Article
Oncology
Marija Mojic, Kiyomi Shitaoka, Chikako Ohshima, Sisca Ucche, Fulian Lyu, Hiroshi Hamana, Hideaki Tahara, Hiroyuki Kishi, Yoshihiro Hayakawa
Summary: By analyzing the immunological status of tumor antigen-specific CD8(+) T cells during tumor progression, it was found that NKG2D can control the fate and TOX expression of tumor-reacting CD8(+) T cells.
Editorial Material
Immunology
Tiani L. Louis, John T. Chang
Summary: In this study, Hirai et al. demonstrate the competition for the cytokine TGF beta as a key factor in regulating the persistence and occupancy of CD8(+) tissue-resident memory T cells in the skin epidermal niche.
Review
Immunology
Mercedes Beatriz Fuertes, Carolina Ines Domaica, Norberto Walter Zwirner
Summary: Immune checkpoint inhibitors have revolutionized immuno-oncology by achieving durable immune control of cancer, however, tumor immune evasion mechanisms pose a challenge for treatment development. Combination therapies targeting NK cell-activating receptors like NKG2D are emerging as frontrunners in immuno-oncology, with strategies to boost MICA/B expression and inhibit their shedding being proposed for enhancing antitumor immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Rebecca Harris, Mahinbanu Mammadli, Shannon Hiner, Liye Suo, Qi Yang, Jyoti Misra Sen, Mobin Karimi
Summary: Cancer immunotherapy relies on improving T cell effector functions against malignancies, but the biological functions of key transcription factors (TFs) in this process are not well understood. In this study, a murine model was utilized to investigate the role of TCF-1 in T cell response to cancer. The results showed that TCF-1 suppresses NKG2D expression on CD8 T cells and regulates critical molecules responsible for peripheral CD8 T cell effector functions.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Immunology
Vanaja Konduri, Damilola Oyewole-Said, Jonathan Vazquez-Perez, Scott A. Weldon, Matthew M. Halpert, Jonathan M. Levitt, William K. Decker
Summary: NK1.1 and its human homolog CD161 are expressed on various immune cells and play different roles in NK cells, T cells, and NKT cells. CD161-expressing CD8(+) T cells, initially studied in viral infections, have potential implications in tumor immunology, although their exact role is not well understood.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Eliza Mari Kwesi-Maliepaard, Heinz Jacobs, Fred van Leeuwen
Summary: T-AIM cells are a subset of memory T cells that develop memory features independently of antigen exposure. They exhibit characteristics similar to conventional memory cells, including antigen-specific responses and responsiveness to innate stimuli. T-AIM cells are suggested to provide additional levels of protection against infections and cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Yanhua Gao, Ira Bergman
Summary: Simple and reliable methods are needed to detect anti-tumor memory T-cells for clinical tumor vaccination. A mouse model of curative viral onco-immunotherapy showed that peritoneal tumor challenge can identify an oligoclonal anti-tumor memory CD4 and CD8 T-cell response. Different clonotypes were found among challenged animals, but were consistent in blood, spleen, and peritoneal cells of the same animal. These findings suggest that this methodology can be used to assess the effectiveness of tumor vaccines or therapeutic T-cell vaccines using blood and tissue sampling.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Ravikumar Muthuswamy, A. J. Robert McGray, Sebastiano Battaglia, Wenjun He, Anthony Miliotto, Cheryl Eppolito, Junko Matsuzaki, Tsuji Takemasa, Richard Koya, Thinle Chodon, Brian D. Lichty, Protul Shrikant, Kunle Odunsi
Summary: Resident memory CD8 T cells, characterized by their ability to reside in peripheral tissues, play a crucial role in adaptive sentinel activity and amplifying immune responses. The study focused on the chemotactic mechanisms governing the localization, retention, and residency of memory CD8 T cells in the ovarian tumor microenvironment. Results indicated that CXCR6 is a key marker for resident memory tumor-specific CD8 T cells, with its deficiency resulting in reduced retention in tumor tissues and poor control of ovarian cancer. Further research is needed to explore the potential of utilizing CXCR6 to enhance resident memory responses in cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederick J. Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that affects motor neurons and muscle control, with different gene mutations defining subtypes. A specific immune signature has been identified in ALS4 patients, potentially serving as a biomarker for disease progression.
