo O. Rangel Rivera, Amalia M. Rivera-Reyes, Connor J. Dwyer, Michael B. Ware, Anna C. Cole, David M. Neskey, Mark P. Rubinstein, Bei Liu, Jessica E. Thaxton, Eric Bartee, Chrystal M. Paulos
Summary: TLR agonists can be repurposed ex vivo to condition T cells, improving immunotherapy and revealing the vital role of B cells in the generation of potent CD8(+) T cell-based therapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Juan Estrada, Jinghui Zhan, Petia Mitchell, Jonathan Werner, Pedro J. Beltran, Jason DeVoss, Jing Qing, Keegan S. Cooke
Summary: In a mouse tumor model, combination treatment with OncoVEX(mGM-CSF) and checkpoint inhibitors led to increased tumor growth inhibition, reduced lung metastases, and prolonged animal survival. OncoVEX(mGM-CSF) induced both neoantigen-specific and tumor antigen-specific T-cell responses. These findings suggest that the combination of T-VEC and checkpoint inhibition may be effective in treating patients with advanced melanoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
DQ. Cai, Diankui Cai, Yiping Zou, Xumeng Chen, Zhixiang Jian, Mude Shi, Ye Lin, Jueming Chen
Summary: CD8+ T cell exhaustion has been found to negatively impact immunotherapy outcomes. The molecular functions and mechanisms of action of this exhaustion in chemoresistance are still unclear. In this study, a chemoresistant TILCD8T signature (cr-TILCD8TSig) was identified using gene expression data, and it was found to independently predict prognosis, chemotherapy response, and immunotherapy outcomes in breast cancer patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Saad M. Khan, Rupen Desai, Andrew Coxon, Alexandra Livingstone, Gavin P. Dunn, Allegra Petti, Tanner M. Johanns
Summary: Dysfunctional CD4 T cells are associated with terminal CD8 T-cell exhaustion in glioblastoma, influencing the efficacy of PD-1 blockade. Adding a CD40 agonist to PD-1 blockade therapy improves survival rates in glioblastoma, suggesting a potential synergistic immunotherapeutic approach.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
David Noyes, Arup Bag, Saheed Oseni, Jon Semidey-Hurtado, Ling Cen, Amod A. Sarnaik, Vernon K. Sondak, Dennis Adeegbe
Summary: This study demonstrates that the accumulation of Tregs contributes to the dysfunction and clonal constriction of tumor-infiltrating CD8 +T cells. The dysfunctional phenotype of CD8 +T cells is reversed upon reduction of Tregs, and this is mediated by Treg-expressed CTLA-4.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Endocrinology & Metabolism
Eun-Kyung Choi, Hyun-Jung Park, Ok-Joo Su, Monisha Rajasekaran, Rina Yu, Hye-Seon Choi
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2015)
Article
Biochemistry & Molecular Biology
Huan Hu, Jiyoung Moon, Ji Hyung Chung, Oh Yoen Kim, Rina Yu, Min-Jeong Shin
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Biochemistry & Molecular Biology
Tsuyoshi Goto, Young-Il Kim, Tomoya Furuzono, Nobuyuki Takahashi, Kanae Yamakuni, Ha-Eun Yang, Yongjia Li, Ryuji Ohue, Wataru Nomura, Tatsuya Sugawara, Rina Yu, Nahoko Kitamura, Si-Bum Park, Shigenobu Kishino, Jun Ogawa, Teruo Kawada
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Endocrinology & Metabolism
Miyoung Lee, Su Jin Song, Myung-Sook Choi, Rina Yu, Taesun Park
Article
Biochemistry & Molecular Biology
Thai H. Tu, Chu-Sook Kim, Il S. Nam-Goong, Chang W. Nam, Young-Il Kim, Tsuyoshi Goto, Teruo Kawada, Taesun Park, Jung H. Yoon Park, Zae Y. Ryoo, Jeong W. Park, Hye-Seon Choi, Rina Yu
Article
Endocrinology & Metabolism
Shizuka Hirai, Chie Ohyane, Young-Il Kim, Shan Lin, Tsuyoshi Goto, Nobuyuki Takahashi, Chu-Sook Kim, Jihey Kang, Rina Yu, Teruo Kawada
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2014)
Article
Immunology
Quang-Tam Nguyen, Thu-Ha T. Nguyen, Seong-A Ju, Yea-Sol Lee, Seung Hyun Han, Sang-Chul Lee, Byoung S. Kwon, Rina Yu, Gyu Yeol Kim, Byung Ju Lee, Byung-Sam Kim
INFECTION AND IMMUNITY
(2013)
Article
Biochemistry & Molecular Biology
Yoo Jin Jung, Jae In Jung, Han Jin Cho, Myung-Sook Choi, Mi-Kyung Sung, Rina Yu, Young-Hee Kang, Jung Han Yoon Park
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2014)
Article
Biochemistry & Molecular Biology
Hyun Sook Lee, Han Jin Cho, Rina Yu, Ki Won Lee, Hyang Sook Chun, Jung Han Yoon Park
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2014)
Article
Endocrinology & Metabolism
Eun-Kyung Choi, Woon-Ki Kim, Ok-Joo Sul, Yun-Kyung Park, Eun-Sook Kim, Jae-Hee Suh, Rina Yu, Hye-Seon Choi
JOURNAL OF ENDOCRINOLOGY
(2014)
Article
Chemistry, Medicinal
Hye-Ji Noh, Chu-Sook Kim, Ji-Hye Kang, Jun-Young Park, Suck-Young Choe, Soon-Myoung Hong, Hoon Yoo, Taesun Park, Rina Yu
JOURNAL OF MEDICINAL FOOD
(2014)
Article
Cell Biology
Ngoc Hoan Le, Chu-Sook Kim, Thai Hien Tu, Hye-Sun Choi, Byung-Sam Kim, Teruo Kawada, Tsuyoshi Goto, Taesun Park, Jung Han Yoon Park, Rina Yu
MEDIATORS OF INFLAMMATION
(2013)
Article
Cell Biology
Thai Hien Tu, Yeonsoo Joe, Hye-Seon Choi, Hun Taeg Chung, Rina Yu
MEDIATORS OF INFLAMMATION
(2014)
Article
Cell Biology
Ngoc Hoan Le, Chu-Sook Kim, Taesun Park, Jung Han Yoon Park, Mi-Kyung Sung, Dong Gun Lee, Sun-Myung Hong, Suck-Young Choe, Tsuyoshi Goto, Teruo Kawada, Rina Yu
MEDIATORS OF INFLAMMATION
(2014)
Article
Food Science & Technology
Narae Kuem, Su Jin Song, Rina Yu, Jong Won Yun, Taesun Park
MOLECULAR NUTRITION & FOOD RESEARCH
(2014)