Article
Multidisciplinary Sciences
Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederic Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jimenez-Alcazar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang, Albert R. La Spada, Ivan Marazzi
Summary: This study describes the presence of clonally expanded T-EMRA CD8 T cells in ALS4 knock-in mice and ALS4 patients, which may be related to disease progression and anti-glioma immunity. The results provide evidence for unraveling the disease mechanisms and serve as a potential biomarker of ALS4.
Article
Immunology
Marko Sustic, Maja Cokaric Brdovcak, Berislav Lisnic, Jelena Materljan, Vanda Juranic Lisnic, Carmen Rozmanic, Daniela Indenbirken, Lea Hirsl, Dirk H. Busch, Ilija Brizic, Astrid Krmpotic, Stipan Jonjic
Summary: CMV vectors have the potential to induce strong immune responses, with RAE-1 gamma MCMV showing enhanced immunoprotection against bacterial and tumor challenges. The phenotypic and functional characteristics of memory CD8 T cells induced by RAE-1 gamma MCMV were distinct compared to control vectors, with differences in cytokine production and cytotoxic potential. Adoptive transfer of cells primed with RAE-1 gamma MCMV led to efficient rejection of established tumors, highlighting the importance of latent infection and cell numbers in enhancing anti-tumor responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Frederick J. Kohlhapp, Jeremy A. O'Sullivan, Tamson V. Moore, Andrew Zloza, Jose A. Guevara-Patino
Summary: CD8 T cells are important for fighting intracellular pathogens and cancer. T cell-based vaccines aim to induce long-lasting and effective immune responses, particularly CD8 T cells that can produce multiple cytokines. NKG2D engagement on CD8 T cells enhances their effector response, shifting the balance from single to multiple cytokine production. This previously unrecognized process provides insights for improving immune responses.
MOLECULAR IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Seon-Hee Kim, Eunjung Cho, Yu Kim, Chungyong Han, Beom K. Choi, Byoung S. Kwon
Summary: The study demonstrates that post-conditioning treatment with anti-CD4 can enhance the anti-tumor efficacy of adoptive T cell therapy (ACT) by promoting the expansion of IL-18R alpha(hi) CD8(+) T cells. This combination treatment accelerates proliferation and differentiation of tumor-reactive CD8(+) T cells and improves tumor suppression and host survival. The enrichment of polyfunctional IL-18R alpha(hi) CD8(+) T cells plays a key role in the induced tumor suppression, mediated by IL-18 signaling and TCR-MHC I interaction.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Georgiana Toma, Ioana Maria Lemnian, Eliza Karapetian, Ivo Grosse, Barbara Seliger
Summary: Memory CD8(+) T cells increase with aging, leading to higher susceptibility to infections and decreased vaccine efficiency. In this study, the age-dependent expression profile of CD8(+) T cells from young and old donors was analyzed. The results showed that CD8(+)CD45RA(-) memory T cells from old donors maintained the characteristics of total CD8(+) T cells, including increased cytokine secretion and JAK-STAT pathway transcripts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Saeed Daneshmandi, Teresa Cassel, Penghui Lin, Richard M. Higashi, Gerburg M. Wulf, Vassiliki A. Boussiotis, Teresa W-M Fan, Pankaj Seth
Summary: Genetic ablation or pharmacologic inhibition of the PPP enzyme 6PGD enhances the generation of potent CD8(+) T effector cells, which show strong anti-tumor functions through metabolic reprogramming and balancing ROS production.
Article
Immunology
Emilia Rutkowski, Stefan Leibelt, Christina Born, Miriam E. Friede, Stefan Bauer, Sandra Weil, Joachim Koch, Alexander Steinle
JOURNAL OF IMMUNOLOGY
(2017)
Article
Immunology
Miriam E. Friede, Stefan Leibelt, Diana Dudziak, Alexander Steinle
JOURNAL OF IMMUNOLOGY
(2018)
Article
Oncology
Stefanie Maurer, Korbinian Nepomuk Kropp, Gerd Klein, Alexander Steinle, Sebastian P. Haen, Juliane S. Walz, Clemens Hinterleitner, Melanie Maerklin, Hans-Georg Kopp, Helmut Rainer Salih
Article
Oncology
Korbinian N. Kropp, Stefanie Maurer, Kathrin Rothfelder, Bastian J. Schmied, Kim L. Clar, Moritz Schmidt, Benedikt Strunz, Hans-Georg Kopp, Alexander Steinle, Frank Gruenebach, Susanne M. Rittig, Helmut R. Salih, Daniela Doerfel
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)
Article
Immunology
Sebastian Neuss, Yvonne Bartel, Christina Born, Sandra Weil, Joachim Koch, Christian Behrends, Meike Hoffmeister, Alexander Steinle
JOURNAL OF IMMUNOLOGY
(2018)
Article
Immunology
Tobias Zoeller, Mareike Wittenbrink, Meike Hoffmeister, Alexander Steinle
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Oncology
Francisca F. Almeida, Sara Tognarelli, Antoine Marcais, Andrew J. Kueh, Miriam E. Friede, Yang Liao, Simon N. Willis, Kylie Luong, Fabrice Faure, Francois E. Mercier, Justine Galluso, Matthew Firth, Emilie Narni-Mancinelli, Bushra Rais, David T. Scadden, Francesco Spallotta, Sandra Weil, Ariane Giannattasio, Franziska Kalensee, Tobias Zoeller, Nicholas D. Huntington, Ulrike Schleicher, Andreas G. Chiocchetti, Sophie Ugolini, Marco J. Herold, Wei Shi, Joachim Koch, Alexander Steinle, Eric Vivier, Thierry Walzer, Gabrielle T. Belz, Evelyn Ullrich
Review
Pharmacology & Pharmacy
Mariya Lazarova, Alexander Steinle
EXPERT OPINION ON THERAPEUTIC TARGETS
(2019)
Article
Multidisciplinary Sciences
Anna M. Paczulla, Kathrin Rothfelder, Simon Raffel, Martina Konantz, Julia Steinbacher, Hui Wang, Claudia Tandler, Marcelle Mbarga, Thorsten Schaefer, Mattia Falcone, Eva Nievergall, Daniela Dorfel, Pauline Hanns, Jakob R. Passweg, Christoph Lutz, Juerg Schwaller, Robert Zeiser, Bruce R. Blazar, Michael A. Caligiuri, Stephan Dirnhofer, Pontus Lundberg, Lothar Kanz, Leticia Quintanilla-Martinez, Alexander Steinle, Andreas Trumpp, Helmut R. Salih, Claudia Lengerke
Review
Immunology
Mariya Lazarova, Alexander Steinle
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Mariya Lazarova, Winfried S. Wels, Alexander Steinle
EXPERT OPINION ON BIOLOGICAL THERAPY
(2020)
Article
Immunology
Younghoon Kim, Christina Born, Mathieu Blery, Alexander Steinle
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Mariya Lazarova, Younghoon Kim, Alexander Steinle
Summary: The study examined the expression of ULBP4 in human peripheral blood mononuclear cells and monocytes, revealing that ULBP4 is not expressed by monocytes and likely not by other peripheral blood immune cells. This expression pattern is distinct from other human NKG2DL.
Article
Hematology
Berengere Salome, Alejandra Gomez-Cadena, Romain Loyon, Madeleine Suffiotti, Valentina Salvestrini, Tania Wyss, Giulia Vanoni, Dan Fu Ruan, Marianna Rossi, Alessandra Tozzo, Paolo Tentorio, Elena Bruni, Carsten Riether, Eva-Maria Jacobsen, Peter Jandus, Curdin Conrad, Manfred Hoenig, Ansgar Schulz, Katarzyna Michaud, Matteo Giovanni Della Porta, Silvia Salvatore, Ping-Chih Ho, David Gfeller, Adrian Ochsenbein, Domenico Mavilio, Antonio Curti, Emanuela Marcenaro, Alexander Steinle, Amir Horowitz, Pedro Romero, Sara Trabanelli, Camilla Jandus
Article
Oncology
Tobias Weiss, Hannah Schneider, Manuela Silginer, Alexander Steinle, Martin Pruschy, Bojan Polic, Michael Weller, Patrick Roth
CLINICAL CANCER RESEARCH
(2018)